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Integrated Microanalytical Technology Enabling Rapid and Automated Protein Identification
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Delayed Extraction Improves Specificity in Database Searches by Matrix-assisted Laser Desorption/Ionization Peptide Maps
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Picoliter to nanoliter deposition of peptide and protein solutions for matrix-assisted laser desorption/ionization mass spectrometry
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Homogeneous sample preparation for automated high throughput analysis with matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry
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Protein identification in DNA databases by peptide mass fingerprinting
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Probing the solution structure of the DNA‐binding protein Max by a combination of proteolysis and mass spectrometry
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Attomole detection of proteins by matrix‐assisted laser desorption/ionization mass spectrometry with the use of picolitre vials
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Delayed extraction matrix‐assisted laser desorption time‐of‐flight mass spectrometry
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Porous Silicon Carrier Matrices in Micro Enzyme Reactors-Influence of Matrix Depth
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A spectrophotometric determination of trypsin and chymotrypsin
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Int. J. Mass Spectrom. Ion Processes
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Silicon wafer integrated enzyme reactors
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Silicon microtechnology and microstructures in separation science
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Pore morphology influence on catalytic turn-over for enzyme activated porous silicon matrices
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[11] Adsorption and inorganic bridge formations
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Tryptic mapping of recombinant proteins by matrix-assisted laser desorption/ionization mass spectrometry
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Comparative Mapping of Recombinant Proteins and Glycoproteins by Plasma Desorption and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
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Rapid Tryptic Mapping Using Enzymically Active Mass Spectrometer Probe Tips
inferredcites →https://doi.org/10.1021/ac950914hopenalex-snapshot
Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels
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MALDI on a Chip: Analysis of Arrays of Low-Femtomole to Subfemtomole Quantities of Synthetic Oligonucleotides and DNA Diagnostic Products Dispensed by a Piezoelectric Pipet
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Picoliter Sample Preparation in MALDI-TOF MS Using a Micromachined Silicon Flow-Through Dispenser
inferredcites →https://doi.org/10.1021/ac980754kopenalex-snapshot
Nanoliter Chemistry Combined with Mass Spectrometry for Peptide Mapping of Proteins from Single Mammalian Cell Lysates
inferredcites →https://doi.org/10.1073/pnas.91.24.11290openalex-snapshot
The emergence of mass spectrometry in biochemical research.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Nano‐ MALDI and Nano‐ ESI MS
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Current Awareness on Comparative and Functional Genomics
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Organic Chemistry in Microreactors
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Electrospray interfacing of polymer microfluidics to MALDI‐MS
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Functionalized magnetic micro‐ and nanoparticles: Optimization and application to μ‐chip tryptic digestion
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Less common applications of monoliths: I. Microscale protein mapping with proteolytic enzymes immobilized on monolithic supports
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Progress in capillary electrophoresis coupled to matrix‐assisted laser desorption/ionization – time of flight mass spectrometry
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Microfluidic technologies for MALDI‐MS in proteomics
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Microfluidics for multiplexed MS analysis
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Recent advances in capillary and microfluidic platforms with MS detection for the analysis of phosphoproteins
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Recent advances in miniaturization—The role of microchip electrophoresis in clinical analysis
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Fundamentals and applications of immobilized microfluidic enzymatic reactors
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Microfluidic chips for mass spectrometry‐based proteomics
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Microscale enzyme reactors comprising gold nanoparticles with immobilized trypsin for efficient protein digestion
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Capillary columns in liquid chromatography: between conventional columns and microchips
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Chararacterization of a monolithic immobilized trypsin microreactor with on‐line coupling to ESI‐MS
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Integrated microfluidic devices with enhanced separation performance: Application to phosphoproteome analyses of differentiated cell model systems
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Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: Past and Present
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Microfabricated devices: A new sample introduction approach to mass spectrometry
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Lab‐on‐a‐plate: Extending the functionality of MALDI‐MS and LDI‐MS targets
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Automated, on‐line two‐dimensional nano liquid chromatography tandem mass spectrometry for rapid analysis of complex protein digests
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The application of a microfluidic reactor including spontaneously adsorbed trypsin for rapid protein digestion of human tear samples
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Time‐of‐flight mass spectrometric analysis of ions produced from adjacent sample spots irradiated simultaneously by a single 337 nm laser
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Analytical characterization of a facile porous polymer monolithic trypsin microreactor enabling peptide mass mapping using mass spectrometry
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Preliminary investigation of electrodynamic charged droplet processing to couple capillary liquid chromatography with matrix‐assisted laser desorption/ionization mass spectrometry
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Highly efficient enrichment and subsequent digestion of proteins in the mesoporous molecular sieve silicate SBA‐15 for matrix‐assisted laser desorption/ionization mass spectrometry with time‐of‐flight/time‐of‐flight analyzer peptide mapping
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A solid‐phase bioreactor with continuous sample deposition for matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
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Microfluidic Devices for Bioapplications
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Mass-Spectrometry-Linked Screening of Protein Fractions for Enzymatic Activities—A Tool for Functional Genomics
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1.1.3.1 Definitions and fundamental relations
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Post-polymerization Modification of Surface-Bound Polymers
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Porous Silicon Immunoaffinity Microarrays
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Porous Silicon Immunoaffinity Microarrays
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Porous Silicon Immunoaffinity Microarrays
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A Microsystem Platform Interfacing MALDI-TOF MS for High Speed Automated Protein Identification
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Optimization of the Droplet Formation in a Piezo-Electric Flow-Through Microdispenser
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Selective extraction of small proteins from biological samples using a novel restricted access column with cation exchange properties
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Microfluidic enzymatic reactors for proteome research
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Comprehensive identification of the binding sites of cisplatin in hen egg white lysozyme
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Development of an enzymatic reactor applying spontaneously adsorbed trypsin on the surface of a PDMS microfluidic device
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Micro total analysis system (�-TAS) in biotechnology
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Microdroplet generation in gaseous and liquid environments
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Recent advances in proteolysis and peptide/protein separation by chromatographic strategies
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Identification of carboxyl terminal peptide of Fibrinogen as a potential serum biomarker for gastric cancer
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Analytical methods for evaluating and characterizing recombinant proteins
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Micro- and Nanotechnology for Proteomics
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Microfluidics with MALDI analysis for proteomics—A review
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MALDI-target integrated platform for affinity-captured protein digestion
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Rapid protein digestion and identification using monolithic enzymatic microreactor coupled with nano-liquid chromatography-electrospray ionization mass spectrometry
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On-line single droplet deposition for MALDI mass spectrometry
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Development of an automated digestion and droplet deposition microfluidic chip for MALDI-TOF MS
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A flow-through nanoporous alumina trypsin bioreactor for mass spectrometry peptide fingerprinting
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Microchips, microarrays, biochips and nanochips: personal laboratories for the 21st century
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Proteomics–protein profiling technology: the trend towards a microfabricated toolbox concept
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Chapter 6 Microtechnology principles and platforms for proteomic analysis
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Chapter 18 High-Throughput Analysis
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Bio-affinity Extraction for the Analysis of Cytokine and Proteomic Samples
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The Beauty of Silicon Micromachined Microstructures Interfaced to MALDI-TOF Mass Spectrometry
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Chapter 11 Microfabricated analytical devices
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Silicon microstructures for high-speed and high-sensitivity protein identifications
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Bi-enzymatic and capillary electrophoretic analysis of non-fluorescent compounds in microfluidic devices
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Introduction to micro-analytical systems: bioanalytical and pharmaceutical applications
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Picodroplet-deposition of enzymes on functionalized self-assembled monolayers as a basis for miniaturized multi-sensor structures
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Advances in mass spectrometry for proteome analysis
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Multidimensional separations in the pharmaceutical arena
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Lab-on-a-chip: applications in proteomics
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Gas-phase ion/ion interactions between peptides or proteins and iron ions in a quadrupole ion trap
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Microfluidic components for protein characterization
inferred← citeshttps://doi.org/10.1016/s1535-5535(04)00107-8openalex-snapshot
Microdispensing and Nanovial Arrays Provides Rapid Automated Protein/Peptide Identification using MALDI-TOF MS
inferred← citeshttps://doi.org/10.1016/s1535-5535(04)00108-xopenalex-snapshot
An Automated and Integrated Protein Workstation Interfacing Capillary HPLC with MALDI-TOF Mass Spectrometry Using Piezoelectric Microdispensing
inferred← citeshttps://doi.org/10.1021/ac000176jopenalex-snapshot
Protein Concentration and Enzyme Digestion on Microbeads for MALDI-TOF Peptide Mass Mapping of Proteins from Dilute Solutions
inferred← citeshttps://doi.org/10.1021/ac000421zopenalex-snapshot
An On-Line Protein Digestion Device for Rapid Peptide Mapping by Electrospray Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/ac000648uopenalex-snapshot
Development of A Microchamber Array for Picoliter PCR
inferred← citeshttps://doi.org/10.1021/ac000734uopenalex-snapshot
Signal Amplification Using “Spot-on-a-Chip” Technology for the Identification of Proteins via MALDI-TOF MS
inferred← citeshttps://doi.org/10.1021/ac001126hopenalex-snapshot
Integrated Microfluidic System Enabling Protein Digestion, Peptide Separation, and Protein Identification
inferred← citeshttps://doi.org/10.1021/ac0011888openalex-snapshot
A CE−MALDI Interface Based on the Use of Prestructured Sample Supports
inferred← citeshttps://doi.org/10.1021/ac001488popenalex-snapshot
Identification of Individual Proteins in Complex Protein Mixtures by High-Resolution, High-Mass-Accuracy MALDI TOF-Mass Spectrometry Analysis of In-Solution Thermal Denaturation/Enzymatic Digestion
inferred← citeshttps://doi.org/10.1021/ac001533topenalex-snapshot
A Polymeric Microfluidic Chip for CE/MS Determination of Small Molecules
inferred← citeshttps://doi.org/10.1021/ac015638nopenalex-snapshot
MALDI-TOF-MS Analysis of Droplets Prepared in an Electrodynamic Balance: “Wall-less” Sample Preparation
inferred← citeshttps://doi.org/10.1021/ac020180qopenalex-snapshot
Enzymatic Microreactor-on-a-Chip: Protein Mapping Using Trypsin Immobilized on Porous Polymer Monoliths Molded in Channels of Microfluidic Devices
inferred← citeshttps://doi.org/10.1021/ac020710iopenalex-snapshot
Functional Microfabricated Sample Targets for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Analysis of Ribonucleic Acids
inferred← citeshttps://doi.org/10.1021/ac025768bopenalex-snapshot
Membrane-Based Nanoscale Proteolytic Reactor Enabling Protein Digestion, Peptide Separation, and Protein Identification Using Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/ac0300901openalex-snapshot
A Microfluidic Electrocapture Device in Sample Preparation for Protein Analysis by MALDI Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/ac034108jopenalex-snapshot
Dual-Function Microanalytical Device by In Situ Photolithographic Grafting of Porous Polymer Monolith: Integrating Solid-Phase Extraction and Enzymatic Digestion for Peptide Mass Mapping
inferred← citeshttps://doi.org/10.1021/ac034258uopenalex-snapshot
Chip-Based Analysis of Protein−Protein Interactions by Fluorescence Detection and On-Chip Immunoprecipitation Combined with μLC−MS/MS Analysis
inferred← citeshttps://doi.org/10.1021/ac0346860openalex-snapshot
Analysis in Ultrasmall Volumes: Microdispensing of Picoliter Droplets and Analysis without Protection from Evaporation
inferred← citeshttps://doi.org/10.1021/ac035318zopenalex-snapshot
Integrated and Ultrasensitive Gel Protein Identification
inferred← citeshttps://doi.org/10.1021/ac048152qopenalex-snapshot
Integrated Sample Processing System Involving On-Column Protein Adsorption, Sample Washing, and Enzyme Digestion for Protein Identification by LC−ESI MS/MS
inferred← citeshttps://doi.org/10.1021/ac049345gopenalex-snapshot
Microchip Atmospheric Pressure Chemical Ionization Source for Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/ac050201ropenalex-snapshot
Microchip Immobilized Enzyme Reactors for Hydrolysis of Methyl Cellulose
inferred← citeshttps://doi.org/10.1021/ac051348lopenalex-snapshot
Efficient and Specific Trypsin Digestion of Microgram to Nanogram Quantities of Proteins in Organic−Aqueous Solvent Systems
inferred← citeshttps://doi.org/10.1021/ac060116zopenalex-snapshot
Nanopore-Based Proteolytic Reactor for Sensitive and Comprehensive Proteomic Analyses
inferred← citeshttps://doi.org/10.1021/ac060405nopenalex-snapshot
Adjustable Fragmentation in Laser Desorption/Ionization from Laser-Induced Silicon Microcolumn Arrays
inferred← citeshttps://doi.org/10.1021/ac070705kopenalex-snapshot
Photopatterning Enzymes on Polymer Monoliths in Microfluidic Devices for Steady-State Kinetic Analysis and Spatially Separated Multi-Enzyme Reactions
inferred← citeshttps://doi.org/10.1021/ac302353qopenalex-snapshot
Accurate and Highly Reproducible Picoliter Injection System for Capillary Electrophoresis
inferred← citeshttps://doi.org/10.1021/ac900550qopenalex-snapshot
Macroporous Materials as Novel Catalysts for Efficient and Controllable Proteolysis
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b02169openalex-snapshot
Microwave-Assisted Protein Digestion in a Plate Well for Facile Sampling and Rapid Digestion
inferred← citeshttps://doi.org/10.1021/cc020101oopenalex-snapshot
Automated MALDI-TOF-MS Sample Preparation in Combinatorial Polymer Research
inferred← citeshttps://doi.org/10.1021/cr5000943openalex-snapshot
Immobilization of Antibodies and Enzymes on 3-Aminopropyltriethoxysilane-Functionalized Bioanalytical Platforms for Biosensors and Diagnostics
inferred← citeshttps://doi.org/10.1021/jasms.3c00038openalex-snapshot
Analysis of Protein Glycosylation after Rapid Digestion Using Protease-Containing Membranes in Spin Columns
inferred← citeshttps://doi.org/10.1021/la7033577openalex-snapshot
Photochemical Functionalization of Polymer Surfaces for Microfabricated Devices
inferred← citeshttps://doi.org/10.1021/pr0255452openalex-snapshot
High-Throughput Peptide Mass Mapping Using a Microdevice Containing Trypsin Immobilized on a Porous Polymer Monolith Coupled to MALDI TOF and ESI TOF Mass Spectrometers
inferred← citeshttps://doi.org/10.1021/pr049889zopenalex-snapshot
Titania and Alumina Sol−Gel-Derived Microfluidics Enzymatic-Reactors for Peptide Mapping: Design, Characterization, and Performance
inferred← citeshttps://doi.org/10.1021/pr050142yopenalex-snapshot
Chemically Modified, Immobilized Trypsin Reactor with Improved Digestion Efficiency
inferred← citeshttps://doi.org/10.1021/pr060558ropenalex-snapshot
Microchip Reactor Packed with Metal-Ion Chelated Magnetic Silica Microspheres for Highly Efficient Proteolysis
inferred← citeshttps://doi.org/10.1021/pr100300topenalex-snapshot
Aptamer Microarray Mediated Capture and Mass Spectrometry Identification of Biomarker in Serum Samples
inferred← citeshttps://doi.org/10.1039/9781849732284-00209openalex-snapshot
Analysis of Proteins at the Single Cell Level
inferred← citeshttps://doi.org/10.1039/b001125hopenalex-snapshot
Lab-on-valve: universal microflow analyzer based on sequential and bead injection
inferred← citeshttps://doi.org/10.1039/b209579nopenalex-snapshot
A microchip-based proteolytic digestion system driven by electroosmotic pumping
inferred← citeshttps://doi.org/10.1039/b306278nopenalex-snapshot
Recent progress in the development of μTAS for clinical analysis
inferred← citeshttps://doi.org/10.1039/b314962eopenalex-snapshot
Combinatorial mixing of microfluidic streams
inferred← citeshttps://doi.org/10.1039/b408222bopenalex-snapshot
Microfluidic enzymatic-reactors for peptide mapping: strategy, characterization, and performance
inferred← citeshttps://doi.org/10.1039/b418663jopenalex-snapshot
Laser induced disruption of bacterial spores on a microchip
inferred← citeshttps://doi.org/10.1039/b606394bopenalex-snapshot
PDMS-based microfluidics for proteomic analysis
inferred← citeshttps://doi.org/10.1039/b715238hopenalex-snapshot
Controlled proteolysis of normal and pathological prion protein in a microfluidic chip
inferred← citeshttps://doi.org/10.1039/b916556hopenalex-snapshot
Development of an efficient on-chip digestion system for protein analysis using MALDI-TOF MS
inferred← citeshttps://doi.org/10.1039/bk9780854041299-00239openalex-snapshot
On-line and Off-line MALDI from a Microfluidic Device
inferred← citeshttps://doi.org/10.1039/c1ob05392bopenalex-snapshot
Effect of ester chemical structure and peptide bond conformation in fragmentation pathways of differently metal cationized cyclodepsipeptides
inferred← citeshttps://doi.org/10.1039/c1py00314copenalex-snapshot
Azlactone-functionalized polymers as reactive platforms for the design of advanced materials: Progress in the last ten years
inferred← citeshttps://doi.org/10.1039/c8an01330fopenalex-snapshot
Multi-lumen capillary based trypsin micro-reactor for the rapid digestion of proteins
inferred← citeshttps://doi.org/10.1051/ata/2000021openalex-snapshot
PERSPECTIVES. Plus vite, plus petit, plus sensible. Analyse et Séparations à l'aube du 3èmeMillénaire
inferred← citeshttps://doi.org/10.1063/1.4816934openalex-snapshot
Protein immobilization techniques for microfluidic assays
inferred← citeshttps://doi.org/10.1080/15422110903095136openalex-snapshot
Microchip‐Based Capillary Electrophoresis for DNA Analysis in Modern Biotechnology: A Review
inferred← citeshttps://doi.org/10.1088/0960-1317/17/5/r01openalex-snapshot
Lab-on-chip technologies: making a microfluidic network and coupling it into a complete microsystem—a review
inferred← citeshttps://doi.org/10.1109/jmems.2004.839000openalex-snapshot
Miniaturized flowthrough microdispenser with piezoceramic tripod actuation
inferred← citeshttps://doi.org/10.1111/j.1651-2227.2005.tb01842.xopenalex-snapshot
Proteomic evaluation of milk from different mammalian species as a substitute for breast milk
inferred← citeshttps://doi.org/10.1117/12.580145openalex-snapshot
Protein stamping for MALDI mass spectrometry using an electrowetting-based microfluidic platform
inferred← citeshttps://doi.org/10.1126/science.290.5496.1540openalex-snapshot
Microfabricating Conjugated Polymer Actuators
inferred← citeshttps://doi.org/10.1128/mmbr.66.1.39-63.2002openalex-snapshot
Molecular Biologist's Guide to Proteomics
inferred← citeshttps://doi.org/10.1155/2000/235613openalex-snapshot
Current Awareness on Comparative and Functional Genomics
inferred← citeshttps://doi.org/10.1201/9780824747343.ch28openalex-snapshot
Protein Interfacial Behavior in Microfabricated Analysis Systems and Microarrays
inferred← citeshttps://doi.org/10.1201/9781420018677.ch14openalex-snapshot
Bio-MEMS Devices for Proteomics
inferred← citeshttps://doi.org/10.1201/9781420042696.ch2openalex-snapshot
Instrumentation and Techniques of Mass Spectrometry
inferred← citeshttps://doi.org/10.1201/b15110-12openalex-snapshot
8Chapter Applications to Cellular/Particle Analysis
inferred← citeshttps://doi.org/10.1246/cl.2006.272openalex-snapshot
Ink-jet Microchip Interface between Liquid Flow and Flame-ionization Detector
inferred← citeshttps://doi.org/10.1366/000370202760171581openalex-snapshot
Flow-through Picoliter Dispenser: A New Approach for Solvent Elimination in FT-IR Spectroscopy
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