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Atomic and Molecular Imaging at the Single-Cell Level with TOF-SIMS

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Sample preparation of animal tissues and cell cultures for secondary ion mass spectrometry (SIMS) microscopy

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Molecular Imaging Secondary Ion Mass Spectrometry for the Characterization of Patterned Self-Assembled Monolayers on Silver and Gold

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Imaging with Ion Beams and Laser Postionization

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Intracellular localization of diffusible elements in frozen-hydrated biological specimens with ion microscopy

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Generalized rank annihilation factor analysis

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Cationization of organic molecules in secondary ion mass spectrometry

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Ring-strain-promoted 1,2-carbanionic rearrangements

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Diffusible ion localization by ion microscopy: a comparison of chemically prepared and fast‐frozen, freeze‐dried, unfixed liver sections

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Imaging intracellular elemental distribution and ion fluxes in cultured cells using ion microscopy: a freeze‐fracture methodology

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Pellicle of Paramecium caudatum as Revealed by Freeze Etching

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Paramecium: A Current Survey

What points at this work

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inferred← citeshttps://doi.org/10.1021/ac2032589openalex-snapshot

Cluster Secondary Ion Mass Spectrometry and the Temperature Dependence of Molecular Depth Profiles

inferred← citeshttps://doi.org/10.1021/ac301337hopenalex-snapshot

Single Cell Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/ac303038jopenalex-snapshot

Single-Cell Lipidomics: Characterizing and Imaging Lipids on the Surface of Individual Aplysia californica Neurons with Cluster Secondary Ion Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/ac403421vopenalex-snapshot

MALDI Mass Spectrometry Imaging in Microscope Mode with Infrared Lasers: Bypassing the Diffraction Limits

inferred← citeshttps://doi.org/10.1021/ac801591ropenalex-snapshot

MS/MS Methodology To Improve Subcellular Mapping of Cholesterol Using TOF-SIMS

inferred← citeshttps://doi.org/10.1021/ac900636vopenalex-snapshot

Fixation and Drying Protocols for the Preparation of Cell Samples for Time-of-Flight Secondary Ion Mass Spectrometry Analysis

inferred← citeshttps://doi.org/10.1021/ac9026466openalex-snapshot

Atmospheric Pressure Femtosecond Laser Imaging Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/ac970888iopenalex-snapshot

Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS

inferred← citeshttps://doi.org/10.1021/ac990694yopenalex-snapshot

One-Dimensional Protein Analysis of an HT29 Human Colon Adenocarcinoma Cell

inferred← citeshttps://doi.org/10.1021/acs.analchem.0c00349openalex-snapshot

ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray

inferred← citeshttps://doi.org/10.1021/acs.analchem.0c01125openalex-snapshot

Cryo-OrbiSIMS for 3D Molecular Imaging of a Bacterial Biofilm in Its Native State

inferred← citeshttps://doi.org/10.1021/acs.analchem.1c01927openalex-snapshot

Correlative Imaging of Trace Elements and Intact Molecular Species in a Single-Tissue Sample at the 50 μm Scale

inferred← citeshttps://doi.org/10.1021/acs.analchem.1c04436openalex-snapshot

Development of Machine-Learning Techniques for Time-of-Flight Secondary Ion Mass Spectrometry Spectral Analysis: Application for the Identification of Silane Coupling Agents in Multicomponent Films

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c04795openalex-snapshot

Nano-DESI Mass Spectrometry Imaging of Proteoforms in Biological Tissues with High Spatial Resolution

inferred← citeshttps://doi.org/10.1021/acs.analchem.4c06087openalex-snapshot

A Low-Cost, High-Resolution Thermoplastic Microfluidic Probe for Mass Spectrometry Imaging of Biological Tissue Samples

inferred← citeshttps://doi.org/10.1021/acs.analchem.6b01212openalex-snapshot

Nanotip Ambient Ionization Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/acs.analchem.6c02482openalex-snapshot

Sequential MALDI and Nano-DESI MS Imaging of Lipids and Proteins on Stretched Tissue Samples

inferred← citeshttps://doi.org/10.1021/acs.analchem.8b00551openalex-snapshot

Quantitative Extraction and Mass Spectrometry Analysis at a Single-Cell Level

inferred← citeshttps://doi.org/10.1021/acs.analchem.8b05598openalex-snapshot

Colocalization Features for Classification of Tumors Using Desorption Electrospray Ionization Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/acs.analchem.9b01542openalex-snapshot

Biophysical and Biochemical Characteristics as Complementary Indicators of Melanoma Progression

inferred← citeshttps://doi.org/10.1021/acs.analchem.9b03322openalex-snapshot

Visualizing ToF-SIMS Hyperspectral Imaging Data Using Color-Tagged Toroidal Self-Organizing Maps

inferred← citeshttps://doi.org/10.1021/acs.chemrev.6c00098openalex-snapshot

Computational Mass Spectrometry Imaging in the Era of AI

inferred← citeshttps://doi.org/10.1021/acsami.9b21800openalex-snapshot

Multiplex Protein Imaging with Secondary Ion Mass Spectrometry Using Metal Oxide Nanoparticle-Conjugated Antibodies

inferred← citeshttps://doi.org/10.1021/acsnano.5b00659openalex-snapshot

Co-registered Topographical, Band Excitation Nanomechanical, and Mass Spectral Imaging Using a Combined Atomic Force Microscopy/Mass Spectrometry Platform

inferred← citeshttps://doi.org/10.1021/acssuschemeng.2c03863openalex-snapshot

Three Birds with One Stone: N/P Recovery, Dewaterability Improvement, and Facilitating Liquid Digestate Treatment of Anaerobically Digested Sludge

inferred← citeshttps://doi.org/10.1021/co100024dopenalex-snapshot

Combinatorial Optimization of Multiple MALDI Matrices on a Single Tissue Sample Using Inkjet Printing

inferred← citeshttps://doi.org/10.1021/cr100012copenalex-snapshot

Mass Spectrometric Imaging for Biomedical Tissue Analysis

inferred← citeshttps://doi.org/10.1021/cr980137wopenalex-snapshot

Imaging with Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/ja051223yopenalex-snapshot

Vitamin E Imaging and Localization in the Neuronal Membrane

inferred← citeshttps://doi.org/10.1021/ja992078popenalex-snapshot

Molecule Specific Imaging of Freeze-Fractured, Frozen-Hydrated Model Membrane Systems Using Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/jacs.5c18392openalex-snapshot

Ultrafast Mass Spectrometry Imaging via Laser-Based Mass Spectrometry Microscopy

inferred← citeshttps://doi.org/10.1021/jasms.0c00167openalex-snapshot

High-Resolution Ion Microscope Imaging over Wide Mass Ranges Using Electrodynamic Postextraction Differential Acceleration

inferred← citeshttps://doi.org/10.1021/jasms.0c00187openalex-snapshot

MALDI Mass Spectrometry Imaging in a Primary Demyelination Model of Murine Spinal Cord

inferred← citeshttps://doi.org/10.1021/jasms.3c00233openalex-snapshot

Identification and Imaging of Prostaglandin Isomers Utilizing MS3 Product Ions and Silver Cationization

inferred← citeshttps://doi.org/10.1021/jasms.5c00279openalex-snapshot

Development of Low-Flow High-Resolution Desorption Electrospray Ionization Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/jp810408vopenalex-snapshot

Imaging with Mass Spectrometry: A Secondary Ion and VUV-Photoionization Study of Ion-Sputtered Atoms and Clusters from GaAs and Au

inferred← citeshttps://doi.org/10.1021/la001209topenalex-snapshot

Characterization of Adsorbed Protein Films by Time-of-Flight Secondary Ion Mass Spectrometry with Principal Component Analysis

inferred← citeshttps://doi.org/10.1021/la703741yopenalex-snapshot

Combined Use of Atomic Force Microscopy, X-ray Photoelectron Spectroscopy, and Secondary Ion Mass Spectrometry for Cell Surface Analysis

inferred← citeshttps://doi.org/10.1021/la800292eopenalex-snapshot

Freeze-Etching and Vapor Matrix Deposition for ToF-SIMS Imaging of Single Cells

inferred← citeshttps://doi.org/10.1021/pr049762+openalex-snapshot

Infrared Mass Spectrometric Imaging below the Diffraction Limit

inferred← citeshttps://doi.org/10.1038/nprot.2007.117openalex-snapshot

Imaging mass spectrometry at cellular length scales

inferred← citeshttps://doi.org/10.1038/s41598-017-17049-yopenalex-snapshot

Automated Interpretation and Extraction of Topographic Information from Time of Flight Secondary Ion Mass Spectrometry Data

inferred← citeshttps://doi.org/10.1039/b913575hopenalex-snapshot

Cellular imaging with secondary ion mass spectrometry

inferred← citeshttps://doi.org/10.1039/b920572aopenalex-snapshot

Applications of modern micro-Raman spectroscopy for cell analyses

inferred← citeshttps://doi.org/10.1039/c2an36337bopenalex-snapshot

Lipid imaging by mass spectrometry – a review

inferred← citeshttps://doi.org/10.1039/c6an01346eopenalex-snapshot

Comparing surface properties of melanoma cells using time of flight secondary ions mass spectrometry

inferred← citeshttps://doi.org/10.1039/c7an00885fopenalex-snapshot

Profiling and quantifying endogenous molecules in single cells using nano-DESI MS

inferred← citeshttps://doi.org/10.1039/c8an01190gopenalex-snapshot

Recent advances in single-cell analysis by mass spectrometry

inferred← citeshttps://doi.org/10.1039/c8an01448eopenalex-snapshot

High throughput screening of complex biological samples with mass spectrometry – from bulk measurements to single cell analysis

inferred← citeshttps://doi.org/10.1039/c8an02452aopenalex-snapshot

Effect of energy per atom (E/n) on the Ar gas cluster ion beam (Ar-GCIB) and O2+ cosputter process

inferred← citeshttps://doi.org/10.1039/c9ja00164fopenalex-snapshot

A concise tutorial review of TOF-SIMS based molecular and cellular imaging

inferred← citeshttps://doi.org/10.1039/d0an00768dopenalex-snapshot

Investigation of heart lipid changes in acute β-AR activation-induced sudden cardiac death by time-of-flight secondary ion mass spectrometry

inferred← citeshttps://doi.org/10.1039/d3an00370aopenalex-snapshot

Mass spectrometry-based techniques for single-cell analysis

inferred← citeshttps://doi.org/10.1039/d3lc00637aopenalex-snapshot

A monolithic microfluidic probe for ambient mass spectrometry imaging of biological tissues

inferred← citeshttps://doi.org/10.1063/1.1382641openalex-snapshot

Collisions of ions with surfaces at chemically relevant energies: Instrumentation and phenomena

inferred← citeshttps://doi.org/10.1063/1.4766938openalex-snapshot

The application of the fast, multi-hit, pixel imaging mass spectrometry sensor to spatial imaging mass spectrometry

inferred← citeshttps://doi.org/10.1063/1.4772396openalex-snapshot

Microscope mode secondary ion mass spectrometry imaging with a Timepix detector

inferred← citeshttps://doi.org/10.1063/1.5142271openalex-snapshot

Microscope imaging mass spectrometry with a reflectron

inferred← citeshttps://doi.org/10.1063/5.0037370openalex-snapshot

Development of novel projection-type imaging mass spectrometer

inferred← citeshttps://doi.org/10.1063/5.0283704openalex-snapshot

Tandem electrostatic lens as a zoom system to achieve ultra-high magnification in microscope imaging mass spectrometry

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