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Nrf2 as a target for cancer chemoprevention
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1006/bbrc.1997.6943openalex-snapshot
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
inferredcites →https://doi.org/10.1006/bbrc.1999.1109openalex-snapshot
Up-Regulation of the Human γ-Glutamylcysteine Synthetase Regulatory Subunit Gene Involves Binding of Nrf-2 to an Electrophile Responsive Element
inferredcites →https://doi.org/10.1006/bbrc.2000.3830openalex-snapshot
Inhibition of ERK and p38 MAP Kinases Inhibits Binding of Nrf2 and Induction of GCS Genes
inferredcites →https://doi.org/10.1006/taap.2001.9176openalex-snapshot
Accelerated DNA Adduct Formation in the Lung of the Nrf2 Knockout Mouse Exposed to Diesel Exhaust
inferredcites →https://doi.org/10.1007/bf03401947openalex-snapshot
Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2-Dithiole-3-thione
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2004.04.033openalex-snapshot
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
inferredcites →https://doi.org/10.1016/s0300-9084(01)01250-0openalex-snapshot
Degradation of oxidized proteins by the 20S proteasome
inferredcites →https://doi.org/10.1038/ng1248openalex-snapshot
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
inferredcites →https://doi.org/10.1042/bst0280033openalex-snapshot
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
inferredcites →https://doi.org/10.1073/pnas.0305902101openalex-snapshot
Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway
inferredcites →https://doi.org/10.1073/pnas.0307301101openalex-snapshot
Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
inferredcites →https://doi.org/10.1073/pnas.0403886101openalex-snapshot
Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage
inferredcites →https://doi.org/10.1073/pnas.051618798openalex-snapshot
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
inferredcites →https://doi.org/10.1073/pnas.172398899openalex-snapshot
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
inferredcites →https://doi.org/10.1073/pnas.85.4.1000openalex-snapshot
Glutathione S-transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression.
inferredcites →https://doi.org/10.1073/pnas.90.23.11366openalex-snapshot
Isolation of cDNA encoding the human NF-E2 protein.
inferredcites →https://doi.org/10.1073/pnas.90.23.11371openalex-snapshot
Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
inferredcites →https://doi.org/10.1073/pnas.93.25.14960openalex-snapshot
Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene
inferredcites →https://doi.org/10.1073/pnas.94.10.5361openalex-snapshot
Functional antioxidant responsive elements
inferredcites →https://doi.org/10.1073/pnas.96.22.12731openalex-snapshot
Nrf2 is essential for protection against acute pulmonary injury in mice
inferredcites →https://doi.org/10.1074/jbc.274.10.6443openalex-snapshot
Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3
inferredcites →https://doi.org/10.1074/jbc.274.37.26071openalex-snapshot
Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene
inferredcites →https://doi.org/10.1074/jbc.274.47.33627openalex-snapshot
Regulation of γ-Glutamylcysteine Synthetase Subunit Gene Expression by the Transcription Factor Nrf2
inferredcites →https://doi.org/10.1074/jbc.275.21.16023openalex-snapshot
Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
inferredcites →https://doi.org/10.1074/jbc.m004037200openalex-snapshot
Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism
inferredcites →https://doi.org/10.1074/jbc.m100734200openalex-snapshot
Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells
inferredcites →https://doi.org/10.1074/jbc.m109380200openalex-snapshot
Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 Cells
inferredcites →https://doi.org/10.1074/jbc.m206911200openalex-snapshot
Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription
inferredcites →https://doi.org/10.1074/jbc.m207293200openalex-snapshot
Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element
inferredcites →https://doi.org/10.1074/jbc.m211898200openalex-snapshot
Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway
inferredcites →https://doi.org/10.1074/jbc.m300931200openalex-snapshot
Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
inferredcites →https://doi.org/10.1093/carcin/24.3.461openalex-snapshot
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
inferredcites →https://doi.org/10.1093/toxsci/kfg083openalex-snapshot
Erk Activation Is Required for Nrf2 Nuclear Localization during Pyrrolidine Dithiocarbamate Induction of Glutamate Cysteine Ligase Modulatory Gene Expression in HepG2 Cells
inferredcites →https://doi.org/10.1101/gad.13.1.76openalex-snapshot
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
inferredcites →https://doi.org/10.1126/science.278.5340.1073openalex-snapshot
Recent Advances in Chemoprevention of Cancer
inferredcites →https://doi.org/10.1128/mcb.15.8.4184openalex-snapshot
Cloning and Characterization of a Novel Erythroid Cell-Derived CNC Family Transcription Factor Heterodimerizing with the Small Maf Family Proteins
inferredcites →https://doi.org/10.1128/mcb.22.9.2883-2892.2002openalex-snapshot
Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter
inferredcites →https://doi.org/10.1128/mcb.23.20.7198-7209.2003openalex-snapshot
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival
inferredcites →https://doi.org/10.1128/mcb.23.23.8786-8794.2003openalex-snapshot
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway
inferredcites →https://doi.org/10.1128/mcb.24.1.36-45.2004openalex-snapshot
Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1906openalex-snapshot
Nrf2 Is Essential for the Chemopreventive Efficacy of Oltipraz against Urinary Bladder Carcinogenesis
inferredcites →https://doi.org/10.1165/ajrcmb.26.2.4501openalex-snapshot
Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice
inferredcites →https://doi.org/10.1167/iovs.04-1120openalex-snapshot
Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice
inferredcites →https://doi.org/10.1172/jci200421146openalex-snapshot
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
inferredcites →https://doi.org/10.4049/jimmunol.173.5.3467openalex-snapshot
Nrf2 Is a Key Transcription Factor That Regulates Antioxidant Defense in Macrophages and Epithelial Cells: Protecting against the Proinflammatory and Oxidizing Effects of Diesel Exhaust Chemicals
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.3352498openalex-extracted
Non-Covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation
inferred← citeshttps://doi.org/10.1002/9783527626588.ch4openalex-snapshot
Mechanisms of Chemoprevention, Antimutagenesis, and Anticarcinogenesis: An Overview
inferred← citeshttps://doi.org/10.1002/bdrc.20085openalex-snapshot
Oxidative stress as a mechanism of teratogenesis
inferred← citeshttps://doi.org/10.1002/biof.1008openalex-snapshot
Effects of anthocyanin‐rich tea “Sunrouge” on dextran sodium sulfate‐induced colitis in mice
inferred← citeshttps://doi.org/10.1002/cbf.70149openalex-snapshot
Exploring the Impact of NRF2 Signaling on Atherosclerosis: Insights Into Hydrogen Sulfide, NLRP3 Inflammasome, microRNAs, and HO‐1
inferred← citeshttps://doi.org/10.1002/ijc.24106openalex-snapshot
γ‐Tocopherol‐enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice
inferred← citeshttps://doi.org/10.1002/jmv.29059openalex-snapshot
Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage
inferred← citeshttps://doi.org/10.1002/jsfa.13157openalex-snapshot
Effects of dietary citrus pulp level on the growth and intestinal health of largemouth bass (Micropterus salmoides)
inferred← citeshttps://doi.org/10.1002/mc.20234openalex-snapshot
Butylated hydroxyanisole regulates ARE‐mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells
inferred← citeshttps://doi.org/10.1002/med.21257openalex-snapshot
Small Molecule Modulators of K eap1‐ N rf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents
inferred← citeshttps://doi.org/10.1002/mnfr.200800558openalex-snapshot
Protective effect of sulforaphane on indomethacin‐induced cytotoxicity via heme oxygenase‐1 expression in human intestinal Int 407 cells
inferred← citeshttps://doi.org/10.1002/mnfr.201000204openalex-snapshot
Coffee, broccoli and spices are strong inducers of electrophile response element‐dependent transcription in vitro and in vivo – Studies in electrophile response element transgenic mice
inferred← citeshttps://doi.org/10.1002/mnfr.201300861openalex-snapshot
The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications
inferred← citeshttps://doi.org/10.1002/mnfr.201500297openalex-snapshot
Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- ando-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog
inferred← citeshttps://doi.org/10.1007/978-1-4614-9227-6_3openalex-snapshot
Nrf2-Target Approaches in Cancer Chemoprevention Mediated by Dietary Phytochemicals
inferred← citeshttps://doi.org/10.1007/978-3-319-02096-9_26openalex-snapshot
Nonimmune-Mediated Drug-Induced Hepatotoxicity
inferred← citeshttps://doi.org/10.1007/978-3-7091-1428-5_10openalex-snapshot
Nrf2 Transcription Factor and Heme Oxygenase-1 as Modulators of Vascular Injury and Angiogenesis
inferred← citeshttps://doi.org/10.1007/978-94-007-2923-0_5openalex-snapshot
Dietary Biofactors in the Management of Cancer: Myth or Reality?
inferred← citeshttps://doi.org/10.1007/978-94-007-4575-9_21openalex-snapshot
Anthocyanins: Janus Nutraceuticals Displaying Chemotherapeutic and Neuroprotective Properties
inferred← citeshttps://doi.org/10.1007/978-94-007-5787-5_12openalex-snapshot
Redox Regulation of Stem Cell Function
inferred← citeshttps://doi.org/10.1007/978-94-007-5881-0_2openalex-snapshot
Nrf2 and Antioxidant Defense Against CYP2E1 Toxicity
inferred← citeshttps://doi.org/10.1007/978-981-10-2579-2_12openalex-snapshot
Preclinical Development of Chemopreventive Agents for Chemoprevention
inferred← citeshttps://doi.org/10.1007/978-981-95-7068-3_67openalex-snapshot
Potential Adverse Effects of Phytochemicals
inferred← citeshttps://doi.org/10.1007/s00204-011-0675-4openalex-snapshot
Nrf2: control of sensitivity to carcinogens
inferred← citeshttps://doi.org/10.1007/s00428-017-2218-8openalex-snapshot
Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level
inferred← citeshttps://doi.org/10.1007/s10741-016-9590-3openalex-snapshot
Molecular mechanisms of heart failure: insights from Drosophila
inferred← citeshttps://doi.org/10.1007/s10787-021-00860-5openalex-snapshot
Management of COVID-19-induced cytokine storm by Keap1-Nrf2 system: a review
inferred← citeshttps://doi.org/10.1007/s11095-006-9099-xopenalex-snapshot
Pharmacogenomics of Phenolic Antioxidant Butylated Hydroxyanisole (BHA) in the Small Intestine and Liver of Nrf2 Knockout and C57BL/6J Mice
inferred← citeshttps://doi.org/10.1007/s11356-022-19466-7openalex-snapshot
Simvastatin as an emerging pollutant on non-target aquatic invertebrates: effects on antioxidant-related genes in Daphnia magna
inferred← citeshttps://doi.org/10.1007/s12263-007-0063-0openalex-snapshot
NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals
inferred← citeshttps://doi.org/10.1007/s12551-016-0244-4openalex-snapshot
The Keap1–Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases
inferred← citeshttps://doi.org/10.1007/s13105-015-0401-4openalex-snapshot
The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression
inferred← citeshttps://doi.org/10.1016/j.abb.2006.08.005openalex-snapshot
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion
inferred← citeshttps://doi.org/10.1016/j.abb.2011.05.004openalex-snapshot
Carotenoids inhibit proliferation and regulate expression of peroxisome proliferators-activated receptor gamma (PPARγ) in K562 cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbalip.2016.07.013openalex-snapshot
Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration
inferred← citeshttps://doi.org/10.1016/j.bbrc.2008.06.004openalex-snapshot
Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2007.11.049openalex-snapshot
Differential gene expression involved in oxidative stress response caused by triethylene glycol dimethacrylate
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.09.049openalex-snapshot
Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110259openalex-snapshot
The ameliorative impacts of Moringa oleifera leaf extract against oxidative stress and methotrexate-induced hepato-renal dysfunction
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2017.12.012openalex-snapshot
Nrf2 as regulator of innate immunity: A molecular Swiss army knife!
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.03.013openalex-snapshot
Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction
inferred← citeshttps://doi.org/10.1016/j.canep.2010.06.012openalex-snapshot
Nrf2–ARE signaling pathway and natural products for cancer chemoprevention
inferred← citeshttps://doi.org/10.1016/j.canlet.2012.11.053openalex-snapshot
Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B
inferred← citeshttps://doi.org/10.1016/j.cca.2014.06.004openalex-snapshot
Antioxidants and human diseases
inferred← citeshttps://doi.org/10.1016/j.chembiol.2019.07.011openalex-snapshot
Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation
inferred← citeshttps://doi.org/10.1016/j.devcel.2007.12.002openalex-snapshot
Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113475openalex-snapshot
Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117711openalex-snapshot
Insights of affinity-based probes for target identification in drug discovery
inferred← citeshttps://doi.org/10.1016/j.fct.2007.07.015openalex-snapshot
Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin
inferred← citeshttps://doi.org/10.1016/j.fct.2007.09.082openalex-snapshot
Anticarcinogenesis by dietary phytochemicals: Cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-κB and AP-1 in abnormal cancer cells
inferred← citeshttps://doi.org/10.1016/j.fct.2010.07.035openalex-snapshot
A polyacetylene from Gymnaster koraiensis exerts hepatoprotective effects in vivo and in vitro
inferred← citeshttps://doi.org/10.1016/j.fct.2013.02.033openalex-snapshot
Platycodi Radix attenuates dimethylnitrosamine-induced liver fibrosis in rats by inducing Nrf2-mediated antioxidant enzymes
inferred← citeshttps://doi.org/10.1016/j.foodres.2010.10.023openalex-snapshot
Antioxidant and cytoprotective activities of native Australian fruit polyphenols
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2010.02.024openalex-snapshot
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2011.07.021openalex-snapshot
Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2020.05.001openalex-snapshot
Isolation, characterization and cytoprotective effects against UV radiation of exopolysaccharide produced from Paenibacillus polymyxa PYQ1
inferred← citeshttps://doi.org/10.1016/j.jep.2007.05.014openalex-snapshot
The potent protective effect of wild ginseng (Panax ginseng C.A. Meyer) against benzo[α]pyrene-induced toxicity through metabolic regulation of CYP1A1 and GSTs
inferred← citeshttps://doi.org/10.1016/j.jep.2009.10.022openalex-snapshot
The protective effects of Acanthopanax senticosus Harms aqueous extracts against oxidative stress: Role of Nrf2 and antioxidant enzymes
inferred← citeshttps://doi.org/10.1016/j.jmb.2007.11.074openalex-snapshot
Small Maf Proteins in Mammalian Gene Control: Mere Dimerization Partners or Dynamic Transcriptional Regulators?
inferred← citeshttps://doi.org/10.1016/j.lwt.2009.02.003openalex-snapshot
Comparative antioxidant, antiproliferative and phase II enzyme inducing potential of sorghum (Sorghum bicolor) varieties
inferred← citeshttps://doi.org/10.1016/j.mam.2012.03.006openalex-snapshot
How does the macula protect itself from oxidative stress?
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2005.05.017openalex-snapshot
Mechanistic approaches to chemoprevention of mutation and cancer
inferred← citeshttps://doi.org/10.1016/j.mrrev.2007.11.006openalex-snapshot
Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
inferred← citeshttps://doi.org/10.1016/j.neuro.2015.12.019openalex-snapshot
Genistein alleviates lead-induced neurotoxicity in vitro and in vivo : Involvement of multiple signaling pathways
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2012.09.008openalex-snapshot
Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression
inferred← citeshttps://doi.org/10.1016/j.phrs.2015.07.024openalex-snapshot
Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2017.03.002openalex-snapshot
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
inferred← citeshttps://doi.org/10.1016/j.redox.2020.101714openalex-snapshot
Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis
inferred← citeshttps://doi.org/10.1016/j.taap.2009.06.010openalex-snapshot
Nrf2 protects against As(III)-induced damage in mouse liver and bladder
inferred← citeshttps://doi.org/10.1016/j.tiv.2010.06.017openalex-snapshot
Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells
inferred← citeshttps://doi.org/10.1016/j.tox.2009.10.010openalex-snapshot
Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention
inferred← citeshttps://doi.org/10.1016/j.toxicon.2008.04.166openalex-snapshot
Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms
inferred← citeshttps://doi.org/10.1016/j.toxlet.2006.10.012openalex-snapshot
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice
inferred← citeshttps://doi.org/10.1016/j.visres.2009.08.018openalex-snapshot
Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration
inferred← citeshttps://doi.org/10.1016/j.ygeno.2019.07.019openalex-snapshot
Exploring the correlation between deltamethrin stress and Keap1-Nrf2-ARE pathway from Drosophila melanogaster RNASeq data
inferred← citeshttps://doi.org/10.1016/s1734-1140(12)70863-0openalex-snapshot
Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics
inferred← citeshttps://doi.org/10.1017/s0029665111003272openalex-snapshot
Soyabean glyceollins: biological effects and relevance to human health
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.4c00422openalex-snapshot
Arsenic Trioxide (ATOIII) Induces NAD(P)H Quinone Oxidoreductase 1 (NQO1) Expression in Hepatic and Extrahepatic Tissues of C57BL/6 Mice
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c02210openalex-snapshot
Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01451openalex-snapshot
Medicinal Chemistry of Inhibiting RING-Type E3 Ubiquitin Ligases
inferred← citeshttps://doi.org/10.1021/jf071933iopenalex-snapshot
Anthocyanins Induce the Activation of Phase II Enzymes through the Antioxidant Response Element Pathway against Oxidative Stress-Induced Apoptosis
inferred← citeshttps://doi.org/10.1021/jf300005vopenalex-snapshot
Synergistic Effect of Cyanidin and PPAR Agonist against Nonalcoholic Steatohepatitis-Mediated Oxidative Stress-Induced Cytotoxicity through MAPK and Nrf2 Transduction Pathways
inferred← citeshttps://doi.org/10.1021/jf8035066openalex-snapshot
Sorghum 3-Deoxyanthocyanins Possess Strong Phase II Enzyme Inducer Activity and Cancer Cell Growth Inhibition Properties
inferred← citeshttps://doi.org/10.1038/aps.2010.147openalex-snapshot
Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells
inferred← citeshttps://doi.org/10.1038/aps.2016.176openalex-snapshot
Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer treatment
inferred← citeshttps://doi.org/10.1038/ncponc0536openalex-snapshot
Dichotomies in cancer research: some suggestions for a new synthesis
inferred← citeshttps://doi.org/10.1038/nrc2129openalex-snapshot
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
inferred← citeshttps://doi.org/10.1038/nrm2455openalex-snapshot
Cancer as an overhealing wound: an old hypothesis revisited
inferred← citeshttps://doi.org/10.1038/onc.2008.79openalex-snapshot
The role of Nrf2 in increased reactive oxygen species and DNA damage in prostate tumorigenesis
inferred← citeshttps://doi.org/10.1038/onc.2010.492openalex-snapshot
NRF2, cancer and calorie restriction
inferred← citeshttps://doi.org/10.1038/sj.emboj.7601243openalex-snapshot
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
inferred← citeshttps://doi.org/10.1039/c6fo01231kopenalex-snapshot
Characteristic single glucosinolates from Moringa oleifera: Induction of detoxifying enzymes and lack of genotoxic activity in various model systems
inferred← citeshttps://doi.org/10.1042/bst20230490openalex-snapshot
Interactions between zinc and NRF2 in vascular redox signalling
inferred← citeshttps://doi.org/10.1055/s-0030-1250203openalex-snapshot
Cancer Chemopreventive Activity of Maslinic Acid: Suppression of COX-2 Expression and Inhibition of NF- κ B and AP-1 Activation in Raji Cells
inferred← citeshttps://doi.org/10.1074/jbc.m109.075770openalex-snapshot
Interaction between Oxidative Stress Sensor Nrf2 and Xenobiotic-activated Aryl Hydrocarbon Receptor in the Regulation of the Human Phase II Detoxifying UDP-glucuronosyltransferase 1A10
inferred← citeshttps://doi.org/10.1074/jbc.m112.383430openalex-snapshot
Identification of UV-protective Activators of Nuclear Factor Erythroid-derived 2-Related Factor 2 (Nrf2) by Combining a Chemical Library Screen with Computer-based Virtual Screening
inferred← citeshttps://doi.org/10.1074/jbc.m604620200openalex-snapshot
Nrf2-mediated Induction of Cytoprotective Enzymes by 15-Deoxy-Δ12,14-Prostaglandin J2 Is Attenuated by Alkenal/one Oxidoreductase
inferred← citeshttps://doi.org/10.1080/01635581.2011.538953openalex-snapshot
Molecular Pathways for Cancer Chemoprevention by Dietary Phytochemicals
inferred← citeshttps://doi.org/10.1080/01635581.2011.596646openalex-snapshot
Potential Antioxidant, Antiinflammatory, and Proapoptotic Anticancer Activities of Kakadu Plum and Illawarra Plum Polyphenolic Fractions
inferred← citeshttps://doi.org/10.1080/10715760801975735openalex-snapshot
Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts
inferred← citeshttps://doi.org/10.1080/13543776.2017.1325464openalex-snapshot
Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)
inferred← citeshttps://doi.org/10.1081/e-ebaf-120042296openalex-snapshot
Chemoprevention with Dietary Phytopharmaceuticals
inferred← citeshttps://doi.org/10.1089/adt.2009.0246openalex-snapshot
Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult
inferred← citeshttps://doi.org/10.1089/ars.2014.6074openalex-snapshot
A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response
inferred← citeshttps://doi.org/10.1093/carcin/bgn292openalex-snapshot
Chemical genomics of cancer chemopreventive dithiolethiones
inferred← citeshttps://doi.org/10.1093/jb/mvr065openalex-snapshot
Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes
inferred← citeshttps://doi.org/10.1097/01.jto.0000282963.30308.d8openalex-snapshot
M11-03: Natural agents for chemoprevention
inferred← citeshttps://doi.org/10.1097/pat.0b013e328359d54bopenalex-snapshot
Nrf2 expression is associated with poor outcome in osteosarcoma
inferred← citeshttps://doi.org/10.1111/acel.12078openalex-snapshot
Declining signal dependence of N rf2‐ M af S ‐regulated gene expression correlates with aging phenotypes
inferred← citeshttps://doi.org/10.1111/j.1600-079x.2010.00756.xopenalex-snapshot
Effect of melatonin on the expression of Nrf2 and NF‐κB during cyclophosphamide‐induced urinary bladder injury in rat
inferred← citeshttps://doi.org/10.1111/j.1745-7254.2007.00549.xopenalex-snapshot
Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells
inferred← citeshttps://doi.org/10.1111/j.1745-7254.2007.00694.xopenalex-snapshot
Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models
inferred← citeshttps://doi.org/10.1111/j.1747-0285.2011.01240.xopenalex-snapshot
Kinetic Analyses of Keap1–Nrf2 Interaction and Determination of the Minimal Nrf2 Peptide Sequence Required for Keap1 Binding Using Surface Plasmon Resonance
inferred← citeshttps://doi.org/10.1111/jnc.13895openalex-snapshot
The effect of nuclear factor erythroid 2‐related factor/antioxidant response element signalling pathway in the lanthanum chloride‐induced impairment of learning and memory in rats
inferred← citeshttps://doi.org/10.1126/scisignal.2000762openalex-snapshot
Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration
inferred← citeshttps://doi.org/10.1128/mcb.01204-10openalex-snapshot
SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
inferred← citeshttps://doi.org/10.1128/mcb.01811-08openalex-snapshot
The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1142/s0192415x16500348openalex-snapshot
The Roles of 4β-Hydroxywithanolide E from Physalis peruviana on the Nrf2-Anti-Oxidant System and the Cell Cycle in Breast Cancer Cells
inferred← citeshttps://doi.org/10.1152/physiolgenomics.00199.2009openalex-snapshot
Interaction between SNPs in the NRF2 gene and elite endurance performance
inferred← citeshttps://doi.org/10.1155/2009/420194openalex-snapshot
LAS0811: From Combinatorial Chemistry to Activation of Antioxidant Response Element
inferred← citeshttps://doi.org/10.1155/2015/407580openalex-snapshot
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation
inferred← citeshttps://doi.org/10.1155/2019/7090534openalex-snapshot
Role of Nrf2 and Its Activators in Respiratory Diseases
inferred← citeshttps://doi.org/10.1155/2021/6693955openalex-snapshot
Systems Biology and Chemoinformatics‐Based Strategies to Explore the Biological Mechanism of Fugui Wenyang Decoction in Treating Vascular Dementia Rats
inferred← citeshttps://doi.org/10.1155/anu/5594216openalex-snapshot
Potential Mechanisms of Dietary Potassium Diformate and Sodium Propionate Driving Intestinal Microbiota and Lipid Metabolites to Modulate Intestinal Health of Trachinotus ovatus
inferred← citeshttps://doi.org/10.1158/0008-5472.can-06-4534openalex-snapshot
The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice
inferred← citeshttps://doi.org/10.1158/0008-5472.can-10-0713openalex-snapshot
High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-07-0180openalex-snapshot
Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities
inferred← citeshttps://doi.org/10.1158/1940-6207.capr-08-0192openalex-snapshot
Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in Helicobacter pylori –Infected Mice and Humans
inferred← citeshttps://doi.org/10.1159/000338432openalex-snapshot
Sulforaphane Enhances Protection and Repair of Gastric Mucosa against Oxidative Stress via Nrf2-Dependent Mechanisms
inferred← citeshttps://doi.org/10.1159/000346169openalex-snapshot
Retinal Microenvironment Imbalance in Dry Age-Related Macular Degeneration: A Mini-Review
inferred← citeshttps://doi.org/10.1159/000365701openalex-snapshot
Melatonin and Its Role in Lower Urinary Tract Function: An Article Review
inferred← citeshttps://doi.org/10.1161/circresaha.109.215715openalex-snapshot
Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2
inferred← citeshttps://doi.org/10.1177/1087057111430124openalex-snapshot
Optimization of Fluorescently Labeled Nrf2 Peptide Probes and the Development of a Fluorescence Polarization Assay for the Discovery of Inhibitors of Keap1-Nrf2 Interaction
inferred← citeshttps://doi.org/10.1186/1755-8794-3-37openalex-snapshot
The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel
inferred← citeshttps://doi.org/10.1186/s12906-019-2511-yopenalex-snapshot
Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes
inferred← citeshttps://doi.org/10.1186/s12906-021-03404-0openalex-snapshot
Potent Nrf2-inducing, antioxidant, and anti-inflammatory effects and identification of constituents validate the anti-cancer use of Uvaria chamae and Olax subscorpioidea
inferred← citeshttps://doi.org/10.1186/s12964-024-01479-zopenalex-snapshot
Mitochondria-derived methylmalonic acid aggravates ischemia–reperfusion injury by activating reactive oxygen species-dependent ferroptosis
inferred← citeshttps://doi.org/10.1201/9781420015584.ch33openalex-snapshot
Development and Delivery of Anti-Angiogenic Functional Food Products
inferred← citeshttps://doi.org/10.1271/bbb.100606openalex-snapshot
Protective Effects of Decursin and Decursinol Angelate against Amyloid β-Protein-Induced Oxidative Stress in the PC12 Cell Line: The Role of Nrf2 and Antioxidant Enzymes
inferred← citeshttps://doi.org/10.1371/journal.pone.0014662openalex-snapshot
Analysis of Common and Specific Mechanisms of Liver Function Affected by Nitrotoluene Compounds
inferred← citeshttps://doi.org/10.1371/journal.pone.0114764openalex-snapshot
Benefits and Risks of the Hormetic Effects of Dietary Isothiocyanates on Cancer Prevention
inferred← citeshttps://doi.org/10.1517/17425250903143769openalex-snapshot
Nrf2 and antioxidant defense against CYP2E1 toxicity
inferred← citeshttps://doi.org/10.15760/etd.7721openalex-snapshot
Mechanisms of Substrate Recognition by the Cul3-based E3 Ligase
inferred← citeshttps://doi.org/10.17352/2394-8418.000078openalex-snapshot
Autophagy and the potential linkage with the human oral diseases
inferred← citeshttps://doi.org/10.18388/abp.2020_6034openalex-snapshot
Long noncoding RNA TPTEP1 suppresses diabetic retinopathy by reducing oxidative stress and targeting the miR-489-3p/NRF2 axis
inferred← citeshttps://doi.org/10.20517/cdr.2019.57openalex-snapshot
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies
inferred← citeshttps://doi.org/10.2174/0929867321666140217104648openalex-snapshot
Updated Research and Applications of Small Molecule Inhibitors of Keap1-Nrf2 Protein-Protein Interaction: a Review
inferred← citeshttps://doi.org/10.2174/1381612823666170207103943openalex-snapshot
Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress
inferred← citeshttps://doi.org/10.2174/138920112798868610openalex-snapshot
Cancer Chemoprevention by Dietary Phytochemicals: Promises and Pitfalls
inferred← citeshttps://doi.org/10.2174/1389450116666150506112817openalex-snapshot
Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth
inferred← citeshttps://doi.org/10.2174/2212796811307020008openalex-snapshot
Mechanisms Underlying Chemopreventive Effects of Flavonoids via Multiple Signaling Nodes within Nrf2-ARE and AhR-XRE Gene Regulatory Networks
inferred← citeshttps://doi.org/10.2298/bg20131112maticopenalex-snapshot
In vitro investigation of antitumor activities of extracts of endemic plant species Helichrysum zivojini ?ernjavski et So?ka U
inferred← citeshttps://doi.org/10.2478/v10078-012-0012-xopenalex-snapshot
The GABPB1 gene A/G polymorphism in Polish rowers
inferred← citeshttps://doi.org/10.3109/10408363.2014.968703openalex-snapshot
Oxidative stress in dry age-related macular degeneration and exfoliation syndrome
inferred← citeshttps://doi.org/10.3109/10715762.2012.724771openalex-snapshot
2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense
inferred← citeshttps://doi.org/10.31989/ffhd.v8i8.529openalex-snapshot
An invitro study on the regulation of oxidative protective genes in human gingival and intestinal epithelial cells after treatment with salmon protein hydrolysate peptides
inferred← citeshttps://doi.org/10.3233/jad-2010-100519openalex-snapshot
Neuroprotection through Stimulation of Mitochondrial Antioxidant Protein Expression
inferred← citeshttps://doi.org/10.3389/fonc.2018.00611openalex-snapshot
PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway
inferred← citeshttps://doi.org/10.3389/fphar.2022.853383openalex-snapshot
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis
inferred← citeshttps://doi.org/10.3389/fvets.2021.817183openalex-snapshot
The Protective Impact of Salsola imbricata Leaf Extract From Taif Against Acrylamide-Induced Hepatic Inflammation and Oxidative Damage: The Role of Antioxidants, Cytokines, and Apoptosis-Associated Genes
inferred← citeshttps://doi.org/10.3390/antiox11122404openalex-snapshot
Broccoli-Derived Glucoraphanin Activates AMPK/PGC1α/NRF2 Pathway and Ameliorates Dextran-Sulphate-Sodium-Induced Colitis in Mice
inferred← citeshttps://doi.org/10.3390/antiox13091060openalex-snapshot
The Antitumour Mechanisms of Carotenoids: A Comprehensive Review
inferred← citeshttps://doi.org/10.3390/antiox9020127openalex-snapshot
A Novel Pectic Polysaccharide of Jujube Pomace: Structural Analysis and Intracellular Antioxidant Activities
inferred← citeshttps://doi.org/10.3390/cancers2020483openalex-snapshot
Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression
inferred← citeshttps://doi.org/10.3390/fishes7010048openalex-snapshot
Effect of Feed Supplementation with Bacillus coagulans on Nrf Gene Family Expression in Common Carp (Cyprinus carpio) under Long-Term Exposure to Cd2+
inferred← citeshttps://doi.org/10.3390/ijms17050722openalex-snapshot
Nrf2 Expressions Correlate with WHO Grades in Gliomas and Meningiomas
inferred← citeshttps://doi.org/10.3390/ijms20184445openalex-snapshot
Emerging Screening Approaches in the Development of Nrf2–Keap1 Protein–Protein Interaction Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules15053338openalex-snapshot
The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells
inferred← citeshttps://doi.org/10.3390/molecules16119234openalex-snapshot
Icariside II Enhances Nrf2 Nuclear Translocation to Upregulate Phase II Detoxifying Enzyme Expression Coupled with the ERK, Akt and JNK Signaling Pathways
inferred← citeshttps://doi.org/10.3390/nano11061365openalex-snapshot
Lipoperoxide Nanoemulsion as Adjuvant in Cisplatin Cancer Therapy: In Vitro Study on Human Colon Adenocarcinoma DLD-1 Cells
inferred← citeshttps://doi.org/10.3402/fnr.v60.30323openalex-snapshot
Cytoprotective mechanism of ferulic acid against high glucose-induced oxidative stress in cardiomyocytes and hepatocytes
inferred← citeshttps://doi.org/10.3746/pnf.2017.22.4.306openalex-snapshot
Inhibitory Effects of Butein on Adipogenesis through Upregulation of the Nrf2/HO-1 Pathway in 3T3-L1 Adipocytes
inferred← citeshttps://doi.org/10.3892/ijo_00000071openalex-snapshot
Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by α-lipoic acid in human leukemia HL-60 cells
inferred← citeshttps://doi.org/10.3892/mmr.2014.2087openalex-snapshot
Effect of the human SOD1-G93A gene on the Nrf2/ARE signaling pathway in NSC-34 cells
inferred← citeshttps://doi.org/10.4062/biomolther.2012.20.6.499openalex-snapshot
Targeting Nrf2-Mediated Gene Transcription by Triterpenoids and Their Derivatives
inferred← citeshttps://doi.org/10.4161/epi.6.6.15773openalex-snapshot
Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
inferred← citeshttps://doi.org/10.4239/wjd.v3.i1.19openalex-snapshot
Role of nuclear factor (erythroid-derived 2)-like 2 in metabolic homeostasis and insulin action: A novel opportunity for diabetes treatment?
inferred← citeshttps://doi.org/10.5282/edoc.16905openalex-snapshot
Non-neuronale Expression und Funktion des sensorischen Kationenkanals TRPA1 in Tumorzellen
inferred← citeshttps://doi.org/10.5897/jmpr2019.6746openalex-snapshot
In vitro evaluation of fruit extracts of Annona stenophylla diels and Flacourtia indica for incorporation into formulations for management of cancer
inferred← citeshttps://doi.org/10.6084/m9.figshare.16640800openalex-snapshot
Additional file 1 of Potent Nrf2-inducing, antioxidant, and anti-inflammatory effects and identification of constituents validate the anti-cancer use of Uvaria chamae and Olax subscorpioidea
inferred← citeshttps://doi.org/10.6084/m9.figshare.25025833openalex-snapshot
Additional file 1 of Mitochondria-derived methylmalonic acid aggravates ischemia–reperfusion injury by activating reactive oxygen species-dependent ferroptosis
inferred← citeshttps://doi.org/10.6084/m9.figshare.25026025openalex-snapshot
Additional file 2 of Mitochondria-derived methylmalonic acid aggravates ischemia–reperfusion injury by activating reactive oxygen species-dependent ferroptosis
inferred← citeshttps://doi.org/10.70675/d6b2929ezc1c9z4870z8243zec5abc38de89openalex-snapshot
The pro-fibrotic miR-143/145 cluster promotes mesenchymal phenotypic plasticity associated with resistance to targeted therapies in melanoma
inferred← citeshttps://doi.org/10.7150/jca.69811openalex-snapshot
Peroxiredoxins - Urinary Surveillance Biomarkers in Urothelial Cancer
inferred← citeshttps://doi.org/10.7282/t3xs5vn5openalex-snapshot
Prostate cancer chemoprevention by dietary phytochemicals
inferred← citeshttps://doi.org/10.7314/apjcp.2015.16.17.7943openalex-snapshot
Mechanism of Action of Nigella sativa on Human Colon Cancer Cells: the Suppression of AP-1 and NF-κB Transcription Factors and the Induction of Cytoprotective Genes
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