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Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism

https://doi.org/10.1016/j.tem.2017.10.007
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1 of the 59 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1007/s00125-011-2130-8 (notice 2026-02-06).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.20458openalex-snapshot
The isoform‐specific functions of the c‐Jun N‐terminal Kinases (JNKs): differences revealed by gene targeting
inferredcites →https://doi.org/10.1007/s00018-008-8170-7openalex-snapshot
The complexity of mitogen-activated protein kinases (MAPKs) made simple
inferredcites →https://doi.org/10.1007/s00125-010-1944-0openalex-snapshot
Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity
inferredcites →https://doi.org/10.1007/s00125-011-2130-8openalex-snapshot
RETRACTED ARTICLE: Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease
inferredcites →https://doi.org/10.1007/s11010-016-2878-8openalex-snapshot
Protein kinases: mechanisms and downstream targets in inflammation-mediated obesity and insulin resistance
inferredcites →https://doi.org/10.1016/j.biochi.2004.10.018openalex-snapshot
The role of MAPKs in adipocyte differentiation and obesity
inferredcites →https://doi.org/10.1016/j.biochi.2017.03.004openalex-snapshot
ERK1 and ERK2 activation modulates diet-induced obesity in mice
inferredcites →https://doi.org/10.1016/j.ceb.2007.02.001openalex-snapshot
The JNK signal transduction pathway
inferredcites →https://doi.org/10.1016/j.cell.2004.12.041openalex-snapshot
Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases
inferredcites →https://doi.org/10.1016/j.cell.2008.11.018openalex-snapshot
Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis
inferredcites →https://doi.org/10.1016/j.cell.2011.08.034openalex-snapshot
Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation
inferredcites →https://doi.org/10.1016/j.cellsig.2006.08.015openalex-snapshot
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1
inferredcites →https://doi.org/10.1016/j.celrep.2016.02.026openalex-snapshot
Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK
inferredcites →https://doi.org/10.1016/j.cmet.2006.05.010openalex-snapshot
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity
inferredcites →https://doi.org/10.1016/j.cmet.2009.09.007openalex-snapshot
Prevention of Steatosis by Hepatic JNK1
inferredcites →https://doi.org/10.1016/j.cmet.2014.06.010openalex-snapshot
The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway
inferredcites →https://doi.org/10.1016/j.cmet.2015.04.004openalex-snapshot
Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis
inferredcites →https://doi.org/10.1016/j.cmet.2017.08.002openalex-snapshot
Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases
inferredcites →https://doi.org/10.1016/j.jhep.2014.12.032openalex-snapshot
Hepatic p38α regulates gluconeogenesis by suppressing AMPK
inferredcites →https://doi.org/10.1016/j.mce.2012.03.025openalex-snapshot
MEK/ERK pathway mediates insulin-promoted degradation of MKP-3 protein in liver cells
inferredcites →https://doi.org/10.1016/j.phrs.2012.04.005openalex-snapshot
ERK1/2 MAP kinases: Structure, function, and regulation
inferredcites →https://doi.org/10.1016/j.tem.2017.03.003openalex-snapshot
Unraveling the Regulation of Hepatic Metabolism by Insulin
inferredcites →https://doi.org/10.1016/s0959-437x(01)00258-1openalex-snapshot
The JNK signal transduction pathway
inferredcites →https://doi.org/10.1038/embor.2010.160openalex-snapshot
MAPK signalling in cellular metabolism: stress or wellness?
inferredcites →https://doi.org/10.1038/nature07976openalex-snapshot
Autophagy regulates lipid metabolism
inferredcites →https://doi.org/10.1038/ng2033openalex-snapshot
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
inferredcites →https://doi.org/10.1038/nm.2449openalex-snapshot
p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis
inferredcites →https://doi.org/10.1038/nm.4350openalex-snapshot
Insulin action and resistance in obesity and type 2 diabetes
inferredcites →https://doi.org/10.1038/nutd.2016.11openalex-snapshot
Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo
inferredcites →https://doi.org/10.1042/bj20100323openalex-snapshot
Mechanisms and functions of p38 MAPK signalling
inferredcites →https://doi.org/10.1074/jbc.m105945200openalex-snapshot
p38 Mitogen-activated Protein Kinase Activates Peroxisome Proliferator-activated Receptor α
inferredcites →https://doi.org/10.1074/jbc.m110.210237openalex-snapshot
Loss of Mitogen-activated Protein Kinase Phosphatase-1 Protects from Hepatic Steatosis by Repression of Cell Death-inducing DNA Fragmentation Factor A (DFFA)-like Effector C (CIDEC)/Fat-specific Protein 27
inferredcites →https://doi.org/10.1074/jbc.m205277200openalex-snapshot
A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation
inferredcites →https://doi.org/10.1074/jbc.m303264200openalex-snapshot
Cross-talk between JNK/SAPK and ERK/MAPK Pathways
inferredcites →https://doi.org/10.1074/jbc.m506223200openalex-snapshot
p38 Mitogen-activated Protein Kinase Plays a Stimulatory Role in Hepatic Gluconeogenesis
inferredcites →https://doi.org/10.1093/toxsci/kft230openalex-snapshot
The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease
inferredcites →https://doi.org/10.1111/febs.14209openalex-snapshot
Nonalcoholic fatty liver disease promotes hepatocellular carcinoma through direct and indirect effects on hepatocytes
inferredcites →https://doi.org/10.1111/j.1742-4658.2012.08716.xopenalex-snapshot
Dual‐specificity MAP kinase phosphatases (MKPs)
inferredcites →https://doi.org/10.1113/jp271457openalex-snapshot
The roles of c‐Jun NH2‐terminal kinases (JNKs) in obesity and insulin resistance
inferredcites →https://doi.org/10.1124/pr.107.00106openalex-snapshot
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
inferredcites →https://doi.org/10.1126/science.1068873openalex-snapshot
MAP Kinase Phosphatase As a Locus of Flexibility in a Mitogen-Activated Protein Kinase Signaling Network
inferredcites →https://doi.org/10.1126/science.1072682openalex-snapshot
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
inferredcites →https://doi.org/10.1126/science.1227568openalex-snapshot
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
inferredcites →https://doi.org/10.1126/science.7839144openalex-snapshot
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
inferredcites →https://doi.org/10.1128/mcb.00503-14openalex-snapshot
Hepatic Mitogen-Activated Protein Kinase Phosphatase 1 Selectively Regulates Glucose Metabolism and Energy Homeostasis
inferredcites →https://doi.org/10.1128/mcb.01162-09openalex-snapshot
Role of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance
inferredcites →https://doi.org/10.1128/mmbr.00031-10openalex-snapshot
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
inferredcites →https://doi.org/10.1136/gutjnl-2013-305507openalex-snapshot
Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
inferredcites →https://doi.org/10.1146/annurev-physiol-021909-135846openalex-snapshot
Macrophages, Inflammation, and Insulin Resistance
inferredcites →https://doi.org/10.1152/physrev.00028.2011openalex-snapshot
Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update
inferredcites →https://doi.org/10.1152/physrev.1999.79.1.143openalex-snapshot
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
inferredcites →https://doi.org/10.1161/jaha.113.000361openalex-snapshot
Hepatic Extracellular Signal–Regulated Kinase 2 Suppresses Endoplasmic Reticulum Stress and Protects From Oxidative Stress and Endothelial Dysfunction
inferredcites →https://doi.org/10.1172/jci43250openalex-snapshot
MAPK phosphatase–3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
inferredcites →https://doi.org/10.1371/journal.pone.0041168openalex-snapshot
Mapping MKP-3/FOXO1 Interaction and Evaluating the Effect on Gluconeogenesis
inferredcites →https://doi.org/10.15252/embj.201591857openalex-snapshot
p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration
inferredcites →https://doi.org/10.1530/jme-15-0146openalex-snapshot
Stress kinases in the modulation of metabolism and energy balance
inferredcites →https://doi.org/10.2337/db14-0066openalex-snapshot
Mitogen-Activated Protein Kinase Phosphatase 3 (MKP-3)–Deficient Mice Are Resistant to Diet-Induced Obesity
inferredcites →https://doi.org/10.2337/diabetes.54.2.402openalex-snapshot
The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis
inferredcites →https://doi.org/10.3892/mmr.2016.5966openalex-snapshot
Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Dual‐Specificity Phosphatase 9 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through ASK1 Suppression
inferred← citeshttps://doi.org/10.1002/hep.30485openalex-snapshot
Dual‐Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta–Activated Kinase 1 Suppression
inferred← citeshttps://doi.org/10.1002/hep.30851openalex-snapshot
ASKing No More: The Emerging Role of Dual‐Specific Phosphatase 12 in the Regulation of Hepatic Lipid Metabolism
inferred← citeshttps://doi.org/10.1002/hep.31390openalex-snapshot
Protective and Detrimental Roles of p38α Mitogen‐Activated Protein Kinase in Different Stages of Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1002/hep.32179openalex-snapshot
OTUB1 alleviates NASH through inhibition of the TRAF6‐ASK1 signaling pathways
inferred← citeshttps://doi.org/10.1002/hep4.1279openalex-snapshot
Inhibition of Adenosine Monophosphate–Activated Protein Kinase–3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance
inferred← citeshttps://doi.org/10.1002/hep4.1366openalex-snapshot
Is Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis?
inferred← citeshttps://doi.org/10.1002/jcp.28540openalex-snapshot
Dephosphorylation‐induced EZH2 activation mediated RECK downregulation by ERK1/2 signaling
inferred← citeshttps://doi.org/10.1002/mco2.283openalex-snapshot
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A High‐Fat High‐Fructose Diet Dysregulates the Homeostatic Crosstalk Between Gut Microbiome, Metabolome, and Immunity in an Experimental Model of Obesity
inferred← citeshttps://doi.org/10.1007/s00109-019-01765-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00204-019-02590-8openalex-snapshot
Transcriptome analysis revealed the mechanism of the metabolic toxicity and susceptibility of di-(2-ethylhexyl)phthalate on adolescent male ICR mice with type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1007/s10126-020-09974-3openalex-snapshot
Transcriptomic Response to Selective Breeding for Fast Growth in Rainbow Trout (Oncorhynchus mykiss)
inferred← citeshttps://doi.org/10.1007/s10142-021-00798-5openalex-snapshot
A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity
inferred← citeshttps://doi.org/10.1007/s10528-026-11321-5openalex-snapshot
Potential Targets in Nonalcoholic Steatohepatitis Based on Bioinformatics Analysis and Machine Learning Strategies
inferred← citeshttps://doi.org/10.1007/s10719-023-10131-wopenalex-snapshot
Konjac glucomannan attenuate high-fat diet-fed obesity through enhancing β-adrenergic-mediated thermogenesis in inguinal white adipose tissue in mice
inferred← citeshttps://doi.org/10.1007/s11033-022-07965-2openalex-snapshot
HADHA alleviates hepatic steatosis and oxidative stress in NAFLD via inactivation of the MKK3/MAPK pathway
inferred← citeshttps://doi.org/10.1007/s11033-022-08206-2openalex-snapshot
Human milk-derived extracellular vesicles alleviate high fat diet-induced non-alcoholic fatty liver disease in mice
inferred← citeshttps://doi.org/10.1007/s13273-021-00119-8openalex-snapshot
Prevention of acetaminophen-induced hepatocyte injury: JNK inhibition and GSTA1 involvement
inferred← citeshttps://doi.org/10.1007/s43188-024-00263-yopenalex-snapshot
Rocaglamide-A mitigates LPS-induced hepatic inflammation by modulating JNK/AP-1 signaling cascade and ROS production in hepatocytes
inferred← citeshttps://doi.org/10.1016/j.ajpath.2024.08.003openalex-snapshot
Hepatocyte-Specific Casein Kinase 1 Epsilon Ablation Ameliorates Metabolic Dysfunction–Associated Steatohepatitis by Up-Regulating Tumor Necrosis Factor Receptor–Associated Factor 3 in Mice
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MicroRNA-29b ameliorates hepatic inflammation via suppression of STAT3 in alcohol-associated liver disease
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Inhibition of GSK3B phosphorylation improves glucose and lipid metabolism disorder
inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.08.027openalex-snapshot
Djmek is involved in planarian regeneration by regulation of cell proliferation and apoptosis
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Methyldopa reduces plasma bile acid concentrations in a murine model of estrogen-induced cholestasis
inferred← citeshttps://doi.org/10.1016/j.carres.2026.110000openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.141922openalex-snapshot
Recent advances in toxicological research of di-(2-ethylhexyl)-phthalate: Focus on endoplasmic reticulum stress pathway
inferred← citeshttps://doi.org/10.1016/j.cmet.2021.05.019openalex-snapshot
Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2021.104229openalex-snapshot
In silico analysis of non-coding RNAs and putative target genes implicated in metabolic syndrome
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2021.104243openalex-snapshot
Construction and analysis of protein-protein interaction network of non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2019.109977openalex-snapshot
Acute 1-NP exposure induces inflammatory responses through activating various inflammatory signaling pathways in mouse lungs and human A549 cells
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114712openalex-snapshot
Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176365openalex-snapshot
Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis
inferred← citeshttps://doi.org/10.1016/j.envint.2023.107973openalex-snapshot
Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish
inferred← citeshttps://doi.org/10.1016/j.envpol.2021.117080openalex-snapshot
Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR–Nrf2 pathway
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Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response
inferred← citeshttps://doi.org/10.1016/j.fbio.2024.104862openalex-snapshot
The role of lycopene in alleviating nanoplastic-induced liver inflammation and steatosis: Insights from gut microbiota remodeling
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Advances in structure-hypoglycemic activity relationship and mechanisms of berry polysaccharides
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Carvacrol inhibits cytochrome P450 and protects against binge alcohol-induced liver toxicity
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Sangyod rice extract attenuates oleic acid–induced hepatic steatosis by modulating apoptotic, inflammatory, and lipid metabolic pathways
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The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver
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The global perspective on peroxisome proliferator-activated receptor γ (PPARγ) in ectopic fat deposition: A review
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Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice
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Dark and bright side of targeting fibroblast growth factor receptor 4 in the liver
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Hepatocyte glutathione S-transferase mu 2 prevents non-alcoholic steatohepatitis by suppressing ASK1 signaling
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Inhibition of MAP4K4 signaling initiates metabolic reprogramming to protect hepatocytes from lipotoxic damage
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Treatment with 1.25% cholesterol enriched diet produces severe fatty liver disease characterized by advanced fibrosis and inflammation and impaired autophagy in mice
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GSTM1 upregulation contributes to ursolic acid–alleviated hepatic steatosis and liver injury in chronic alcohol-fed mice
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The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions
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KR-36996, an orally active urotensin II receptor antagonist, attenuates hepatic inflammation and fibrosis in methionine- and choline-deficient diet-induced fibrosing steatohepatitis
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Signaling pathways shaping the field of lipidomics
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Epigallocatechin gallate improves oleic acid-induced hepatic steatosis in laying hen hepatocytes via the MAPK pathway
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Peroxiredoxin 5 ameliorates obesity-induced non-alcoholic fatty liver disease through the regulation of oxidative stress and AMP-activated protein kinase signaling
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LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels
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Lipid-lowering effect of industrial hemp (Cannabis sativa L.) powder on Drosophila melanogaster larvae fed a high-sucrose diet
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Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress
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Maternal-Periconceptional Vitamin B12 Deficiency in Wistar Rats Leads to Sex-Specific Programming for Cardiometabolic Disease Risk in the Next Generation
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Study on the metabolism toxicity, susceptibility and mechanism of di-(2-ethylhexyl) phthalate on rat liver BRL cells with insulin resistance in vitro
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Transcriptomic implications of low herbicide concentrations in hepatic cells: Insights into the individual and combined effects of 2,4-D, glyphosate, and AMPA
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The transcriptomic-based disease network reveals synergistic therapeutic effect of total alkaloids from Coptis chinensis and total ginsenosides from Panax ginseng on type 2 diabetes mellitus
inferred← citeshttps://doi.org/10.1021/acs.jafc.0c05077openalex-snapshot
Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System
inferred← citeshttps://doi.org/10.1021/acs.jafc.0c07125openalex-snapshot
Chemical Characterization and Hepatoprotective Effects of a Standardized Triterpenoid-Enriched Guava Leaf Extract
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c06258openalex-snapshot
Molecular Targets and Mechanisms of Casein-Derived Tripeptides Ile-Pro-Pro and Val-Pro-Pro on Hepatic Glucose Metabolism
inferred← citeshttps://doi.org/10.1038/s41401-024-01226-7openalex-snapshot
Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways
inferred← citeshttps://doi.org/10.1038/s41467-022-33493-5openalex-snapshot
Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK
inferred← citeshttps://doi.org/10.1038/s41467-023-41145-5openalex-snapshot
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention
inferred← citeshttps://doi.org/10.1038/s41587-021-00946-zopenalex-snapshot
Prediction of drug efficacy from transcriptional profiles with deep learning
inferred← citeshttps://doi.org/10.1038/s41598-020-59485-3openalex-snapshot
Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1039/d0fo03171bopenalex-snapshot
JNK pathway and heat shock response mediate the survival of C26 colon carcinoma bearing mice fed with the mushroom Pleurotus eryngii var. eryngii without affecting tumor growth or cachexia
inferred← citeshttps://doi.org/10.1039/d1fo00478fopenalex-snapshot
Role of mitochondria-endoplasmic reticulum coupling in lycopene preventing DEHP-induced hepatotoxicity
inferred← citeshttps://doi.org/10.1039/d5tb02128fopenalex-snapshot
Glucagon-like peptide-1 mimotopes screened from an Fv-antibody library
inferred← citeshttps://doi.org/10.1053/j.gastro.2019.05.002openalex-snapshot
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.1055/s-0040-1713115openalex-snapshot
Nonalcoholic Steatohepatitis Promoting Kinases
inferred← citeshttps://doi.org/10.1080/13543784.2020.1721457openalex-snapshot
Fatty liver disease and primary liver cancer: disease mechanisms, emerging therapies and the role of bariatric surgery
inferred← citeshttps://doi.org/10.1085/jgp.202113008openalex-snapshot
Burmese pythons exhibit a transient adaptation to nutrient overload that prevents liver damage
inferred← citeshttps://doi.org/10.1089/jmf.2020.4739openalex-snapshot
Jaceosidin Ameliorates Insulin Resistance and Kidney Dysfunction by Enhancing Insulin Receptor Signaling and the Antioxidant Defense System in Type 2 Diabetic Mice
inferred← citeshttps://doi.org/10.1093/pnasnexus/pgag279openalex-snapshot
Estradiol mitigates lipid accumulation, oxidative stress, apoptosis, and MAPKs activation in NASH rat model with bilateral orchidectomy
inferred← citeshttps://doi.org/10.1096/fj.202100571rropenalex-snapshot
Pro‐atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation
inferred← citeshttps://doi.org/10.1097/hep.0000000000001606openalex-snapshot
KLF9 drives intermittent hypoxia-induced MASLD by suppressing the NR4A1–p38 MAPK hepatic metabolic axis
inferred← citeshttps://doi.org/10.1126/scisignal.aba3043openalex-snapshot
An allosteric site on MKP5 reveals a strategy for small-molecule inhibition
inferred← citeshttps://doi.org/10.1126/scitranslmed.ade7347openalex-snapshot
Multispecies transcriptomics identifies SIKE as a MAPK repressor that prevents NASH progression
inferred← citeshttps://doi.org/10.1139/apnm-2021-0241openalex-snapshot
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-051921-121923openalex-snapshot
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?
inferred← citeshttps://doi.org/10.1146/annurev-physiol-022724-105540openalex-snapshot
Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics
inferred← citeshttps://doi.org/10.1152/ajpendo.00199.2024openalex-snapshot
Hepatic p38α at the forefront of diet-induced insulin resistance and hepatic steatosis
inferred← citeshttps://doi.org/10.1155/2022/3589525openalex-snapshot
Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4
inferred← citeshttps://doi.org/10.1172/jci148552openalex-snapshot
Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies
inferred← citeshttps://doi.org/10.1177/1934578x231180076openalex-snapshot
Integrated Serum Metabolomics and Network Pharmacology Approach to Reveal the Potential Mechanisms of Diwuyanggan Prescription in the Prevention of Acute Liver Injury
inferred← citeshttps://doi.org/10.1186/s11658-024-00557-xopenalex-snapshot
The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
inferred← citeshttps://doi.org/10.1186/s12864-021-07875-wopenalex-snapshot
Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
inferred← citeshttps://doi.org/10.1186/s12906-026-05409-zopenalex-snapshot
The integration of network pharmacology and multiomics reveals the mechanism by which Malus hupehensis leaves inhibit acute liver injury
inferred← citeshttps://doi.org/10.1186/s12951-026-04202-xopenalex-snapshot
UBQLN1 Inhibition reduces MASH progression through downregulating SIKE/p38 MAPK pathway in hepatocyte
inferred← citeshttps://doi.org/10.1186/s13287-019-1547-8openalex-snapshot
Mesenchymal stem cells alleviate liver injury induced by chronic-binge ethanol feeding in mice via release of TSG6 and suppression of STAT3 activation
inferred← citeshttps://doi.org/10.1186/s40364-025-00887-8openalex-snapshot
Stratifying high-risk prediabetes clusters using blood-based epigenetic markers
inferred← citeshttps://doi.org/10.1186/s43141-023-00462-4openalex-snapshot
Repressing effect of transformed ginsenoside Rg3-mix against LPS-induced inflammation in RAW264.7 macrophage cells
inferred← citeshttps://doi.org/10.1210/er.2017-00232openalex-snapshot
The RASopathy Family: Consequences of Germline Activation of the RAS/MAPK Pathway
inferred← citeshttps://doi.org/10.1242/dmm.049327openalex-snapshot
Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway
inferred← citeshttps://doi.org/10.1371/journal.pone.0347246openalex-snapshot
Unveiling the mechanism of calcitriol in treating type 2 diabetes mellitus: A combined network pharmacology and in vitro approach targeting ERS-related pathways
inferred← citeshttps://doi.org/10.1371/journal.ppat.1012377openalex-snapshot
Gut mycobiome alterations and implications for liver diseases
inferred← citeshttps://doi.org/10.14814/phy2.70720openalex-snapshot
Renalase deficiency suppresses hepatic triglyceride accumulation in the progression to MASLD / MASH by GAN diet in male mice
inferred← citeshttps://doi.org/10.1515/jcim-2021-0479openalex-snapshot
Bombax ceiba Linn. leaf extract rich in phenolic compounds to mitigate non-alcoholic fatty liver-related complications in experimental model
inferred← citeshttps://doi.org/10.1590/1519-6984.268781openalex-snapshot
Comparative effects of thymol and vitamin E on nonalcoholic fatty liver disease in male Wistar rats
inferred← citeshttps://doi.org/10.18632/aging.205485openalex-snapshot
Prepared radix polygoni multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition
inferred← citeshttps://doi.org/10.21608/blj.2021.184392openalex-snapshot
Effect of Sorafenib on Liver Biochemistry Prior to Vitamin B17 Coadministration in Ehrlich Ascites Carcinoma Mice Model: Preliminary Phase Study
inferred← citeshttps://doi.org/10.21608/bvmj.2021.65038.1347openalex-snapshot
Therapeutic Potential And Hepatoprotective Activity Of Proanthocyanidins And In Combination With Clopidogrel Against Bimolecular Disturbances Related To Non Alcoholic Fatty Liver Disease Induced In Rats
inferred← citeshttps://doi.org/10.2174/0113892029280454240214072212openalex-snapshot
Effect of Calebin-A on Critical Genes Related to NAFLD: A Protein-Protein Interaction Network and Molecular Docking Study
inferred← citeshttps://doi.org/10.2174/0115680266398364250811231140openalex-snapshot
Comprehension of the Function of Antioxidants in Targeting Different Signaling Pathways to Cure Oxidative Stress-induced Hepatotoxicity
inferred← citeshttps://doi.org/10.2478/rjim-2025-0007openalex-snapshot
Latest Insights in Alcohol-Related Liver Disease and Alcoholic Hepatitis
inferred← citeshttps://doi.org/10.33696/signaling.2.049openalex-snapshot
Function of Mitogen-Activated Protein Kinases in Hepatic Inflammation
inferred← citeshttps://doi.org/10.33696/signaling.5.108openalex-snapshot
MKP-2 Deficiency Leads to Lipolytic and Inflammatory Response to Fasting in Mice
inferred← citeshttps://doi.org/10.3389/fendo.2020.611213openalex-snapshot
Integrated Analysis of Key Genes and Pathways Involved in Nonalcoholic Steatohepatitis Improvement After Roux-en-Y Gastric Bypass Surgery
inferred← citeshttps://doi.org/10.3389/fendo.2022.792439openalex-snapshot
MiR-200c-3p Regulates DUSP1/MAPK Pathway in the Nonalcoholic Fatty Liver After Laparoscopic Sleeve Gastrectomy
inferred← citeshttps://doi.org/10.3389/fendo.2023.1148934openalex-snapshot
Obesity, non-alcoholic fatty liver disease and hepatocellular carcinoma: current status and therapeutic targets
inferred← citeshttps://doi.org/10.3389/fonc.2025.1526206openalex-snapshot
Hepatocellular carcinoma: pathogenesis, molecular mechanisms, and treatment advances
inferred← citeshttps://doi.org/10.3389/fphar.2019.00661openalex-snapshot
Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review
inferred← citeshttps://doi.org/10.3389/fphar.2020.586806openalex-snapshot
Mechanism of Paeoniflorin in the Treatment of Bile Duct Ligation-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology
inferred← citeshttps://doi.org/10.3389/fphar.2022.909280openalex-snapshot
Nootkatone, a Sesquiterpene Ketone From Alpiniae oxyphyllae Fructus, Ameliorates Metabolic-Associated Fatty Liver by Regulating AMPK and MAPK Signaling
inferred← citeshttps://doi.org/10.3389/fphys.2025.1576310openalex-snapshot
Subacute exposure to apigenin induces changes in protein synthesis in the liver of Swiss mice
inferred← citeshttps://doi.org/10.3390/cells14040261openalex-snapshot
Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Promotes Hyperglycemia and Susceptibility to Streptozotocin-Induced Diabetes in Female Mice In Vivo
inferred← citeshttps://doi.org/10.3390/ijms19123904openalex-snapshot
Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis
inferred← citeshttps://doi.org/10.3390/ijms21041241openalex-snapshot
Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer
inferred← citeshttps://doi.org/10.3390/ijms21134693openalex-snapshot
Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review
inferred← citeshttps://doi.org/10.3390/ijms21176069openalex-snapshot
Structure-Dependent Effects of Phthalates on Intercellular and Intracellular Communication in Liver Oval Cells
inferred← citeshttps://doi.org/10.3390/ijms21228691openalex-snapshot
Bioinformatic Reconstruction and Analysis of Gene Networks Related to Glucose Variability in Diabetes and Its Complications
inferred← citeshttps://doi.org/10.3390/metabo15040255openalex-snapshot
Drug Repurposing for Non-Alcoholic Fatty Liver Disease by Analyzing Networks Among Drugs, Diseases, and Genes
inferred← citeshttps://doi.org/10.3390/molecules27175657openalex-snapshot
Misuse of Cardiac Lipid upon Exposure to Toxic Trace Elements—A Focused Review
inferred← citeshttps://doi.org/10.3390/molecules28031476openalex-snapshot
Effect of Isoquercitrin on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells
inferred← citeshttps://doi.org/10.3390/nu13113941openalex-snapshot
Fasting-Induced Upregulation of MKP-1 Modulates the Hepatic Response to Feeding
inferred← citeshttps://doi.org/10.3390/nu14122475openalex-snapshot
Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease
inferred← citeshttps://doi.org/10.3390/nu16040542openalex-snapshot
Bulbils of Aerial Yam Attenuate Ethanol-Induced Hepatotoxicity in HepG2 Cells through Inhibition of Oxidative Stress by Activation of the Nuclear Factor Erythroid-2-Related Factor 2 Signaling Pathway
inferred← citeshttps://doi.org/10.3390/ph12020070openalex-snapshot
Deregulation of Hepatic Mek1/2–Erk1/2 Signaling Module in Iron Overload Conditions
inferred← citeshttps://doi.org/10.3390/ph15070832openalex-snapshot
Hepatoprotective Role of Carvedilol against Ischemic Hepatitis Associated with Acute Heart Failure via Targeting miRNA-17 and Mitochondrial Dynamics-Related Proteins: An In Vivo and In Silico Study
inferred← citeshttps://doi.org/10.3390/v10060305openalex-snapshot
Tumor Necrosis Factor Receptor-Associated Factor 5 Interacts with the NS3 Protein and Promotes Classical Swine Fever Virus Replication
inferred← citeshttps://doi.org/10.3892/etm.2020.8707openalex-snapshot
Interleukin‑22 regulates gastric cancer cell proliferation through regulation of the JNK signaling pathway
inferred← citeshttps://doi.org/10.3892/mmr.2023.13149openalex-snapshot
Tea seed saponin‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells
inferred← citeshttps://doi.org/10.4254/wjh.v16.i10.1142openalex-snapshot
Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
inferred← citeshttps://doi.org/10.4254/wjh.v16.i10.1322openalex-snapshot
Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
inferred← citeshttps://doi.org/10.6084/m9.figshare.14978456openalex-snapshot
Additional file 1 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
inferred← citeshttps://doi.org/10.6084/m9.figshare.14978459openalex-snapshot
Additional file 2 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
inferred← citeshttps://doi.org/10.6084/m9.figshare.14978462openalex-snapshot
Additional file 3 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
inferred← citeshttps://doi.org/10.6084/m9.figshare.14978465openalex-snapshot
Additional file 4 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
inferred← citeshttps://doi.org/10.6084/m9.figshare.14978468openalex-snapshot
Additional file 5 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
inferred← citeshttps://doi.org/10.6084/m9.figshare.14978471openalex-snapshot
Additional file 6 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
inferred← citeshttps://doi.org/10.6084/m9.figshare.14978474openalex-snapshot
Additional file 7 of Transcriptome analysis uncovers the key pathways and candidate genes related to the treatment of Echinococcus granulosus protoscoleces with the repurposed drug pyronaridine
inferred← citeshttps://doi.org/10.6084/m9.figshare.25397538openalex-snapshot
Additional file 1 of The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
inferred← citeshttps://doi.org/10.64187/aff.2025010202openalex-snapshot
Aucubin Ameliorated Insulin Resistance in HepG2 Cells by Regulating miR-373-3p/IRS2/PI3K/AKT Signaling Pathway
inferred← citeshttps://doi.org/10.70675/b0d081a3z3492z4457za237zcabd6ccc0a76openalex-snapshot
Etude des anomalies du métabolisme énergétique associées au syndrome de Noonan
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