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Metabolic Effect Level Index Links Multivariate Metabolic Fingerprints to Ecotoxicological Effect Assessment

https://doi.org/10.1021/acs.est.5b01386

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Simultaneous Inference in General Parametric Models

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Changed physiology in wheat plants treated with the herbicide Methabenzthiazuron

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Decision tree supported substructure prediction of metabolites from GC-MS profiles

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Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants

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Effect of atrazine herbicide on growth, photosynthesis, protein synthesis, and fatty acid composition in the unicellular green alga Chlorella kessleri

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Spatial and temporal variation in metabolic fingerprints of field-growing Myriophyllum spicatum

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Changes in gene transcription and whole organism responses in larval fathead minnow (Pimephales promelas) following short-term exposure to the synthetic pyrethroid bifenthrin

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Development and validation of a new fluorescence-based bioassay for aquatic macrophyte species

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Concentration–response concept in ecotoxicoproteomics: Effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome

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Effects of toxicants with different modes of action on Myriophyllum spicatum in test systems with varying complexity

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1H NMR metabolomics of earthworm exposure to sub-lethal concentrations of phenanthrene in soil

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Anchoring metabolic changes to phenotypic effects in the chlorophyte Scenedesmus vacuolatus under chemical exposure

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Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals—From QSAR to QBAR

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Interactions of Herbicides with Photosynthetic Electron Transport

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XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification

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Toxicogenomics in Regulatory Ecotoxicology

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A New Transcriptional Effect Level Index (TELI) for Toxicogenomics-based Toxicity Assessment

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Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays

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A Quantitative Toxicogenomics Assay Reveals the Evolution and Nature of Toxicity during the Transformation of Environmental Pollutants

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Comparative and Mechanistic Genotoxicity Assessment of Nanomaterials via a Quantitative Toxicogenomics Approach across Multiple Species

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Gene Expression Profiling in Daphnia magna Part I: Concentration-Dependent Profiles Provide Support for the No Observed Transcriptional Effect Level

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Hepatic Transcriptomic and Metabolomic Responses in the Stickleback (Gasterosteus aculeatus) Exposed to Environmentally Relevant Concentrations of Dibenzanthracene

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Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

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Linking toxicity and adaptive responses across the transcriptome, proteome, and phenotype of Chlamydomonas reinhardtii exposed to silver

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Cross-Validatory Estimation of the Number of Components in Factor and Principal Components Models

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Antioxidants, Oxidative Damage and Oxygen Deprivation Stress: a Review

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Metabonomics in Toxicology: A Review

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A Method to Integrate Benchmark Dose Estimates with Genomic Data to Assess the Functional Effects of Chemical Exposure

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Automated Quantitative Dose-Response Modeling and Point of Departure Determination for Large Toxicogenomic and High-Throughput Screening Data Sets

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Application of Transcriptional Benchmark Dose Values in Quantitative Cancer and Noncancer Risk Assessment

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Environmental metabolomics: an emerging approach to study organism responses to environmental stressors

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Metabolomics of aquatic organisms: the new omics on the block

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Responses of marine pathogen Vibrio parahaemolyticus to 6:2 and 8:2 polyfluoroalkyl phosphate diesters at environmentally relevant concentrations: Concentration-dependent but not fluorocarbon chain length-dependent

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Comparative toxicity analysis of benzo[a]pyrene and PAH4 on HepG2 cells using transcriptomics and metabolomics

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Integration of transcriptomics and metabolomics reveals anlotinib-induced cytotoxicity in colon cancer cells

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A multi-omics concentration-response framework uncovers novel understanding of triclosan effects in the chlorophyte Scenedesmus vacuolatus

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Developmental and metabolic responses of zebrafish (Danio rerio) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure

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Comparing the disrupting effects of short-, medium- and long-chain chlorinated Paraffins on cell viability and metabolism

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Exposure to short-chain chlorinated paraffins inhibited PPARα-mediated fatty acid oxidation and stimulated aerobic glycolysis in vitro in human cells

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Graphene oxide enhanced the endocrine disrupting effects of bisphenol A in adult male zebrafish: Integrated deep learning and metabolomics studies

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Metabolic perturbations in zebrafish (Danio rerio) larvae exposed to sulfentrazone and imidacloprid

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DRomics: A Turnkey Tool to Support the Use of the Dose–Response Framework for Omics Data in Ecological Risk Assessment

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Renal Medulla is More Sensitive to Cisplatin than Cortex Revealed by Untargeted Mass Spectrometry-Based Metabolomics in Rats

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