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Specific chemotherapy of Chagas disease: controversies and advances

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0002-8703(94)90521-5openalex-snapshot
Treatment of chronic Chagas' disease with benznidazole: Clinical and serologic evolution of patients with long-term follow-up
inferredcites →https://doi.org/10.1016/0009-2797(90)90106-wopenalex-snapshot
Sensitivity of parasites to free radical damage by antiparasitic drugs
inferredcites →https://doi.org/10.1016/0035-9203(92)90156-7openalex-snapshot
Specific chemotherapy of Chagas disease: a comparison between the response in patients and experimental animals inoculated with the same strains
inferredcites →https://doi.org/10.1016/0166-6851(89)90029-7openalex-snapshot
Leupeptin alters the proteolytic processing of P126, the major parasitophorous vacuole antigen of Plasmodium falciparum
inferredcites →https://doi.org/10.1016/0169-4758(96)10058-2openalex-snapshot
Autoimmunity in chagas disease cardiomyopathy: Fulfilling the criteria at last?
inferredcites →https://doi.org/10.1016/s0001-706x(01)00202-9openalex-snapshot
Pathogenesis of Chagas heart disease: role of autoimmunity
inferredcites →https://doi.org/10.1016/s0020-7519(01)00158-8openalex-snapshot
Parasite persistence in the aetiology of Chagas disease
inferredcites →https://doi.org/10.1016/s0020-7519(02)00283-7openalex-snapshot
Severity of chronic Chagas disease is associated with cytokine/antioxidant imbalance in chronically infected individuals
inferredcites →https://doi.org/10.1016/s0140-6736(96)04128-1openalex-snapshot
Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection
inferredcites →https://doi.org/10.1016/s0166-6851(01)00246-8openalex-snapshot
The acidocalcisome
inferredcites →https://doi.org/10.1016/s0166-6851(02)00206-2openalex-snapshot
Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana
inferredcites →https://doi.org/10.1016/s0166-6851(02)00282-7openalex-snapshot
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics
inferredcites →https://doi.org/10.1016/s0169-4758(00)01815-9openalex-snapshot
Reaching Maturity — 25 Years of the TDR
inferredcites →https://doi.org/10.1016/s0169-4758(97)01018-1openalex-snapshot
Etiological treatment for chagas disease—The National Health Foundation of Brazil
inferredcites →https://doi.org/10.1016/s0169-4758(99)01398-8openalex-snapshot
Chagas Disease Etiology: Autoimmunity or Parasite Persistence?
inferredcites →https://doi.org/10.1016/s0924-8579(02)00273-xopenalex-snapshot
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease
inferredcites →https://doi.org/10.1016/s0924-8579(02)00274-1openalex-snapshot
Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains
inferredcites →https://doi.org/10.1016/s0925-4439(02)00088-1openalex-snapshot
Inhibitors of dihydrofolate reductase in leishmania and trypanosomes
inferredcites →https://doi.org/10.1016/s1074-5521(00)00045-4openalex-snapshot
Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi
inferredcites →https://doi.org/10.1016/s1471-4922(03)00020-5openalex-snapshot
Trypanosomiasis control: surmounting diminishing returns
inferredcites →https://doi.org/10.1021/jm010459jopenalex-snapshot
Synthesis and Structure−Activity Relationship Study of Potent Trypanocidal Thio Semicarbazone Inhibitors of the Trypanosomal Cysteine Protease Cruzain
inferredcites →https://doi.org/10.1074/jbc.m103950200openalex-snapshot
Bisphosphonates Are Potent Inhibitors of Trypanosoma cruzi Farnesyl Pyrophosphate Synthase
inferredcites →https://doi.org/10.1084/jem.188.4.725openalex-snapshot
Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection
inferredcites →https://doi.org/10.1086/315743openalex-snapshot
Immunological and Clinical Evaluation of Chagasic Patients Subjected to Chemotherapy during the Acute Phase ofTrypanosoma cruziInfection 14–30 Years Ago
inferredcites →https://doi.org/10.1086/342415openalex-snapshot
Experimental Chemotherapy againstTrypanosoma cruziInfection: Essential Role of Endogenous Interferon‐γ in Mediating Parasitologic Cure
inferredcites →https://doi.org/10.1093/jac/48.4.515openalex-snapshot
Treatment of Trypanosoma cruzi-infected children with nifurtimox: a 3 year follow-up by PCR
inferredcites →https://doi.org/10.1097/00001432-200112000-00012openalex-snapshot
Specific treatment of Chagas disease: current status and new developments
inferredcites →https://doi.org/10.1126/science.289.5484.1508openalex-snapshot
Therapeutic Approaches to Bone Diseases
inferredcites →https://doi.org/10.1128/9781555818418openalex-snapshot
Emerging Infections 3
inferredcites →https://doi.org/10.1128/9781555818418.ch8openalex-snapshot
Chagas' Disease (American Trypanosomiasis): a Tropical Disease Now Emerging in the United States
inferredcites →https://doi.org/10.1128/aac.44.9.2498-2502.2000openalex-snapshot
In Vitro Antiproliferative Effects and Mechanism of Action of the New Triazole Derivative UR-9825 against the Protozoan ParasiteTrypanosoma(Schizotrypanum)cruzi
inferredcites →https://doi.org/10.1128/aac.45.4.1210-1215.2001openalex-snapshot
Potent Anti- Trypanosoma cruzi Activities of Oxidosqualene Cyclase Inhibitors
inferredcites →https://doi.org/10.1128/aac.46.11.3472-3477.2002openalex-snapshot
Proinflammatory and Cytotoxic Effects of Hexadecylphosphocholine (Miltefosine) against Drug-Resistant Strains of Trypanosoma cruzi
inferredcites →https://doi.org/10.1159/000237653openalex-snapshot
Immnunological Control of Trypanosoma cruzi Infection and Pathogenesis of Chagas’ Disease
inferredcites →https://doi.org/10.1179/000349803125002751openalex-snapshot
Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the regression and prevention of electrocardiographic abnormalities during 9 years of follow-up
inferredcites →https://doi.org/10.1517/13543776.13.5.661openalex-snapshot
New chemotherapeutic approaches for the treatment of Chagas disease (American Trypanosomiasis)
inferredcites →https://doi.org/10.1590/s0036-46652000000300009openalex-snapshot
Persistent infections in chronic Chagas' disease patients treated with anti-Trypanosoma cruzi nitroderivatives
inferredcites →https://doi.org/10.1590/s0037-86821988000200011openalex-snapshot
Ineficácia do allopurinol em pacientes na fase aguda da doença de Chagas
inferredcites →https://doi.org/10.1590/s0037-86822000000200006openalex-snapshot
Avaliação do tratamento específico para o Trypanosoma cruzi em crianças, na evolução da fase indeterminada
inferredcites →https://doi.org/10.1590/s0074-02761999000700064openalex-snapshot
Criteria of Chagas disease cure
inferredcites →https://doi.org/10.1590/s0074-02761999000700068openalex-snapshot
Parasitological cure of Chagas disease: is it possible? Is it relevant?
inferredcites →https://doi.org/10.1590/s0074-02761999000700070openalex-snapshot
Treatment of Trypanosoma cruzi infection in the undetermined phase. Experience and current guidelines of treatment in Argentina
inferredcites →https://doi.org/10.1590/s0074-02762001000600014openalex-snapshot
Parasite persistence in treated chagasic patients revealed by xenodiagnosis and polymerase chain reaction
inferredcites →https://doi.org/10.1590/s0074-02762002000100001openalex-snapshot
A Critical Review on Chagas Disease Chemotherapy
inferredcites →https://doi.org/10.2174/1381612013397528openalex-snapshot
The Major Cysteine Proteinase of Trypanosoma cruzi: A Valid Target for Chemotherapy of Chagas Disease
inferredcites →https://doi.org/10.2174/1381612013397546openalex-snapshot
Recent Developments in the Chemotherapy of Chagas Disease
inferredcites →https://doi.org/10.2174/1381612023396177openalex-snapshot
Chemotherapy of Chagas Disease
inferredcites →https://doi.org/10.2174/1389450003349290openalex-snapshot
Cysteine Proteinases of Trypanosome Parasites Novel Targets for Chemotherapy
inferredcites →https://doi.org/10.2174/1568005013343191openalex-snapshot
Bisphosphonates as Chemotherapeutic Agents Against Trypanosomatid and Apicomplexan Parasites.
inferredcites →https://doi.org/10.2174/1568026023393048openalex-snapshot
Enzymes of the Trypanothione Metabolism as Targets for Antitrypanosomal Drug Development
inferredcites →https://doi.org/10.4269/ajtmh.1998.59.133openalex-snapshot
Treatment of chronic Chagas' disease with itraconazole and allopurinol.
inferredcites →https://doi.org/10.4269/ajtmh.1998.59.526openalex-snapshot
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease.
inferredcites →https://doi.org/10.4269/ajtmh.1999.60.726openalex-snapshot
Myocardial parasite persistence in chronic chagasic patients.
inferredcites →https://doi.org/10.4269/ajtmh.2000.63.111openalex-snapshot
Progressive chronic Chagas heart disease ten years after treatment with anti-Trypanosoma cruzi nitroderivatives.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Predictive Assay Using Human Whole Blood and Flow Cytometry Analysis to Predict Immunomodulatory Effect of Anti-Trypanosoma Cruzi Drugs
inferred← citeshttps://doi.org/10.1002/9780470495131.ch7openalex-snapshot
ABC Proteins Involved in Protozoan Parasite Resistance
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Ergosterol Biosynthesis for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials
inferred← citeshttps://doi.org/10.1002/9783527670383.ch7openalex-snapshot
Function of Glycosomes in the Metabolism of Trypanosomatid Parasites and the Promise of Glycosomal Proteins as Drug Targets
inferred← citeshttps://doi.org/10.1002/ardp.201900213openalex-snapshot
New aryloxy‐quinone derivatives with promising activity on Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1002/clc.20091openalex-snapshot
Cardiac manifestations of parasitic infections part 2: Parasitic myocardial disease
inferred← citeshttps://doi.org/10.1002/cmdc.202000616openalex-snapshot
Synthesis and Structure−Activity Relationships of Imidazopyridine/Pyrimidine‐ and Furopyridine‐Based Anti‐infective Agents against Trypanosomiases
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Selenocyanate‐Containing Molecules as Trypanosoma cruzi Inhibitors: Impact of Regioisomerism, Conformational Restriction, and Second‐Ring Substitution
inferred← citeshttps://doi.org/10.1002/ddr.20454openalex-snapshot
Clinical aspects of Chagas disease and implications for novel therapies
inferred← citeshttps://doi.org/10.1002/ejic.201900904openalex-snapshot
Organometallic Gold(III) Complexes with Tridentate Halogen‐Substituted Thiosemicarbazones: Effects of Halogenation on Cytotoxicity and Anti‐Parasitic Activity
inferred← citeshttps://doi.org/10.1002/jcc.21374openalex-snapshot
Designing novel antitrypanosomal agents from a mixed graph‐theoretical substructural approach
inferred← citeshttps://doi.org/10.1002/pauz.200900346openalex-snapshot
Erfolgreiches Konzept: Proteasen als Zielstrukturen für Antiinfektiva. Neue Angriffspunkte in der Infektionstherapie
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Proteomics in Trypanosoma cruzi – localization of novel proteins to various organelles
inferred← citeshttps://doi.org/10.1002/pmic.200800874openalex-snapshot
Phosphoproteomic analysis of the human pathogen Trypanosoma cruzi at the epimastigote stage
inferred← citeshttps://doi.org/10.1002/prot.22614openalex-snapshot
Binding of nitrogen‐containing bisphosphonates (N‐BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer
inferred← citeshttps://doi.org/10.1002/ptr.3653openalex-snapshot
Trypanocidal Activity of Ergosterol Peroxide from Pleurotus ostreatus
inferred← citeshttps://doi.org/10.1002/qua.24213openalex-snapshot
Theoretical models for the antitrypanosomal activity of thiosemicarbazone derivatives
inferred← citeshttps://doi.org/10.1007/7355_2011_12openalex-snapshot
Overview of Neglected Tropical Diseases
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Sterol 14-Demethylase Inhibitors for Trypanosoma cruzi Infections
inferred← citeshttps://doi.org/10.1007/978-1-4614-2182-5_9openalex-snapshot
Delivering on Promises? The Impact of Kinetoplastid Genomics on Sleeping Sickness, Chagas Disease and Leishmaniasis
inferred← citeshttps://doi.org/10.1007/978-1-60327-595-8_38openalex-snapshot
Drug Resistance Assays for Parasites
inferred← citeshttps://doi.org/10.1007/978-3-030-00054-7_11openalex-snapshot
Orally Transmitted Chagas Disease: Biology, Epidemiology, and Clinical Aspects of a Foodborne Infection
inferred← citeshttps://doi.org/10.1007/978-3-030-47948-0_17openalex-snapshot
Surgical Management of Parasitic Diseases Involving the Heart
inferred← citeshttps://doi.org/10.1007/978-3-319-75022-4_13openalex-snapshot
New Therapeutic Strategies
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Infektionen
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Infektionen
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The Expected Outcome of the Trypanosoma cruzi Proteomic Map: A Review of Its Potential Biological Applications for Drug Target Discovery
inferred← citeshttps://doi.org/10.1007/978-94-007-7305-9_2openalex-snapshot
Selection of Molecular Targets for Drug Development Against Trypanosomatids
inferred← citeshttps://doi.org/10.1007/s00203-026-04930-6openalex-snapshot
Beyond the catalysis of Trypanosoma cruzi trans-sialidases: structure, function, post-translational modifications, intrinsically disordered regions and use of CRISPR/Cas9
inferred← citeshttps://doi.org/10.1007/s00436-006-0326-5openalex-snapshot
Effect of oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) essential oils on Trypanosoma cruzi (Protozoa: Kinetoplastida) growth and ultrastructure
inferred← citeshttps://doi.org/10.1007/s00436-006-0327-4openalex-snapshot
In vitro and in vivo activity of lignan lactones derivatives against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1007/s00436-008-0876-9openalex-snapshot
The toxic effects of piperine against Trypanosoma cruzi: ultrastructural alterations and reversible blockage of cytokinesis in epimastigote forms
inferred← citeshttps://doi.org/10.1007/s00436-008-1264-1openalex-snapshot
Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole
inferred← citeshttps://doi.org/10.1007/s00436-010-1725-1openalex-snapshot
(−)−Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles for Chagas disease
inferred← citeshttps://doi.org/10.1007/s00436-010-2002-zopenalex-snapshot
Association of clomipramine and allopurinol for the treatment of the experimental infection with Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1007/s00436-011-2275-xopenalex-snapshot
Trypanosoma cruzi: evaluation of (−)-cubebin derivatives activity in the messenger RNAs processing
inferred← citeshttps://doi.org/10.1007/s00436-013-3689-4openalex-snapshot
Stem cell therapy for the treatment of parasitic infections: is it far away?
inferred← citeshttps://doi.org/10.1007/s00775-013-1024-2openalex-snapshot
Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells
inferred← citeshttps://doi.org/10.1007/s00775-018-1535-yopenalex-snapshot
Ibandronate metal complexes: solution behavior and antiparasitic activity
inferred← citeshttps://doi.org/10.1007/s00775-020-01779-yopenalex-snapshot
Multi-target heteroleptic palladium bisphosphonate complexes
inferred← citeshttps://doi.org/10.1007/s10103-019-02795-4openalex-snapshot
Anti–Trypanosoma cruzi effect of the photodynamic antiparasitic chemotherapy using phenothiazine derivatives as photosensitizers
inferred← citeshttps://doi.org/10.1007/s10822-016-9985-1openalex-snapshot
Identification of novel Trypanosoma cruzi prolyl oligopeptidase inhibitors by structure-based virtual screening
inferred← citeshttps://doi.org/10.1007/s10863-010-9268-9openalex-snapshot
Mechanism of Trypanosoma cruzi death induced by Cratylia mollis seed lectin
inferred← citeshttps://doi.org/10.1007/s10973-011-1371-6openalex-snapshot
Polymorphic screen and drug–excipient compatibility studies of the antichagasic benznidazole
inferred← citeshttps://doi.org/10.1007/s11030-006-9044-2openalex-snapshot
Application of linear discriminant analysis in the virtual screening of antichagasic drugs through trypanothione reductase inhibition
inferred← citeshttps://doi.org/10.1007/s11033-025-10331-7openalex-snapshot
Current trends in application of CRISPR/Cas9 in gene editing and diagnostics in Neglected tropical diseases (NTDs)
inferred← citeshttps://doi.org/10.1007/s11095-011-0586-3openalex-snapshot
Mitochondria and Trypanosomatids: Targets and Drugs
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Nanotechnological interventions for treatment of trypanosomiasis in humans and animals
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Nanosuspensions: a new approach for organ and cellular targeting in infectious diseases
inferred← citeshttps://doi.org/10.1007/s43450-026-00761-0openalex-snapshot
Antitrypanosomal Activity of Allium sativum and Allicin Encapsulated in TiO2 and ZrO2 Nanoparticles
inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00226-1openalex-snapshot
Overview of Parasitic Infections
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Biochemistry of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/b978-0-12-384876-5.00025-3openalex-snapshot
Pathological Consequences of Host Response to Parasite
inferred← citeshttps://doi.org/10.1016/b978-0-12-385863-4.00007-1openalex-snapshot
Genetic Epidemiology of Chagas Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-801029-7.00017-4openalex-snapshot
Biochemistry of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/b978-0-323-46152-8.00013-5openalex-snapshot
Nanocarrier-Assisted Antimicrobial Therapy Against Intracellular Pathogens
inferred← citeshttps://doi.org/10.1016/b978-0-323-55512-8.00103-4openalex-snapshot
American Trypanosomiasis (Chagas Disease)
inferred← citeshttps://doi.org/10.1016/b978-1-4160-4044-6.50238-7openalex-snapshot
TRYPANOSOMIASIS
inferred← citeshttps://doi.org/10.1016/b978-1-4160-4390-4.00098-9openalex-snapshot
American Trypanosomiasis (Chagas disease)
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Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in vitro-induced resistance to benznidazole
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Effect of l-leucine methyl ester on growth and ultrastructure of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.actatropica.2008.04.011openalex-snapshot
Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole
inferred← citeshttps://doi.org/10.1016/j.actatropica.2009.02.007openalex-snapshot
Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.actatropica.2009.10.023openalex-snapshot
Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches
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Research needs for Chagas disease prevention
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In vitro and in vivo trypanocidal activity of some benzimidazole derivatives against two strains of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.actatropica.2012.11.014openalex-snapshot
The natural compounds piperovatine and piperlonguminine induce autophagic cell death on Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.actatropica.2015.02.012openalex-snapshot
Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease
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Oxidative stress, cardiomyocytes premature senescence and contractile dysfunction in in vitro and in vivo experimental models of Chagas disease
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Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles☆
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Nanotechnological approaches against Chagas disease
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DNA topoisomerase I from parasitic protozoa: A potential target for chemotherapy
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Inorganic phosphate uptake in Trypanosoma cruzi is coupled to K+ cycling and to active Na+ extrusion
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Molecular cloning and characterization of ouabain-insensitive Na+-ATPase in the parasitic protist, Trypanosoma cruzi
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Protein kinases as drug targets in trypanosomes and Leishmania
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Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi
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Activity of “reversed” diamidines against Trypanosoma cruzi “in vitro”
inferred← citeshttps://doi.org/10.1016/j.biochi.2023.09.014openalex-snapshot
At the outer part of the active site in Trypanosoma cruzi glucokinase: The role of phenylalanine 337
inferred← citeshttps://doi.org/10.1016/j.bioorg.2010.06.003openalex-snapshot
3-Hydroxy-2-methylene-3-(4-nitrophenylpropanenitrile): A new highly active compound against epimastigote and trypomastigote form of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.bioorg.2017.03.008openalex-snapshot
Aryl- or heteroaryl-based hydrazinylphthalazine derivatives as new potential antitrypanosomal agents
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Synthesis and biological evaluation of new quinoline derivatives as antileishmanial and antitrypanosomal agents
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Antitrypanosomal activity of isololiolide isolated from the marine hydroid Macrorhynchia philippina (Cnidaria, Hydrozoa)
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Synthetic and medicinal chemistry of phthalazines: Recent developments, opportunities and challenges
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Synthesis, bio-physical and anti-leishmanial studies of some novel indolo[3,2-a]phenanthridine derivatives
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New drugs with antiprotozoal activity from marine algae: a review
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New 3-piperonylcoumarins as inhibitors of glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) from Trypanosoma cruzi
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Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies
inferred← citeshttps://doi.org/10.1016/j.bmc.2006.09.048openalex-snapshot
Synthesis and trypanocidal activity of ent-kaurane glycosides
inferred← citeshttps://doi.org/10.1016/j.bmc.2006.09.067openalex-snapshot
Synthesis, in vitro evaluation, and SAR studies of a potential antichagasic 1H-pyrazolo[3,4-b]pyridine series
inferred← citeshttps://doi.org/10.1016/j.bmc.2006.12.033openalex-snapshot
1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.bmc.2007.07.031openalex-snapshot
Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action
inferred← citeshttps://doi.org/10.1016/j.bmc.2007.11.077openalex-snapshot
Imidazolidines as new anti-Trypanosoma cruzi agents: Biological evaluation and structure–activity relationships
inferred← citeshttps://doi.org/10.1016/j.bmc.2008.08.057openalex-snapshot
Anacardic acid derivatives as inhibitors of glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.bmc.2008.11.065openalex-snapshot
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.02.056openalex-snapshot
Molecular modeling studies and in vitro bioactivity evaluation of a set of novel 5-nitro-heterocyclic derivatives as anti-T. cruzi agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.05.071openalex-snapshot
Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure–activity relationships
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.07.068openalex-snapshot
Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.09.013openalex-snapshot
5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.12.062openalex-snapshot
Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.05.018openalex-snapshot
Synthesis, structural elucidation and in vitro antiparasitic activity against Trypanosoma cruzi and Leishmania chagasi parasites of novel tetrahydro-1-benzazepine derivatives
inferred← citeshttps://doi.org/10.1016/j.bmc.2011.02.037openalex-snapshot
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase
inferred← citeshttps://doi.org/10.1016/j.bmc.2011.09.009openalex-snapshot
Synthesis, molecular modeling and preliminary biological evaluation of a set of 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazole as potential antibacterial, anti-Trypanosoma cruzi and antifungal agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.06.028openalex-snapshot
Chemoenzymatic synthesis and biological evaluation of 2- and 3-hydroxypyridine derivatives against Leishmania mexicana
inferred← citeshttps://doi.org/10.1016/j.bmc.2013.01.050openalex-snapshot
Design, structure–activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.bmc.2017.10.016openalex-snapshot
Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation
inferred← citeshttps://doi.org/10.1016/j.bmcl.2004.06.042openalex-snapshot
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
inferred← citeshttps://doi.org/10.1016/j.bmcl.2004.07.003openalex-snapshot
In vitro anti-parasitic activity of Cyclosporin A analogs on Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.bmcl.2004.10.007openalex-snapshot
Synthesis and antitrypanosomal profile of new functionalized 1,3,4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues
inferred← citeshttps://doi.org/10.1016/j.bmcl.2005.07.060openalex-snapshot
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase
inferred← citeshttps://doi.org/10.1016/j.bmcl.2006.05.041openalex-snapshot
Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas’ disease
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.07.012openalex-snapshot
Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation
inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.05.013openalex-snapshot
Synthesis and in vitro activity of new tetrahydronaphtho[1,2-b]azepine derivatives against Trypanosoma cruzi and Leishmania chagasi parasites
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.08.055openalex-snapshot
Selective inactivation of triosephosphate isomerase from Trypanosoma cruzi by brevifolin carboxylate derivatives isolated from Geranium bellum Rose
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.07.112openalex-snapshot
Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.02.045openalex-snapshot
Phosphonium lipocations as antiparasitic agents
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.02.054openalex-snapshot
New antiprotozoal agents: Their synthesis and biological evaluations
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.08.015openalex-snapshot
Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents
inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.02.046openalex-snapshot
Synthesis and tripanocidal activity of ferrocenyl and benzyl diamines against Trypanosoma brucei and Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.10.082openalex-snapshot
An abietane diterpene from Salvia cuspidata and some new derivatives are active against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.06.013openalex-snapshot
Synthesis and biological evaluation of 2-methyl-1H-benzimidazole-5-carbohydrazides derivatives as modifiers of redox homeostasis of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.bmcl.2019.05.037openalex-snapshot
Discovery of antichagasic inhibitors by high-throughput screening with Trypanosoma cruzi glucokinase
inferred← citeshttps://doi.org/10.1016/j.bmcl.2021.128227openalex-snapshot
Synthesis, biochemical, and biological evaluation of C2 linkage derivatives of amino sugars, inhibitors of glucokinase from Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.ccr.2023.215608openalex-snapshot
Biosynthesis of ergosterol as a relevant molecular target of metal-based antiparasitic and antifungal compounds
inferred← citeshttps://doi.org/10.1016/j.ceca.2020.102284openalex-snapshot
IP3 receptor-mediated Ca2+ release from acidocalcisomes regulates mitochondrial bioenergetics and prevents autophagy in Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.chemolab.2016.03.023openalex-snapshot
Variable-selection approaches to generate QSAR models for a set of antichagasic semicarbazones and analogues
inferred← citeshttps://doi.org/10.1016/j.chroma.2005.10.063openalex-snapshot
Development and characterization of an immobilized enzyme reactor (IMER) based on human glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies
inferred← citeshttps://doi.org/10.1016/j.drudis.2006.06.014openalex-snapshot
Targeting atypical trypanosomatid DNA topoisomerase I
inferred← citeshttps://doi.org/10.1016/j.drudis.2007.12.004openalex-snapshot
Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease
inferred← citeshttps://doi.org/10.1016/j.dyepig.2010.09.001openalex-snapshot
Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides
inferred← citeshttps://doi.org/10.1016/j.eimc.2010.03.014openalex-snapshot
Co-infection with two emergent old pathogens: Trypanosoma cruzi and Helicobacter pylori
inferred← citeshttps://doi.org/10.1016/j.ejmech.2008.06.024openalex-snapshot
In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles
inferred← citeshttps://doi.org/10.1016/j.ejmech.2010.01.052openalex-snapshot
Naftifine-analogues as anti-Trypanosoma cruzi agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.07.013openalex-snapshot
Synthesis and biological evaluation of some novel 1-indanone thiazolylhydrazone derivatives as anti-Trypanosoma cruzi agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.12.015openalex-snapshot
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.04.022openalex-snapshot
Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.04.065openalex-snapshot
Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.09.009openalex-snapshot
Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.08.012openalex-snapshot
2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: Structural design, synthesis and pharmacological evaluation
inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.01.065openalex-snapshot
Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir
inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.03.063openalex-snapshot
Bond-based bilinear indices for computational discovery of novel trypanosomicidal drug-like compounds through virtual screening
inferred← citeshttps://doi.org/10.1016/j.ejmech.2015.04.028openalex-snapshot
Design, synthesis and biological evaluation of quinazoline derivatives as anti-trypanosomatid and anti-plasmodial agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.09.045openalex-snapshot
Novel 2-arylazoimidazole derivatives as inhibitors of Trypanosoma cruzi proliferation: Synthesis and evaluation of their biological activity
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.01.022openalex-snapshot
Design, synthesis, structure-activity relationship and mechanism of action studies of a series of 4-chloro-1-phthalazinyl hydrazones as a potent agent against Leishmania braziliensis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.09.047openalex-snapshot
Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.07.018openalex-snapshot
2-(phenylthio)ethylidene derivatives as anti-Trypanosoma cruzi compounds: Structural design, synthesis and antiparasitic activity
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114624openalex-snapshot
Rational design of a trypanocidal peptide derived from Dinoponera quadriceps venom
inferred← citeshttps://doi.org/10.1016/j.ejps.2009.10.007openalex-snapshot
Computational discovery of novel trypanosomicidal drug-like chemicals by using bond-based non-stochastic and stochastic quadratic maps and linear discriminant analysis
inferred← citeshttps://doi.org/10.1016/j.ejps.2015.07.014openalex-snapshot
QSAR study and conformational analysis of 4-arylthiazolylhydrazones derived from 1-indanones with anti-Trypanosoma cruzi activity
inferred← citeshttps://doi.org/10.1016/j.ejps.2018.07.005openalex-snapshot
Preclinical pharmacokinetics of benznidazole-loaded interpolyelectrolyte complex-based delivery systems
inferred← citeshttps://doi.org/10.1016/j.emchg.2005.01.004openalex-snapshot
Colites parasitaires
inferred← citeshttps://doi.org/10.1016/j.exppara.2007.05.013openalex-snapshot
Trypanosoma cruzi: Characterisation of the gene encoding tyrosine aminotransferase in benznidazole-resistant and susceptible populations
inferred← citeshttps://doi.org/10.1016/j.exppara.2009.01.013openalex-snapshot
Trypanosoma cruzi: Antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro
inferred← citeshttps://doi.org/10.1016/j.exppara.2009.02.005openalex-snapshot
Trypanosoma cruzi: Isolation and characterization of aspartyl proteases
inferred← citeshttps://doi.org/10.1016/j.exppara.2010.06.015openalex-snapshot
Corticosterone evaluation in Wistar rats infected with the Y strain of Trypanosoma cruzi during the chronic phase
inferred← citeshttps://doi.org/10.1016/j.exppara.2011.01.009openalex-snapshot
Trypanocidal properties, structure–activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives
inferred← citeshttps://doi.org/10.1016/j.exppara.2012.02.028openalex-snapshot
In vitro activity of N-benzenesulfonylbenzotriazole on Trypanosoma cruzi epimastigote and trypomastigote forms
inferred← citeshttps://doi.org/10.1016/j.exppara.2013.04.005openalex-snapshot
In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection
inferred← citeshttps://doi.org/10.1016/j.exppara.2016.04.007openalex-snapshot
Antiparasitic evaluation of betulinic acid derivatives reveals effective and selective anti-Trypanosoma cruzi inhibitors
inferred← citeshttps://doi.org/10.1016/j.exppara.2019.01.011openalex-snapshot
Anti-leishmanial effect of spiro dihydroquinoline-oxindoles on volume regulation decrease and sterol biosynthesis of Leishmania braziliensis
inferred← citeshttps://doi.org/10.1016/j.exppara.2023.108490openalex-snapshot
A functional assay using human whole blood and flow cytometry analysis to evaluate cytotoxicity and immunomodulatory effect of anti-Trypanosoma cruzi drugs
inferred← citeshttps://doi.org/10.1016/j.femsre.2004.06.004openalex-snapshot
Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target
inferred← citeshttps://doi.org/10.1016/j.heliyon.2019.e01304openalex-snapshot
QSAR study of anti-Human African Trypanosomiasis activity for 2-phenylimidazopyridines derivatives using DFT and Lipinski's descriptors
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2005.12.012openalex-snapshot
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2007.11.001openalex-snapshot
In vitro effects of suramin on Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.ijantimicag.2012.03.009openalex-snapshot
Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2019.12.101openalex-snapshot
Structure of Urocanate Hydratase from the protozoan Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.151379openalex-snapshot
Chitosan nanogels for the improvement of benznidazole activity
inferred← citeshttps://doi.org/10.1016/j.ijpara.2004.05.002openalex-snapshot
Proteome analysis of the causative agent of Chagas disease: Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.ijpara.2005.08.004openalex-snapshot
Gene expression profiles in response to Fas stimulation in Trypanosoma cruzi-infected host cells
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2011.12.002openalex-snapshot
Recent developments in sterol 14-demethylase inhibitors for Chagas disease
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2014.02.002openalex-snapshot
Drug repurposing and human parasitic protozoan diseases
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2005.10.004openalex-snapshot
Development of parenteral formulations and evaluation of the biological activity of the trypanocide drug benznidazole
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124417openalex-snapshot
Supramolecular eutectogel as new oral paediatric delivery system to enhance benznidazole bioavailability
inferred← citeshttps://doi.org/10.1016/j.imbio.2009.05.005openalex-snapshot
Immunomodulatory effects of zinc and DHEA on the Th-1 immune response in rats infected with Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.intimp.2019.105961openalex-snapshot
Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy
inferred← citeshttps://doi.org/10.1016/j.jep.2006.07.028openalex-snapshot
Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice
inferred← citeshttps://doi.org/10.1016/j.jfluchem.2018.08.004openalex-snapshot
Thiosemicarbazones and thiadiazines derived from fluorinated benzoylthioureas: Synthesis, crystal structure and anti-Trypanosoma cruzi activity
inferred← citeshttps://doi.org/10.1016/j.jim.2017.07.002openalex-snapshot
Avian antibodies (IgY) against Trypanosoma cruzi : Purification and characterization studies
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2010.08.004openalex-snapshot
Risedronate metal complexes potentially active against Chagas disease
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2012.08.024openalex-snapshot
Activity on Trypanosoma cruzi, erythrocytes lysis and biologically relevant physicochemical properties of Pd(II) and Pt(II) complexes of thiosemicarbazones derived from 1-indanones
inferred← citeshttps://doi.org/10.1016/j.jmgm.2005.09.008openalex-snapshot
Conformational analyses and docking studies of a series of 5-nitrofuran- and 5-nitrothiophen-semicarbazone derivatives in three possible binding sites of trypanothione and glutathione reductases
inferred← citeshttps://doi.org/10.1016/j.jmgm.2006.02.001openalex-snapshot
Characterization of the farnesyl pyrophosphate synthase of Trypanosoma cruzi by homology modeling and molecular dynamics
inferred← citeshttps://doi.org/10.1016/j.jmgm.2009.08.011openalex-snapshot
Molecular docking of a series of peptidomimetics in the trypanothione binding site of T. cruzi Trypanothione Reductase
inferred← citeshttps://doi.org/10.1016/j.jmgm.2017.07.013openalex-snapshot
In silico molecular docking studies of new potential 4-phthalazinyl-hydrazones on selected Trypanosoma cruzi and Leishmania enzyme targets
inferred← citeshttps://doi.org/10.1016/j.lfs.2007.04.033openalex-snapshot
Nifurtimox nitroreductase activity in different cellular fractions from male rat pancreas. Biochemical and ultrastructural alterations
inferred← citeshttps://doi.org/10.1016/j.micinf.2004.11.009openalex-snapshot
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B
inferred← citeshttps://doi.org/10.1016/j.micinf.2010.04.011openalex-snapshot
Role of CCL3/MIP-1α and CCL5/RANTES during acute Trypanosoma cruzi infection in rats
inferred← citeshttps://doi.org/10.1016/j.micres.2005.10.003openalex-snapshot
The influence of culture conditions on the biosynthesis of secondary metabolites by Penicillium verrucosum Dierck
inferred← citeshttps://doi.org/10.1016/j.micres.2013.07.014openalex-snapshot
Pharmaceutically active secondary metabolites of marine actinobacteria
inferred← citeshttps://doi.org/10.1016/j.micron.2008.08.003openalex-snapshot
Different cell death pathways induced by drugs in Trypanosoma cruzi: An ultrastructural study
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2005.09.018openalex-snapshot
Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: A unified nomenclature
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2005.12.001openalex-snapshot
Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in vitro-induced benznidazole resistance in Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2009.04.001openalex-snapshot
Functional characterization of stage-specific aminotransferases from trypanosomatids
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2010.05.019openalex-snapshot
Identification, cloning and characterization of an aldo-keto reductase from Trypanosoma cruzi with quinone oxido-reductase activity
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2011.01.010openalex-snapshot
Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2012.07.009openalex-snapshot
Functional characterization of enzymes involved in cysteine biosynthesis and H2S production in Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2015.12.004openalex-snapshot
Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase
inferred← citeshttps://doi.org/10.1016/j.parint.2004.11.001openalex-snapshot
Inhibitory action of marine algae extracts on the Trypanosoma cruzi dihydroorotate dehydrogenase activity and on the protozoan growth in mammalian cells
inferred← citeshttps://doi.org/10.1016/j.parint.2005.08.001openalex-snapshot
Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms
inferred← citeshttps://doi.org/10.1016/j.parint.2013.02.004openalex-snapshot
Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection
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