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Aptamer-Linked CRISPR/Cas12a-Based Immunoassay

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00216-019-02211-4openalex-snapshot
Rapid and sensitive exosome detection with CRISPR/Cas12a
inferredcites →https://doi.org/10.1016/0019-2791(71)90454-xopenalex-snapshot
Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G
inferredcites →https://doi.org/10.1016/j.cell.2014.05.010openalex-snapshot
Development and Applications of CRISPR-Cas9 for Genome Engineering
inferredcites →https://doi.org/10.1016/j.molcel.2018.11.021openalex-snapshot
Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
inferredcites →https://doi.org/10.1016/j.tibtech.2019.04.005openalex-snapshot
CRISPR/Cas Powered Multiplexed Biosensing
inferredcites →https://doi.org/10.1016/s1470-2045(01)00560-5openalex-snapshot
Trends in biomarker research for cancer detection
inferredcites →https://doi.org/10.1021/ac400047dopenalex-snapshot
Silver Nanoparticle-Enhanced Fluorescence Resonance Energy Transfer Sensor for Human Platelet-Derived Growth Factor-BB Detection
inferredcites →https://doi.org/10.1021/acs.analchem.9b01526openalex-snapshot
Cas12aVDet: A CRISPR/Cas12a-Based Platform for Rapid and Visual Nucleic Acid Detection
inferredcites →https://doi.org/10.1021/acs.analchem.9b04403openalex-snapshot
CRISPR/Cas13a Signal Amplification Linked Immunosorbent Assay for Femtomolar Protein Detection
inferredcites →https://doi.org/10.1021/acs.analchem.9b05597openalex-snapshot
Universal and Naked-Eye Gene Detection Platform Based on the Clustered Regularly Interspaced Short Palindromic Repeats/Cas12a/13a System
inferredcites →https://doi.org/10.1021/ja303787eopenalex-snapshot
Ultrahigh Nanoparticle Stability against Salt, pH, and Solvent with Retained Surface Accessibility via Depletion Stabilization
inferredcites →https://doi.org/10.1021/jacs.9b09211openalex-snapshot
Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic-Acid Targets
inferredcites →https://doi.org/10.1021/la201938uopenalex-snapshot
Kinetically Controlled Seeded Growth Synthesis of Citrate-Stabilized Gold Nanoparticles of up to 200 nm: Size Focusing versus Ostwald Ripening
inferredcites →https://doi.org/10.1038/nrd3141openalex-snapshot
Aptamers as therapeutics
inferredcites →https://doi.org/10.1038/s41422-018-0022-xopenalex-snapshot
CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA
inferredcites →https://doi.org/10.1038/s41467-019-11648-1openalex-snapshot
A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules
inferredcites →https://doi.org/10.1038/s41596-019-0210-2openalex-snapshot
SHERLOCK: nucleic acid detection with CRISPR nucleases
inferredcites →https://doi.org/10.1039/c3cc44783aopenalex-snapshot
A fluorescent peroxidase probe increases the sensitivity of commercial ELISAs by two orders of magnitude
inferredcites →https://doi.org/10.1073/pnas.0508821102openalex-snapshot
Light-switching excimer probes for rapid protein monitoring in complex biological fluids
inferredcites →https://doi.org/10.1126/science.1232033openalex-snapshot
RNA-Guided Human Genome Engineering via Cas9
inferredcites →https://doi.org/10.1126/science.aam9321openalex-snapshot
Nucleic acid detection with CRISPR-Cas13a/C2c2
inferredcites →https://doi.org/10.1126/science.aar6245openalex-snapshot
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
inferredcites →https://doi.org/10.1186/s13059-019-1742-zopenalex-snapshot
CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Highly Sensitive Crispr/Cas12a Bioassay for Aflatoxin B1 by Single Metal Nanoparticle Counting
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Nanotechnology Strategies for Plant Genetic Engineering
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Repurposing CRISPR/Cas to Discover SARS‐CoV‐2 Detecting and Neutralizing Aptamers
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CRISPR Assays for Disease Diagnosis: Progress to and Barriers Remaining for Clinical Applications
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A CRISPR mediated point‐of‐care assay for the detection of mucosal calprotectin in an animal model of ulcerative colitis
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CRISPR Assays for Protein Detection
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Sensitive Measurement of ALKBH3 Activity using a Dual DNA Amplifier by Coupling DNA Circuits with CRISPR/Cas12a
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Potentiating In Vivo Precision Cancer Therapy With Modularized Aptamer‐Chemotherapeutics Conjugates Based on DNA Tiling‐Mediated Structural Nanotechnology
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CRISPR/Cas Systems‐Inspired Nano/Biosensors for Detecting Infectious Viruses and Pathogenic Bacteria
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Allosteric probe‐driven catalytic CRISPR‐Cas12a and dual‐colored persistent luminescence nanoparticles tandem biosensing for ultrasensitive MRSA detection
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SERS-based CRISPR/Cas12a assays for protein biomarker prostate-specific antigen detection
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A multifunctional approach: merging CRISPR/Cas technology with DNA nanomachines for advanced biosensing
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Understanding the Origin and Evolution of Tea (Camellia sinensis [L.]): Genomic Advances in Tea
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Gene editing and its applications in biomedicine
inferred← citeshttps://doi.org/10.1016/b978-0-323-91808-4.00015-8openalex-snapshot
Molecular engineering of CRISPR-Cas system toward in vitro diagnostics
inferred← citeshttps://doi.org/10.1016/j.aca.2021.338747openalex-snapshot
Hydrazone ligation assisted DNAzyme walking nanomachine coupled with CRISPR-Cas12a for lipopolysaccharide analysis
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A CRISPR/Cas12a-assisted on-fibre immunosensor for ultrasensitive small protein detection in complex biological samples
inferred← citeshttps://doi.org/10.1016/j.aca.2022.340357openalex-snapshot
Aptamer-based colorimetric detection of methicillin-resistant Staphylococcus aureus by using a CRISPR/Cas12a system and recombinase polymerase amplification
inferred← citeshttps://doi.org/10.1016/j.aca.2023.341211openalex-snapshot
Bi-functional antibody-CRISPR/Cas12a ribonucleoprotein conjugate for improved immunoassay performance
inferred← citeshttps://doi.org/10.1016/j.aca.2023.342106openalex-snapshot
CRISPR/Cas12a linked sandwich aptamer assay for sensitive detection of thrombin
inferred← citeshttps://doi.org/10.1016/j.aca.2026.346010openalex-snapshot
Construction of the CRISPR/Cas12a-digital integrated immunoassay technology for CD44 detection
inferred← citeshttps://doi.org/10.1016/j.bioelechem.2022.108167openalex-snapshot
CRISPR/Cas12a-based electrochemical biosensor for highly sensitive detection of cTnI
inferred← citeshttps://doi.org/10.1016/j.bios.2021.113525openalex-snapshot
SERS-based serodiagnosis of acute febrile diseases using plasmonic nanopopcorn microarray platforms
inferred← citeshttps://doi.org/10.1016/j.bios.2022.114152openalex-snapshot
An RNA-based catalytic hairpin assembly circuit coupled with CRISPR-Cas12a for one-step detection of microRNAs
inferred← citeshttps://doi.org/10.1016/j.bios.2022.114424openalex-snapshot
A novel “signal on-off-super on” sandwich-type aptamer sensor of CRISPR-Cas12a coupled voltage enrichment assay for VEGF detection
inferred← citeshttps://doi.org/10.1016/j.bios.2022.114501openalex-snapshot
CRISPR/Cas-engineered technology: Innovative approach for biosensor development
inferred← citeshttps://doi.org/10.1016/j.bios.2022.114559openalex-snapshot
Novel non-nucleic acid targets detection strategies based on CRISPR/Cas toolboxes: A review
inferred← citeshttps://doi.org/10.1016/j.bios.2022.114646openalex-snapshot
Smart NIR light-gated CRISPR/Cas12a fluorescent biosensor with boosted biological delivery and trans-cleavage activity for high-performance in vivo operation
inferred← citeshttps://doi.org/10.1016/j.bios.2023.115102openalex-snapshot
A universal CRISPR/Cas12a-powered intelligent point-of-care testing platform for multiple small molecules in the healthcare, environment, and food
inferred← citeshttps://doi.org/10.1016/j.bios.2023.115158openalex-snapshot
Using time-shared scanning optical tweezers assisted two-photon fluorescence imaging to establish a versatile CRISPR/Cas12a-mediated biosensor
inferred← citeshttps://doi.org/10.1016/j.bios.2023.115189openalex-snapshot
CRISPR-based biosensors for pathogenic biosafety
inferred← citeshttps://doi.org/10.1016/j.bios.2025.117968openalex-snapshot
Self-phosphorylating DNAzyme DK1 enables programmable multi-analyte readout via PfAgo
inferred← citeshttps://doi.org/10.1016/j.bios.2026.118649openalex-snapshot
Surface-confined CRISPR-Cas12a biosensor with metal-enhanced fluorescence for rapid and ultrasensitive detection of SARS-CoV-2 nucleocapsid protein
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2022.108047openalex-snapshot
CRISPR-Cas13 technology portfolio and alliance with other genetic tools
inferred← citeshttps://doi.org/10.1016/j.cej.2024.152038openalex-snapshot
Advances of engineered microfluidic biosensors via CRISPR/Cas in bacteria and virus monitoring
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.125211openalex-snapshot
A CRISPR/Cas12a-based fluorescence aptasensor for the rapid and sensitive detection of ampicillin
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.140675openalex-snapshot
RNA aptamer-based CRISPR-Cas12a system for enhanced small molecule detection and point-of-care testing
inferred← citeshttps://doi.org/10.1016/j.jinf.2025.106526openalex-snapshot
From Cas proteins to cutting-edge biosensors: A new era in clinical pathogen diagnostics
inferred← citeshttps://doi.org/10.1016/j.lmd.2024.100011openalex-snapshot
Advances in the applications of CRISPR/Cas system for tumor molecular diagnostics
inferred← citeshttps://doi.org/10.1016/j.microc.2025.114294openalex-snapshot
CRISPR-Cas12a mediated magnetic aptasensors for direct detection of Brain-derived neurotrophic factor
inferred← citeshttps://doi.org/10.1016/j.snb.2021.130533openalex-snapshot
A versatile CRISPR/Cas12a-based sensitivity amplifier suitable for commercial HRP-based ELISA kits
inferred← citeshttps://doi.org/10.1016/j.snb.2021.131228openalex-snapshot
CRISPR/Cas12a-based biosensor for colorimetric detection of serum prostate-specific antigen by taking nonenzymatic and isothermal amplification
inferred← citeshttps://doi.org/10.1016/j.snb.2022.131743openalex-snapshot
An exceptional and universal DNA walker amplified “one-to-many” CRISPR/Cas12a-mediated fluorescent biosensor for ultrasensitive detection of non-DNA biomarkers
inferred← citeshttps://doi.org/10.1016/j.snb.2023.134777openalex-snapshot
Near-infrared light activated and hybridization chain reaction cascaded CRISPR/Cas12a system under the enhancement of Mn2+ for intracellular biosensing
inferred← citeshttps://doi.org/10.1016/j.snb.2025.138743openalex-snapshot
Homogeneous sensitive PDGF detection by directly coupled PLA-CRISPR free of amplification
inferred← citeshttps://doi.org/10.1016/j.synbio.2021.09.007openalex-snapshot
Integrating PCR-free amplification and synergistic sensing for ultrasensitive and rapid CRISPR/Cas12a-based SARS-CoV-2 antigen detection
inferred← citeshttps://doi.org/10.1016/j.talanta.2022.123469openalex-snapshot
A Simple and Versatile Crispr/Cas12a-Based Immunosensing Platform: Towards Attomolar Level Sensitivity for Small Protein Diagnostics
inferred← citeshttps://doi.org/10.1016/j.talanta.2022.123795openalex-snapshot
A novel label-free universal biosensing platform based on CRISPR/Cas12a for biomarker detection
inferred← citeshttps://doi.org/10.1016/j.talanta.2024.125828openalex-snapshot
Electrochemiluminescence aptasensing method for ultrasensitive determination of lipopolysaccharide based on CRISPR-Cas12a accessory cleavage activity
inferred← citeshttps://doi.org/10.1016/j.talanta.2025.127612openalex-snapshot
An integrated and multifunctional homemade cell sensor platform based on Si-d-CQDs and CRISPR-Cas12a for CD31 detection during endothelial-to-mesenchymal transition
inferred← citeshttps://doi.org/10.1016/j.talanta.2025.128306openalex-snapshot
A novel one-tube RPA/CRISPR melting curve detection sensing system based on unique 3′-toehold nucleic acid aptamer for Bacillus anthracis detection
inferred← citeshttps://doi.org/10.1016/j.tibtech.2025.04.012openalex-snapshot
CRISPR-based non-nucleic acid detection
inferred← citeshttps://doi.org/10.1016/j.trac.2022.116775openalex-snapshot
CRISPR/Cas systems accelerating the development of aptasensors
inferred← citeshttps://doi.org/10.1016/j.trac.2023.117431openalex-snapshot
CRISPR-associated “genetic scissors” for multiplexing analysis
inferred← citeshttps://doi.org/10.1016/j.trac.2024.117594openalex-snapshot
Challenges and perspectives of CRISPR-based technology for diagnostic applications
inferred← citeshttps://doi.org/10.1016/j.trac.2024.117796openalex-snapshot
CRISPR/Cas biosensing technology: From lab assays to integrated portable devices towards wearables
inferred← citeshttps://doi.org/10.1016/j.trac.2025.118174openalex-snapshot
CRISPR-Cas technology for rapid detection of pathogens
inferred← citeshttps://doi.org/10.1016/j.trac.2025.118179openalex-snapshot
Comprehensive approaches to expanding CRISPR biosensor applications beyond nucleic acid targets
inferred← citeshttps://doi.org/10.1016/j.trac.2026.118730openalex-snapshot
Genetically encoded fluorescent neurotransmitter sensors: A new frontier in molecular diagnostics and real-time brain imaging
inferred← citeshttps://doi.org/10.1016/j.trac.2026.118773openalex-snapshot
CRISPR/Cas system for real-time water quality monitoring: Advances and challenges
inferred← citeshttps://doi.org/10.1016/j.trac.2026.118924openalex-snapshot
CRISPR/Cas-based biosensing platforms for comprehensive food safety monitoring: Mechanisms, strategies, and applications
inferred← citeshttps://doi.org/10.1016/j.watres.2021.117553openalex-snapshot
CRISPR/Cas12a-powered immunosensor suitable for ultra-sensitive whole Cryptosporidium oocyst detection from water samples using a plate reader
inferred← citeshttps://doi.org/10.1021/acs.analchem.1c00805openalex-snapshot
Universal and Programmable Rolling Circle Amplification-CRISPR/Cas12a-Mediated Immobilization-Free Electrochemical Biosensor
inferred← citeshttps://doi.org/10.1021/acs.analchem.1c01403openalex-snapshot
Biomimetic Chip Enhanced Time-Gated Luminescent CRISPR-Cas12a Biosensors under Functional DNA Regulation
inferred← citeshttps://doi.org/10.1021/acs.analchem.1c03094openalex-snapshot
Metal-Tagged CRISPR/Cas12a Bioassay Enables Ultrasensitive and Highly Selective Evaluation of Kanamycin Bioaccumulation in Fish Samples
inferred← citeshttps://doi.org/10.1021/acs.analchem.1c03183openalex-snapshot
3D DNA Walker-Assisted CRISPR/Cas12a Trans-Cleavage for Ultrasensitive Electrochemiluminescence Detection of miRNA-141
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c02283openalex-snapshot
Amplification-Free, Single-Microbead-Based Cas12a Assay for One-Step DNA Detection at the Single-Molecule Level
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c02776openalex-snapshot
Boronic Ester-Mediated Dual Recognition Coupled with a CRISPR/Cas12a System for Lipopolysaccharide Analysis
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c04315openalex-snapshot
Switching the Activity of CRISPR/Cas12a Using an Allosteric Inhibitory Aptamer for Biosensing
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c00218openalex-snapshot
Sensitive CRISPR-Cas12a-Assisted Immunoassay for Small Molecule Detection in Homogeneous Solution
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c07110openalex-snapshot
β-Galactosidase-Mediated, Mn2+-Activated CRISPR/Cas12a Cascade Reaction for Immunosorbent Assay of Carbendazim
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c08069openalex-snapshot
Exogenous-Label-Free Colorimetric/SERS Dual-Mode Immunosensing Platform Driven by Au NCs@Pt Nanozyme for Ultrasensitive and Rapid Detection of the Pancreatic Cancer Biomarker CA19-9
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Re-Engineering CRISPR-Cas12a into a Multimodal Biosensing Platform with Programmable Precursor crRNA
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c04548openalex-snapshot
Fluorescent Detection of Two Pesticides Based on CRISPR-Cas12a and Its Application for the Construction of Four Molecular Logic Gates
inferred← citeshttps://doi.org/10.1021/acs.jafc.3c03619openalex-snapshot
CRISPR/Cas System: The Accelerator for the Development of Non-nucleic Acid Target Detection in Food Safety
inferred← citeshttps://doi.org/10.1021/acsami.2c08823openalex-snapshot
Photoswitchable CRISPR/Cas12a-Amplified and Co3O4@Au Nanoemitter Based Triple-Amplified Diagnostic Electrochemiluminescence Biosensor for Detection of miRNA-141
inferred← citeshttps://doi.org/10.1021/acsami.3c03399openalex-snapshot
Ultrasensitive Detection of miRNA via CRISPR/Cas12a Coupled with Strand Displacement Amplification Reaction
inferred← citeshttps://doi.org/10.1021/acsnano.1c02372openalex-snapshot
Advances in Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)-Based Diagnostic Assays Assisted by Micro/Nanotechnologies
inferred← citeshttps://doi.org/10.1021/acssensors.4c00370openalex-snapshot
One-Pot Detection of Proteins Using a Two-Way Extension-Based Assay with Cas12a
inferred← citeshttps://doi.org/10.1021/acssensors.4c02733openalex-snapshot
Origami Paper-Based Immunoassay Device with CRISPR/Cas12a Signal Amplification
inferred← citeshttps://doi.org/10.1021/acssensors.6c00469openalex-snapshot
A Review of Activator Strand Engineering Strategies for Smart CRISPR/Cas12a Diagnostics
inferred← citeshttps://doi.org/10.1021/acssynbio.4c00161openalex-snapshot
Multiplexed Detection Strategies for Biosensors Based on the CRISPR-Cas System
inferred← citeshttps://doi.org/10.1039/d2an01048hopenalex-snapshot
CRISPR/Cas12a-based fluorescence immunoassay: combination of efficient signal generation with specific molecule recognition
inferred← citeshttps://doi.org/10.1039/d3an02020gopenalex-snapshot
A MnO 2 nanosheet-mediated CRISPR/Cas12a system for the detection of organophosphorus pesticides in environmental water
inferred← citeshttps://doi.org/10.1039/d5ay01903fopenalex-snapshot
An aptamer-CRISPR/Cas12a biosensor for rapid and sensitive detection of florfenicol
inferred← citeshttps://doi.org/10.1039/d6an00123hopenalex-snapshot
Aptamer-based CRISPR–Cas12a fluorescent biosensors for serum biomarker detection
inferred← citeshttps://doi.org/10.1186/s12951-024-02535-zopenalex-snapshot
Three-dimensional DNA nanomachine biosensor coupled with CRISPR Cas12a cascade amplification for ultrasensitive detection of carcinoembryonic antigen
inferred← citeshttps://doi.org/10.1186/s13765-023-00771-9openalex-snapshot
Aptamer-based CRISPR-Cas powered diagnostics of diverse biomarkers and small molecule targets
inferred← citeshttps://doi.org/10.2139/ssrn.5202790openalex-snapshot
Crispr-Cas12a Mediated Magnetic Aptasensors for Direct Detection of Brain-Derived Neurotrophic Factor
inferred← citeshttps://doi.org/10.3389/fbioe.2021.752514openalex-snapshot
Study on Factors Affecting the Performance of a CRISPR/Cas-Assisted New Immunoassay: Detection of Salivary Insulin as an Example
inferred← citeshttps://doi.org/10.3389/fbioe.2022.851712openalex-snapshot
Powerful CRISPR-Based Biosensing Techniques and Their Integration With Microfluidic Platforms
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1331981openalex-snapshot
Shifting the paradigm in RNA virus detection: integrating nucleic acid testing and immunoassays through single-molecule digital ELISA
inferred← citeshttps://doi.org/10.3390/bioengineering9100512openalex-snapshot
Recent Advances in CRISPR/Cas-Based Biosensors for Protein Detection
inferred← citeshttps://doi.org/10.3390/bios13020276openalex-snapshot
AIEgens-Doped Photonic Crystals for High Sensitivity Fluorescence Detection of Tumor Markers
inferred← citeshttps://doi.org/10.3390/molecules27031114openalex-snapshot
An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology
inferred← citeshttps://doi.org/10.5772/intechopen.102516openalex-snapshot
CRISPR Technology: Emerging Tools of Genome Editing and Protein Detection
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Additional file 1 of Three-dimensional DNA nanomachine biosensor coupled with CRISPR Cas12a cascade amplification for ultrasensitive detection of carcinoembryonic antigen
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