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Comparative Analysis of Sample Preparation Methods To Handle the Complexity of the Blood Fluid Metabolome: When Less Is More

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Matrix effects on accurate mass measurements of low‐molecular weight compounds using liquid chromatography‐electrospray‐quadrupole time‐of‐flight mass spectrometry
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Mass spectrometry‐based metabolomics
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Critical evaluation of sample pretreatment techniques
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Metabolomics: building on a century of biochemistry to guide human health
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Metabolic fingerprinting of high-fat plasma samples processed by centrifugation- and filtration-based protein precipitation delineates significant differences in metabolite information coverage
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Metabolomics Study of Human Urinary Metabolome Modifications After Intake of Almond (Prunus dulcis(Mill.) D.A. Webb) Skin Polyphenols
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Metabolomics Unveils Urinary Changes in Subjects with Metabolic Syndrome following 12-Week Nut Consumption
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The emerging field of lipidomics
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Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidaemia
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Metagenes and molecular pattern discovery using matrix factorization
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Lipidomics reveals a remarkable diversity of lipids in human plasma
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The Human Serum Metabolome
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Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women

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Determination of methylarginines in infant plasma by CE-LIF
inferred← citeshttps://doi.org/10.1039/c8an01219aopenalex-snapshot
Merging metabolomics and lipidomics into one analytical run
inferred← citeshttps://doi.org/10.1039/c8ra01372aopenalex-snapshot
A sensitive approach for simultaneous quantification of carbonyl and hydroxyl steroids using 96-well SPE plates based on stable isotope coded-derivatization-UPLC-MRM: method development and application
inferred← citeshttps://doi.org/10.1039/d0an01319fopenalex-snapshot
Assessment of human plasma and urine sample preparation for reproducible and high-throughput UHPLC-MS clinical metabolic phenotyping
inferred← citeshttps://doi.org/10.1039/d4an01015aopenalex-snapshot
Evaluating protocols for reproducible targeted metabolomics by NMR
inferred← citeshttps://doi.org/10.1039/d4mo00015copenalex-snapshot
Extraction and untargeted analysis of metabolome from undemineralised cortical bone matrix
inferred← citeshttps://doi.org/10.1080/10408398.2020.1791794openalex-snapshot
Interactions of dietary polyphenols with epithelial lipids: advances from membrane and cell models in the study of polyphenol absorption, transport and delivery to the epithelium
inferred← citeshttps://doi.org/10.1089/omi.2012.0121openalex-snapshot
Postgenomics Diagnostics: Metabolomics Approaches to Human Blood Profiling
inferred← citeshttps://doi.org/10.1177/1087057116671490openalex-snapshot
Untargeted LC-HRMS-Based Metabolomics for Searching New Biomarkers of Pancreatic Ductal Adenocarcinoma: A Pilot Study
inferred← citeshttps://doi.org/10.1177/14690667251359789openalex-snapshot
Liquid chromatography-tandem mass spectrometry method for quantification of ertugliflozin in human plasma: Application to disposition kinetics
inferred← citeshttps://doi.org/10.1186/s11658-023-00452-xopenalex-snapshot
Comparison between 5 extractions methods in either plasma or serum to determine the optimal extraction and matrix combination for human metabolomics
inferred← citeshttps://doi.org/10.1360/n032017-00118openalex-snapshot
Analysis of small molecule compounds in complex mixture system by LC-MS
inferred← citeshttps://doi.org/10.15252/embr.202255747openalex-snapshot
Metabolomics meets systems immunology
inferred← citeshttps://doi.org/10.2139/ssrn.4899988openalex-snapshot
Comprehensive Analysis of Tryptophan-Melatonin Metabolites: Simultaneous Quantification of Circulating and Urinary Analytes Using Fast and Sensitive Uhplc–Ms/Ms
inferred← citeshttps://doi.org/10.2174/2213235x02666140214201251openalex-snapshot
UPLC-MS Metabonomics Reveals Perturbed Metabolites in HIV-Infected Sera
inferred← citeshttps://doi.org/10.2174/2666338408999200614155440openalex-snapshot
Comparison of Different Sample Preparation Techniques for Untargeted Metabolomics Utilizing Q-TOF LC/MS and MetaboAnalyst 4.0
inferred← citeshttps://doi.org/10.33380/2305-2066-2019-8-3-86-90openalex-snapshot
Influence of the Method of Treatment of Samples of Biological Nature on the Results of Determination of Heavy Metals by Atomic Emission Spectroscopy
inferred← citeshttps://doi.org/10.3389/fmicb.2020.595910openalex-snapshot
A Comparative Evaluation of Tools to Predict Metabolite Profiles From Microbiome Sequencing Data
inferred← citeshttps://doi.org/10.3389/fmolb.2023.1125582openalex-snapshot
Quantitative plasma profiling by 1H NMR-based metabolomics: impact of sample treatment
inferred← citeshttps://doi.org/10.3389/fpls.2025.1640426openalex-snapshot
Development of plant extracts as substrates for untargeted transporter substrate identification in Xenopus oocytes
inferred← citeshttps://doi.org/10.3389/fpubh.2021.653599openalex-snapshot
Data Processing Thresholds for Abundance and Sparsity and Missed Biological Insights in an Untargeted Chemical Analysis of Blood Specimens for Exposomics
inferred← citeshttps://doi.org/10.3390/antiox10060846openalex-snapshot
Metabolomics Technologies for the Identification and Quantification of Dietary Phenolic Compound Metabolites: An Overview
inferred← citeshttps://doi.org/10.3390/ijms150610492openalex-snapshot
Mass Spectrometry Methodology in Lipid Analysis
inferred← citeshttps://doi.org/10.3390/ijms17071017openalex-snapshot
Stable Isotope-Assisted Evaluation of Different Extraction Solvents for Untargeted Metabolomics of Plants
inferred← citeshttps://doi.org/10.3390/ijms262411808openalex-snapshot
Untargeted Metabolomic Study for Urinary Characterization of Adult Patients with Phenylketonuria
inferred← citeshttps://doi.org/10.3390/metabo10030103openalex-snapshot
Simultaneous Measurement of Tricarboxylic Acid Cycle Intermediates in Different Biological Matrices Using Liquid Chromatography–Tandem Mass Spectrometry; Quantitation and Comparison of TCA Cycle Intermediates in Human Serum, Plasma, Kasumi-1 Cell and Murine Liver Tissue
inferred← citeshttps://doi.org/10.3390/metabo12010015openalex-snapshot
Defining Blood Plasma and Serum Metabolome by GC-MS
inferred← citeshttps://doi.org/10.3390/metabo7020013openalex-snapshot
Sample Preparation Strategies for the Effective Quantitation of Hydrophilic Metabolites in Serum by Multi-Targeted HILIC-MS/MS
inferred← citeshttps://doi.org/10.3390/polym14193968openalex-snapshot
Preparation of Molecularly Imprinted Polymer Microspheres for Selective Solid-Phase Extraction of Capecitabine in Urine Samples
inferred← citeshttps://doi.org/10.35333/jrp.2020.111openalex-snapshot
Liquid-liquid extraction and ultrafiltration based sample preparation technique for Q-TOF LC/MS analysis of non-polar metabolites in human plasma samples
inferred← citeshttps://doi.org/10.4155/bio-2015-0010openalex-snapshot
Methods Used to Increase The Comprehensive Coverage of Urinary and Plasma Metabolomes by MS
inferred← citeshttps://doi.org/10.4155/bio-2016-0078openalex-snapshot
Systematic Evaluation of Serum and Plasma Collection on The Endogenous Metabolome
inferred← citeshttps://doi.org/10.4155/bio-2021-0144openalex-snapshot
Review on In Vivo Profiling of Drug Metabolites with Lc-Ms/Ms in the Past Decade
inferred← citeshttps://doi.org/10.4155/bio.14.173openalex-snapshot
Recent Advances in Hydrophilic Interaction Chromatography for Quantitative Analysis of Endogenous and Pharmaceutical Compounds in Plasma Samples
inferred← citeshttps://doi.org/10.48550/arxiv.2102.00765openalex-snapshot
Molecular origin of blood-based infrared fingerprints
inferred← citeshttps://doi.org/10.5821/dissertation-2117-95503openalex-snapshot
Machine learning methods for the analysis of liquid chromatography-mass spectrometry datasets in metabolomics
inferred← citeshttps://doi.org/10.64898/2026.07.30.741666openalex-snapshot
Non-Invasive Embryo Quality Assessment via Matrix-Optimized Untargeted LC-MS Metabolomics of Spent Embryo Culture Media and Weighted Ensemble Machine Learning
inferred← citeshttps://doi.org/10.70675/52008c97z46a9z49a0za8d4z1e87a43af372openalex-snapshot
Les approches –omiques, métabolomique et protéomique, pour l’étude de la relation de cause à effet entre contaminants émergents, produits pharmaceutiques et organismes marins, Mytilus galloprovincialis
inferred← citeshttps://doi.org/10.70675/bf09e78azcb98z43d0z9b93z4e5bd3bd61d8openalex-snapshot
Methodological developments for the non-targeted characterization of the human internal chemical exposome in epidemiological studies : optimizing and implementing a high-throughput workflow for the identification of new biomarkers of exposure in blood plasma and serum samples
inferred← citeshttps://doi.org/10.70675/c80bc0b8z130cz4f16zbd73zf65bc059a493openalex-snapshot
Recherche de marqueurs associés à la production de méthane entérique chez la vache laitière par des approches métabolomiques multiplateformes
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