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Ouabain modulates airway remodeling caused by Th2-high asthma in mice

https://doi.org/10.1016/j.intimp.2022.108808

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The Role of TGF‐β in Pulmonary Fibrosis

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Mitogen‐activated protein kinases and asthma

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InhaledCissampelos sympodialisDown‐Regulates Airway Allergic Reaction by Reducing Lung CD3+T Cells

inferredcites →https://doi.org/10.1007/s00011-017-1092-9openalex-snapshot

Ouabain attenuates ovalbumin-induced airway inflammation

inferredcites →https://doi.org/10.1007/s00436-012-3146-9openalex-snapshot

Immunomodulatory activity of ouabain in Leishmania leishmania amazonensis-infected Swiss mice

inferredcites →https://doi.org/10.1007/s00441-016-2566-8openalex-snapshot

Airway remodeling in asthma: what really matters

inferredcites →https://doi.org/10.1007/s10787-019-00602-8openalex-snapshot

Ouabain reduces the expression of the adhesion molecule CD18 in neutrophils

inferredcites →https://doi.org/10.1007/s10787-021-00882-zopenalex-snapshot

Ouabain inhibits p38 activation in mice neutrophils

inferredcites →https://doi.org/10.1007/s11010-006-9180-0openalex-snapshot

The effect of Na+-K+ ATPase inhibition by ouabain on histamine release from human cutaneous mast cells

inferredcites →https://doi.org/10.1016/j.anai.2014.04.011openalex-snapshot

High blood eosinophil count is associated with more frequent asthma attacks in asthma patients

inferredcites →https://doi.org/10.1016/j.cellbi.2008.07.012openalex-snapshot

Ouabain inhibits p38 activation in thymocytes

inferredcites →https://doi.org/10.1016/j.coi.2007.07.017openalex-snapshot

Cytokines and growth factors in airway remodeling in asthma

inferredcites →https://doi.org/10.1016/j.coi.2013.08.002openalex-snapshot

Th17-mediated inflammation in asthma

inferredcites →https://doi.org/10.1016/j.ejphar.2005.08.015openalex-snapshot

Induction of a late asthmatic response associated with airway inflammation in mice

inferredcites →https://doi.org/10.1016/j.expneurol.2013.04.008openalex-snapshot

Chronic asthma results in cognitive dysfunction in immature mice

inferredcites →https://doi.org/10.1016/j.imbio.2011.03.002openalex-snapshot

Modulation of mature B cells in mice following treatment with ouabain

inferredcites →https://doi.org/10.1016/j.imbio.2015.09.020openalex-snapshot

Dynamics of murine B lymphocytes is modulated by in vivo treatment with steroid ouabain

inferredcites →https://doi.org/10.1016/j.jaci.2003.09.047openalex-snapshot

Allergic rhinitis

inferredcites →https://doi.org/10.1016/j.jaci.2008.01.031openalex-snapshot

Immunologic and inflammatory mechanisms that drive asthma progression to remodeling

inferredcites →https://doi.org/10.1016/j.jaip.2014.09.004openalex-snapshot

The Allergic Asthma Phenotype

inferredcites →https://doi.org/10.1016/j.jneuroim.2014.06.005openalex-snapshot

Inhaled budesonide protects against chronic asthma-induced neuroinflammation in mouse brain

inferredcites →https://doi.org/10.1016/j.neuropharm.2013.06.006openalex-snapshot

Ouabain activates NFκB through an NMDA signaling pathway in cultured cerebellar cells

inferredcites →https://doi.org/10.1016/j.prrv.2019.08.002openalex-snapshot

Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes

inferredcites →https://doi.org/10.1016/j.rmed.2011.09.007openalex-snapshot

The role of mast cells in allergic inflammation

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The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells

inferredcites →https://doi.org/10.1038/cr.2009.5openalex-snapshot

TGF-β-induced epithelial to mesenchymal transition

inferredcites →https://doi.org/10.1038/nature07201openalex-snapshot

Origin and physiological roles of inflammation

inferredcites →https://doi.org/10.1038/nri2870openalex-snapshot

Functions of T cells in asthma: more than just TH2 cells

inferredcites →https://doi.org/10.1046/j.1365-3083.2003.01269.xopenalex-snapshot

Less Sensitivity for Late Airway Inflammation in Males than Females in BALB/c Mice

inferredcites →https://doi.org/10.1074/jbc.m808355200openalex-snapshot

Changes in Sodium Pump Expression Dictate the Effects of Ouabain on Cell Growth

inferredcites →https://doi.org/10.1091/mbc.e05-08-0735openalex-snapshot

Binding of Src to Na+/K+-ATPase Forms a Functional Signaling Complex

inferredcites →https://doi.org/10.1093/jmcb/mjr042openalex-snapshot

Inflammasome-IL-1-Th17 response in allergic lung inflammation

inferredcites →https://doi.org/10.1097/smj.0b013e3181b01c68openalex-snapshot

Management of Patients with Allergic Rhinitis and Asthma: Literature Review

inferredcites →https://doi.org/10.1111/cea.12712openalex-snapshot

Chronic inflammatory airway diseases: the central role of the epithelium revisited

inferredcites →https://doi.org/10.1111/cea.12897openalex-snapshot

The sensitization pattern differs according to rhinitis and asthma multimorbidity in adults: the EGEA study

inferredcites →https://doi.org/10.1111/j.1365-2222.2005.02362.xopenalex-snapshot

Female mice are more susceptible to the development of allergic airway inflammation than male mice

inferredcites →https://doi.org/10.1111/j.1749-6632.2008.03969.xopenalex-snapshot

Modulation of the Immune System by Ouabain

inferredcites →https://doi.org/10.1111/resp.13688openalex-snapshot

Reduced lung elastic recoil and fixed airflow obstruction in asthma

inferredcites →https://doi.org/10.1134/s0006297920040112openalex-snapshot

Ouabain and Marinobufagenin: Physiological Effects on Human Epithelial and Endothelial Cells

inferredcites →https://doi.org/10.1136/thx.54.3.268openalex-snapshot

How much asthma is really attributable to atopy?

inferredcites →https://doi.org/10.1146/annurev-physiol-021909-135725openalex-snapshot

The Physiological Significance of the Cardiotonic Steroid/Ouabain-Binding Site of the Na,K-ATPase

inferredcites →https://doi.org/10.1152/ajpcell.1993.264.6.c1367openalex-snapshot

Physiological effects of endogenous ouabain: control of intracellular Ca2+ stores and cell responsiveness

inferredcites →https://doi.org/10.1152/ajplung.00322.2015openalex-snapshot

Regulation of myofibroblast differentiation by cardiac glycosides

inferredcites →https://doi.org/10.1155/2010/318029openalex-snapshot

Airway Remodelling in Asthma: From Benchside to Clinical Practice

inferredcites →https://doi.org/10.1155/2011/912925openalex-snapshot

Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

inferredcites →https://doi.org/10.1155/2015/265798openalex-snapshot

Ouabain Modulates Zymosan‐Induced Peritonitis in Mice

inferredcites →https://doi.org/10.1161/atvbaha.110.221135openalex-snapshot

Signaling Mechanisms That Regulate Smooth Muscle Cell Differentiation

inferredcites →https://doi.org/10.1164/arrd.1987.135.2.433openalex-snapshot

Local allergen challenge and bronchoalveolar lavage of allergic asthmatic lungs. Description of the model and local airway inflammation.

inferredcites →https://doi.org/10.1183/09031936.00087506openalex-snapshot

Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms

inferredcites →https://doi.org/10.1186/1471-2466-6-s1-s5openalex-snapshot

Allergic rhinitis and asthma: inflammation in a one-airway condition

inferredcites →https://doi.org/10.1242/dmm.000323openalex-snapshot

Mouse models of allergic asthma: acute and chronic allergen challenge

inferredcites →https://doi.org/10.12659/msm.908627openalex-snapshot

Ouabain Protects Mice Against Lipopolysaccharide-Induced Acute Lung Injury

inferredcites →https://doi.org/10.1371/journal.pone.0168363openalex-snapshot

Downregulation of TGF-β Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase

inferredcites →https://doi.org/10.1378/chest.06-2434openalex-snapshot

Regulatory T Cells in Allergy and Asthma

inferredcites →https://doi.org/10.1513/pats.200808-089rmopenalex-snapshot

Remodeling in Asthma

inferredcites →https://doi.org/10.2174/156652408785161023openalex-snapshot

Airway Fibrosis and Angiogenesis due to Eosinophil Trafficking in Chronic Asthma

inferredcites →https://doi.org/10.2353/ajpath.2010.100019openalex-snapshot

Alveolar Macrophages Stimulate Enhanced Cytokine Production by Pulmonary CD4+ T-Lymphocytes in an Exacerbation of Murine Chronic Asthma

inferredcites →https://doi.org/10.3389/fped.2017.00117openalex-snapshot

Regulatory T Cells in Allergy and Asthma

inferredcites →https://doi.org/10.3389/fphys.2017.00895openalex-snapshot

Much More than a Cardiotonic Steroid: Modulation of Inflammation by Ouabain

inferredcites →https://doi.org/10.4049/jimmunol.165.10.5597openalex-snapshot

Cyclic AMP Activates p38 Mitogen-Activated Protein Kinase in Th2 Cells: Phosphorylation of GATA-3 and Stimulation of Th2 Cytokine Gene Expression

inferredcites →https://doi.org/10.4193/rhino15.300openalex-snapshot

Serum allergen-specific IgE, allergic rhinitis severity, and age

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Digoxin Derivative BD-8 Attenuates Oxidative Stress and Neuroinflammation in an LPS-Induced Experimental Model

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Group 2 innate lymphoid cells (ILC2s) in childhood allergic diseases: A review of the mechanisms and therapeutic advances

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Zika virus: Antiviral immune response, inflammation, and cardiotonic steroids as antiviral agents

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Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway

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Toxicarioside H-mediated modulation of the immune microenvironment attenuates ovalbumin-induced allergic airway inflammation by inhibiting NETosis

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Therapeutic potential of Platycodin D in allergic asthma through anti-inflammatory and anti-remodeling effects

inferred← citeshttps://doi.org/10.1016/j.ymthe.2024.12.021openalex-snapshot

Antiviral and immunomodulatory effects of ouabain against congenital Zika syndrome model

inferred← citeshttps://doi.org/10.1039/d5np00050eopenalex-snapshot

Cardiac glycosides: structural diversity, chemical ecology, bioactivity, and artificial synthesis

inferred← citeshttps://doi.org/10.1080/02770903.2024.2401537openalex-snapshot

Protective effects of Parkin knockout on asthma-induced changes in juvenile mice: inflammation, airway resistance, and oxidative stress

inferred← citeshttps://doi.org/10.1152/ajpcell.00273.2023openalex-snapshot

Sensational site: the sodium pump ouabain-binding site and its ligands

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Anti-allergic and anti-inflammatory effects of Gastrodia elata Blume extract in ovalbumin-induced asthma rat model

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The production, function, and clinical applications of IL-33 in type 2 inflammation-related respiratory diseases

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Na,K-ATPase mediated and cardiotonic induced signaling in health and disease

inferred← citeshttps://doi.org/10.3390/cells13181568openalex-snapshot

Evaluation of Anti-Inflammatory Activity of the New Cardiotonic Steroid γ-Benzylidene Digoxin 8 (BD-8) in Mice

inferred← citeshttps://doi.org/10.3390/jcm14124132openalex-snapshot

Cardiotonic Steroids as a Potential Novel Approach for Immunomodulation in Inflammatory Bowel Disease

inferred← citeshttps://doi.org/10.3390/microorganisms13020269openalex-snapshot

Evaluation of the Anti-Mycobacterial and Anti-Inflammatory Activities of the New Cardiotonic Steroid γ-Benzylidene Digoxin-15 in Macrophage Models of Infection

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