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Dark-Field Microscopy: Recent Advances in Accurate Analysis and Emerging Applications

https://doi.org/10.1021/acs.analchem.0c04390

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Noise-Free Dual-Wavelength Difference Imaging of Plasmonic Resonant Nanoparticles in Living Cells

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Gold Triangular Nanoplates Based Single-Particle Dark-Field Microscopy Assay of Pyrophosphate

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Automated Nanoplasmonic Analysis of Spherical Nucleic Acids Clusters in Single Cells

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Enzyme Activity Triggered Blocking of Plasmon Resonance Energy Transfer for Highly Selective Detection of Acid Phosphatase

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Ultrasensitive Detection of MicroRNA via a Au@Ag Nanosnowman

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Imaging Single Nanobubbles of H2 and O2 During the Overall Water Electrolysis with Single-Molecule Fluorescence Microscopy

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Hydrogel-Based Colorimetric Assay for Multiplexed MicroRNA Detection in a Microfluidic Device

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Activated Plasmonic Nanoaggregates for Dark-Field in Situ Imaging for HER2 Protein Imaging on Cell Surfaces

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Tracking Underpotential Deposition of Copper on Individual Silver Nanocubes by Real-Time Single-Particle Plasmon Scattering Imaging

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Patterning Nanogaps: Spatial Control of the Distribution of Nanogaps between Gold Nanoparticles and Gold Substrates

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Precision Plasmonics with Monomers and Dimers of Spherical Gold Nanoparticles: Nonequilibrium Dynamics at the Time and Space Limits

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Nanotraffic Lights: Rayleigh Scattering Microspectroscopy of Optically Trapped Octahedral Gold Nanoparticles

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In Situ Monitoring of Individual Plasmonic Nanoparticles Resolves Multistep Nanoscale Sulfidation Reactions Hidden by Ensemble Average

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Enhanced Electrochemical Dark-Field Scattering Modulation on a Single Hybrid Core–Shell Nanostructure

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Potential-Scanning Localized Plasmon Sensing with Single and Coupled Gold Nanorods

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Dual-Receptor-Targeted (DRT) Radiation Nanomedicine Labeled with 177Lu Is More Potent for Killing Human Breast Cancer Cells That Coexpress HER2 and EGFR Than Single-Receptor-Targeted (SRT) Radiation Nanomedicines

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Single Gold Nanorod Charge Modulation in an Ion Gel Device

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Optomechanics of Single Aluminum Nanodisks

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Hybrid Lithographic and DNA-Directed Assembly of a Configurable Plasmonic Metamaterial That Exhibits Electromagnetically Induced Transparency

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Chiral Plasmonic Nanostructures Fabricated by Circularly Polarized Light

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Light-Driven Nano-oscillators for Label-Free Single-Molecule Monitoring of MicroRNA

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Conformational Dynamics of a Single Protein Monitored for 24 h at Video Rate

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Plasmon Rulers as a Probe for Real-Time Microsecond Conformational Dynamics of Single Molecules

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Tuning Chemical Interface Damping: Interfacial Electronic Effects of Adsorbate Molecules and Sharp Tips of Single Gold Bipyramids

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Reversible Tuning of the Plasmoelectric Effect in Noble Metal Nanostructures Through Manipulation of Organic Ligand Energy Levels

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Mapping Hot Electron Response of Individual Gold Nanocrystals on a TiO2 Photoanode

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Programming Surface-Enhanced Raman Scattering of DNA Origami-templated Metamolecules

inferredcites →https://doi.org/10.1021/acs.nanolett.9b05199openalex-snapshot

Controlled Fabrication of Optical Signal Input/Output Sites on Plasmonic Nanowires

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Single-Molecular Catalysis Identifying Activation Energy of the Intermediate Product and Rate-Limiting Step in Plasmonic Photocatalysis

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Tunable Plasmonic Cavity for Label-free Detection of Small Molecules

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Plasmon Coupling Effect-Enhanced Imaging of Metal Ions in Living Cells Using DNAzyme Assembled Core–Satellite Structures

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Revealing Lectin–Sugar Interactions with a Single Au@Ag Nanocube

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Light-Induced Coalescence of Plasmonic Dimers and Clusters

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Temperature- and pH-Responsive Star Polymers as Nanocarriers with Potential for in Vivo Agrochemical Delivery

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Optical Sorting at the Single-Particle Level with Single-Nanometer Precision Using Coordinated Intensity and Phase Gradient Forces

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Single Plasmonic Nanosprings for Visualizing Reactive-Oxygen-Species-Activated Localized Mechanical Force Transduction in Live Cells

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Photoinduced Electron Transfer Process Visualized on Single Silver Nanoparticles

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Monodisperse Dual Plasmonic Au@Cu2–xE (E= S, Se) Core@Shell Supraparticles: Aqueous Fabrication, Multimodal Imaging, and Tumor Therapy at in Vivo Level

inferredcites →https://doi.org/10.1021/acsnano.7b08673openalex-snapshot

Exploration of the Kinetics of Toehold-Mediated Strand Displacement via Plasmon Rulers

inferredcites →https://doi.org/10.1021/acsnano.8b00025openalex-snapshot

Three-Dimensional Orientation of Anisotropic Plasmonic Aggregates at Intracellular Nuclear Indentation Sites by Integrated Light Sheet Super-Resolution Microscopy

inferredcites →https://doi.org/10.1021/acsnano.8b02932openalex-snapshot

Direct Assembly of Large Area Nanoparticle Arrays

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Antibody–Antigen Interaction Dynamics Revealed by Analysis of Single-Molecule Equilibrium Fluctuations on Individual Plasmonic Nanoparticle Biosensors

inferredcites →https://doi.org/10.1021/acsnano.8b09198openalex-snapshot

Large-Scale and Low-Cost Fabrication of Silicon Mie Resonators

inferredcites →https://doi.org/10.1021/acsnano.8b09636openalex-snapshot

Tracking Sub-Nanometer Shift in the Scattering Centroid of Single Gold Nanorods during Electrochemical Charging

inferredcites →https://doi.org/10.1021/acsnano.9b03019openalex-snapshot

Age-Dependent Translocation of Gold Nanoparticles across the Air–Blood Barrier

inferredcites →https://doi.org/10.1021/acsnano.9b03084openalex-snapshot

Controlled Overgrowth of Five-Fold Concave Nanoparticles into Plasmonic Nanostars and Their Single-Particle Scattering Properties

inferredcites →https://doi.org/10.1021/acsnano.9b04046openalex-snapshot

Chiral Scatterometry on Chemically Synthesized Single Plasmonic Nanoparticles

inferredcites →https://doi.org/10.1021/acsnano.9b04491openalex-snapshot

Direct Observation of Spatiotemporal Heterogeneous Gelation by Rotational Tracking of a Single Anisotropic Nanoprobe

inferredcites →https://doi.org/10.1021/acsnano.9b06492openalex-snapshot

Effect of Nanogap Morphology on Plasmon Coupling

inferredcites →https://doi.org/10.1021/acsnano.9b09987openalex-snapshot

Anapole Excitations in Oxygen-Vacancy-Rich TiO2–x Nanoresonators: Tuning the Absorption for Photocatalysis in the Visible Spectrum

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Uniform Chiral Gap Synthesis for High Dissymmetry Factor in Single Plasmonic Gold Nanoparticle

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Evaluation of Single Hydrogel Nanofiber Mechanics Using Persistence Length Analysis

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Vibrational Spectroscopy and Morphological Studies on Protein-Capped Biosynthesized Silver Nanoparticles

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Nonlinear Scattering of Near-Infrared Light for Imaging Plasmonic Nanoparticles in Deep Tissue

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Correlative Dark-Field and Photoluminescence Spectroscopy of Individual Plasmon–Molecule Hybrid Nanostructures in a Strong Coupling Regime

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Naked-Eye Enumeration of Single Chlamydia pneumoniae Based on Light Scattering of Gold Nanoparticle Probe

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Single-Particle Assay of Poly(ADP-ribose) Polymerase-1 Activity with Dark-Field Optical Microscopy

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Dual-Mode Scattering Nanoprobes for Imaging Hydrogen Sulfide in Living Cells

inferred← citeshttps://doi.org/10.1021/acsanm.1c04049openalex-snapshot

Telomerase Activity Assay via 3,3′,5,5′-Tetramethylbenzidine Dilation Etching of Gold Nanorods

inferred← citeshttps://doi.org/10.1021/acsanm.4c06857openalex-snapshot

Multispectral Interferometric Scattering Microscopy Imaging of Gold and Silver Nanoparticles

inferred← citeshttps://doi.org/10.1021/acsanm.5c03720openalex-snapshot

Impact of DNA Density on the Aggregation Kinetics of DNA/PEG-Modified Gold Nanoparticles Induced by DNA Hybridization: Implications for Colorimetric Nucleic Acid Detection

inferred← citeshttps://doi.org/10.1021/acscatal.1c04919openalex-snapshot

Energy Flow during the Plasmon Resonance-Driven Photocatalytic Reactions on Single Nanoparticles

inferred← citeshttps://doi.org/10.1021/acscatal.4c03566openalex-snapshot

Photocatalysis on Hybrid Plasmonic Nanomaterials: From Catalytic Mechanism Study at Single-Particle Level to Materials Design

inferred← citeshttps://doi.org/10.1021/acsinfocus.7e9016openalex-snapshot

Single Entity Electrochemistry

inferred← citeshttps://doi.org/10.1021/acsnano.4c12996openalex-snapshot

Surface-Enhanced Raman Scattering-Based Multimodal Techniques: Advances and Perspectives

inferred← citeshttps://doi.org/10.1021/acsnano.5c05069openalex-snapshot

Multiphoton Luminescence Imaging: A Label-Free Tool for Visualizing the Long-Term Fate of Gold Nanoparticles in Tissue

inferred← citeshttps://doi.org/10.1021/acsnano.6c09692openalex-snapshot

Four in One: Parallel Determination of Optical Activity and Optical Anisotropy from Single Plasmonic Nanostructures

inferred← citeshttps://doi.org/10.1021/acsnanoscienceau.1c00041openalex-snapshot

Through the Eyes of Creators: Observing Artificial Molecular Motors

inferred← citeshttps://doi.org/10.1021/acsomega.5c12694openalex-snapshot

A Simple and Fast Colorimetric Assay for the Detection of Chloride Ions Based on Etching of Silver Triangular Nanoplates

inferred← citeshttps://doi.org/10.1021/acssensors.5c01339openalex-snapshot

Optical Resolution of the Morphological Change of Single Nanoparticles at Native Conditions: A Nonsuper-Resolution Approach

inferred← citeshttps://doi.org/10.1021/acssensors.5c02121openalex-snapshot

Rapid Quantification of Virus-Like Particles via Gold Nanoparticle Sensors and Dark-Field Differential Dynamic Microscopy

inferred← citeshttps://doi.org/10.1038/s41467-025-58130-9openalex-snapshot

Imaging of coexisting classical and non-classical oriented attachment growth pathways in covalent organic framework microcrystals

inferred← citeshttps://doi.org/10.1038/s41566-022-00956-6openalex-snapshot

Metasurface-based bijective illumination collection imaging provides high-resolution tomography in three dimensions

inferred← citeshttps://doi.org/10.1038/s41598-024-68659-2openalex-snapshot

Correcting directional dark field x-ray imaging artefacts using position dependent image deblurring and attenuation removal

inferred← citeshttps://doi.org/10.1038/s44303-024-00064-wopenalex-snapshot

From superior contrast to super resolution label free optical microscopy

inferred← citeshttps://doi.org/10.1039/d1cc00587aopenalex-snapshot

Direct visualization of photo-induced disulfide through oxidative coupling of para -aminothiophenol

inferred← citeshttps://doi.org/10.1039/d1nr08030jopenalex-snapshot

Toehold-mediated strand displacement coupled with single nanoparticle dark-field microscopy imaging for ultrasensitive biosensing

inferred← citeshttps://doi.org/10.1039/d1nr08130fopenalex-snapshot

Correlating structure, morphology and properties of metal nanostructures by combining single-particle optical spectroscopy and electron microscopy

inferred← citeshttps://doi.org/10.1039/d2cc05139gopenalex-snapshot

Detection of monoamine oxidase B using dark-field light scattering imaging and colorimetry

inferred← citeshttps://doi.org/10.1039/d3cc01026kopenalex-snapshot

Visual identification of 1 O 2 -induced crystal structure transformation of single Zr-MOF by dark-field microscopy

inferred← citeshttps://doi.org/10.1039/d3cs00793fopenalex-snapshot

Plasmonic silver and gold nanoparticles: shape- and structure-modulated plasmonic functionality for point-of-caring sensing, bio-imaging and medical therapy

inferred← citeshttps://doi.org/10.1039/d3nr04294dopenalex-snapshot

Super resolution label-free dark-field microscopy by deep learning

inferred← citeshttps://doi.org/10.1039/d4nr01288gopenalex-snapshot

Two-color interferometric scattering (iSCAT) microscopy reveals structural dynamics in discrete plasmonic molecules

inferred← citeshttps://doi.org/10.1039/d4nr03055aopenalex-snapshot

Optical dark-field spectroscopy of single plasmonic nanoparticles for molecular biosciences

inferred← citeshttps://doi.org/10.1039/d4nr04092aopenalex-snapshot

Axial electrokinetic trapping of label-free nanoparticles using evanescent field scattering

inferred← citeshttps://doi.org/10.1039/d4ra07510bopenalex-snapshot

An ensemble model of machine learning regression techniques and color spaces integrated with a color sensor: application to color-changing biochemical assays

inferred← citeshttps://doi.org/10.1039/d5an00833fopenalex-snapshot

Optical characterization of a nanogel–nanostar plasmonic nanocomposite for microfluidic sensing and surface-enhanced Raman scattering

inferred← citeshttps://doi.org/10.1039/d5qm00642bopenalex-snapshot

In situ optical imaging of sub-particle heterogeneity at electrochemical interfaces in batteries and (photo)electrocatalysis

inferred← citeshttps://doi.org/10.1039/d6an00174bopenalex-snapshot

Shell-switchable SERS blocking strategy for quantitative copper ion detection using single-particle SERS probes

inferred← citeshttps://doi.org/10.1039/d6ay00142dopenalex-snapshot

Development of a YOLO-guided automated (microplastic) particle analysis workflow

inferred← citeshttps://doi.org/10.1039/d6cc03614gopenalex-snapshot

Engineering multiphoton-active gold and carbon nanoparticles for precision biophotonics

inferred← citeshttps://doi.org/10.1039/d6cs00641hopenalex-snapshot

Optical multi-physical field imaging within single cells

inferred← citeshttps://doi.org/10.1063/5.0090949openalex-snapshot

Nanoscale reaction monitoring using localized surface plasmon resonance scatterometry

inferred← citeshttps://doi.org/10.1073/pnas.2423223122openalex-snapshot

Planar device–enabled speckle illumination for dark-field label-free imaging beyond the diffraction limit

inferred← citeshttps://doi.org/10.1080/00107514.2023.2292380openalex-snapshot

Quantum light microscopy

inferred← citeshttps://doi.org/10.1080/05704928.2025.2495022openalex-snapshot

Gold nanoparticles in imaging: advances, applications, and future perspectives

inferred← citeshttps://doi.org/10.1085/jgp.202613979openalex-snapshot

Label-free real-time imaging of mitochondrial matrix volume changes and permeability transition in living cells

inferred← citeshttps://doi.org/10.1088/1361-6463/acf324openalex-snapshot

Label-free identification of cell death mechanism using scattering-based microscopy and deep learning

inferred← citeshttps://doi.org/10.1088/1361-6501/ad6b40openalex-snapshot

Design and experiment of a lightweight cloud particle imager

inferred← citeshttps://doi.org/10.1088/1361-6501/ae1aaeopenalex-snapshot

Circumferential scanning dark-field microscopy based on lateral illumination for micro–nano defect detection

inferred← citeshttps://doi.org/10.1088/1361-6528/adb6a4openalex-snapshot

Recent advances in localized surface plasmon resonance (LSPR) sensing technologies

inferred← citeshttps://doi.org/10.1088/2051-672x/ad6b3copenalex-snapshot

Axial peak extraction in the measurement of subsurface structures with annular illumination confocal microscopy

inferred← citeshttps://doi.org/10.1093/plankt/fbag069openalex-snapshot

Seeing the unseen: an introduction to underwater plankton imaging systems

inferred← citeshttps://doi.org/10.1109/access.2026.3736887openalex-snapshot

Explainable Artificial Intelligence Approaches for Autism Spectrum Disorder Classification via Hyperspectral Imaging Analysis of Red Blood Cells

inferred← citeshttps://doi.org/10.1109/aisomt64170.2024.10992037openalex-snapshot

Multi-Angle Annular Illumination Microscopy and Image Processing Strategy for Wafer Defect Inspection

inferred← citeshttps://doi.org/10.1109/cme67420.2025.11239403openalex-snapshot

Research on Automatic Exposure Algorithm Based on Chemiluminescence Imaging

inferred← citeshttps://doi.org/10.1126/sciadv.adz8131openalex-snapshot

Direct imaging of facet development during growth of single-crystal covalent organic frameworks

inferred← citeshttps://doi.org/10.1186/s13036-026-00677-2openalex-snapshot

Multi-technique characterization of gold nanoparticle-based DNA biosensor with smartphone-enabled photometry for accelerated detection of Campylobacter jejuni

inferred← citeshttps://doi.org/10.1246/bcsj.20220272openalex-snapshot

Size-Dependent Oscillation in Optical Spectra from Fly Ash Cenospheres: Particle Sizing Using Darkfield Hyperspectral Interferometry

inferred← citeshttps://doi.org/10.1364/boe.505267openalex-snapshot

Fast Fourier ptychographic quantitative phase microscopy for in vitro label-free imaging

inferred← citeshttps://doi.org/10.1364/boe.578659openalex-snapshot

Exploring the 3D architecture of brain tissue using digital holographic microscopy

inferred← citeshttps://doi.org/10.1364/josab.543394openalex-snapshot

Ultracompact optical microscopes made of liquid crystal Pancharatnam–Berry optical elements

inferred← citeshttps://doi.org/10.1364/oe.480578openalex-snapshot

3D full-wave multi-scattering forward solver for coherent microscopes

inferred← citeshttps://doi.org/10.1364/oe.565594openalex-snapshot

Adaptive double refraction interference microscopy for label-free imaging of living cells

inferred← citeshttps://doi.org/10.1364/oe.592479openalex-snapshot

Dark-field synthetic-aperture digital holographic microscopy with an enhanced numerical aperture

inferred← citeshttps://doi.org/10.1364/ol.551939openalex-snapshot

Polarization-multiplexing metafiber for dual-mode bright-field and dark-field microscopy

inferred← citeshttps://doi.org/10.1364/ol.569320openalex-snapshot

Resolution enhancement in evanescent light illumination microscopy using microsphere lenses

inferred← citeshttps://doi.org/10.1364/ol.585515openalex-snapshot

3D-printed micro-optical dark-field condenser

inferred← citeshttps://doi.org/10.1364/opticaopen.24541036openalex-snapshot

Multifunctional imaging enabled by optical bound states in the continuum with broken symmetry

inferred← citeshttps://doi.org/10.1364/opticaopen.24541036.v1openalex-snapshot

Multifunctional imaging enabled by optical bound states in the continuum with broken symmetry

inferred← citeshttps://doi.org/10.1364/prj.503974openalex-snapshot

Computational and dark-field ghost imaging with ultraviolet light

inferred← citeshttps://doi.org/10.15388/vu.thesis.904openalex-snapshot

Fluorescence dynamics of plasmon–exciton polaritonic states

inferred← citeshttps://doi.org/10.32657/10356/173277openalex-snapshot

FERRITIN nanocages used as programmable bricks for biomolecular electronics

inferred← citeshttps://doi.org/10.3390/bios12121105openalex-snapshot

Single-Particle Optical Imaging for Ultrasensitive Bioanalysis

inferred← citeshttps://doi.org/10.3390/bios13110977openalex-snapshot

Plasmonic Nanoparticle-Enhanced Optical Techniques for Cancer Biomarker Sensing

inferred← citeshttps://doi.org/10.3390/catal12070764openalex-snapshot

Single-Particle Measurements of Nanocatalysis with Dark-Field Microscopy

inferred← citeshttps://doi.org/10.3390/chemosensors11030172openalex-snapshot

Biosensing Strategies Based on Particle Behavior

inferred← citeshttps://doi.org/10.3390/chemosensors11090489openalex-snapshot

Emerging Luminescent Materials for Information Encryption and Anti-Counterfeiting: Stimulus-Response AIEgens and Room-Temperature Phosphorescent Materials

inferred← citeshttps://doi.org/10.3390/coatings14070846openalex-snapshot

The Use of Polyurethane Composites with Sensing Polymers as New Coating Materials for Surface Acoustic Wave-Based Chemical Sensors—Part III: Ultrasonic Analyses and Optical Microscopy Characterization of the Coating Results

inferred← citeshttps://doi.org/10.3390/coatings15020139openalex-snapshot

Structural Aspects and Adhesion of Polyurethane Composite Coatings for Surface Acoustic Wave Sensors

inferred← citeshttps://doi.org/10.3390/ma16031010openalex-snapshot

Classification of Thermally Degraded Concrete by Acoustic Resonance Method and Image Analysis via Machine Learning

inferred← citeshttps://doi.org/10.3390/nano13132027openalex-snapshot

Plasmonic Nanomaterials in Dark Field Sensing Systems

inferred← citeshttps://doi.org/10.3390/ph19050722openalex-snapshot

Potential of Silver Nanoparticles in Imaging Diagnostics and Image-Guided Applications: A Narrative Review

inferred← citeshttps://doi.org/10.3390/s24051529openalex-snapshot

On-Chip Photonic Detection Techniques for Non-Invasive In Situ Characterizations at the Microfluidic Scale

inferred← citeshttps://doi.org/10.3390/s26041271openalex-snapshot

High-Sensitivity Defect Inspection for Unpatterned Wafers via Integrating Dark-Field Scattering and Diffraction Phase Microscopy

inferred← citeshttps://doi.org/10.3390/targets3010002openalex-snapshot

Application of Machine Learning in Cell Detection

inferred← citeshttps://doi.org/10.3788/aos240428openalex-snapshot

二维光子晶体板动量空间中的偏振场（特邀）

inferred← citeshttps://doi.org/10.3788/lop241988openalex-snapshot

暗场光散射成像-表面增强拉曼散射联用技术及其分析检测应用

inferred← citeshttps://doi.org/10.54097/hset.v3i.700openalex-snapshot

Application of dark-field microscopy for detection of DNA and protein

inferred← citeshttps://doi.org/10.70675/748c7a21z8f69z407az9076z217e8a9bf0caopenalex-snapshot

Diarylethenes used as molecular switches for the connection of gold nanoparticles

inferred← citeshttps://doi.org/10.70675/e24d7801zdd5ez49aez9cf5z6c725013c6deopenalex-snapshot

Ferritin nanocages used as programmable bricks for biomolecular electronics

inferred← citeshttps://doi.org/10.70675/e5dd9cefzc1bcz4be3zaaf2z1cd7fd8050e8openalex-snapshot

Spatial filtering for flood illumination ophthalmoscope

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