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Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jnr.490240111openalex-snapshot
Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brain
inferredcites →https://doi.org/10.1016/0006-8993(90)90024-6openalex-snapshot
Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain
inferredcites →https://doi.org/10.1016/0028-3908(92)90058-wopenalex-snapshot
Antioxidant and free radical scavenging activities of Gastrodia elata Bl. and Uncaria rhynchophylla (Miq.) Jacks
inferredcites →https://doi.org/10.1016/0031-9422(94)00771-kopenalex-snapshot
Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia
inferredcites →https://doi.org/10.1016/0092-8674(88)90147-xopenalex-snapshot
c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
inferredcites →https://doi.org/10.1016/0301-0082(92)90023-8openalex-snapshot
Experimental complex partial seizures induced by a microinjection of kainic acid into limbic structures
inferredcites →https://doi.org/10.1016/0306-4522(80)90181-5openalex-snapshot
Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study
inferredcites →https://doi.org/10.1016/0306-4522(84)90288-4openalex-snapshot
Maturation of kainic acid seizure-brain damage syndrome in the rat. i. clinical, electrographic and metabolic observations
inferredcites →https://doi.org/10.1016/0306-4522(85)90299-4openalex-snapshot
Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
inferredcites →https://doi.org/10.1016/0306-4522(96)00053-xopenalex-snapshot
Long-term expression of the 35,000 mol. wt fos-related antigen in rat brain after kainic acid treatment
inferredcites →https://doi.org/10.1016/j.yebeh.2005.12.009openalex-snapshot
Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions
inferredcites →https://doi.org/10.1016/s0006-8993(97)00744-0openalex-snapshot
Characterization of the long-lasting activator protein-1 complex induced by kainic acid treatment
inferredcites →https://doi.org/10.1016/s0024-3205(00)00706-2openalex-snapshot
Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats
inferredcites →https://doi.org/10.1016/s0024-3205(99)00473-7openalex-snapshot
Anticonvulsive and free radical scavenging actions of two herbs, Uncaria rhynchophylla (Miq) jack and Gastrodia elata Bl., in kainic acid-treated rats
inferredcites →https://doi.org/10.1016/s0026-895x(25)11251-0openalex-snapshot
In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.
inferredcites →https://doi.org/10.1016/s0169-328x(97)00067-3openalex-snapshot
The effect of cycloheximide on the regulation of proenkephalin and prodynorphin gene expressions induced by kainic acid in rat hippocampus
inferredcites →https://doi.org/10.1016/s0301-0082(99)00042-8openalex-snapshot
JNK and p38 stresskinases — degenerative effectors of signal-transduction-cascades in the nervous system
inferredcites →https://doi.org/10.1016/s0304-3940(01)02296-0openalex-snapshot
Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus
inferredcites →https://doi.org/10.1016/s0378-8741(00)00313-5openalex-snapshot
4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain
inferredcites →https://doi.org/10.1016/s0891-5849(00)00219-7openalex-snapshot
The JNK and P38 MAP kinase signaling pathways in T cell–mediated immune responses44This team of investigators has contributed extensively to the field of MAP kinase signal transduction in thymocyte and T cell differentiation.
inferredcites →https://doi.org/10.1016/s1016-8478(23)17017-8openalex-snapshot
Possible Roles of JNK Pathway in the Regulation of Hippocampal Proenkephalin and Immediate Early Gene Expression Induced by Kainic Acid
inferredcites →https://doi.org/10.1038/363166a0openalex-snapshot
Continuous c-fos expression precedes programmed cell death in vivo
inferredcites →https://doi.org/10.1038/39899openalex-snapshot
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
inferredcites →https://doi.org/10.1073/pnas.94.17.9422openalex-snapshot
A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year
inferredcites →https://doi.org/10.1080/15216540500097111openalex-snapshot
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
inferredcites →https://doi.org/10.1111/j.1471-4159.1990.tb04892.xopenalex-snapshot
Chronic Electroconvulsive Seizures Down–Regulate Expression of the Immediate‐Early Genes c‐fos and c‐jun in Rat Cerebral Cortex
inferredcites →https://doi.org/10.1111/j.1471-4159.1993.tb05839.xopenalex-snapshot
Kainate‐Induced Changes in Opioid Peptide Genes and AP‐1 Protein Expression in the Rat Hippocampus
inferredcites →https://doi.org/10.1111/j.1745-4522.2002.tb00206.xopenalex-snapshot
ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITIES OF EDIBLE MUSHROOMS
inferredcites →https://doi.org/10.1126/science.3037702openalex-snapshot
Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
inferredcites →https://doi.org/10.1128/mcb.14.9.5997openalex-snapshot
Activation of AP-1 and of a Nuclear Redox Factor, Ref-1, in the Response of HT29 Colon Cancer Cells to Hypoxia
inferredcites →https://doi.org/10.1142/s0192415x01000356openalex-snapshot
Anticonvulsive and Free Radical Scavenging Activities of Gastrodia elata Bl. in Kainic Acid-Treated Rats
inferredcites →https://doi.org/10.1142/s0192415x0500320xopenalex-snapshot
Gastrodia elataBL Mediates the Suppression of nNOS and Microglia Activation to Protect Against Neuronal Damage in Kainic Acid-Treated Rats
inferredcites →https://doi.org/10.1248/bpb.28.1016openalex-snapshot
Gastrodia elata Blume and an Active Component, p-Hydroxybenzyl Alcohol Reduce Focal Ischemic Brain Injury through Antioxidant Related Gene Expressions
inferredcites →https://doi.org/10.1248/bpb.29.261openalex-snapshot
Anxiolytic-Like Effects of Gastrodia elata and Its Phenolic Constituents in Mice
inferredcites →https://doi.org/10.1254/jphs.91.177openalex-snapshot
Stress and Vascular Responses: Mitogen-Activated Protein Kinases and Activator Protein-1 as Promising Therapeutic Targets of Vascular Remodeling
inferredcites →https://doi.org/10.1523/jneurosci.14-07-03998.1994openalex-snapshot
Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment
inferredcites →https://doi.org/10.18926/amo/32111openalex-snapshot
Natural antioxidants may prevent posttraumatic epilepsy: a proposal based on experimental animal studies.
inferredcites →https://doi.org/10.3760/cma.j.issn.1001-9391.2003.02.016openalex-snapshot
The antagonistic action of Gastrodia elata combined with E-gelatin on lead-induced down regulation of c-fos expression in rat brain
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4020822openalex-extracted
The Mechanism Study of YZG-331 on Sedative and Hypnotic Effect
inferred← citeshttps://doi.org/10.1002/epi4.12372openalex-snapshot
The antiepileptic effect of Gastrodiae Rhizoma through modulating overexpression of mTOR and attenuating astrogliosis in pilocarpine mice model
inferred← citeshttps://doi.org/10.1007/s10528-020-09983-wopenalex-snapshot
De Novo Assembly and Annotation of the Juvenile Tuber Transcriptome of a Gastrodia elata Hybrid by RNA Sequencing: Detection of SSR Markers
inferred← citeshttps://doi.org/10.1007/s11064-014-1453-5openalex-snapshot
Effects of Pentylenetetrazole Kindling on Mitogen-Activated Protein Kinases Levels in Neocortex and Hippocampus of Mice
inferred← citeshttps://doi.org/10.1007/s11094-017-1584-5openalex-snapshot
The Chemical Composition, Pharmacological Effects, Clinical Applications and Market Analysis of Gastrodia Elata
inferred← citeshttps://doi.org/10.1007/s13659-019-0213-2openalex-snapshot
Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata
inferred← citeshttps://doi.org/10.1016/j.bbr.2022.113885openalex-snapshot
The mechanism study of YZG-331 on sedative and hypnotic effects
inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.01.179openalex-snapshot
Gastrodin inhibits osteoclastogenesis via down-regulating the NFATc1 signaling pathway and stimulates osseointegration in vitro
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2022.03.037openalex-snapshot
Sequential gastrodin release PU/n-HA composite scaffolds reprogram macrophages for improved osteogenesis and angiogenesis
inferred← citeshttps://doi.org/10.1016/j.bone.2014.12.059openalex-snapshot
Gastrodin: An ancient Chinese herbal medicine as a source for anti-osteoporosis agents via reducing reactive oxygen species
inferred← citeshttps://doi.org/10.1016/j.chroma.2008.01.011openalex-snapshot
Evaluation of the extraction efficiency of thermally labile bioactive compounds in Gastrodia elata Blume by pressurized hot water extraction and microwave-assisted extraction
inferred← citeshttps://doi.org/10.1016/j.eplepsyres.2020.106376openalex-snapshot
Herb-drug interaction of gastrodiae rhizoma on carbamazepine: A pharmacokinetic study in rats
inferred← citeshttps://doi.org/10.1016/j.jchromb.2010.05.034openalex-snapshot
Determination and pharmacokinetics of gastrodin in human plasma by HPLC coupled with photodiode array detector
inferred← citeshttps://doi.org/10.1016/j.jep.2011.11.048openalex-snapshot
Modulation of LPS-stimulated neuroinflammation in BV-2 microglia by Gastrodia elata: 4-Hydroxybenzyl alcohol is the bioactive candidate
inferred← citeshttps://doi.org/10.1016/j.jep.2016.02.001openalex-snapshot
Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling
inferred← citeshttps://doi.org/10.1016/j.jep.2016.06.057openalex-snapshot
The rhizome of Gastrodia elata Blume – An ethnopharmacological review
inferred← citeshttps://doi.org/10.1016/j.jfda.2015.02.006openalex-snapshot
Method development and validation for the high-performance liquid chromatography assay of gastrodin in water extracts from different sources of Gastrodia elata Blume
inferred← citeshttps://doi.org/10.1016/j.mcp.2025.102035openalex-snapshot
Gastrodin promotes osteogenic differentiation by stimulating the Wnt/β-catenin signaling pathway
inferred← citeshttps://doi.org/10.1016/j.phymed.2008.02.012openalex-snapshot
Determination and pharmacokinetics of gastrodin and p-hydroxybenzylalcohol after oral administration of Gastrodia elata Bl. extract in rats by high-performance liquid chromatography–electrospray ionization mass spectrometric method
inferred← citeshttps://doi.org/10.1016/j.phymed.2016.09.001openalex-snapshot
Gastrodia elata and epilepsy: Rationale and therapeutic potential
inferred← citeshttps://doi.org/10.1016/s0254-6272(15)30158-8openalex-snapshot
Neuroprotective effect of ethyl acetate extract from gastrodia elata against transient focal cerebral ischemia in rats induced by middle cerebral artery occlusion
inferred← citeshttps://doi.org/10.1016/s2225-4110(16)30054-2openalex-snapshot
Gastrodiae Rhizoma (天麻 tiān má): a review of biological activity and antidepressant mechanisms
inferred← citeshttps://doi.org/10.1021/jf503132copenalex-snapshot
Down-regulation of Slit–Robo Pathway Mediating Neuronal Cytoskeletal Remodeling Processes Facilitates the Antidepressive-like Activity of Gastrodia elata Blume
inferred← citeshttps://doi.org/10.1039/c8ra01972jopenalex-snapshot
4-Hydroxybenzyl alcohol derivatives and their sedative–hypnotic activities
inferred← citeshttps://doi.org/10.1080/10799893.2019.1590410openalex-snapshot
The c-Jun N-terminal kinase signaling pathway in epilepsy: activation, regulation, and therapeutics
inferred← citeshttps://doi.org/10.1097/ana.0b013e3181667c27openalex-snapshot
Glutamate-induced c-Jun Expression in Neuronal PC12 Cells
inferred← citeshttps://doi.org/10.1097/wco.0b013e3282f47918openalex-snapshot
Complementary and alternative medical therapies
inferred← citeshttps://doi.org/10.1111/j.1460-9568.2010.07158.xopenalex-snapshot
c‐Jun N‐terminal kinase signaling pathway in excitotoxic cell death following kainic acid‐induced status epilepticus
inferred← citeshttps://doi.org/10.1142/s0192415x08005618openalex-snapshot
The Antidepressant Effect ofGastrodia elataBl. on the Forced-Swimming Test in Rats
inferred← citeshttps://doi.org/10.1142/s0192415x09006898openalex-snapshot
Uncaria rhynchophyllaandRhynchophyllineInhibit c-Jun N-Terminal Kinase Phosphorylation and Nuclear Factor-κB Activity in Kainic Acid-Treated Rats
inferred← citeshttps://doi.org/10.1155/2013/514095openalex-snapshot
Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model
inferred← citeshttps://doi.org/10.1155/2015/309261openalex-snapshot
Neuropharmacological Potential ofGastrodia elataBlume and Its Components
inferred← citeshttps://doi.org/10.1155/2022/9539944openalex-snapshot
Analysis of Medication Rule of Primary Epilepsy Based on Xiaocheng Yan’s Clinical Experience Collection of Epilepsy
inferred← citeshttps://doi.org/10.1159/000362637openalex-snapshot
Influence of Xingnaojing Injection on the Expression of c-fos and c-jun Proteins in Brains of Rats in a Kindling Model of Epilepsy Chronically Induced by Pentetrazol
inferred← citeshttps://doi.org/10.1186/s12871-022-01915-yopenalex-snapshot
Gastrodin improves neuroinflammation-induced cognitive dysfunction in rats by regulating NLRP3 inflammasome
inferred← citeshttps://doi.org/10.1186/s13020-025-01088-zopenalex-snapshot
New advances in Traditional Chinese Medicine interventions for epilepsy: where are we and what do we know?
inferred← citeshttps://doi.org/10.1186/s40543-020-00211-zopenalex-snapshot
A simplified LC−MS/MS approach for simultaneous quantification and pharmacokinetics of five compounds in rats following oral administration of Gastrodia elata extract
inferred← citeshttps://doi.org/10.1371/journal.pone.0150647openalex-snapshot
Simultaneous Qualitative Assessment and Quantitative Analysis of Metabolites (Phenolics, Nucleosides and Amino Acids) from the Roots of Fresh Gastrodia elata Using UPLC-ESI-Triple Quadrupole Ion MS and ESI- Linear Ion Trap High-Resolution MS
inferred← citeshttps://doi.org/10.14406/acu.2022.029openalex-snapshot
Proteomic Analysis for Neuroprotective Effect of Gastrodia elata Blume in the Substantia Nigra of Mice
inferred← citeshttps://doi.org/10.14670/hh-18-239openalex-snapshot
Microglia mediated neuroinflammation - signaling regulation and therapeutic considerations with special reference to some natural compounds.
inferred← citeshttps://doi.org/10.18926/amo/46853openalex-snapshot
Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains.
inferred← citeshttps://doi.org/10.2174/1874091x01206010056openalex-snapshot
Tianma Modulates Blood Vessel Tonicity
inferred← citeshttps://doi.org/10.32598/ppj.25.1.80openalex-snapshot
Anticonvulsant effect of acute curcumin nanoparticle on pentylenetetrazole-induced seizures in mice: non-involvement of JNK restoration
inferred← citeshttps://doi.org/10.3389/fneur.2025.1574277openalex-snapshot
Neuropharmacological effects of Gastrodia elata Blume and its active ingredients
inferred← citeshttps://doi.org/10.3389/fnins.2021.682821openalex-snapshot
Chinese Herbal Medicine for Treating Epilepsy
inferred← citeshttps://doi.org/10.3389/fphar.2025.1641443openalex-snapshot
From molecules to medicine: a systematic review of Gastrodia elata’s bioactive metabolites and therapeutic potential
inferred← citeshttps://doi.org/10.3390/jof12080614openalex-snapshot
Research Advances in Gastrodia elata Endophytes: Diversity, Secondary Metabolites and Pharmacological Activities
inferred← citeshttps://doi.org/10.3390/molecules24132436openalex-snapshot
Gastrodia elata Blume Polysaccharides: A Review of Their Acquisition, Analysis, Modification, and Pharmacological Activities
inferred← citeshttps://doi.org/10.3390/molecules26154443openalex-snapshot
Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota
inferred← citeshttps://doi.org/10.4103/0973-1296.211027openalex-snapshot
Anti-epileptic effects of valepotriate isolated from Valeriana jatamansi jones and its possible mechanisms
inferred← citeshttps://doi.org/10.4236/ajac.2013.48050openalex-snapshot
Pressurized Hot Water Extraction of Alkaloids in Goldenseal
inferred← citeshttps://doi.org/10.5530/pc.2012.suppl1.2openalex-snapshot
Plants and Plant Products with Potential Anticonvulsant Activity – A Review
inferred← citeshttps://doi.org/10.6116/kjh.2016.31.2.21.openalex-snapshot
Systemic Review on The Research Trend of Gastrodiae Rhizoma and Relationship Between the Herbology and KCD-code
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