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HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

https://doi.org/10.1016/j.molcel.2016.03.008

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones

inferred← citeshttps://doi.org/10.1038/s41467-021-23800-xopenalex-snapshot

Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition

inferred← citeshttps://doi.org/10.1038/s41467-021-24361-9openalex-snapshot

Serine-linked PARP1 auto-modification controls PARP inhibitor response

inferred← citeshttps://doi.org/10.1038/s41467-021-24723-3openalex-snapshot

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

inferred← citeshttps://doi.org/10.1038/s41467-021-26172-4openalex-snapshot

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome

inferred← citeshttps://doi.org/10.1038/s41467-021-26691-0openalex-snapshot

Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining

inferred← citeshttps://doi.org/10.1038/s41467-021-27043-8openalex-snapshot

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

inferred← citeshttps://doi.org/10.1038/s41467-021-27867-4openalex-snapshot

Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones

inferred← citeshttps://doi.org/10.1038/s41467-022-30785-8openalex-snapshot

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration

inferred← citeshttps://doi.org/10.1038/s41467-022-33731-wopenalex-snapshot

Mammalian N1-adenosine PARylation is a reversible DNA modification

inferred← citeshttps://doi.org/10.1038/s41467-023-38793-yopenalex-snapshot

Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling

inferred← citeshttps://doi.org/10.1038/s41467-023-44209-8openalex-snapshot

Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation

inferred← citeshttps://doi.org/10.1038/s41467-024-45237-8openalex-snapshot

Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1

inferred← citeshttps://doi.org/10.1038/s41467-024-48314-0openalex-snapshot

Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG

inferred← citeshttps://doi.org/10.1038/s41467-024-50158-7openalex-snapshot

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks

inferred← citeshttps://doi.org/10.1038/s41467-024-50912-xopenalex-snapshot

PARP1-dependent DNA-protein crosslink repair

inferred← citeshttps://doi.org/10.1038/s41467-025-56085-5openalex-snapshot

CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair

inferred← citeshttps://doi.org/10.1038/s41467-025-58309-0openalex-snapshot

FTO suppresses DNA repair by inhibiting PARP1

inferred← citeshttps://doi.org/10.1038/s41467-025-61834-7openalex-snapshot

Single nucleosome imaging reveals principles of transient multiscale chromatin reorganization triggered by histone ADP-ribosylation at DNA lesions

inferred← citeshttps://doi.org/10.1038/s41467-026-71311-4openalex-snapshot

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling

inferred← citeshttps://doi.org/10.1038/s41467-026-73677-xopenalex-snapshot

Deciphering cytokine-driven ADP-ribosylation signaling networks via Af1521-based mass spectrometry analysis of labile Glu/Asp-linkages

inferred← citeshttps://doi.org/10.1038/s41556-021-00792-wopenalex-snapshot

XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair

inferred← citeshttps://doi.org/10.1038/s41556-021-00807-6openalex-snapshot

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin

inferred← citeshttps://doi.org/10.1038/s41573-020-0076-6openalex-snapshot

Poly(ADP-ribose) polymerase inhibition: past, present and future

inferred← citeshttps://doi.org/10.1038/s41580-018-0029-7openalex-snapshot

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

inferred← citeshttps://doi.org/10.1038/s41580-021-00394-2openalex-snapshot

Cellular functions of the protein kinase ATM and their relevance to human disease

inferred← citeshttps://doi.org/10.1038/s41586-020-2013-6openalex-snapshot

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

inferred← citeshttps://doi.org/10.1038/s41586-020-2725-7openalex-snapshot

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

inferred← citeshttps://doi.org/10.1038/s41586-025-09414-zopenalex-snapshot

NASP modulates histone turnover to drive PARP inhibitor resistance

inferred← citeshttps://doi.org/10.1038/s41589-018-0097-1openalex-snapshot

Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

inferred← citeshttps://doi.org/10.1038/s41589-025-01974-5openalex-snapshot

Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation

inferred← citeshttps://doi.org/10.1038/s41589-025-02045-5openalex-snapshot

Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage

inferred← citeshttps://doi.org/10.1038/s41594-020-0412-xopenalex-snapshot

Tickling PARPs into serine action

inferred← citeshttps://doi.org/10.1038/s41594-023-00977-xopenalex-snapshot

HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage

inferred← citeshttps://doi.org/10.1038/s41594-023-00987-9openalex-snapshot

PARP1 and HPF1 team up to flag down DNA-repair machinery

inferred← citeshttps://doi.org/10.1038/s41594-024-01279-6openalex-snapshot

Deregulated DNA ADP-ribosylation impairs telomere replication

inferred← citeshttps://doi.org/10.1038/s41594-025-01715-1openalex-snapshot

Filament formation and NAD processing by noncanonical human FAM118 sirtuins

inferred← citeshttps://doi.org/10.1038/s41598-021-01665-wopenalex-snapshot

Role of FRG1 in predicting the overall survivability in cancers using multivariate based optimal model

inferred← citeshttps://doi.org/10.1038/s41598-024-70368-9openalex-snapshot

Unveiling FRG1’s DNA repair role in breast cancer

inferred← citeshttps://doi.org/10.1038/s42003-021-02770-2openalex-snapshot

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

inferred← citeshttps://doi.org/10.1038/s42003-021-02780-0openalex-snapshot

Dual function of HPF1 in the modulation of PARP1 and PARP2 activities

inferred← citeshttps://doi.org/10.1042/bcj20210280openalex-snapshot

Beyond protein modification: the rise of non-canonical ADP-ribosylation

inferred← citeshttps://doi.org/10.1042/bsr20240986openalex-snapshot

Interferon-induced ADP-ribosylation: technical developments driving ICAB discovery

inferred← citeshttps://doi.org/10.1042/bst20180416openalex-snapshot

ADP-ribosylation and intracellular traffic: an emerging role for PARP enzymes

inferred← citeshttps://doi.org/10.1042/bst20180418openalex-snapshot

PARPs in genome stability and signal transduction: implications for cancer therapy

inferred← citeshttps://doi.org/10.1042/bst20220366openalex-snapshot

Revisiting PARP2 and PARP1 trapping through quantitative live-cell imaging

inferred← citeshttps://doi.org/10.1042/bst20220749openalex-snapshot

The function and regulation of ADP-ribosylation in the DNA damage response

inferred← citeshttps://doi.org/10.1053/j.seminoncol.2023.08.001openalex-snapshot

PARP1 roles in DNA repair and DNA replication: The basi(c)s of PARP inhibitor efficacy and resistance

inferred← citeshttps://doi.org/10.1073/pnas.2003613117openalex-snapshot

Live-cell protein engineering with an ultra-short split intein

inferred← citeshttps://doi.org/10.1073/pnas.2019408118openalex-snapshot

Zinc finger protein E4F1 cooperates with PARP-1 and BRG1 to promote DNA double-strand break repair

inferred← citeshttps://doi.org/10.1073/pnas.2121979119openalex-snapshot

Inhibitors of PARP: Number crunching and structure gazing

inferred← citeshttps://doi.org/10.1073/pnas.2322689121openalex-snapshot

Histone ADP-ribosylation promotes resistance to PARP inhibitors by facilitating PARP1 release from DNA lesions

inferred← citeshttps://doi.org/10.1080/10409238.2017.1394265openalex-snapshot

Specificity of reversible ADP-ribosylation and regulation of cellular processes

inferred← citeshttps://doi.org/10.1080/10409238.2020.1818686openalex-snapshot

Mechanisms governing PARP expression, localization, and activity in cells

inferred← citeshttps://doi.org/10.1080/13543776.2026.2722028openalex-snapshot

Selective PARP1 inhibitors (2021–2025): patent landscape, structural evolution, and future therapeutic opportunities

inferred← citeshttps://doi.org/10.1093/mutage/gez045openalex-snapshot

Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage

inferred← citeshttps://doi.org/10.1093/nar/gkab269openalex-snapshot

HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation

inferred← citeshttps://doi.org/10.1093/nar/gkab618openalex-snapshot

Why structure and chain length matter: on the biological significance underlying the structural heterogeneity of poly(ADP-ribose)

inferred← citeshttps://doi.org/10.1093/nar/gkab771openalex-snapshot

TARG1 protects against toxic DNA ADP-ribosylation

inferred← citeshttps://doi.org/10.1093/nar/gkac711openalex-snapshot

ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs

inferred← citeshttps://doi.org/10.1093/nar/gkac948openalex-snapshot

PARP1 proximity proteomics reveals interaction partners at stressed replication forks

inferred← citeshttps://doi.org/10.1093/nar/gkad1119openalex-snapshot

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids

inferred← citeshttps://doi.org/10.1093/nar/gkad514openalex-snapshot

Updated protein domain annotation of the PARP protein family sheds new light on biological function

inferred← citeshttps://doi.org/10.1093/nar/gkad515openalex-snapshot

The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions

inferred← citeshttps://doi.org/10.1093/nar/gkae211openalex-snapshot

APLF facilitates interstrand DNA crosslink repair and replication fork protection to confer cisplatin resistance

inferred← citeshttps://doi.org/10.1093/nar/gkae439openalex-snapshot

The loss of DNA polymerase epsilon accessory subunits POLE3–POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

inferred← citeshttps://doi.org/10.1093/nar/gkae708openalex-snapshot

Dispensability of HPF1 for cellular removal of DNA single-strand breaks

inferred← citeshttps://doi.org/10.1093/nar/gkae756openalex-snapshot

PARP1-TRIM44-MRN loop dictates the response to PARP inhibitors

inferred← citeshttps://doi.org/10.1093/nar/gkaf1170openalex-snapshot

Histone PARylation factor 1: a review of its role in the DNA damage response

inferred← citeshttps://doi.org/10.1093/nar/gkaf864openalex-snapshot

Deciphering the dark side of histone ADP-ribosylation: what structural features of damaged nucleosome regulate the activities of PARP1 and PARP2

inferred← citeshttps://doi.org/10.1093/nar/gkag183openalex-snapshot

HPF1 regulates the formation of FUS-dependent compartments by PARP1 and PARP2 activation on damaged DNA

inferred← citeshttps://doi.org/10.1093/nar/gkag860openalex-snapshot

Navigating the base excision repair pathway in chromatin—focus on oxidative DNA damage

inferred← citeshttps://doi.org/10.1093/nar/gkag939openalex-snapshot

Structural basis of PARP2 recognition of nucleosomal DNA breaks and inhibitor trapping

inferred← citeshttps://doi.org/10.1093/nar/gkw710openalex-snapshot

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

inferred← citeshttps://doi.org/10.1093/nar/gkw859openalex-snapshot

Analyzing structure–function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLaPARP1knock-out cells

inferred← citeshttps://doi.org/10.1093/nar/gkz120openalex-snapshot

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

inferred← citeshttps://doi.org/10.1093/nar/gkz305openalex-snapshot

Reversible ADP-ribosylation of RNA

inferred← citeshttps://doi.org/10.1093/nar/gkz820openalex-snapshot

Poly(ADP-ribose)-dependent chromatin unfolding facilitates the association of DNA-binding proteins with DNA at sites of damage

inferred← citeshttps://doi.org/10.1093/narcan/zcad043openalex-snapshot

The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors

inferred← citeshttps://doi.org/10.1097/jp9.0000000000000160openalex-snapshot

Synergistic effects of resveratrol with gemcitabine in pancreatic cancer chemotherapy by inhibiting the c-Met/PARP1 axis

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