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Targeting STING for cancer immunotherapy: From mechanisms to translation

https://doi.org/10.1016/j.intimp.2022.109304

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00262-015-1713-5openalex-snapshot

STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice

inferredcites →https://doi.org/10.1007/s00262-019-02400-1openalex-snapshot

Activation of dendritic cells by targeted DNA: a potential addition to the armamentarium for anti-cancer immunotherapy

inferredcites →https://doi.org/10.1007/s00280-002-0529-0openalex-snapshot

Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

inferredcites →https://doi.org/10.1007/s10495-021-01669-xopenalex-snapshot

RETRACTED ARTICLE: The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells

inferredcites →https://doi.org/10.1007/s11010-020-03967-5openalex-snapshot

Activation of STING inhibits cervical cancer tumor growth through enhancing the anti-tumor immune response

inferredcites →https://doi.org/10.1007/s11426-019-9662-5openalex-snapshot

Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human stimulator of interferon genes (STING) variants

inferredcites →https://doi.org/10.1007/s12094-020-02519-zopenalex-snapshot

Cancer cell-intrinsic STING is associated with CD8 + T-cell infiltration and might serve as a potential immunotherapeutic target in hepatocellular carcinoma

inferredcites →https://doi.org/10.1007/s12274-022-4598-6openalex-snapshot

A prodrug nanoplatform via esterification of STING agonist and IDO inhibitor for synergistic cancer immunotherapy

inferredcites →https://doi.org/10.1016/bs.ai.2015.12.005openalex-snapshot

Combinatorial Cancer Immunotherapies

inferredcites →https://doi.org/10.1016/j.annonc.2020.08.712openalex-snapshot

598TiP A phase I/Ib dose-escalation study of intravenously administered SB 11285 alone and in combination with nivolumab in patients with advanced solid tumours

inferredcites →https://doi.org/10.1016/j.annonc.2020.10.559openalex-snapshot

71P A phase II study of ADU-S100 in combination with pembrolizumab in adult patients with PD-L1+ recurrent or metastatic HNSCC: Preliminary safety, efficacy and PK/PD results

inferredcites →https://doi.org/10.1016/j.bbrc.2005.01.093openalex-snapshot

3′,5′-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation

inferredcites →https://doi.org/10.1016/j.bbrc.2016.09.021openalex-snapshot

STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation

inferredcites →https://doi.org/10.1016/j.bpj.2017.10.027openalex-snapshot

Dynamic Structural Differences between Human and Mouse STING Lead to Differing Sensitivity to DMXAA

inferredcites →https://doi.org/10.1016/j.canlet.2017.10.032openalex-snapshot

The role of nitric oxide in metabolic regulation of Dendritic cell immune function

inferredcites →https://doi.org/10.1016/j.canlet.2019.02.029openalex-snapshot

STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity

inferredcites →https://doi.org/10.1016/j.ccell.2020.11.006openalex-snapshot

DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

inferredcites →https://doi.org/10.1016/j.cell.2013.07.023openalex-snapshot

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

inferredcites →https://doi.org/10.1016/j.cell.2013.08.014openalex-snapshot

Cyclic Dinucleotides and the Innate Immune Response

inferredcites →https://doi.org/10.1016/j.cellimm.2021.104384openalex-snapshot

STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer

inferredcites →https://doi.org/10.1016/j.celrep.2014.08.010openalex-snapshot

Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA

inferredcites →https://doi.org/10.1016/j.celrep.2015.01.039openalex-snapshot

Bruton’s Tyrosine Kinase Phosphorylates DDX41 and Activates Its Binding of dsDNA and STING to Initiate Type 1 Interferon Response

inferredcites →https://doi.org/10.1016/j.celrep.2015.04.031openalex-snapshot

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

inferredcites →https://doi.org/10.1016/j.celrep.2015.12.029openalex-snapshot

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

inferredcites →https://doi.org/10.1016/j.celrep.2018.11.047openalex-snapshot

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

inferredcites →https://doi.org/10.1016/j.celrep.2019.09.065openalex-snapshot

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

inferredcites →https://doi.org/10.1016/j.imbio.2013.07.007openalex-snapshot

The interferon response to intracellular DNA: Why so many receptors?

inferredcites →https://doi.org/10.1016/j.immuni.2013.07.012openalex-snapshot

Oncology Meets Immunology: The Cancer-Immunity Cycle

inferredcites →https://doi.org/10.1016/j.immuni.2013.10.019openalex-snapshot

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

inferredcites →https://doi.org/10.1016/j.immuni.2014.10.017openalex-snapshot

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

inferredcites →https://doi.org/10.1016/j.immuni.2014.10.019openalex-snapshot

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

inferredcites →https://doi.org/10.1016/j.immuni.2020.05.013openalex-snapshot

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

inferredcites →https://doi.org/10.1016/j.immuni.2021.04.019openalex-snapshot

The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

inferredcites →https://doi.org/10.1016/j.intimp.2020.106700openalex-snapshot

Mechanisms of immune escape in the cancer immune cycle

inferredcites →https://doi.org/10.1016/j.isci.2021.102519openalex-snapshot

Activation of cGAS/STING pathway upon paramyxovirus infection

inferredcites →https://doi.org/10.1016/j.it.2020.01.003openalex-snapshot

T Cell Co-stimulation and Functional Modulation by Innate Signals

inferredcites →https://doi.org/10.1016/j.jconrel.2015.08.026openalex-snapshot

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma

inferredcites →https://doi.org/10.1016/j.jconrel.2022.03.054openalex-snapshot

Systemic nano-delivery of low-dose STING agonist targeted to CD103+ dendritic cells for cancer immunotherapy

inferredcites →https://doi.org/10.1016/j.molcel.2013.05.022openalex-snapshot

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

inferredcites →https://doi.org/10.1016/j.molcel.2014.03.040openalex-snapshot

The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling

inferredcites →https://doi.org/10.1016/j.molcel.2018.07.034openalex-snapshot

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

inferredcites →https://doi.org/10.1016/j.molcel.2020.07.026openalex-snapshot

DNA Damage and Cancer Immunotherapy: A STING in the Tale

inferredcites →https://doi.org/10.1016/j.molimm.2017.12.001openalex-snapshot

STING, DCs and the link between innate and adaptive tumor immunity

inferredcites →https://doi.org/10.1016/j.molmed.2019.02.007openalex-snapshot

Pharmacological Modulation of the STING Pathway for Cancer Immunotherapy

inferredcites →https://doi.org/10.1016/j.semcancer.2021.03.036openalex-snapshot

Predictive biomarkers for response to immune checkpoint inhibition

inferredcites →https://doi.org/10.1016/j.trecan.2017.09.006openalex-snapshot

Migrating into the Tumor: a Roadmap for T Cells

inferredcites →https://doi.org/10.1016/j.vaccine.2019.07.019openalex-snapshot

The STING activator c-di-AMP exerts superior adjuvant properties than the formulation poly(I:C)/CpG after subcutaneous vaccination with soluble protein antigen or DEC-205-mediated antigen targeting to dendritic cells

inferredcites →https://doi.org/10.1016/s0140-6736(18)30789-xopenalex-snapshot

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

inferredcites →https://doi.org/10.1016/s0360-3016(98)00358-7openalex-snapshot

Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid

inferredcites →https://doi.org/10.1021/acs.chemrev.1c00750openalex-snapshot

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy

inferredcites →https://doi.org/10.1021/acs.jmedchem.0c01900openalex-snapshot

Structure–Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists

inferredcites →https://doi.org/10.1021/acs.jmedchem.1c01795openalex-snapshot

Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor

inferredcites →https://doi.org/10.1021/acs.jmedchem.1c01986openalex-snapshot

Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization

inferredcites →https://doi.org/10.1021/acs.jmedchem.1c02197openalex-snapshot

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer

inferredcites →https://doi.org/10.1021/acs.jmedchem.9b01567openalex-snapshot

Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists

inferredcites →https://doi.org/10.1021/cb400264nopenalex-snapshot

Anticancer Flavonoids Are Mouse-Selective STING Agonists

inferredcites →https://doi.org/10.1038/nature06013openalex-snapshot

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

inferredcites →https://doi.org/10.1038/nature10429openalex-snapshot

STING is a direct innate immune sensor of cyclic di-GMP

inferredcites →https://doi.org/10.1038/nature12305openalex-snapshot

Structural mechanism of cytosolic DNA sensing by cGAS

inferredcites →https://doi.org/10.1038/nature12306openalex-snapshot

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

inferredcites →https://doi.org/10.1038/nature12640openalex-snapshot

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

inferredcites →https://doi.org/10.1038/nature23890openalex-snapshot

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

inferredcites →https://doi.org/10.1038/nchembio.1661openalex-snapshot

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

inferredcites →https://doi.org/10.1038/ni.2091openalex-snapshot

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

inferredcites →https://doi.org/10.1038/ni.2118openalex-snapshot

STING-dependent signaling

inferredcites →https://doi.org/10.1038/ni.3558openalex-snapshot

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

inferredcites →https://doi.org/10.1038/nri3845openalex-snapshot

Type I interferons in anticancer immunity

inferredcites →https://doi.org/10.1038/nri3921openalex-snapshot

STING: infection, inflammation and cancer

inferredcites →https://doi.org/10.1038/s41418-019-0302-0openalex-snapshot

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

inferredcites →https://doi.org/10.1038/s41423-019-0341-yopenalex-snapshot

Targeting innate sensing in the tumor microenvironment to improve immunotherapy

inferredcites →https://doi.org/10.1038/s41435-018-0029-9openalex-snapshot

TMEM173 variants and potential importance to human biology and disease

inferredcites →https://doi.org/10.1038/s41467-017-00573-wopenalex-snapshot

Signalling strength determines proapoptotic functions of STING

inferredcites →https://doi.org/10.1038/s41467-022-28509-zopenalex-snapshot

RETRACTED ARTICLE: Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer

inferredcites →https://doi.org/10.1038/s41467-022-30568-1openalex-snapshot

STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer

inferredcites →https://doi.org/10.1038/s41565-018-0342-5openalex-snapshot

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

inferredcites →https://doi.org/10.1038/s41568-020-0285-7openalex-snapshot

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

inferredcites →https://doi.org/10.1038/s41573-018-0007-yopenalex-snapshot

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

inferredcites →https://doi.org/10.1038/s41576-019-0151-1openalex-snapshot

DNA sensing by the cGAS–STING pathway in health and disease

inferredcites →https://doi.org/10.1038/s41580-020-0244-xopenalex-snapshot

Molecular mechanisms and cellular functions of cGAS–STING signalling

inferredcites →https://doi.org/10.1038/s41586-018-0705-yopenalex-snapshot

Design of amidobenzimidazole STING receptor agonists with systemic activity

inferredcites →https://doi.org/10.1038/s41586-019-0998-5openalex-snapshot

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

inferredcites →https://doi.org/10.1038/s41586-019-1593-5openalex-snapshot

Harnessing innate immunity in cancer therapy

inferredcites →https://doi.org/10.1038/sj.bjc.6600992openalex-snapshot

Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent

inferredcites →https://doi.org/10.1038/srep19049openalex-snapshot

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response

inferredcites →https://doi.org/10.1038/srep39858openalex-snapshot

Decreased expression of STING predicts poor prognosis in patients with gastric cancer

inferredcites →https://doi.org/10.1073/pnas.1222694110openalex-snapshot

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

inferredcites →https://doi.org/10.1073/pnas.1512832112openalex-snapshot

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

inferredcites →https://doi.org/10.1073/pnas.1621363114openalex-snapshot

cGAS is essential for the antitumor effect of immune checkpoint blockade

inferredcites →https://doi.org/10.1073/pnas.1919690117openalex-snapshot

Selective reactivation of STING signaling to target Merkel cell carcinoma

inferredcites →https://doi.org/10.1073/pnas.2013598118openalex-snapshot

Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma

inferredcites →https://doi.org/10.1080/15384101.2022.2029996openalex-snapshot

STING agonist enhances the efficacy of programmed death-ligand 1 monoclonal antibody in breast cancer immunotherapy by activating the interferon-β signalling pathway

inferredcites →https://doi.org/10.1080/2162402x.2020.1777624openalex-snapshot

Trial watch: STING agonists in cancer therapy

inferredcites →https://doi.org/10.1080/23723556.2018.1558682openalex-snapshot

cGAS-independent STING activation in response to DNA damage

inferredcites →https://doi.org/10.1093/annonc/mdw217openalex-snapshot

Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

inferredcites →https://doi.org/10.1097/cji.0000000000000195openalex-snapshot

CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS- and STING-dependent Maturation

inferredcites →https://doi.org/10.1111/imm.13482openalex-snapshot

cGAS modulates cytokine secretion and bacterial burdens by altering the release of mitochondrial DNA in pseudomonas pulmonary infection

inferredcites →https://doi.org/10.1126/science.1229963openalex-snapshot

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

inferredcites →https://doi.org/10.1126/science.1232458openalex-snapshot

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

inferredcites →https://doi.org/10.1126/science.aar4060openalex-snapshot

Cancer immunotherapy using checkpoint blockade

inferredcites →https://doi.org/10.1126/science.aat1022openalex-snapshot

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

inferredcites →https://doi.org/10.1126/science.aba6098openalex-snapshot

An orally available non-nucleotide STING agonist with antitumor activity

inferredcites →https://doi.org/10.1126/science.abb4255openalex-snapshot

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

inferredcites →https://doi.org/10.1126/sciimmunol.aaz2738openalex-snapshot

NK cells mediate clearance of CD8 + T cell–resistant tumors in response to STING agonists

inferredcites →https://doi.org/10.1126/scisignal.2002521openalex-snapshot

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

inferredcites →https://doi.org/10.1126/scitranslmed.aay9013openalex-snapshot

cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

inferredcites →https://doi.org/10.1136/jitc-2019-000282openalex-snapshot

Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma

inferredcites →https://doi.org/10.1136/jitc-2020-002195openalex-snapshot

STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer

inferredcites →https://doi.org/10.1136/jitc-2021-003246openalex-snapshot

High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege

inferredcites →https://doi.org/10.1136/jitc-2021-003459openalex-snapshot

CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T H 1 and T H 9 cells

inferredcites →https://doi.org/10.1136/jitc-2021-003960openalex-snapshot

Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy

inferredcites →https://doi.org/10.1136/jitc-2021-sitc2021.495openalex-snapshot

495 Trial of SNX281, a systemically delivered small molecule STING agonist, in solid tumors and lymphomas

inferredcites →https://doi.org/10.1146/annurev-immunol-032713-120231openalex-snapshot

Interferon-Stimulated Genes: A Complex Web of Host Defenses

inferredcites →https://doi.org/10.1158/0008-5472.can-15-1885openalex-snapshot

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-1939openalex-snapshot

5,6-Dimethylxanthenone-4-Acetic Acid in the Treatment of Refractory Tumors: a Phase I Safety Study of a Vascular Disrupting Agent

inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-1362openalex-snapshot

Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer

inferredcites →https://doi.org/10.1158/1078-0432.ccr-21-1963openalex-snapshot

Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas

inferredcites →https://doi.org/10.1158/1535-7163.mct-21-0780openalex-snapshot

Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non–Muscle Invasive Murine Bladder Cancer

inferredcites →https://doi.org/10.1158/1538-7445.am2019-4456openalex-snapshot

Abstract 4456: Discovery of E7766: A representative of a novel class of macrocycle-bridged STING agonists (MBSAs) with superior potency and pan-genotypic activity

inferredcites →https://doi.org/10.1158/1538-7445.am2021-1738openalex-snapshot

Abstract 1738: XMT-2056, a well-tolerated, Immunosynthen-based STING-agonist antibody-drug conjugate which induces anti-tumor immune activity

inferredcites →https://doi.org/10.1158/1538-7445.am2021-ct217openalex-snapshot

Abstract CT217: Phase I, first-in-human trial evaluating BI 1387446 (STING agonist) alone and in combination with ezabenlimab (BI 754091; anti-PD-1) in solid tumors

inferredcites →https://doi.org/10.1158/1538-7445.am2022-3503openalex-snapshot

Abstract 3503: XMT-2056, a HER2-targeted Immunosynthen STING-agonist antibody-drug conjugate, binds a novel epitope of HER2 and shows increased anti-tumor activity in combination with trastuzumab and pertuzumab

inferredcites →https://doi.org/10.1158/1541-7786.mcr-18-0504openalex-snapshot

Ovarian Cancer Cells Commonly Exhibit Defective STING Signaling Which Affects Sensitivity to Viral Oncolysis

inferredcites →https://doi.org/10.1158/2326-6066.cir-13-0123openalex-snapshot

STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer

inferredcites →https://doi.org/10.1158/2326-6066.cir-17-0581openalex-snapshot

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

inferredcites →https://doi.org/10.1158/2326-6066.cir-19-0229openalex-snapshot

STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity

inferredcites →https://doi.org/10.1167/iovs.08-2068openalex-snapshot

Transient Retinal Effects of 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA, ASA404), an Antitumor Vascular-Disrupting Agent in Phase I Clinical Trials

inferredcites →https://doi.org/10.1172/jci125413openalex-snapshot

STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

inferredcites →https://doi.org/10.1186/s40425-019-0573-5openalex-snapshot

STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models

inferredcites →https://doi.org/10.1200/jco.2011.35.0660openalex-snapshot

Randomized Phase III Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the Vascular Disrupting Agent Vadimezan (ASA404) in Advanced Non–Small-Cell Lung Cancer

inferredcites →https://doi.org/10.1371/journal.pone.0077846openalex-snapshot

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides

inferredcites →https://doi.org/10.1515/hsz-2020-0367openalex-snapshot

DDX41: a multifunctional DEAD-box protein involved in pre-mRNA splicing and innate immunity

inferredcites →https://doi.org/10.26508/lsa.201800282openalex-snapshot

Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

inferredcites →https://doi.org/10.3389/fimmu.2020.00238openalex-snapshot

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H

inferredcites →https://doi.org/10.3389/fimmu.2020.02090openalex-snapshot

Tumor-Derived cGAMP Regulates Activation of the Vasculature

inferredcites →https://doi.org/10.3389/fimmu.2021.771201openalex-snapshot

Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review

inferredcites →https://doi.org/10.3389/fonc.2020.00896openalex-snapshot

Activation of STING by cGAMP Regulates MDSCs to Suppress Tumor Metastasis via Reversing Epithelial-Mesenchymal Transition

inferredcites →https://doi.org/10.3390/ijms20061445openalex-snapshot

Differential Regulation of Type I and Type III Interferon Signaling

inferredcites →https://doi.org/10.3390/jcm11030865openalex-snapshot

The Potential Cardiotoxicity of Immune Checkpoint Inhibitors

inferredcites →https://doi.org/10.3390/v14040666openalex-snapshot

The Interplay between Viruses and Host DNA Sensors

inferredcites →https://doi.org/10.3390/vaccines9020138openalex-snapshot

Targeting Innate Immunity in Cancer Therapy

inferredcites →https://doi.org/10.4049/jimmunol.1300097openalex-snapshot

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

inferredcites →https://doi.org/10.4049/jimmunol.1401869openalex-snapshot

STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells

inferredcites →https://doi.org/10.4049/jimmunol.1601585openalex-snapshot

The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele

inferredcites →https://doi.org/10.4049/jimmunol.1601694openalex-snapshot

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity

inferredcites →https://doi.org/10.4049/jimmunol.1601999openalex-snapshot

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

inferredcites →https://doi.org/10.4049/jimmunol.174.8.4465openalex-snapshot

Cutting Edge: Type I IFNs Provide a Third Signal to CD8 T Cells to Stimulate Clonal Expansion and Differentiation

inferredcites →https://doi.org/10.7150/ijbs.65019openalex-snapshot

Rocaglamide promotes the infiltration and antitumor immunity of NK cells by activating cGAS-STING signaling in non-small cell lung cancer

inferredcites →https://doi.org/10.7150/jca.32806openalex-snapshot

STING signaling is a potential immunotherapeutic target in colorectal cancer

inferredcites →https://doi.org/10.7150/thno.37574openalex-snapshot

STING activation in cancer immunotherapy

inferredcites →https://doi.org/10.7150/thno.37745openalex-snapshot

Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells

inferredcites →https://doi.org/10.7554/elife.00047openalex-snapshot

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Selective BCL-2 inhibitor triggers STING-dependent antitumor immunity via inducing mtDNA release

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Single-cell transcriptome analysis profiles the expression features of TMEM173 in BM cells of high-risk B-cell acute lymphoblastic leukemia

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Additional file 1 of Single-cell transcriptome analysis profiles the expression features of TMEM173 in BM cells of high-risk B-cell acute lymphoblastic leukemia

inferred← citeshttps://doi.org/10.6084/m9.figshare.22688597openalex-snapshot

Additional file 2 of Single-cell transcriptome analysis profiles the expression features of TMEM173 in BM cells of high-risk B-cell acute lymphoblastic leukemia

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The cGAS-STING Pathway: Insights into Regulatory Mechanisms, Disease Dysregulation, and Therapeutic Development

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