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Solvent-Dependent Metabolite Distribution, Clustering, and Protein Extraction for Serum Profiling with Mass Spectrometry

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What this work says

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Detecting low-abundance vasoactive peptides in plasma: Progress toward absolute quantitation using nano liquid chromatography–mass spectrometry
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Complexity and pitfalls of mass spectrometry-based targeted metabolomics in brain research
inferred← citeshttps://doi.org/10.1016/j.ab.2010.07.015openalex-snapshot
Differences in metabolite profile between blood plasma and serum
inferred← citeshttps://doi.org/10.1016/j.ab.2015.01.003openalex-snapshot
Extraction parameters for metabolomics from cultured cells
inferred← citeshttps://doi.org/10.1016/j.ab.2017.05.002openalex-snapshot
Deproteinization assessment using isotopically enriched compounds to trace the coprecipitation of low-molecular-weight selenium species with proteins
inferred← citeshttps://doi.org/10.1016/j.ab.2020.113980openalex-snapshot
LC-MS/MS quantification of fat soluble vitamers – A systematic review
inferred← citeshttps://doi.org/10.1016/j.ab.2021.114153openalex-snapshot
Systematic evaluation of sample preparation strategy for GC-MS-based plasma metabolomics and its application in osteoarthritis
inferred← citeshttps://doi.org/10.1016/j.aca.2009.01.054openalex-snapshot
Analysis of highly polar metabolites in human plasma by ultra-performance hydrophilic interaction liquid chromatography coupled with quadrupole-time of flight mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.aca.2009.06.033openalex-snapshot
Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.aca.2011.09.042openalex-snapshot
Liquid chromatography–mass spectrometry based global metabolite profiling: A review
inferred← citeshttps://doi.org/10.1016/j.aca.2011.12.065openalex-snapshot
Metabolic fingerprinting of high-fat plasma samples processed by centrifugation- and filtration-based protein precipitation delineates significant differences in metabolite information coverage
inferred← citeshttps://doi.org/10.1016/j.aca.2013.10.025openalex-snapshot
Metabolite profiling of human plasma by different extraction methods through gas chromatography–mass spectrometry—An objective comparison
inferred← citeshttps://doi.org/10.1016/j.aca.2018.07.034openalex-snapshot
Evaluation of two-step liquid-liquid extraction protocol for untargeted metabolic profiling of serum samples to achieve broader metabolome coverage by UPLC-Q-TOF-MS
inferred← citeshttps://doi.org/10.1016/j.aca.2018.08.004openalex-snapshot
Optimization of Folch, Bligh-Dyer, and Matyash sample-to-extraction solvent ratios for human plasma-based lipidomics studies
inferred← citeshttps://doi.org/10.1016/j.aca.2019.12.062openalex-snapshot
Implementation of liquid chromatography–high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorial
inferred← citeshttps://doi.org/10.1016/j.aca.2020.12.025openalex-snapshot
Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial
inferred← citeshttps://doi.org/10.1016/j.aninu.2025.08.014openalex-snapshot
Integrated multi-omics of the ruminal microbiome and host metabolome reveals compensatory growth in response to dietary energy restriction and re-alimentation in growing beef bulls
inferred← citeshttps://doi.org/10.1016/j.anireprosci.2026.108121openalex-snapshot
Multi-omics profiling uncovers metabolic regulation in cumulus cells during oocyte maturation
inferred← citeshttps://doi.org/10.1016/j.apsb.2026.06.024openalex-snapshot
Xiangshao granules regulate the dopaminergic synapse pathway and improve menopausal anxiety in peri- and postmenopausal Chinese women: A multi-center, double-blind, randomized controlled trial
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.112931openalex-snapshot
Losartan ameliorates renal interstitial fibrosis through metabolic pathway and Smurfs-TGF-β/Smad
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116876openalex-snapshot
Butyrate improves recovery from experimental necrotizing enterocolitis by metabolite hesperetin through potential inhibition the PI3K-Akt pathway
inferred← citeshttps://doi.org/10.1016/j.cbd.2010.07.002openalex-snapshot
Global analysis of circulating metabolites in hibernating ground squirrels
inferred← citeshttps://doi.org/10.1016/j.cbd.2026.101799openalex-snapshot
Multi-omics analysis reveals molecular disruption in mouse testes following cumulative heat stress
inferred← citeshttps://doi.org/10.1016/j.cbd.2026.101847openalex-snapshot
Integrated transcriptomic and metabolomic analysis reveals the molecular mechanisms of salinity stress adaptation in the intertidal gastropod (Chlorostoma rustica)
inferred← citeshttps://doi.org/10.1016/j.cbd.2026.101975openalex-snapshot
Integrated transcriptomic and metabolomic analysis unravels the molecular basis of conspecific aggression in Pelodiscus sinensis
inferred← citeshttps://doi.org/10.1016/j.cbpa.2013.06.015openalex-snapshot
Human metabolomics: strategies to understand biology
inferred← citeshttps://doi.org/10.1016/j.cbpa.2026.111996openalex-snapshot
Comparative analysis of the gut microbiome and bile acid profiles in sympatric Rana chensinensis and Fejervarya multistriata tadpoles
inferred← citeshttps://doi.org/10.1016/j.cca.2011.07.031openalex-snapshot
A metabolic profiling analysis of symptomatic gout in human serum and urine using high performance liquid chromatography-diode array detector technique
inferred← citeshttps://doi.org/10.1016/j.cclet.2015.03.001openalex-snapshot
Bioanalytical methods for metabolomic profiling: Detection of head and neck cancer, including oral cancer
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.07.005openalex-snapshot
Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP
inferred← citeshttps://doi.org/10.1016/j.chroma.2013.04.017openalex-snapshot
Liquid chromatography–mass spectrometry in metabolomics research: Mass analyzers in ultra high pressure liquid chromatography coupling
inferred← citeshttps://doi.org/10.1016/j.chroma.2013.04.030openalex-snapshot
New sample preparation approach for mass spectrometry-based profiling of plasma results in improved coverage of metabolome
inferred← citeshttps://doi.org/10.1016/j.chroma.2014.09.001openalex-snapshot
A new approach for plasma (xeno)metabolomics based on solid-phase extraction and nanoflow liquid chromatography-nanoelectrospray ionisation mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.chroma.2014.11.050openalex-snapshot
Current state-of-the-art of nontargeted metabolomics based on liquid chromatography–mass spectrometry with special emphasis in clinical applications
inferred← citeshttps://doi.org/10.1016/j.chroma.2015.10.057openalex-snapshot
Tracking matrix effects in the analysis of DNA adducts of polycyclic aromatic hydrocarbons
inferred← citeshttps://doi.org/10.1016/j.chroma.2019.460419openalex-snapshot
Comparison of underivatized silica and zwitterionic sulfobetaine hydrophilic interaction liquid chromatography stationary phases for global metabolomics of human plasma
inferred← citeshttps://doi.org/10.1016/j.chroma.2024.464816openalex-snapshot
Comprehensive profiling of amino acids and derivatives in biological samples: A robust UHPLC-MS/MS method for investigating acute lung injury
inferred← citeshttps://doi.org/10.1016/j.chroma.2026.467124openalex-snapshot
Stereoselective neuroprotective activity and blood-brain barrier permeability of Schisandrin B enantiomers
inferred← citeshttps://doi.org/10.1016/j.clinbiochem.2010.08.016openalex-snapshot
Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review
inferred← citeshttps://doi.org/10.1016/j.copbio.2020.03.001openalex-snapshot
Metabolic cell communication within tumour microenvironment: models, methods and perspectives
inferred← citeshttps://doi.org/10.1016/j.cpb.2025.100443openalex-snapshot
Diurnal nectar secretion dynamics in Roscoea cautleoides (Zingiberaceae) reveal the role of non-sugar chemicals in plant–pollinator interaction
inferred← citeshttps://doi.org/10.1016/j.dcmed.2023.07.009openalex-snapshot
Mechanisms of Yangxin Tongmai Formula for blood stasis syndrome in coronary heart disease rats based on untargeted plasma metabolomics and intestinal flora 16S rRNA sequencing
inferred← citeshttps://doi.org/10.1016/j.drudis.2006.10.004openalex-snapshot
Systems biology, metabolic modelling and metabolomics in drug discovery and development
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2016.01.015openalex-snapshot
Significance of metabolite extraction method for evaluating sulfamethazine toxicity in adult zebrafish using metabolomics
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115664openalex-snapshot
Hepatotoxicity effects of Ageratina adenophora, as indicated by network toxicology combined with metabolomics and transcriptomics
inferred← citeshttps://doi.org/10.1016/j.envres.2024.118751openalex-snapshot
Multi-omics association study of hexadecane degradation in haloarchaeal strain Halogranum rubrum RO2-11
inferred← citeshttps://doi.org/10.1016/j.envres.2024.118874openalex-snapshot
Effects of dietary selenized glucose on intestinal microbiota and tryptophan metabolism in rats: Assessing skatole reduction potential
inferred← citeshttps://doi.org/10.1016/j.envres.2026.124615openalex-snapshot
Microbial community and functional characteristics across the water–sediment continuum in typical rivers of the Yellow River Delta
inferred← citeshttps://doi.org/10.1016/j.fbio.2023.102716openalex-snapshot
Effect of flours addition on the physicochemical and metabolome in Suanjiang, a Chinese traditional fermentation coagulant
inferred← citeshttps://doi.org/10.1016/j.fochx.2025.102553openalex-snapshot
Influence of fermented feed on lipid composition and volatile flavor profile of duck eggs: Insights from multi-omics analysis
inferred← citeshttps://doi.org/10.1016/j.foodchem.2010.10.064openalex-snapshot
Metabolomic approach for the detection of mechanically recovered meat in food products
inferred← citeshttps://doi.org/10.1016/j.foodchem.2021.129132openalex-snapshot
Novel browning alleviation technology for fresh-cut products: Preservation effect of the combination of Sonchus oleraceus L. extract and ultrasound in fresh-cut potatoes
inferred← citeshttps://doi.org/10.1016/j.foodchem.2021.131218openalex-snapshot
A sensitive and simple HPLC-FLD-based method for the measurement of intracellular glucose uptake
inferred← citeshttps://doi.org/10.1016/j.foodchem.2026.150448openalex-snapshot
Flavor profile and deterioration mechanism of Niubie juice during low-temperature storage based on flavoromics and metabolomics
inferred← citeshttps://doi.org/10.1016/j.foodres.2023.113679openalex-snapshot
Effects of lactic acid bacteria-derived fermented feed on the taste and quality of duck meat
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.06.052openalex-snapshot
miRNAome-metabolome wide association study reveals effects of miRNA regulation in male diabetic erectile dysfunction
inferred← citeshttps://doi.org/10.1016/j.heliyon.2018.e00856openalex-snapshot
Evaluation of sample preparation methods for NMR-based metabolomics of cow milk
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.147868openalex-snapshot
Novel FAD-dependent uricase produced by food-sourced Priestia megaterium and activity assessment using hyperuricemia Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.ijms.2010.02.007openalex-snapshot
Metabolic profiling of human blood by high-resolution ion mobility mass spectrometry (IM-MS)
inferred← citeshttps://doi.org/10.1016/j.indcrop.2018.05.002openalex-snapshot
Metabolomic elucidation of recovery of Melissa officinalis from UV-B irradiation stress
inferred← citeshttps://doi.org/10.1016/j.indcrop.2024.119164openalex-snapshot
The flavonoids in root regulated rhizosphere microbiome of Angelica dahurica var. formosana in genuine producing area
inferred← citeshttps://doi.org/10.1016/j.indcrop.2026.124047openalex-snapshot
Pseudomonas sp. CD1-mediated fermentation valorization of steviol glycoside production waste liquor and construction of a plant growth-promoting salt-tolerant formulation
inferred← citeshttps://doi.org/10.1016/j.jare.2023.08.002openalex-snapshot
Resuscitation of viable but nonculturable bacteria promoted by ATP-mediated NAD+ synthesis
inferred← citeshttps://doi.org/10.1016/j.jasms.2010.04.003openalex-snapshot
Dealing with the unknown: Metabolomics and Metabolite Atlases
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2017.01.015openalex-snapshot
Evaluation of a novel system for analyzing hydrophilic blood metabolites
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2008.07.114openalex-snapshot
An alternative method for blood plasma preparation prior to metabonomics study
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2008.07.115openalex-snapshot
Analysis of highly polar components in human plasma by hydrophilic interaction chromatography for metabonomic studies
inferred← citeshttps://doi.org/10.1016/j.jcf.2015.02.004openalex-snapshot
Impact of storage conditions on metabolite profiles of sputum samples from persons with cystic fibrosis
inferred← citeshttps://doi.org/10.1016/j.jchromb.2007.03.048openalex-snapshot
GC/MS analysis of the rat urine for metabonomic research
inferred← citeshttps://doi.org/10.1016/j.jchromb.2008.04.030openalex-snapshot
A sample extraction and chromatographic strategy for increasing LC/MS detection coverage of the erythrocyte metabolome
inferred← citeshttps://doi.org/10.1016/j.jchromb.2008.04.031openalex-snapshot
Analytical strategies for LC–MS-based targeted metabolomics
inferred← citeshttps://doi.org/10.1016/j.jchromb.2008.04.033openalex-snapshot
Gas chromatography/mass spectrometry in metabolic profiling of biological fluids
inferred← citeshttps://doi.org/10.1016/j.jchromb.2008.04.049openalex-snapshot
Standardizing GC–MS metabolomics
inferred← citeshttps://doi.org/10.1016/j.jchromb.2008.12.028openalex-snapshot
Electrophoresis and liquid chromatography/tandem mass spectrometry in disease biomarker discovery☆
inferred← citeshttps://doi.org/10.1016/j.jchromb.2009.04.041openalex-snapshot
Organic solvent extraction and metabonomic profiling of the metabolites in erythrocytes
inferred← citeshttps://doi.org/10.1016/j.jchromb.2009.05.031openalex-snapshot
Overcoming ionization effects through chromatography: A case study for the ESI-LC–MS/MS quantitation of a hydrophobic therapeutic agent in human serum using a stable-label internal standard
inferred← citeshttps://doi.org/10.1016/j.jchromb.2011.12.030openalex-snapshot
Investigation of endogenous metabolic changes in the urine of pseudo germ-free rats using a metabolomic approach
inferred← citeshttps://doi.org/10.1016/j.jchromb.2014.04.047openalex-snapshot
Serum metabolic profiling study of lung cancer using ultra high performance liquid chromatography/quadrupole time-of-flight mass spectrometry
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