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Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes

https://doi.org/10.1016/j.ymthe.2020.04.023
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Tumor microenvironment and therapeutic response
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Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets
inferredcites →https://doi.org/10.1016/j.cell.2018.11.010openalex-snapshot
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
inferredcites →https://doi.org/10.1016/j.eururo.2019.05.041openalex-snapshot
Safe Use of Immune Checkpoint Inhibitors in the Multidisciplinary Management of Urological Cancer: The European Association of Urology Position in 2019
inferredcites →https://doi.org/10.1016/j.immuni.2015.01.006openalex-snapshot
The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
inferredcites →https://doi.org/10.1016/j.vetimm.2019.04.003openalex-snapshot
Mucosal expression of S100A12 (calgranulin C) and S100A8/A9 (calprotectin) and correlation with serum and fecal concentrations in dogs with chronic inflammatory enteropathy
inferredcites →https://doi.org/10.1038/nbt.4096openalex-snapshot
Integrating single-cell transcriptomic data across different conditions, technologies, and species
inferredcites →https://doi.org/10.1038/nbt.4314openalex-snapshot
Dimensionality reduction for visualizing single-cell data using UMAP
inferredcites →https://doi.org/10.1038/ni.3486openalex-snapshot
The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation
inferredcites →https://doi.org/10.1038/nmeth.4402openalex-snapshot
Reversed graph embedding resolves complex single-cell trajectories
inferredcites →https://doi.org/10.1038/nmeth.4463openalex-snapshot
SCENIC: single-cell regulatory network inference and clustering
inferredcites →https://doi.org/10.1038/nrc2067openalex-snapshot
The tumour microenvironment as a target for chemoprevention
inferredcites →https://doi.org/10.1038/nrclinonc.2016.217openalex-snapshot
Tumour-associated macrophages as treatment targets in oncology
inferredcites →https://doi.org/10.1038/nri.2016.80openalex-snapshot
Regulatory circuits of T cell function in cancer
inferredcites →https://doi.org/10.1038/nri.2017.76openalex-snapshot
Single-cell RNA sequencing to explore immune cell heterogeneity
inferredcites →https://doi.org/10.1038/nri2634openalex-snapshot
Transcriptional control of the inflammatory response
inferredcites →https://doi.org/10.1038/s41467-019-09116-xopenalex-snapshot
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
inferredcites →https://doi.org/10.1038/s41467-019-10861-2openalex-snapshot
A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys
inferredcites →https://doi.org/10.1038/s41571-019-0209-1openalex-snapshot
Towards individualized therapy for metastatic renal cell carcinoma
inferredcites →https://doi.org/10.1038/s41581-019-0131-xopenalex-snapshot
The adjuvant treatment of kidney cancer: a multidisciplinary outlook
inferredcites →https://doi.org/10.1038/s41586-018-0698-6openalex-snapshot
Single-cell reconstruction of the early maternal–fetal interface in humans
inferredcites →https://doi.org/10.1038/s41586-019-1324-yopenalex-snapshot
TOX is a critical regulator of tumour-specific T cell differentiation
inferredcites →https://doi.org/10.1038/s41591-018-0096-5openalex-snapshot
Phenotype molding of stromal cells in the lung tumor microenvironment
inferredcites →https://doi.org/10.1089/omi.2011.0118openalex-snapshot
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
inferredcites →https://doi.org/10.1093/bioinformatics/btq170openalex-snapshot
ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking
inferredcites →https://doi.org/10.1093/jnci/djx121openalex-snapshot
Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4
inferredcites →https://doi.org/10.1093/nar/gky900openalex-snapshot
CellMarker: a manually curated resource of cell markers in human and mouse
inferredcites →https://doi.org/10.1126/science.1254257openalex-snapshot
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
inferredcites →https://doi.org/10.1126/science.aat1699openalex-snapshot
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
inferredcites →https://doi.org/10.1155/2013/731023openalex-snapshot
Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
inferredcites →https://doi.org/10.1158/2159-8290.cd-14-1507openalex-snapshot
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma
inferredcites →https://doi.org/10.1158/2159-8290.cd-19-0094openalex-snapshot
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
inferredcites →https://doi.org/10.1158/2326-6066.cir-18-0891openalex-snapshot
Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth
inferredcites →https://doi.org/10.1172/jci120855openalex-snapshot
Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers
inferredcites →https://doi.org/10.1182/blood-2005-01-0428openalex-snapshot
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF- B and enhanced IRF-3/STAT1 activation)
inferredcites →https://doi.org/10.1186/1471-2172-10-18openalex-snapshot
Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells
inferredcites →https://doi.org/10.1186/s12944-017-0574-7openalex-snapshot
Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells
inferredcites →https://doi.org/10.1200/jco.2018.79.2648openalex-snapshot
The Immunobiology of Kidney Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0010966openalex-snapshot
Hypoxia Activates the K-Ras Proto-Oncogene to Stimulate Angiogenesis and Inhibit Apoptosis in Colon Cancer Cells
inferredcites →https://doi.org/10.3322/caac.21492openalex-snapshot
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Transcriptome Features of Glycogenes Correlate with Prognosis, Tumor Microenvironment, and Treatment Response in Kidney Renal Clear Cell Carcinoma
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Renal clear cancer cells regulate the differentiation of urine‐derived stem cells to carcinoma‐associated fibroblasts via RUNX3/TGF‐β1 signaling axis
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Special issue “The advance of solid tumor research in China”: Multi‐omics analysis based on 1311 clear cell renal cell carcinoma samples identifies a glycolysis signature associated with prognosis and treatment response
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Single‐Cell Profiling of the Microenvironment in High‐Risk Neuroblastoma
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IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting Netrin‐4 in an m6A‐dependent manner
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Gene LY96 is an M2 macrophage‐related biomarker and is associated with immunosuppression in renal cell carcinoma
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RETRACTED: Exploring the tumor microenvironment: Chemokine‐related genes and immunotherapy/chemotherapy response in clear‐cell renal cell carcinoma
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Pan-cancer single-cell and spatial transcriptomics implicate cancer-associated fibroblasts in neutrophil immunosuppressive phenotypic transitions and immunotherapy resistance
inferred← citeshttps://doi.org/10.1007/s10238-025-01894-7openalex-snapshot
Single-cell transcriptomics identifies SOCS3+ exhausted T cells as a biomarker facilitating clear cell renal cell carcinoma progression
inferred← citeshttps://doi.org/10.1007/s11033-021-07025-1openalex-snapshot
Investigation of VHL gene associated with miR-223 in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1007/s12672-024-01175-xopenalex-snapshot
A novel cancer-associated fibroblast signature for kidney renal clear cell carcinoma via integrated analysis of single-cell and bulk RNA-sequencing
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Integrated metabolomics and transcriptomics analysis unveils key metabolic pathways and potential biomarkers in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.ajpath.2026.04.001openalex-snapshot
Single-Cell Sequencing Plus Spatial Transcriptomics
inferred← citeshttps://doi.org/10.1016/j.asjsur.2025.04.215openalex-snapshot
TNIP3: A novel prognostic biomarker and immune modulator in clear cell renal cell carcinoma
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Side population analysis in clear cell renal cell carcinoma
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Near-infrared light-induced photothermal and immunotherapy system for lung cancer bone metastasis treatment with simultaneous bone repair
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216350openalex-snapshot
Spatio-temporal heterogeneity in cancer evolution and tumor microenvironment of renal cell carcinoma with tumor thrombus
inferred← citeshttps://doi.org/10.1016/j.ccell.2022.12.001openalex-snapshot
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness
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Unraveling m6A RNA methylation: From epitranscriptomics to therapeutic frontiers in renal cell carcinoma
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SPCS, a Novel Classifier System Based on Senescence Axis Regulators Reveals Tumor Microenvironment Heterogeneity and Guides Frontline Therapy for Clear Cell Renal Carcinoma
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Integrating bulk RNA-seq and scRNA-seq analyses revealed the function and clinical value of thrombospondins in colon cancer
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The extracellular-matrix-remodeling capability exposes therapeutic vulnerability in a subset of renal cell carcinomas with tumor thrombi
inferred← citeshttps://doi.org/10.1016/j.eururo.2023.02.008openalex-snapshot
Single-cell Deconvolution of a Specific Malignant Cell Population as a Poor Prognostic Biomarker in Low-risk Clear Cell Renal Cell Carcinoma Patients
inferred← citeshttps://doi.org/10.1016/j.gendis.2026.102047openalex-snapshot
Comprehensive single-cell transcriptomics atlas reveals tumor microenvironment evolution and SPON2-mediated immunosuppression in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e36599openalex-snapshot
Dissection of the cell communication interactions in lung adenocarcinoma identified a prognostic model with immunotherapy efficacy assessment and a potential therapeutic candidate gene ITGB1
inferred← citeshttps://doi.org/10.1016/j.heliyon.2025.e42540openalex-snapshot
TRIM36 serves as a prognostic indicator linked to immune infiltration in KIRC
inferred← citeshttps://doi.org/10.1016/j.imu.2023.101371openalex-snapshot
GLIPR2 emerges as a potential predictor of prognosis for renal clear cell carcinoma, exhibiting substantial relevance with cellular metastasis and CD8+ T cell infiltration
inferred← citeshttps://doi.org/10.1016/j.intimp.2025.114843openalex-snapshot
Mechanisms of CD8+ T cell exhaustion and its clinical significance in prognosis of anti-tumor therapies: A review
inferred← citeshttps://doi.org/10.1016/j.iotech.2023.100690openalex-snapshot
Distinct spatial landscapes in clear-cell renal cell carcinoma as revealed by whole transcriptome analysis
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104463openalex-snapshot
Single-cell transcriptomes underscore genetically distinct tumor characteristics and microenvironment for hereditary kidney cancers
inferred← citeshttps://doi.org/10.1016/j.isci.2023.108367openalex-snapshot
Large-scale analysis of cell-cell communication reveals angiogenin-dependent tumor progression in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.jpha.2023.08.002openalex-snapshot
27-Hydroxycholesterol/liver X receptor/apolipoprotein E mediates zearalenone-induced intestinal immunosuppression: A key target potentially linking zearalenone and cancer
inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.101457openalex-snapshot
Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system
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Targeting Long Non-coding RNA to Therapeutically Regulate Gene Expression in Cancer
inferred← citeshttps://doi.org/10.1016/j.omtn.2021.04.019openalex-snapshot
Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.omto.2022.10.005openalex-snapshot
Cancer stem/progenitor signatures refine the classification of clear cell renal cell carcinoma with stratified prognosis and decreased immunotherapy efficacy
inferred← citeshttps://doi.org/10.1016/j.tranon.2024.102248openalex-snapshot
Response Gene to Complement 32 is associated with poor patient survival and an inflamed tumor-immune microenvironment in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.trecan.2025.11.001openalex-snapshot
Mapping heterogeneity in the tumor microenvironment of renal cell carcinoma through single-cell omics
inferred← citeshttps://doi.org/10.1038/s41392-022-00990-4openalex-snapshot
High-throughput single-сell sequencing in cancer research
inferred← citeshttps://doi.org/10.1038/s41417-022-00426-9openalex-snapshot
Alternative splicing events in tumor immune infiltration in renal clear cell carcinomas
inferred← citeshttps://doi.org/10.1038/s41417-024-00755-xopenalex-snapshot
The integrate profiling of single-cell and spatial transcriptome RNA-seq reveals tumor heterogeneity, therapeutic targets, and prognostic subtypes in ccRCC
inferred← citeshttps://doi.org/10.1038/s41419-022-04501-9openalex-snapshot
Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study
inferred← citeshttps://doi.org/10.1038/s41419-023-05566-wopenalex-snapshot
Single-cell RNA-seq integrated with multi-omics reveals SERPINE2 as a target for metastasis in advanced renal cell carcinoma
inferred← citeshttps://doi.org/10.1038/s41419-024-06913-1openalex-snapshot
DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway
inferred← citeshttps://doi.org/10.1038/s41420-022-01145-8openalex-snapshot
Up-regulation of SLC27A2 suppresses the proliferation and invasion of renal cancer by down-regulating CDK3-mediated EMT
inferred← citeshttps://doi.org/10.1038/s41421-022-00415-0openalex-snapshot
Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1038/s41435-023-00211-0openalex-snapshot
Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC
inferred← citeshttps://doi.org/10.1038/s41467-023-36560-7openalex-snapshot
Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis
inferred← citeshttps://doi.org/10.1038/s41581-022-00553-4openalex-snapshot
Mapping the human kidney using single-cell genomics
inferred← citeshttps://doi.org/10.1038/s41588-024-01662-5openalex-snapshot
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression
inferred← citeshttps://doi.org/10.1038/s41598-024-52928-1openalex-snapshot
Single-cell analysis reveals ADGRL4+ renal tubule cells as a highly aggressive cell type in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1038/s41598-025-07230-zopenalex-snapshot
RDM1 plays an oncogenic role in clear cell renal cell carcinoma potentially by modulating MCM2
inferred← citeshttps://doi.org/10.1038/s41598-025-15157-8openalex-snapshot
Immune microenvironment and prognostic genes of triple-negative breast cancer in the context of transcriptome and single-cell sequencing
inferred← citeshttps://doi.org/10.1038/s41598-025-86644-1openalex-snapshot
Overexpression of PLCG2 and TMEM38A inhibit tumor progression in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1038/s42003-024-05772-yopenalex-snapshot
Single-cell profiling of the microenvironment in human bone metastatic renal cell carcinoma
inferred← citeshttps://doi.org/10.1080/07853890.2025.2495762openalex-snapshot
A novel glycogene-related signature for prognostic prediction and immune microenvironment assessment in kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.1080/26895293.2023.2199140openalex-snapshot
Advanced analysis and applications of single-cell transcriptome sequencing
inferred← citeshttps://doi.org/10.1101/2021.05.30.444880openalex-snapshot
Landscape of microenvironment in Randall’s plaque by single-cell sequencing
inferred← citeshttps://doi.org/10.1101/2023.09.03.556072openalex-snapshot
A single-cell transcriptome analysis and prognostic model construction of stromal cells for renal cell carcinoma
inferred← citeshttps://doi.org/10.1136/jitc-2021-004206openalex-snapshot
Single-cell transcriptomics reveals a low CD8 + T cell infiltrating state mediated by fibroblasts in recurrent renal cell carcinoma
inferred← citeshttps://doi.org/10.1136/jitc-2023-008475openalex-snapshot
Neoadjuvant toripalimab combined with axitinib in patients with locally advanced clear cell renal cell carcinoma: a single-arm, phase II trial
inferred← citeshttps://doi.org/10.1136/jitc-2024-010183openalex-snapshot
Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1155/2021/3771866openalex-snapshot
CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma
inferred← citeshttps://doi.org/10.1155/2023/3077091openalex-snapshot
Deciphering the Role of Melatonin-Related Signatures in Tumor Immunity and the Prognosis of Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.1158/2326-6066.c.6550523openalex-snapshot
Data from Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-20-0532openalex-snapshot
Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s
inferred← citeshttps://doi.org/10.1177/10732748241272713openalex-snapshot
Construction of a 12-Gene Prognostic Risk Model and Tumor Immune Microenvironment Analysis Based on the Clear Cell Renal Cell Carcinoma Model
inferred← citeshttps://doi.org/10.1177/11795549251348902openalex-snapshot
WD40 Protein NLE1 as a Novel Diagnostic Biomarker Promoting Hepatocellular Carcinoma Proliferation
inferred← citeshttps://doi.org/10.1177/15353702221110659openalex-snapshot
Intra-tumor heterogeneity and prognostic risk signature for hepatocellular carcinoma based on single-cell analysis
inferred← citeshttps://doi.org/10.1186/s12885-022-10302-2openalex-snapshot
CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1186/s12885-025-13534-0openalex-snapshot
Identification and validation of prognostic biomarkers in ccRCC: immune-stromal score and survival prediction
inferred← citeshttps://doi.org/10.1186/s12935-024-03335-zopenalex-snapshot
Unravelling immune microenvironment features underlying tumor progression in the single-cell era
inferred← citeshttps://doi.org/10.1186/s12967-024-04848-xopenalex-snapshot
Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.1186/s13000-024-01493-2openalex-snapshot
Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis
inferred← citeshttps://doi.org/10.1186/s13045-021-01105-2openalex-snapshot
Applications of single-cell sequencing in cancer research: progress and perspectives
inferred← citeshttps://doi.org/10.1186/s13046-024-02960-wopenalex-snapshot
T-cell infiltration and its regulatory mechanisms in cancers: insights at single-cell resolution
inferred← citeshttps://doi.org/10.1186/s13046-025-03293-yopenalex-snapshot
Soluble TIM-3, likely produced by myeloid cells, predicts resistance to immune checkpoint inhibitors in metastatic clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1186/s13059-022-02651-9openalex-snapshot
Decoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing
inferred← citeshttps://doi.org/10.1186/s13062-024-00517-7openalex-snapshot
Disulfidptosis-associated LncRNA signature predicts prognosis and immune response in kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.1186/s13550-024-01182-7openalex-snapshot
The value of radiomics based on 2-[18 F]FDG PET/CT in predicting WHO/ISUP grade of clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1186/s40001-023-01221-4openalex-snapshot
Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1186/s40001-023-01487-8openalex-snapshot
CD72, a new immune checkpoint molecule, is a novel prognostic biomarker for kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.1186/s40364-021-00336-2openalex-snapshot
Application and prospects of single cell sequencing in tumors
inferred← citeshttps://doi.org/10.1186/s40364-025-00811-0openalex-snapshot
Single-cell sequencing technology in renal cancer: insights into tumor biology and clinical application
inferred← citeshttps://doi.org/10.1186/s41065-025-00563-9openalex-snapshot
Integrated single-cell and bulk transcriptome analysis revealed high plasticity subpopulation and promising diagnosis model for clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1371/journal.pone.0310843openalex-snapshot
Screening of differential gene expression patterns through survival analysis for diagnosis, prognosis and therapies of clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.15388/vu.thesis.937openalex-snapshot
Antraštė Single-Cell Transcriptomic Analysis of Healthy and Diseased Human Tissues
inferred← citeshttps://doi.org/10.18632/aging.204280openalex-snapshot
MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.18632/aging.204292openalex-snapshot
Identification of immune and stromal cell infiltration-related gene signature for prognosis prediction in acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.18632/aging.205974openalex-snapshot
Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC
inferred← citeshttps://doi.org/10.20892/j.issn.2095-3941.2023.0303openalex-snapshot
DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation
inferred← citeshttps://doi.org/10.21037/tau-21-581openalex-snapshot
Discovery and construction of prognostic model for clear cell renal cell carcinoma based on single-cell and bulk transcriptome analysis
inferred← citeshttps://doi.org/10.21037/tcr-21-1953openalex-snapshot
N6-methyladenosine methylation related immune biomarkers correlates with clinicopathological characteristics and prognosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.21037/tcr-22-2782openalex-snapshot
Integrated analysis of single-cell and bulk transcriptome identifies a signature based on NK cell marker genes to predict prognosis and therapeutic response in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.21037/tcr-23-1183openalex-snapshot
Genes associated with inflammation for prognosis prediction for clear cell renal cell carcinoma: a multi-database analysis
inferred← citeshttps://doi.org/10.21037/tcr-24-127openalex-snapshot
Identification of a cancer driver gene-associated lncRNA signature for prognostic prediction and immune response evaluation in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1450125/v1openalex-snapshot
Pan-cancer study of PARK7/DJ-1 as a biomarker for prognostic and immunological role in 33 human cancers
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2252314/v1openalex-snapshot
Single-cell RNA sequencing and molecular docking reveal sinomenine can treat postherpetic neuralgia by regulating the expression of MMP2
inferred← citeshttps://doi.org/10.21203/rs.3.rs-261065/v1openalex-snapshot
A fine-grained cell type deconvolution of bulk transcriptome from single-cell RNA-seq data reveals myeloid cells heterogeneity in lung adenocarcinomas
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2643534/v1openalex-snapshot
CENPW as a biological indicator: predicting prognosis and guiding treatment in a patient with Kidney Renal Clear Cell Carcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2870664/v1openalex-snapshot
Construction of five disulfidptosis-related lncRNA signature for predicting prognosis and immune activity in kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3165804/v1openalex-snapshot
Deciphering Tumor Metastasis and Immune Inhibitory Signature of Clear Cell Renal Cell Carcinoma by Single-Cell Transcriptome Analysis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3905745/v1openalex-snapshot
Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis.
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3915249/v1openalex-snapshot
Construction of a five-disulfidptosis-related-lncRNA signature for predicting prognosis and immune activity in kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-507507/v1openalex-snapshot
N6-methyladenosine Methylation Related Immune Biomarkers Correlates With Clinicopathological Characteristics and Prognosis in Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-6566788/v1openalex-snapshot
Cancer-associated Fibroblasts in Pan-Cancer Drive CXCR2+VNN2+ Neutrophils Reprogramming to Mediate Immunosuppression and Immunotherapy Resistance
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9483608/v1openalex-snapshot
Identification of paraptosis related genes in osteosarcoma and development of a risk model based on single cell RNA sequencing and bulk RNA sequencing data
inferred← citeshttps://doi.org/10.2147/ijgm.s353610openalex-snapshot
SIRT7 is a Prognostic Biomarker in Kidney Renal Clear Cell Carcinoma That is Correlated with Immune Cell Infiltration
inferred← citeshttps://doi.org/10.2174/1871520621666210618100857openalex-snapshot
Single-Cell Transcriptome Analysis Reveals the M2 Macrophages and Exhausted T Cells and Intratumoral Heterogeneity in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.2174/1871520621666210720120218openalex-snapshot
Network-Based Analysis Reveals Gene Signature in Tip Cells and Stalk Cells
inferred← citeshttps://doi.org/10.21873/cgp.20322openalex-snapshot
Prognostic Relevance of ZNF844 and Chr 19p13.2 KRAB-Zinc Finger Proteins in Clear Cell Renal Carcinoma
inferred← citeshttps://doi.org/10.32604/or.2023.028051openalex-snapshot
Solute carrier-related signature for assessing prognosis and immunity in patients with clear-cell renal cell carcinoma
inferred← citeshttps://doi.org/10.3389/fcell.2020.00550openalex-snapshot
Identification and Validation of the Immune Subtypes of Lung Adenocarcinoma: Implications for Immunotherapy
inferred← citeshttps://doi.org/10.3389/fcell.2021.794840openalex-snapshot
External Validation of the Prognostic Value of an Immune-Associated Gene Panel for Clear Cell Renal Cell Carcinomas
inferred← citeshttps://doi.org/10.3389/fgene.2022.1015844openalex-snapshot
DHRS7 is an immune-related prognostic biomarker of KIRC and pan-cancer
inferred← citeshttps://doi.org/10.3389/fgene.2022.909556openalex-snapshot
Calreticulin as a prognostic biomarker and correlated with immune infiltrate in kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.3389/fgene.2022.914354openalex-snapshot
Aberrantly hypermethylated ARID1B is a novel biomarker and potential therapeutic target of colon adenocarcinoma
inferred← citeshttps://doi.org/10.3389/fgene.2023.1207233openalex-snapshot
Mapping the tumor microenvironment in clear cell renal carcinoma by single-cell transcriptome analysis
inferred← citeshttps://doi.org/10.3389/fimmu.2021.683330openalex-snapshot
Single-Cell Profiling Reveals Transcriptional Signatures and Cell-Cell Crosstalk in Anti-PLA2R Positive Idiopathic Membranous Nephropathy Patients
inferred← citeshttps://doi.org/10.3389/fimmu.2021.723908openalex-snapshot
Microdissection of the Bulk Transcriptome at Single-Cell Resolution Reveals Clinical Significance and Myeloid Cells Heterogeneity in Lung Adenocarcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2021.745945openalex-snapshot
CD8+ T Cell-Based Molecular Classification With Heterogeneous Immunogenomic Landscapes and Clinical Significance of Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2021.767070openalex-snapshot
Single-Cell Transcriptome Analysis Reveals RGS1 as a New Marker and Promoting Factor for T-Cell Exhaustion in Multiple Cancers
inferred← citeshttps://doi.org/10.3389/fimmu.2022.791158openalex-snapshot
Decoding the Immune Microenvironment of Clear Cell Renal Cell Carcinoma by Single-Cell Profiling to Aid Immunotherapy
inferred← citeshttps://doi.org/10.3389/fimmu.2022.842069openalex-snapshot
Elevated SNRPA1, as a Promising Predictor Reflecting Severe Clinical Outcome via Effecting Tumor Immunity for ccRCC, Is Related to Cell Invasion, Metastasis, and Sunitinib Sensitivity
inferred← citeshttps://doi.org/10.3389/fimmu.2022.861328openalex-snapshot
Crosstalk Between Metabolism and Immune Activity Reveals Four Subtypes With Therapeutic Implications in Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2022.874792openalex-snapshot
Identification and Verification of m7G Modification Patterns and Characterization of Tumor Microenvironment Infiltration via Multi-Omics Analysis in Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2022.933241openalex-snapshot
Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2022.935595openalex-snapshot
A New Thinking: Deciphering the Aberrance and Clinical Implication of IGF Axis Regulation Pattern in Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2022.950536openalex-snapshot
Immunosuppressive landscape in hepatocellular carcinoma revealed by single-cell sequencing
inferred← citeshttps://doi.org/10.3389/fimmu.2022.964190openalex-snapshot
CD8+ T cell trajectory subtypes decode tumor heterogeneity and provide treatment recommendations for hepatocellular carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1288240openalex-snapshot
Single-cell disulfidptosis regulator patterns guide intercellular communication of tumor microenvironment that contribute to kidney renal clear cell carcinoma progression and immunotherapy
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1707375openalex-snapshot
Integrative multi-omics analysis identifies a PTM-related immune signature and IRF9 as a driver in ccRCC
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1727099openalex-snapshot
Machine learning-derived cellular senescence index for predicting prognosis and drug sensitivity in patients with renal cell carcinoma
inferred← citeshttps://doi.org/10.3389/fmolb.2021.684050openalex-snapshot
Characterization of Hypoxia-Related Molecular Subtypes in Clear Cell Renal Cell Carcinoma to Aid Immunotherapy and Targeted Therapy via Multi-Omics Analysis
inferred← citeshttps://doi.org/10.3389/fnagi.2023.1132733openalex-snapshot
Cromolyn prevents cerebral vasospasm and dementia by targeting WDR43
inferred← citeshttps://doi.org/10.3389/fonc.2021.709210openalex-snapshot
Single-Cell Transcriptomics Reveals the Complexity of the Tumor Microenvironment of Treatment-Naive Osteosarcoma
inferred← citeshttps://doi.org/10.3389/fonc.2021.776824openalex-snapshot
Differentially Expressed Genes in Clear Cell Renal Cell Carcinoma as a Potential Marker for Prognostic and Immune Signatures
inferred← citeshttps://doi.org/10.3389/fonc.2022.1008714openalex-snapshot
Comprehensive analysis of a homeobox family gene signature in clear cell renal cell carcinoma with regard to prognosis and immune significance
inferred← citeshttps://doi.org/10.3389/fonc.2022.880100openalex-snapshot
Glia Maturation Factor β as a Novel Independent Prognostic Biomarker and Potential Therapeutic Target of Kidney Renal Clear Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/fonc.2022.943583openalex-snapshot
Cellular milieu in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.3389/fonc.2022.955510openalex-snapshot
Expression and prognosis analysis of PAQR5 in kidney cancer
inferred← citeshttps://doi.org/10.3389/fonc.2023.1164214openalex-snapshot
Systematic pan-cancer analysis identifies gasdermin B as an immunological and prognostic biomarker for kidney renal clear cell carcinoma
inferred← citeshttps://doi.org/10.3389/fphys.2022.1053850openalex-snapshot
Single-cell transcriptomics: A new tool for studying diabetic kidney disease
inferred← citeshttps://doi.org/10.3390/cancers14194943openalex-snapshot
A Potential Fatty Acid Metabolism-Related Gene Signature for Prognosis in Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/cancers14225506openalex-snapshot
Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Reveals a Tissue-Resident Macrophage-Related Signature for Predicting Immunotherapy Response in Breast Cancer Patients
inferred← citeshttps://doi.org/10.3390/cancers15010287openalex-snapshot
Circulating Tumor Cells as Biomarkers for Renal Cell Carcinoma: Ready for Prime Time?
inferred← citeshttps://doi.org/10.3390/cancers15194734openalex-snapshot
Recent Advances in Single-Cell RNA-Sequencing of Primary and Metastatic Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/cancers15245715openalex-snapshot
Long-Term Survival of Patients with Stage T1N0M1 Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/cimb45090485openalex-snapshot
An Overview of Systemic Targeted Therapy in Renal Cell Carcinoma, with a Focus on Metastatic Renal Cell Carcinoma and Brain Metastases
inferred← citeshttps://doi.org/10.3390/diagnostics11122369openalex-snapshot
Does the Urinary Proteome Reflect ccRCC Stage and Grade Progression?
inferred← citeshttps://doi.org/10.3390/ijms24109092openalex-snapshot
Single-Cell RNA-Seq Analysis Reveals Ferroptosis in the Tumor Microenvironment of Clear Cell Renal Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/ijms25021031openalex-snapshot
Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/ijms25074134openalex-snapshot
Boosting Clear Cell Renal Carcinoma-Specific Drug Discovery Using a Deep Learning Algorithm and Single-Cell Analysis
inferred← citeshttps://doi.org/10.3390/ph17050635openalex-snapshot
Evaluating the Role of Neddylation Modifications in Kidney Renal Clear Cell Carcinoma: An Integrated Approach Using Bioinformatics, MLN4924 Dosing Experiments, and RNA Sequencing
inferred← citeshttps://doi.org/10.3390/tomography11010003openalex-snapshot
Dual-Stage AI Model for Enhanced CT Imaging: Precision Segmentation of Kidney and Tumors
inferred← citeshttps://doi.org/10.3724/abbs.2025253openalex-snapshot
A novel biomarker SNHG11 promotes tumor progression and oxidative phosphorylation in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.3892/ijo.2021.5286openalex-snapshot
Increased expression of PSME2 is associated with clear cell renal cell carcinoma invasion by regulating BNIP3‑mediated autophagy
inferred← citeshttps://doi.org/10.4111/icu.20220103openalex-snapshot
Current and future perspectives on CAR-T cell therapy for renal cell carcinoma: A comprehensive review
inferred← citeshttps://doi.org/10.48101/ujms.v129.10632openalex-snapshot
Molecular mechanisms and clinical relevance of endothelial cell cross-talk in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605888openalex-snapshot
Additional file 1 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605891openalex-snapshot
Additional file 2 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605894openalex-snapshot
Additional file 3 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605897openalex-snapshot
Additional file 4 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605900openalex-snapshot
Additional file 5 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605903openalex-snapshot
Additional file 6 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605906openalex-snapshot
Additional file 7 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605909openalex-snapshot
Additional file 8 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26605912openalex-snapshot
Additional file 9 of Multi-omics analysis uncovers clinical, immunological, and pharmacogenomic implications of cuproptosis in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686413openalex-snapshot
Additional file 1 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686416openalex-snapshot
Additional file 2 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686419openalex-snapshot
Additional file 3 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686422openalex-snapshot
Additional file 4 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686425openalex-snapshot
Additional file 5 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686428openalex-snapshot
Additional file 6 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686431openalex-snapshot
Additional file 7 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686434openalex-snapshot
Additional file 8 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686437openalex-snapshot
Additional file 9 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686440openalex-snapshot
Additional file 10 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26686443openalex-snapshot
Additional file 11 of Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
inferred← citeshttps://doi.org/10.6084/m9.figshare.26952337openalex-snapshot
Additional file 1 of Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis
inferred← citeshttps://doi.org/10.6084/m9.figshare.26952340openalex-snapshot
Additional file 2 of Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis
inferred← citeshttps://doi.org/10.6084/m9.figshare.26952346openalex-snapshot
Additional file 3 of Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis
inferred← citeshttps://doi.org/10.6084/m9.figshare.26952349openalex-snapshot
Additional file 4 of Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis
inferred← citeshttps://doi.org/10.6084/m9.figshare.26952352openalex-snapshot
Additional file 5 of Identification of HDAC10 as a candidate oncogene in clear cell renal carcinoma that facilitates tumor proliferation and metastasis
inferred← citeshttps://doi.org/10.70675/059b4951z271fz4649za800z1b92769ff8e2openalex-snapshot
Role of SWI/SNF chromatin-remodeling complexes in tumorigenesis : insights in dedifferentiated melanoma and renal medullary carcinoma
inferred← citeshttps://doi.org/10.70675/909b8153z00efz42f7za922z6b476829dbf2openalex-snapshot
Systems analysis of intercellular communication in the tumor microenvironment
inferred← citeshttps://doi.org/10.70675/bd910e58zda02z4c27z82eczb5f7b203b2d6openalex-snapshot
The role of complement proteins on tumor progression : exploration of the universe of intracellular complement proteins
inferred← citeshttps://doi.org/10.71423/aimed.20250806openalex-snapshot
Immunotherapy in Renal Cell Carcinoma: Modulating the Tumor Microenvironment, Overcoming Resistance Mechanisms, and Implementing Biomarker-Guided Combination Treatments
inferred← citeshttps://doi.org/10.7150/ijbs.72534openalex-snapshot
Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance
inferred← citeshttps://doi.org/10.7150/thno.77281openalex-snapshot
Single-cell atlases link macrophages and CD8+ T-cell subpopulations to disease progression and immunotherapy response in urothelial carcinoma
inferred← citeshttps://doi.org/10.7717/peerj.21057openalex-snapshot
Multi-omics analysis reveals key genes associated with clear cell renal cell carcinoma
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