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Direct Molecular Analysis of Whole-Body Animal Tissue Sections by Imaging MALDI Mass Spectrometry

https://doi.org/10.1021/ac060788p
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Pharmacokinetics and tissue distribution of olanzapine in rats
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Direct profiling and imaging of peptides and proteins from mammalian cells and tissue sections by mass spectrometry
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Profiling and imaging proteins in the mouse epididymis by imaging mass spectrometry
inferredcites →https://doi.org/10.1016/j.mad.2004.09.032openalex-snapshot
MALDI mass spectrometric imaging of biological tissue sections
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inferredcites →https://doi.org/10.1016/s1044-0305(98)00126-3openalex-snapshot
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inferredcites →https://doi.org/10.1016/s1044-0305(99)00103-8openalex-snapshot
Detection of pharmaceutical compounds in tissue by matrix-assisted laser desorption/ionization and laser desorption/chemical ionization tandem mass spectrometry with a quadrupole ion trap
inferredcites →https://doi.org/10.1021/ac9507956openalex-snapshot
Influence of Matrix Solution Conditions on the MALDI-MS Analysis of Peptides and Proteins
inferredcites →https://doi.org/10.1021/ac970888iopenalex-snapshot
Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
inferredcites →https://doi.org/10.1021/pr0341282openalex-snapshot
Assessing Protein Patterns in Disease Using Imaging Mass Spectrometry
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Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissues
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inferredcites →https://doi.org/10.1186/1477-5956-1-2openalex-snapshot
MALDI/MS peptide mass fingerprinting for proteome analysis: identification of hydrophobic proteins attached to eucaryote keratinocyte cytoplasmic membrane using different matrices in concert.
inferredcites →https://doi.org/10.1186/1477-5956-1-7openalex-snapshot
The proteome of human brain microdialysate
inferredcites →https://doi.org/10.2174/1389200023337207openalex-snapshot
Whole-Body Autoradiography In Drug Discovery

What points at this work

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Ambient desorption ionization mass spectrometry (DART, DESI) and its bioanalytical applications
inferred← citeshttps://doi.org/10.1007/s13361-010-0013-8openalex-snapshot
Matrix Pre-Coated MALDI MS Targets for Small Molecule Imaging in Tissues
inferred← citeshttps://doi.org/10.1007/s13361-011-0150-8openalex-snapshot
Reagent Precoated Targets for Rapid In-Tissue Derivatization of the Anti-Tuberculosis Drug Isoniazid Followed by MALDI Imaging Mass Spectrometry
inferred← citeshttps://doi.org/10.1007/s13361-011-0227-4openalex-snapshot
Imaging of Phospholipids in Formalin Fixed Rat Brain Sections by Matrix Assisted Laser Desorption/Ionization Mass Spectrometry
inferred← citeshttps://doi.org/10.1007/s13361-015-1114-1openalex-snapshot
Influence of Desorption Conditions on Analyte Sensitivity and Internal Energy in Discrete Tissue or Whole Body Imaging by IR-MALDESI
inferred← citeshttps://doi.org/10.1007/s13361-016-1557-zopenalex-snapshot
Graphene Oxide as a Novel Evenly Continuous Phase Matrix for TOF-SIMS
inferred← citeshttps://doi.org/10.1016/b978-0-08-043848-1.00028-6openalex-snapshot
The Development of Imaging Mass Spectrometry
inferred← citeshttps://doi.org/10.1016/b978-0-08-046884-6.00106-8openalex-snapshot
The Application of ADME Principles in Pharmaceutical Safety Assessment
inferred← citeshttps://doi.org/10.1016/b978-0-12-384873-4.00019-0openalex-snapshot
High-Resolution Beta Imaging
inferred← citeshttps://doi.org/10.1016/b978-0-12-385095-9.00240-2openalex-snapshot
New Mass Spectrometric Approaches for Uncovering Neuropeptides
inferred← citeshttps://doi.org/10.1016/b978-0-12-385471-1.00012-xopenalex-snapshot
Methods of Analysis of Drugs and Drug Metabolites
inferred← citeshttps://doi.org/10.1016/b978-0-12-387815-1.00010-1openalex-snapshot
Molecular Pathology
inferred← citeshttps://doi.org/10.1016/b978-0-12-394297-5.00004-0openalex-snapshot
Imaging Mass Spectrometry
inferred← citeshttps://doi.org/10.1016/b978-0-12-394446-7.00025-xopenalex-snapshot
Imaging Mass Spectrometry of Intact Biomolecules in Tissue Sections
inferred← citeshttps://doi.org/10.1016/b978-0-12-803620-4.00016-5openalex-snapshot
Molecular Pathology
inferred← citeshttps://doi.org/10.1016/b978-0-12-814395-7.00009-xopenalex-snapshot
High-resolution beta imaging
inferred← citeshttps://doi.org/10.1016/b978-0-12-817109-7.00001-8openalex-snapshot
Metabolomics for crop improvement: Quality and productivity
inferred← citeshttps://doi.org/10.1016/b978-0-12-818607-7.00019-0openalex-snapshot
Imaging mass spectrometry of intact biomolecules in tissue sections
inferred← citeshttps://doi.org/10.1016/b978-0-323-85704-8.00013-xopenalex-snapshot
Molecular Pathology: Applications in Nonclinical Drug Development
inferred← citeshttps://doi.org/10.1016/b978-0-323-95072-5.00007-9openalex-snapshot
Applications of mass spectroscopy in understanding cancer proteomics
inferred← citeshttps://doi.org/10.1016/b978-0-323-99762-1.00086-3openalex-snapshot
Laser-based mass spectrometry
inferred← citeshttps://doi.org/10.1016/b978-0-444-62651-6.00010-6openalex-snapshot
Direct Mass Spectrometry-Based Approaches in Metabolomics
inferred← citeshttps://doi.org/10.1016/bs.acr.2016.11.002openalex-snapshot
Applications of Mass Spectrometry Imaging to Cancer
inferred← citeshttps://doi.org/10.1016/j.abb.2015.08.021openalex-snapshot
An accessible, scalable ecosystem for enabling and sharing diverse mass spectrometry imaging analyses
inferred← citeshttps://doi.org/10.1016/j.aca.2009.02.051openalex-snapshot
MALDI mass spectrometry imaging of gangliosides in mouse brain using ionic liquid matrix
inferred← citeshttps://doi.org/10.1016/j.aca.2019.11.014openalex-snapshot
Precision biomarker discovery powered by microscopy image fusion-assisted high spatial resolution ambient ionization mass spectrometry imaging
inferred← citeshttps://doi.org/10.1016/j.aca.2023.341963openalex-snapshot
Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films
inferred← citeshttps://doi.org/10.1016/j.aca.2024.342345openalex-snapshot
Towards developing a matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) compatible tissue expansion protocol
inferred← citeshttps://doi.org/10.1016/j.addr.2013.03.006openalex-snapshot
Imaging mass spectrometry: From tissue sections to cell cultures
inferred← citeshttps://doi.org/10.1016/j.ajpath.2018.05.018openalex-snapshot
Imaging Mass Microscopy of Kidneys from Azithromycin-Treated Rats with Phospholipidosis
inferred← citeshttps://doi.org/10.1016/j.bbapap.2014.10.023openalex-snapshot
Mass spectrometric analysis of spatio-temporal dynamics of crustacean neuropeptides
inferred← citeshttps://doi.org/10.1016/j.bbapap.2016.10.014openalex-snapshot
MALDI imaging mass spectrometry — From bench to bedside
inferred← citeshttps://doi.org/10.1016/j.bcp.2013.08.026openalex-snapshot
Biomarkers in pharmacology and drug discovery
inferred← citeshttps://doi.org/10.1016/j.bcp.2022.115080openalex-snapshot
Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging
inferred← citeshttps://doi.org/10.1016/j.biochi.2010.05.013openalex-snapshot
Mass spectrometry imaging: Towards a lipid microscope?
inferred← citeshttps://doi.org/10.1016/j.bone.2014.01.017openalex-snapshot
Co-registration of multi-modality imaging allows for comprehensive analysis of tumor-induced bone disease
inferred← citeshttps://doi.org/10.1016/j.cbpa.2006.11.035openalex-snapshot
MALDI-MS-based imaging of small molecules and proteins in tissues
inferred← citeshttps://doi.org/10.1016/j.cbpa.2016.12.018openalex-snapshot
From single cells to our planet—recent advances in using mass spectrometry for spatially resolved metabolomics
inferred← citeshttps://doi.org/10.1016/j.cclet.2014.01.046openalex-snapshot
Design and performance of air flow-assisted ionization imaging mass spectrometry system
inferred← citeshttps://doi.org/10.1016/j.chemphyslip.2018.07.002openalex-snapshot
Evidence of lipid rafts based on the partition and dynamic behavior of sphingomyelins
inferred← citeshttps://doi.org/10.1016/j.chom.2012.04.018openalex-snapshot
Monitoring the Inflammatory Response to Infection through the Integration of MALDI IMS and MRI
inferred← citeshttps://doi.org/10.1016/j.chroma.2015.10.093openalex-snapshot
Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.dmpk.2025.101485openalex-snapshot
Current status of Imaging Mass Spectrometry in drug discovery and development: A survey highlighting technical challenges and future directions
inferred← citeshttps://doi.org/10.1016/j.drudis.2007.01.007openalex-snapshot
Current and future trends in the application of HPLC-MS to metabolite-identification studies
inferred← citeshttps://doi.org/10.1016/j.drudis.2023.103751openalex-snapshot
Metabolomics and lipidomics strategies in modern drug discovery and development
inferred← citeshttps://doi.org/10.1016/j.egg.2025.100431openalex-snapshot
Advanced proteomic approaches for characterizing halophilic bacteria: Insights into protein stability and industrial applications
inferred← citeshttps://doi.org/10.1016/j.ejvs.2010.08.001openalex-snapshot
Imaging Mass Spectrometry Reveals Unique Lipid Distribution in Primary Varicose Veins
inferred← citeshttps://doi.org/10.1016/j.euprot.2014.02.015openalex-snapshot
Mass spectrometric characterization of the crustacean neuropeptidome
inferred← citeshttps://doi.org/10.1016/j.fitote.2020.104679openalex-snapshot
Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging
inferred← citeshttps://doi.org/10.1016/j.foodchem.2026.151101openalex-snapshot
A multi-omic atlas of the maternal-fetal dyad reveals metabolic stratification and prenatal signatures potentially relevant to meat quality development
inferred← citeshttps://doi.org/10.1016/j.ijms.2006.10.007openalex-snapshot
Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections
inferred← citeshttps://doi.org/10.1016/j.ijms.2008.04.005openalex-snapshot
A minimalist approach to MALDI imaging of glycerophospholipids and sphingolipids in rat brain sections
inferred← citeshttps://doi.org/10.1016/j.ijms.2009.02.032openalex-snapshot
Fast and automated large-area imaging MALDI mass spectrometry in microprobe and microscope mode
inferred← citeshttps://doi.org/10.1016/j.ijms.2013.09.012openalex-snapshot
Velocity corrected ion extraction in microscope mode imaging mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.ijms.2014.05.012openalex-snapshot
Assessing drug and metabolite detection in liver tissue by UV-MALDI and IR-MALDESI mass spectrometry imaging coupled to FT-ICR MS
inferred← citeshttps://doi.org/10.1016/j.ijms.2016.10.004openalex-snapshot
MALDI mass spectrometry in medical research and diagnostic routine laboratories
inferred← citeshttps://doi.org/10.1016/j.ijms.2017.12.001openalex-snapshot
In situ metabolomic changes in rat hippocampus after acute cocaine administration
inferred← citeshttps://doi.org/10.1016/j.ijms.2018.01.005openalex-snapshot
Spatial profiling of stapled α–helical peptide ATSP-7041 in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-HPLC-ESI–MS/MS
inferred← citeshttps://doi.org/10.1016/j.ijms.2018.02.007openalex-snapshot
Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review
inferred← citeshttps://doi.org/10.1016/j.jasms.2007.06.010openalex-snapshot
Sublimation as a method of matrix application for mass spectrometric imaging
inferred← citeshttps://doi.org/10.1016/j.jasms.2007.08.005openalex-snapshot
Imaging of aβ-peptide distribution in whole-body mice sections by MALDI mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jasms.2008.03.016openalex-snapshot
Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections
inferred← citeshttps://doi.org/10.1016/j.jasms.2009.10.003openalex-snapshot
MALDI imaging of neutral cuticular lipids in insects and plants
inferred← citeshttps://doi.org/10.1016/j.jprot.2010.02.021openalex-snapshot
Essential tactics of tissue preparation and matrix nano-spotting for successful compound imaging mass spectrometry
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