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Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems

https://doi.org/10.1016/j.molcel.2021.12.032

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.cell.2015.09.038openalex-snapshot

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

inferredcites →https://doi.org/10.1016/j.cell.2016.10.044openalex-snapshot

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

inferredcites →https://doi.org/10.1016/j.cell.2017.03.012openalex-snapshot

Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex

inferredcites →https://doi.org/10.1016/j.cell.2017.06.012openalex-snapshot

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System

inferredcites →https://doi.org/10.1016/j.cell.2018.09.039openalex-snapshot

Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex

inferredcites →https://doi.org/10.1016/j.cell.2020.03.023openalex-snapshot

CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

inferredcites →https://doi.org/10.1016/j.cell.2021.03.006openalex-snapshot

Dual modes of CRISPR-associated transposon homing

inferredcites →https://doi.org/10.1016/j.mib.2017.05.008openalex-snapshot

Diversity, classification and evolution of CRISPR-Cas systems

inferredcites →https://doi.org/10.1016/j.molcel.2012.03.018openalex-snapshot

CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3

inferredcites →https://doi.org/10.1016/j.molcel.2016.02.031openalex-snapshot

Identifying and Visualizing Functional PAM Diversity across CRISPR-Cas Systems

inferredcites →https://doi.org/10.1016/j.molcel.2016.07.027openalex-snapshot

DNA Targeting by a Minimal CRISPR RNA-Guided Cascade

inferredcites →https://doi.org/10.1016/j.molcel.2019.03.014openalex-snapshot

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas

inferredcites →https://doi.org/10.1016/j.molcel.2020.11.003openalex-snapshot

Diverse CRISPR-Cas Complexes Require Independent Translation of Small and Large Subunits from a Single Gene

inferredcites →https://doi.org/10.1016/j.str.2012.06.016openalex-snapshot

Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

inferredcites →https://doi.org/10.1038/emboj.2011.41openalex-snapshot

Cas3 is a single‐stranded DNA nuclease and ATP‐dependent helicase in the CRISPR/Cas immune system

inferredcites →https://doi.org/10.1038/emboj.2012.352openalex-snapshot

In vitro reconstitution of Cascade‐mediated CRISPR immunity in Streptococcus thermophilus

inferredcites →https://doi.org/10.1038/nature10402openalex-snapshot

Structures of the RNA-guided surveillance complex from a bacterial immune system

inferredcites →https://doi.org/10.1038/nature13733openalex-snapshot

Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli

inferredcites →https://doi.org/10.1038/nature14299openalex-snapshot

In vivo genome editing using Staphylococcus aureus Cas9

inferredcites →https://doi.org/10.1038/nbt.1568openalex-snapshot

Automated design of synthetic ribosome binding sites to control protein expression

inferredcites →https://doi.org/10.1038/ncomms14500openalex-snapshot

In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

inferredcites →https://doi.org/10.1038/nmeth.2681openalex-snapshot

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

inferredcites →https://doi.org/10.1038/nrmicro3569openalex-snapshot

An updated evolutionary classification of CRISPR–Cas systems

inferredcites →https://doi.org/10.1038/nsmb.2875openalex-snapshot

Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation

inferredcites →https://doi.org/10.1038/s41467-017-01650-wopenalex-snapshot

Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1

inferredcites →https://doi.org/10.1038/s41467-019-13226-xopenalex-snapshot

CRISPR-Cas3 induces broad and unidirectional genome editing in human cells

inferredcites →https://doi.org/10.1038/s41467-020-15053-xopenalex-snapshot

Multiplexed CRISPR technologies for gene editing and transcriptional regulation

inferredcites →https://doi.org/10.1038/s41467-020-16880-8openalex-snapshot

Repurposing type I–F CRISPR–Cas system as a transcriptional activation tool in human cells

inferredcites →https://doi.org/10.1038/s41467-020-19785-8openalex-snapshot

Structural basis for assembly of non-canonical small subunits into type I-C Cascade

inferredcites →https://doi.org/10.1038/s41579-019-0299-xopenalex-snapshot

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

inferredcites →https://doi.org/10.1038/s41586-019-1323-zopenalex-snapshot

Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration

inferredcites →https://doi.org/10.1038/s41586-020-1978-5openalex-snapshot

The promise and challenge of therapeutic genome editing

inferredcites →https://doi.org/10.1038/s41586-021-03886-5openalex-snapshot

Programmable RNA targeting with the single-protein CRISPR effector Cas7-11

inferredcites →https://doi.org/10.1038/s41587-019-0235-7openalex-snapshot

Targeted transcriptional modulation with type I CRISPR–Cas systems in human cells

inferredcites →https://doi.org/10.1038/s41587-019-0310-0openalex-snapshot

Harnessing type I CRISPR–Cas systems for genome engineering in human cells

inferredcites →https://doi.org/10.1038/s41587-020-0561-9openalex-snapshot

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

inferredcites →https://doi.org/10.1038/s41592-020-00980-wopenalex-snapshot

A compact Cascade–Cas3 system for targeted genome engineering

inferredcites →https://doi.org/10.1038/s41598-017-02460-2openalex-snapshot

Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector

inferredcites →https://doi.org/10.1038/s42003-019-0637-6openalex-snapshot

The repurposing of type I-E CRISPR-Cascade for gene activation in plants

inferredcites →https://doi.org/10.1038/s42003-020-01366-6openalex-snapshot

Genome editing in plants using CRISPR type I-D nuclease

inferredcites →https://doi.org/10.1042/bst20190119openalex-snapshot

Characterization and applications of Type I CRISPR-Cas systems

inferredcites →https://doi.org/10.1073/pnas.1208507109openalex-snapshot

Cas9–crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

inferredcites →https://doi.org/10.1073/pnas.1405079111openalex-snapshot

CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference

inferredcites →https://doi.org/10.1073/pnas.1420024112openalex-snapshot

Multicolor CRISPR labeling of chromosomal loci in human cells

inferredcites →https://doi.org/10.1073/pnas.1709035114openalex-snapshot

Recruitment of CRISPR-Cas systems by Tn7-like transposons

inferredcites →https://doi.org/10.1074/jbc.m113.472233openalex-snapshot

In Vitro Reconstitution of an Escherichia coli RNA-guided Immune System Reveals Unidirectional, ATP-dependent Degradation of DNA Target

inferredcites →https://doi.org/10.1074/jbc.rev120.007034openalex-snapshot

Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation

inferredcites →https://doi.org/10.1080/10717544.2018.1474964openalex-snapshot

Delivering CRISPR: a review of the challenges and approaches

inferredcites →https://doi.org/10.1093/nar/gkab348openalex-snapshot

Genome editing in mammalian cells using the CRISPR type I-D nuclease

inferredcites →https://doi.org/10.1093/nar/gkt1074openalex-snapshot

Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems

inferredcites →https://doi.org/10.1093/nar/gky425openalex-snapshot

CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins

inferredcites →https://doi.org/10.1101/gr.171322.113openalex-snapshot

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

inferredcites →https://doi.org/10.1101/gr.849004openalex-snapshot

WebLogo: A Sequence Logo Generator: Figure 1

inferredcites →https://doi.org/10.1126/science.1138140openalex-snapshot

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

inferredcites →https://doi.org/10.1126/science.1159689openalex-snapshot

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

inferredcites →https://doi.org/10.1126/science.1165771openalex-snapshot

CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA

inferredcites →https://doi.org/10.1126/science.1225829openalex-snapshot

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

inferredcites →https://doi.org/10.1126/science.1231143openalex-snapshot

Multiplex Genome Engineering Using CRISPR/Cas Systems

inferredcites →https://doi.org/10.1126/science.1232033openalex-snapshot

RNA-Guided Human Genome Engineering via Cas9

inferredcites →https://doi.org/10.1126/science.1256328openalex-snapshot

Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli

inferredcites →https://doi.org/10.1126/science.1256996openalex-snapshot

Crystal structure of a CRISPR RNA–guided surveillance complex bound to a ssDNA target

inferredcites →https://doi.org/10.1126/science.aat0839openalex-snapshot

Structure basis for RNA-guided DNA degradation by Cascade and Cas3

inferredcites →https://doi.org/10.1126/science.aat5011openalex-snapshot

CRISPR-Cas guides the future of genetic engineering

inferredcites →https://doi.org/10.1126/science.abk2718openalex-snapshot

The gRAMP CRISPR-Cas effector is an RNA endonuclease complexed with a caspase-like peptidase

inferredcites →https://doi.org/10.1186/1471-2105-5-113openalex-snapshot

MUSCLE: a multiple sequence alignment method with reduced time and space complexity

inferredcites →https://doi.org/10.1186/1745-6150-6-38openalex-snapshot

Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

inferredcites →https://doi.org/10.1186/s13059-018-1515-0openalex-snapshot

All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo

inferredcites →https://doi.org/10.1371/journal.pone.0009490openalex-snapshot

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

inferredcites →https://doi.org/10.1371/journal.pone.0054072openalex-snapshot

OpenCFU, a New Free and Open-Source Software to Count Cell Colonies and Other Circular Objects

inferredcites →https://doi.org/10.1371/journal.pone.0056470openalex-snapshot

CRISPR-Cas Systems in the Cyanobacterium Synechocystis sp. PCC6803 Exhibit Distinct Processing Pathways Involving at Least Two Cas6 and a Cmr2 Protein

inferredcites →https://doi.org/10.3389/fbioe.2020.00062openalex-snapshot

Endogenous Type I CRISPR-Cas: From Foreign DNA Defense to Prokaryotic Engineering

inferredcites →https://doi.org/10.4161/rna.24046openalex-snapshot

CRISPRTarget

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Ablation of CD44 Attenuates Adipogenesis in White Adipocytes via the Tryptophan 5-Hydroxylase 2/5-Hydroxytryptamine Axis to Protect Mice from High-Fat Diet–Induced Obesity

inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.08.005openalex-snapshot

High-resolution crystal structure of the anti-CRISPR protein AcrIC5

inferred← citeshttps://doi.org/10.1016/j.bioactmat.2023.07.003openalex-snapshot

Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2024.108481openalex-snapshot

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Molecular mechanism for Tn7-like transposon recruitment by a type I-B CRISPR effector

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Systematic mining identifies two Type I-C CRISPR systems for efficient genome editing in maize

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inferred← citeshttps://doi.org/10.1016/j.crmeth.2024.100833openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.drudis.2023.103793openalex-snapshot

Genome and transcriptome engineering by compact and versatile CRISPR-Cas systems

inferred← citeshttps://doi.org/10.1016/j.ggedit.2022.100013openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.ggedit.2022.100020openalex-snapshot

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Strategies for improving the genome-editing efficiency of class 2 CRISPR/Cas system

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.124086openalex-snapshot

Functional PAM sequence for DNA interference by CRISPR-Cas I-B system of Leptospira interrogans and the role of LinCas11b encoded within lincas8b

inferred← citeshttps://doi.org/10.1016/j.jmb.2024.168836openalex-snapshot

A Nanobody Toolbox for Recognizing Distinct Epitopes on Cas9

inferred← citeshttps://doi.org/10.1016/j.molcel.2022.06.007openalex-snapshot

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools

inferred← citeshttps://doi.org/10.1016/j.molcel.2023.01.024openalex-snapshot

Structural snapshots of R-loop formation by a type I-C CRISPR Cascade

inferred← citeshttps://doi.org/10.1016/j.molcel.2023.05.036openalex-snapshot

Type IV-A CRISPR-Csf complex: Assembly, dsDNA targeting, and CasDinG recruitment

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Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems

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Genetically engineered hypoimmunogenic iPSCs: Strategies and considerations for clinical applications

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Plasmid targeting and destruction by the DdmDE bacterial defence system

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CRISPR–Cas regulates expression of embedded anti-phage defence systems

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Disarming of type I-F CRISPR-Cas surveillance complex by anti-CRISPR proteins AcrIF6 and AcrIF9

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Immune-cell-mediated tissue engineering strategies for peripheral nerve injury and regeneration

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Cas11 augments Cascade functions in type I-E CRISPR system but is redundant for gene silencing and plasmid interference

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Mechanistic insights into DNA binding and cleavage by a compact type I-F CRISPR-Cas system in bacteriophage

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Structure and mechanism of the type I-G CRISPR effector

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Structural basis of Cas3 activation in type I-C CRISPR-Cas system

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Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition

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DNA large fragment deleting by compact, sequence-motif-free and specific TaqTth-hpRNA assisted with the microhomology-mediated end joining pathway

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Fluorescent Protein-Based Metal Biosensors

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Structural Flexibility of the Monomeric Red Fluorescent Protein DsRed

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Structural Analysis of the Large Stokes Shift Red Fluorescent Protein tKeima

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pH-Induced Conformational Change of the Chromophore of the Large Stokes Shift Fluorescent Protein tKeima

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Gigabase-scale deletion scanning of the human genome

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TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

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TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

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TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

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TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

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