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Streamlined System for Purifying and Quantifying a Diverse Library of Compounds and the Effect of Compound Concentration Measurements on the Accurate Interpretation of Biological Assay Results

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Virtual screening to enrich hit lists from high‐throughput screening: A case study on small‐molecule inhibitors of angiogenin
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A comparative study of commercial liquid chromatographic detectors for the analysis of underivatized amino acids
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Automated analytical/preparative high-performance liquid chromatography–mass spectrometry system for the rapid characterization and purification of compound libraries
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
inferredcites →https://doi.org/10.1016/s0169-409x(02)00003-0openalex-snapshot
Prediction of ‘drug-likeness’
inferredcites →https://doi.org/10.1016/s0169-409x(96)00423-1openalex-snapshot
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
inferredcites →https://doi.org/10.1016/s1056-8719(00)00107-6openalex-snapshot
Drug-like properties and the causes of poor solubility and poor permeability
inferredcites →https://doi.org/10.1021/cr990085qopenalex-snapshot
Combinatorial Chemistry and Mass Spectrometry in the 21st Century Drug Discovery Laboratory
inferredcites →https://doi.org/10.1177/1087057103008003007openalex-snapshot
Studies on Repository Compound Stability in DMSO under Various Conditions
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High Throughput Screening
inferredcites →https://doi.org/10.2174/1386207013331057openalex-snapshot
Quality Assessment of Combinatorial Pooled Libraries Using Mass Spectrometry

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Chemiluminescent Nitrogen Detection (CLND) to Measure Kinetic Aqueous Solubility
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Integrity and Purity
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Effects of Properties on Biological Assays
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Integrity and Purity
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Effects of Properties on Biological Assays
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Identification of Bacillus anthracis PurE inhibitors with antimicrobial activity
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Hit discovery and hit-to-lead approaches
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Avoiding physicochemical artefacts in early ADME–Tox experiments
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2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors
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Predicting aqueous solubility from structure
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Evaporative Light Scattering Detector: Toward a General Molecular Weight Cutoff Characterization of Nanofiltration Membranes
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A Fundamental Source of Misclassification in Single-Concentration Binding Screens
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Solution-Phase Synthesis of a Tricyclic Pyrrole-2-Carboxamide Discovery Library Applying a Stetter−Paal−Knorr Reaction Sequence
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Changing Requirements of Purification as Drug Discovery Programs Evolve from Hit Discovery
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Distributed Drug Discovery, Part 1: Linking Academia and Combinatorial Chemistry to Find Drug Leads for Developing World Diseases
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Fluorescence Spectroscopic Profiling of Compound Libraries
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Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors
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Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
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Acoustic Auditing as a Real-Time, Non-invasive Quality Control Process for Both Source and Assay Plates
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A Chemogenomic Approach to Discovering Target‐Selective Drugs
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Current Applications of Liquid Chromatography/Mass Spectrometry in Pharmaceutical Discovery After a Decade of Innovation
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A Novel Approach to Determine Water Content in DMSO for a Compound Collection Repository
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Just-in-Time Purification: An Effective Solution for Cherry-Picking and Purifying Active Compounds from Large Legacy Libraries
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Characterization of the 5-HT2b Receptor in Evaluation of Aequorin Detection of Calcium Mobilization for Miniaturized GPCR High-Throughput Screening
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Advances in Improving the Quality and Flexibility of Compound Management
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Achieving Accurate Compound Concentration in Cell-Based Screening: Validation of Acoustic Droplet Ejection Technology
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Gradient, Contact-Free Volume Transfers Minimize Compound Loss in Dose-Response Experiments
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A Novel In Vitro Approach for Simultaneous Evaluation of CYP3A4 Inhibition and Kinetic Aqueous Solubility
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Capture and Exploration of Sample Quality Data to Inform and Improve the Management of a Screening Collection
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Establishing and Maintaining a Robust Sample Management System
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IDENTIFYING SELECTIVE LIGANDS FOR GLUTAREDOXIN PROTEINS WITH FRAGMENT BASED DRUG DESIGN APPROACH AND OPTIMIZATION OF THE BACTERIAL SELECTIVE HITS
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In silico identification and experimental validation of hits active against KPC-2 β-lactamase
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Application of Pluronics for Enhancing Aqueous Solubility of Lipophilic Microtubule Destabilizing Compounds on the Sea Urchin Embryo Model
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Lead Optimization in the Drug Discovery Process
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