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Accelerated diabetic wound healing by topical application of combination oral antidiabetic agents-loaded nanofibrous scaffolds: An in vitro and in vivo evaluation study

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Chronic Wound Healing: A Review of Current Management and Treatments
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Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin
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Autologously transplanted dermal fibroblasts improved diabetic wound in rat model
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inferredcites →https://doi.org/10.1016/j.cjtee.2017.06.001openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ijbiomac.2020.06.086openalex-snapshot
Development of Satureja cuneifolia-loaded sodium alginate/polyethylene glycol scaffolds produced by 3D-printing technology as a diabetic wound dressing material
inferredcites →https://doi.org/10.1016/j.ijpharm.2017.08.002openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ijpharm.2020.119782openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.it.2007.09.003openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.jconrel.2014.11.001openalex-snapshot
Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment
inferredcites →https://doi.org/10.1016/j.jdiacomp.2015.12.017openalex-snapshot
Diabetes medications: Impact on inflammation and wound healing
inferredcites →https://doi.org/10.1016/j.jep.2018.10.028openalex-snapshot
The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic β-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats
inferredcites →https://doi.org/10.1016/j.jpha.2014.02.002openalex-snapshot
Pioglitazone: A review of analytical methods
inferredcites →https://doi.org/10.1016/j.matlet.2016.07.110openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.msec.2014.10.051openalex-snapshot
In vitro and in vivo evaluation of electrospun nanofibers of PCL, chitosan and gelatin: A comparative study
inferredcites →https://doi.org/10.1016/j.msec.2016.04.001openalex-snapshot
Electrosprayed nanoparticle delivery system for controlled release
inferredcites →https://doi.org/10.1016/j.taap.2018.10.022openalex-snapshot
PPAR gamma agonist, pioglitazone, rescues liver damage induced by renal ischemia/reperfusion injury
inferredcites →https://doi.org/10.1016/s0002-9440(10)61723-3openalex-snapshot
Blockade of Receptor for Advanced Glycation End-Products Restores Effective Wound Healing in Diabetic Mice
inferredcites →https://doi.org/10.1021/am405329gopenalex-snapshot
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inferredcites →https://doi.org/10.1021/mp100077copenalex-snapshot
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inferredcites →https://doi.org/10.1038/s41598-017-18785-xopenalex-snapshot
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inferredcites →https://doi.org/10.1038/srep43924openalex-snapshot
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inferredcites →https://doi.org/10.1039/b103708kopenalex-snapshot
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inferredcites →https://doi.org/10.1039/c3tb20795aopenalex-snapshot
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inferredcites →https://doi.org/10.1039/c6tb03223kopenalex-snapshot
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inferredcites →https://doi.org/10.1039/c7ra13444dopenalex-snapshot
Nanofibers with diameter below one nanometer from electrospinning
inferredcites →https://doi.org/10.1046/j.1365-2613.2000.00158.xopenalex-snapshot
Antioxidant status in delayed healing type of wounds
inferredcites →https://doi.org/10.1063/1.5110965openalex-snapshot
Experimental and theoretical investigation of the fluid behavior during polymeric fiber formation with and without pressure
inferredcites →https://doi.org/10.1088/0957-4484/24/2/025701openalex-snapshot
Mechanical enhancement of nanofibrous scaffolds through polyelectrolyte complexation
inferredcites →https://doi.org/10.1089/ars.2005.7.1476openalex-snapshot
Hyperglycemia-Induced Reactive Oxygen Species and Impaired Endothelial Progenitor Cell Function
inferredcites →https://doi.org/10.1089/wound.2014.0595openalex-snapshot
Topical Collagen-Based Biomaterials for Chronic Wounds: Rationale and Clinical Application
inferredcites →https://doi.org/10.1098/rsif.2019.0712openalex-snapshot
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inferredcites →https://doi.org/10.1106/nytk-w829-uwc1-pmlwopenalex-snapshot
Chitosan and Gelatin as Engineered Dressing for Wound Repair
inferredcites →https://doi.org/10.1111/j.1440-1681.2009.05216.xopenalex-snapshot
Curcumin‐loaded poly(ε‐caprolactone) nanofibres: Diabetic wound dressing with anti‐oxidant and anti‐inflammatory properties
inferredcites →https://doi.org/10.1134/s1070427218050191openalex-snapshot
Electrospinning of Nanofibers Based on Chitosan/Gelatin Blend for Antibacterial Uses
inferredcites →https://doi.org/10.1155/2013/754802openalex-snapshot
Abnormal Cell Responses and Role of TNF- α in Impaired Diabetic Wound Healing
inferredcites →https://doi.org/10.1155/2014/848243openalex-snapshot
Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride
inferredcites →https://doi.org/10.1159/000433539openalex-snapshot
Receptor-Interacting Protein 140 Orchestrates the Dynamics of Macrophage M1/M2 Polarization
inferredcites →https://doi.org/10.1161/01.atv.0000201938.78044.75openalex-snapshot
Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells
inferredcites →https://doi.org/10.1177/2515221118769324openalex-snapshot
Fabrication and characterization of chitosan/gelatin/thermoplastic polyurethane blend nanofibers
inferredcites →https://doi.org/10.12968/jowc.2020.29.7.388openalex-snapshot
Effect of allicin on wound healing: an experimental diabetes model
inferredcites →https://doi.org/10.12991/mpj.2017.8openalex-snapshot
Antidiabetic effects of Salvia triloba and Thymus praecox subsp. skorpilii var. skorpilii in a rat model of streptozotocin/nicotinamide-induced diabetes
inferredcites →https://doi.org/10.1517/13543784.2014.922951openalex-snapshot
AMP-activated protein kinase activators in diabetic ulcers: from animal studies to Phase II drugs under investigation
inferredcites →https://doi.org/10.2147/dddt.s115466openalex-snapshot
Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy
inferredcites →https://doi.org/10.2147/jir.s86917openalex-snapshot
Hypoglycemic agents and potential anti-inflammatory activity
inferredcites →https://doi.org/10.2174/157339912803529922openalex-snapshot
Biological Activities of Receptor-interacting Protein 140 in Adipocytes and Metabolic Diseases
inferredcites →https://doi.org/10.2217/dmt.15.28openalex-snapshot
Nanotechnology as an innovative approach for accelerating wound healing in diabetes
inferredcites →https://doi.org/10.2337/db12-1450openalex-snapshot
Blocking Interleukin-1β Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes
inferredcites →https://doi.org/10.2337/dc08-9025openalex-snapshot
Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy
inferredcites →https://doi.org/10.2337/dc09-s062openalex-snapshot
Diagnosis and Classification of Diabetes Mellitus
inferredcites →https://doi.org/10.2337/dc11-s062openalex-snapshot
Diagnosis and Classification of Diabetes Mellitus
inferredcites →https://doi.org/10.2337/diacare.27.5.1047openalex-snapshot
Global Prevalence of Diabetes
inferredcites →https://doi.org/10.2353/ajpath.2007.060370openalex-snapshot
Accelerated Wound Closure in Mice Deficient for Interleukin-10
inferredcites →https://doi.org/10.3390/ijms160612925openalex-snapshot
The Effect of Electrospun Gelatin Fibers Alignment on Schwann Cell and Axon Behavior and Organization in the Perspective of Artificial Nerve Design
inferredcites →https://doi.org/10.4103/0976-9668.136168openalex-snapshot
Evaluation of metformin hydrochloride in Wistar rats by FTIR-ATR spectroscopy: A convenient tool in the clinical study of diabetes
inferredcites →https://doi.org/10.4103/2231-4040.101008openalex-snapshot
In vitro-in vivo evaluation of fast-dissolving tablets containing solid dispersion of pioglitazone hydrochloride
inferredcites →https://doi.org/10.4161/21623945.2014.981438openalex-snapshot
Injecting engineered anti-inflammatory macrophages therapeutically induces white adipose tissue browning and improves diet-induced insulin resistance
inferredcites →https://doi.org/10.5455/jice.20160923100135openalex-snapshot
Evaluation of wound healing activity of cow urine ark in diabetic Wistar albino rats
inferredcites →https://doi.org/10.5530/ijper.51.4s.109openalex-snapshot
Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin in Bulk and Tablet Dosage Form
inferredcites →https://doi.org/10.5935/0100-4042.20140243openalex-snapshot
INTERACTIONS OF CHITOSAN/GENIPIN HYDROGELS DURING DRUG DELIVERY: A QSPR APPROACH
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A Synergistic Therapeutic Scheme for Hyperglycemia and Nephrotic Disorders in Diabetes

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Cold-atmospheric plasma augments functionalities of hybrid polymeric carriers regenerating chronic wounds: In vivo experiments
inferred← citeshttps://doi.org/10.1016/j.mtchem.2025.103259openalex-snapshot
Recent advances in electrospun nanofiber-based strategies for diabetic wound healing application
inferred← citeshttps://doi.org/10.1016/j.xphs.2023.12.013openalex-snapshot
Sublingual Administration of Teucrium Polium-Loaded Nanofibers with Ultra-Fast Release in the Treatment of Diabetes Mellitus: In Vitro and In Vivo Evaluation
inferred← citeshttps://doi.org/10.1021/acsami.1c06986openalex-snapshot
Fabrication of Bacterial Cellulose-Based Dressings for Promoting Infected Wound Healing
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.5c00443openalex-snapshot
Improved Diabetic Wound Healing via Flower Extracellular Vesicles and Carbon-Dot-Infused Alginate-Polyethylenimine Antibacterial Hydrogel
inferred← citeshttps://doi.org/10.1021/acsomega.3c00914openalex-snapshot
Design of Cinnamaldehyde- and Gentamicin-Loaded Double-Layer Corneal Nanofiber Patches with Antibiofilm and Antimicrobial Effects
inferred← citeshttps://doi.org/10.1039/d1bm01211hopenalex-snapshot
Nanotechnology-based therapeutic applications: in vitro and in vivo clinical studies for diabetic wound healing
inferred← citeshttps://doi.org/10.1039/d4tb01469copenalex-snapshot
Exploring the potential of an Aloe vera and honey extract loaded bi-layered nanofibrous scaffold of PCL-Col and PCL-SBMA mimicking the skin architecture for the treatment of diabetic wounds
inferred← citeshttps://doi.org/10.1063/5.0071257openalex-snapshot
Core–sheath polymer nanofiber formation by the simultaneous application of rotation and pressure in a novel purpose-designed vessel
inferred← citeshttps://doi.org/10.1080/10717544.2022.2144963openalex-snapshot
Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing
inferred← citeshttps://doi.org/10.1080/10837450.2026.2630171openalex-snapshot
Lepidium sativum and metformin hydrochloride hydrogels for effective management of wounds in an induced diabetic rat model
inferred← citeshttps://doi.org/10.1088/1748-605x/acf25copenalex-snapshot
Biocompatible polyvinyl alcohol nanofibers loaded with amoxicillin and salicylic acid to prevent wound infections
inferred← citeshttps://doi.org/10.1088/1758-5090/acfd60openalex-snapshot
Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing
inferred← citeshttps://doi.org/10.1098/rsif.2023.0166openalex-snapshot
Casein fibres for wound healing
inferred← citeshttps://doi.org/10.1101/2022.02.16.480700openalex-snapshot
Dual-Drug Loaded Biomimetic Chitosan-Collagen Hybrid Nanocomposite Scaffolds for Ameliorating Potential Tissue Regeneration in Diabetic Wounds
inferred← citeshttps://doi.org/10.1111/iwj.14345openalex-snapshot
Topical metformin accelerates wound healing by promoting collagen synthesis and inhibiting apoptosis in a diabetic wound model
inferred← citeshttps://doi.org/10.1177/20417314241231452openalex-snapshot
Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration
inferred← citeshttps://doi.org/10.1186/s12951-021-01065-2openalex-snapshot
Nanofiber-based systems intended for diabetes
inferred← citeshttps://doi.org/10.1208/s12249-025-03172-xopenalex-snapshot
Recent Advances in the Local Drug Delivery Systems for Diabetic Wound Healing: A Comprehensive Review
inferred← citeshttps://doi.org/10.12677/acm.2025.1541070openalex-snapshot
Research Progress on Functional Nanohydrogel Treatment of Chronic Wounds in Diabetes
inferred← citeshttps://doi.org/10.2147/ijn.s395438openalex-snapshot
Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing
inferred← citeshttps://doi.org/10.2174/0113892037276171231016103320openalex-snapshot
Diabetic Wound: Pathophysiology, Complications and Treatment Strategies
inferred← citeshttps://doi.org/10.2174/0115672018279628231221105210openalex-snapshot
Fiber Technology in Drug Delivery and Pharmaceuticals
inferred← citeshttps://doi.org/10.2174/1566524023666220922114701openalex-snapshot
Role of Innate Immune and Inflammatory Responses in the Development of Secondary Diabetic Complications
inferred← citeshttps://doi.org/10.24294/ti.v8.i2.4186openalex-snapshot
A potential role of nanophytocompounds in diabetic foot ulcers
inferred← citeshttps://doi.org/10.26655/jmchemsci.2022.6.19openalex-snapshot
inferred← citeshttps://doi.org/10.29228/jrp.299openalex-snapshot
Production, characterization, and antioxidant activity evaluation of Rheum Ribes L. extract-loaded PLA/PEG nanofibers
inferred← citeshttps://doi.org/10.29228/jrp.527openalex-snapshot
The production of curcumin-loaded PLGA/PEG nanoparticle for the treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.33224/rrch.2024.69.3-4.02openalex-snapshot
Production and antioxidant activity of electrospun polylactic acid (PLA) nanofibrous mats containing naringenin (NAR) for potential wound healing applications
inferred← citeshttps://doi.org/10.3389/fbioe.2024.1354286openalex-snapshot
Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications
inferred← citeshttps://doi.org/10.3389/fbioe.2025.1629912openalex-snapshot
Electrospun bioactive polymer biomaterials enriched with collagen and platelet-rich plasma as a platform for in vitro chondrogenic differentiation of human mesenchymal stem cells
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1882663openalex-snapshot
Advances in diabetic foot ulcer management: a narrative review of novel antibiotics, nanotechnology, and regenerative therapeutics
inferred← citeshttps://doi.org/10.3390/app112210727openalex-snapshot
Levodopa-Loaded 3D-Printed Poly (Lactic) Acid/Chitosan Neural Tissue Scaffold as a Promising Drug Delivery System for the Treatment of Parkinson’s Disease
inferred← citeshttps://doi.org/10.3390/biom12121727openalex-snapshot
Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing
inferred← citeshttps://doi.org/10.3390/biomimetics9090508openalex-snapshot
Development and Evaluation of Fucoidan-Loaded Electrospun Polyvinyl Alcohol/Levan Nanofibers for Wound Dressing Applications
inferred← citeshttps://doi.org/10.3390/fib11020021openalex-snapshot
Nanofibres in Drug Delivery Applications
inferred← citeshttps://doi.org/10.3390/ijms24129900openalex-snapshot
Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers
inferred← citeshttps://doi.org/10.3390/ijms25031780openalex-snapshot
The Potential of PIP3 in Enhancing Wound Healing
inferred← citeshttps://doi.org/10.3390/ijms27156997openalex-snapshot
Healing the Sole: Combining Natural Plant Extracts and Conventional Drugs in Wound Delivery Systems for Diabetic Foot Ulcer Treatment
inferred← citeshttps://doi.org/10.3390/ma14205978openalex-snapshot
Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene
inferred← citeshttps://doi.org/10.3390/ph17101305openalex-snapshot
Silk Fibroin Nanofibers: Advancements in Bioactive Dressings through Electrospinning Technology for Diabetic Wound Healing
inferred← citeshttps://doi.org/10.3390/pharmaceutics13091469openalex-snapshot
Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation
inferred← citeshttps://doi.org/10.3390/pharmaceutics15030986openalex-snapshot
Nanofibrous Scaffolds for Diabetic Wound Healing
inferred← citeshttps://doi.org/10.3390/pharmaceutics18040421openalex-snapshot
Hot-Melt Processed Glibenclamide Glassy Solutions: A Novel Oral Delivery Platform for Enhanced Bioavailability in Diabetes
inferred← citeshttps://doi.org/10.3390/polym14235306openalex-snapshot
Production of 3D Printed Bi-Layer and Tri-Layer Sandwich Scaffolds with Polycaprolactone and Poly (vinyl alcohol)-Metformin towards Diabetic Wound Healing
inferred← citeshttps://doi.org/10.3390/polym17050637openalex-snapshot
Electrospun Coaxial Polycaprolactone/Polyvinylpyrrolidone Fibers Containing Cisplatin: A Potential Local Chemotherapy Delivery System for Cervical Cancer Treatment
inferred← citeshttps://doi.org/10.36306/konjes.1124919openalex-snapshot
GENTAMİSİN YÜKLÜ POLİ(VİNİL ALKOL)/JELATİN NANOFİBERLERİN ELEKTROEĞİRME YÖNTEMİYLE YARA ÖRTÜSÜ MALZEMESİ OLARAK ÜRETİLMESİ
inferred← citeshttps://doi.org/10.3892/wasj.2025.384openalex-snapshot
Mechanistic perspectives on the dermatologic potential of topical metformin: A scoping review
inferred← citeshttps://doi.org/10.47582/jompac.1865602openalex-snapshot
Fast-disintegrating under-eye mask: postbiotic-loaded polyvinylpyrrolidone nanofibers for anti-aging and hydration application
inferred← citeshttps://doi.org/10.52711/0974-360x.2024.00277openalex-snapshot
Development and Characterization Pioglitazone Hydrochloride Loaded Nanoparticle for Management of Diabetes Mellitus
inferred← citeshttps://doi.org/10.54097/1strve65openalex-snapshot
New Advances in the Treatment of Diabetic Wounds
inferred← citeshttps://doi.org/10.5530/ijper.58.3s.92openalex-snapshot
Optimization and Characterization of Lamivudine-Loaded TCS-PEG/MMT Polymeric Nanocomposites for Enhanced Antiretroviral Therapy
inferred← citeshttps://doi.org/10.56294/saludcyt20252665openalex-snapshot
Antidiabetic Effect of Raru (Vatica perakensis) Bark Extract and Mocaf Activated Carbon in Streptozotocin-induced Diabetic Ratsntidiabetic Effect of Raru (Vatica perakensis) Bark Extract and Mocaf Activated Carbon in Streptozotocin-induced Diabetic Rats
inferred← citeshttps://doi.org/10.9734/jpri/2022/v34i53b7230openalex-snapshot
Diabetic Foot Ulcers Healing Promoted by Novel Glibenclamide-loaded Micelle Wound Dressing
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