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Acute Toxicity of a Tire Rubber-Derived Chemical, 6PPD Quinone, to Freshwater Fish and Crustacean Species

https://doi.org/10.1021/acs.estlett.1c00453
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What this work says

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Aquatic Environmental Fates and Risks of Benzotriazoles, Benzothiazoles, and P-Phenylenediamines in a Catchment Providing Water to a Megacity of China
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Bioaccumulation of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its potential cardiotoxicity in larval zebrafish (Danio rerio)
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inferred← citeshttps://doi.org/10.1002/cph4.70092openalex-snapshot
Micro‐Nano Plastics and 6‐ PPD ‐Q in Cardio‐Pulmonary Health: Environmental Sources, Systemic Exposure, and Mechanistic Insights
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inferred← citeshttps://doi.org/10.1002/etc.5487openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/etc.5568openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/etc.5875openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/jat.70420openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10646-024-02836-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.aquatox.2025.107613openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.aquatox.2026.107830openalex-snapshot
Genotoxic effects of 6PPD-quinone on juvenile European seabass (Dicentrarchus labrax): Impacts on DNA replication fidelity and oxidative DNA damage
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Air quality impacts of electric vehicle adoption in California
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inferred← citeshttps://doi.org/10.1016/j.biortech.2024.131847openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cbpc.2023.109697openalex-snapshot
Apical and mechanistic effects of 6PPD-quinone on different life-stages of the fathead minnow (Pimephales promelas)
inferred← citeshttps://doi.org/10.1016/j.cbpc.2023.109759openalex-snapshot
The toxicity effects of the individual and combined exposure of methyl tert-butyl ether (MTBE) and tire rubber powder (RP) on Nile tilapia fish (Oreochromis niloticus)
inferred← citeshttps://doi.org/10.1016/j.cbpc.2024.110062openalex-snapshot
Tire rubber-derived contaminant 6PPD had the potential to induce metabolism disorder in early developmental stage of zebrafish
inferred← citeshttps://doi.org/10.1016/j.cbpc.2025.110161openalex-snapshot
6PPD impairs growth performance by inducing intestinal oxidative stress and ferroptosis in zebrafish
inferred← citeshttps://doi.org/10.1016/j.cbpc.2025.110300openalex-snapshot
6PPD exposure reduced the melanin deposition by inhibiting tyrosinase activity in larval zebrafish
inferred← citeshttps://doi.org/10.1016/j.cbpc.2026.110465openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cej.2025.159307openalex-snapshot
6PPD-quinone degradation by unactivated peroxymonosulfate via direct oxidation and enhanced generation of 1O2
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2023.137913openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.141402openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.142319openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.143205openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2025.144418openalex-snapshot
Analysis of 6PPD-Q in finfish, shellfish, and marine mammal tissues
inferred← citeshttps://doi.org/10.1016/j.chroma.2025.466417openalex-snapshot
Analysis of rubber-derived contaminants in surface water and snow by liquid chromatography coupled with a hybrid linear ion-trap-Orbitrap high-resolution mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.coesh.2025.100666openalex-snapshot
Tire-wear particles and tire-related emerging contaminants: Characteristics, occurrence, and toxicity in the environment
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.116782openalex-snapshot
A review of tire wear particles: Occurrence, adverse effects, and control strategies
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.118456openalex-snapshot
6PPD and 6PPDQ embryonic exposure induced distinct developmental neurotoxicity in zebrafish
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.120082openalex-snapshot
Abiotic transformation of radiolabelled 6-PPD and 6-PPDQ in water and in presence of nitrogen/air/ozone and light
inferred← citeshttps://doi.org/10.1016/j.emcon.2025.100547openalex-snapshot
Transformation pathways, detection, removal, and sustainable alternatives of 6PPD and its quinone derivative (6PPDQ): A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.emcon.2026.100662openalex-snapshot
P-phenylenediamines and their quinones in estuarine-coastal sediments of Zhejiang Province: Occurrence, prioritization, and risk assessment
inferred← citeshttps://doi.org/10.1016/j.emcon.2026.100724openalex-snapshot
Developmental disturbances and deformities in 4th-instar larvae and emerging adults induced by chronic 6 PPD-quinone exposure in the aquatic midge Chironomus riparius
inferred← citeshttps://doi.org/10.1016/j.enceco.2025.05.022openalex-snapshot
6-PPD quinone at environmentally relevant concentrations disrupts citric acid cycle in Caenorhabditis elegans: Role of reduction in acetyl CoA and pyruvate contents
inferred← citeshttps://doi.org/10.1016/j.enceco.2025.11.029openalex-snapshot
Tissue-specific bioaccumulation and hepatotoxicity of 6PPD and 6PPD-Quinone in zebrafish
inferred← citeshttps://doi.org/10.1016/j.enceco.2026.08.013openalex-snapshot
Chronic dietary exposure to cryo-milled tire tread (CMTT) causes hematotoxicity without growth inhibition in common carp
inferred← citeshttps://doi.org/10.1016/j.envint.2022.107374openalex-snapshot
Chiral perspective evaluations: Enantioselective hydrolysis of 6PPD and 6PPD-quinone in water and enantioselective toxicity to Gobiocypris rarus and Oncorhynchus mykiss
inferred← citeshttps://doi.org/10.1016/j.envint.2024.108609openalex-snapshot
Aromatic amine antioxidants (AAs) and p-phenylenediamines-quinones (PPD-Qs) in e-waste recycling industry park: Occupational exposure and liver X receptors (LXRs) disruption potential
inferred← citeshttps://doi.org/10.1016/j.envint.2024.108677openalex-snapshot
Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone
inferred← citeshttps://doi.org/10.1016/j.envint.2024.109004openalex-snapshot
Unraveling the fate of 6PPD-Q in aquatic environment: Insights into formation, dissipation, and transformation under natural conditions
inferred← citeshttps://doi.org/10.1016/j.envint.2024.109042openalex-snapshot
p-Phenylenediamines and p-phenylenediamine quinone derivatives in rubber consumer products and typical urban dust: Sources, transformation profiles, and health risks
inferred← citeshttps://doi.org/10.1016/j.envint.2024.109139openalex-snapshot
Nationwide occurrence and prioritization of tire additives and their transformation products in lake sediments of China
inferred← citeshttps://doi.org/10.1016/j.envint.2025.109329openalex-snapshot
Elucidating the size distribution of p‑Phenylenediamine-Derived quinones in atmospheric particles
inferred← citeshttps://doi.org/10.1016/j.envint.2025.109455openalex-snapshot
Correlation between 6PPD-Q and immune along with metabolic dysregulation induced liver lesions in outdoor workers
inferred← citeshttps://doi.org/10.1016/j.envint.2025.109532openalex-snapshot
Transformations of 6PPD and 6PPD-quinone in soil under redox-driven conditions: Kinetics, product identification, and environmental implications
inferred← citeshttps://doi.org/10.1016/j.envint.2025.109579openalex-snapshot
Chronic exposure to environmental concentrations of 6PPDQ induces neurotoxicity via perturbing multiple neurotransmission pathways in zebrafish
inferred← citeshttps://doi.org/10.1016/j.envint.2026.110307openalex-snapshot
Atmospheric aging of tire rubber antioxidants forms complex mixtures that trigger inflammation in human macrophages
inferred← citeshttps://doi.org/10.1016/j.envint.2026.110479openalex-snapshot
Global multi-media distribution and transport of 6PPD and 6PPD-Q: a source-to-sink continuum
inferred← citeshttps://doi.org/10.1016/j.envpol.2022.119082openalex-snapshot
Concentration and leachability of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its quinone transformation product (6PPD-Q) in road dust collected in Tokyo, Japan
inferred← citeshttps://doi.org/10.1016/j.envpol.2022.120346openalex-snapshot
Unravelling the occurrence of trace contaminants in surface waters using semi-quantitative suspected non-target screening analyses
inferred← citeshttps://doi.org/10.1016/j.envpol.2023.121721openalex-snapshot
Urban runoff mortality syndrome in zooplankton caused by tire wear particles
inferred← citeshttps://doi.org/10.1016/j.envpol.2023.122512openalex-snapshot
Toxicity of 6PPD-quinone to four freshwater invertebrate species
inferred← citeshttps://doi.org/10.1016/j.envpol.2023.122649openalex-snapshot
Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.envpol.2023.122828openalex-snapshot
A mini review on 6PPD quinone: A new threat to aquaculture and fisheries
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.123514openalex-snapshot
In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: Kinetics, pathways, and mechanism
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.123835openalex-snapshot
Mixture toxicity of 6PPD-quinone and polystyrene nanoplastics in zebrafish
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.124313openalex-snapshot
Navigating the environmental dynamics, toxicity to aquatic organisms and human associated risks of an emerging tire wear contaminant 6PPD-quinone
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.125780openalex-snapshot
Effects of tire particles on earthworm (Eisenia andrei) fitness and bioaccumulation of tire-related chemicals
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126114openalex-snapshot
Associations of human exposure to 6PPD and 6PPDQ with colorectal cancer: A mixture analysis
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126229openalex-snapshot
Diurnal impacts of tire wear and waste burning on fine particulate matter concentrations in a metropolitan area
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126352openalex-snapshot
Environmental fate, toxicity, and mitigation of 6PPD and 6PPD-Quinone: Current understanding and future directions
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.127303openalex-snapshot
Developing water quality criteria and assessing ecological risks for 6PPD and 6PPD-Q in freshwater ecosystems
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.127587openalex-snapshot
The humic acid-mediated mechanism of 6PPD-Q during transport process in porous media: Insights from column experiments and molecular dynamics simulations
inferred← citeshttps://doi.org/10.1016/j.envpol.2026.128329openalex-snapshot
Bioconcentration kinetics and underlying mechanisms of tire additives and their transformation products in the fry stage of rainbow trout (Oncorhynchus mykiss)
inferred← citeshttps://doi.org/10.1016/j.envpol.2026.128626openalex-snapshot
Integrated in vitro multi-endpoint framework for assessing 6PPD-Quinone cytotoxicity in fish and mammalian cell lines
inferred← citeshttps://doi.org/10.1016/j.envpol.2026.128694openalex-snapshot
Aquatic ecosystem degradation attributed to tire wear particles in urban roadway runoff
inferred← citeshttps://doi.org/10.1016/j.envpol.2026.129306openalex-snapshot
Environmental exposure risk of typical rubber antioxidant 6PPD and its oxidation product 6PPD-Q
inferred← citeshttps://doi.org/10.1016/j.envres.2022.114721openalex-snapshot
Aquatic environmental fates and risks of benzotriazoles, benzothiazoles, and p-phenylenediamines in a catchment providing water to a megacity of China
inferred← citeshttps://doi.org/10.1016/j.envres.2024.119492openalex-snapshot
Environmental fate of tire-rubber related pollutants 6PPD and 6PPD-Q: A review
inferred← citeshttps://doi.org/10.1016/j.envres.2024.120222openalex-snapshot
Priorities to inform research on tire particles and their chemical leachates: A collective perspective
inferred← citeshttps://doi.org/10.1016/j.envres.2026.123851openalex-snapshot
Evaluating 6PPD-Q bioavailability and biotransformation in zebrafish by diffusive gradients in thin-films
inferred← citeshttps://doi.org/10.1016/j.ese.2025.100567openalex-snapshot
Chronic toxicity mechanisms of 6PPD and 6PPD-Quinone in zebrafish
inferred← citeshttps://doi.org/10.1016/j.etap.2026.104942openalex-snapshot
6PPD and its metabolites induce locomotor dysfunction in zebrafish through dopaminergic disruption with brain accumulation
inferred← citeshttps://doi.org/10.1016/j.eti.2026.105140openalex-snapshot
Spatiotemporal distribution and priority pollutant identification of tire additives and their transformation products in Chao Lake, China
inferred← citeshttps://doi.org/10.1016/j.foodchem.2022.133640openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.139266openalex-snapshot
Explore the toxicological mechanism of 6PPD-Q on human health through a novel perspective: The interaction between lactate dehydrogenase and 6PPD-Q
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.140738openalex-snapshot
Insight into the binding behavior of N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine and its quinone-metabolite with pepsin: Multidisciplinary approaches
inferred← citeshttps://doi.org/10.1016/j.jclepro.2023.140039openalex-snapshot
Ultra-sensitive hexagonal wurtzite zinc oxide-based electrochemical sensor for specific recognition of environmental trace N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine
inferred← citeshttps://doi.org/10.1016/j.jclepro.2025.147426openalex-snapshot
Upcycled diatomite and red mud as bitumen modifiers and multi–functional fillers for durable, eco–efficient asphalt pavements: A critical review
inferred← citeshttps://doi.org/10.1016/j.jece.2025.118858openalex-snapshot
Occurrence, transformation pathway, and toxicity of p-phenylenediamine antioxidants and their transformation products: A review and toxicity prediction
inferred← citeshttps://doi.org/10.1016/j.jece.2026.121842openalex-snapshot
Phytotoxicity of tire-derived IPPD and IPPD-Q in wheat: Integrated physiological response and multi-omics analysis
inferred← citeshttps://doi.org/10.1016/j.jece.2026.123090openalex-snapshot
Trophic transfer and toxicity of 6PPD-quinone in an aquatic food chain: Role of uptake routes
inferred← citeshttps://doi.org/10.1016/j.jece.2026.125342openalex-snapshot
Storm-mobilised tire-wear chemicals beyond 6PPD-quinone: An event-to-decision framework for urban waters
inferred← citeshttps://doi.org/10.1016/j.jece.2026.125358openalex-snapshot
A critical review of environmental fate, aging mechanism, and ecological risk of stormwater-borne tire wear particles in bioretention systems
inferred← citeshttps://doi.org/10.1016/j.jenvman.2025.127919openalex-snapshot
Foliar exposure to 6PPD-Q disturbs photosynthetic processes and induces oxidative stress in Eichhornia crassipes
inferred← citeshttps://doi.org/10.1016/j.jes.2024.07.011openalex-snapshot
Child exposure to N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its derived quinone (6PPDQ) in e-waste areas: Urinary concentrations, sources, and health effect assessment
inferred← citeshttps://doi.org/10.1016/j.jes.2024.09.023openalex-snapshot
Tire rubber derivative 6PPD and 6PPD-Q induce lipid accumulation in hepatocytes through ERRγ pathway
inferred← citeshttps://doi.org/10.1016/j.jes.2025.10.003openalex-snapshot
Interactive toxicity of 6PPD and Cd(II) to algae in microbial community stock culture
inferred← citeshttps://doi.org/10.1016/j.jes.2026.01.010openalex-snapshot
Comparative glycolipid metabolic toxicities and mechanisms of the rubber-derived contaminants 6PPD and its derivative 6PPD-Q in zebrafish
inferred← citeshttps://doi.org/10.1016/j.jes.2026.02.041openalex-snapshot
6PPD-Q: A comprehensive critical review on environmental occurrence, toxicological mechanisms, risk assessment, and mitigating strategies
inferred← citeshttps://doi.org/10.1016/j.jfca.2025.108616openalex-snapshot
Non-target screening, quantitative migration analysis, and toxicity estimation of photodegradation products of tris (2,4-di-tert-butylphenyl) phosphite in disposable biodegradable plastic food container
inferred← citeshttps://doi.org/10.1016/j.jglr.2024.102298openalex-snapshot
Targeted screening of passive samplers as an “Early Warning” of novel contaminants in the Great Lakes Basin
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2021.127623openalex-snapshot
Toxicological effects of 6PPD and 6PPD quinone in zebrafish larvae
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2023.131245openalex-snapshot
Analysis, environmental occurrence, fate and potential toxicity of tire wear compounds 6PPD and 6PPD-quinone
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2023.131601openalex-snapshot
6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2023.131810openalex-snapshot
Organic chemicals associated with rubber are more toxic to marine algae and bacteria than those of thermoplastics
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2023.132127openalex-snapshot
First insights into 6PPD-quinone formation from 6PPD photodegradation in water environment
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2023.132265openalex-snapshot
Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.133580openalex-snapshot
Deep dive into the chronic toxicity of tyre particle mixtures and their leachates
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.134001openalex-snapshot
Aniline antioxidants in road dust, parking lot dust, and green-belt soil in Harbin, a megacity in China: Occurrence, profile, and seasonal variation
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.134357openalex-snapshot
6PPD induced cardiac dysfunction in zebrafish associated with mitochondrial damage and inhibition of autophagy processes
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.135042openalex-snapshot
Are eco-friendly “green” tires also chemically green? Comparing metals, rubbers and selected organic compounds in green and conventional tires
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.135718openalex-snapshot
Photolysis of p-phenylenediamine rubber antioxidants in aqueous environment: Kinetics, pathways and their photo-induced toxicity
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.136099openalex-snapshot
Accurate and stable detection of p-phenylenediamine antioxidants and their transformation products in aquatic products using antioxidant protection – Analysis of actual aquatic products
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.136122openalex-snapshot
Response and adaptation of Chlorella pyrenoidosa to 6PPD: Physiological and genetic mechanisms
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.136400openalex-snapshot
Environmental concentrations of 6PPD and 6PPD-quinone induce hepatic lipid metabolism disorders in male black-spotted frogs
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.136694openalex-snapshot
Toxicity of tire rubber-derived pollutants 6PPD-quinone and 4-tert-octylphenol on marine plankton
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.137373openalex-snapshot
p-Phenylenediamines and their derived quinones: A review of their environmental fate, human exposure, and biological toxicity
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.138432openalex-snapshot
Assessment of tire-derived additives and their metabolites into fruit, root and leafy vegetables and evaluation of dietary intake in Swiss adults
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.138629openalex-snapshot
Predicting estrogen receptor agonists from plastic additives across various aquatic-related species using machine learning and AlphaFold2
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.138805openalex-snapshot
Stepwise screening with LC-Q/TOF-MS and signal subtraction with GC×GC-TOFMS enables rapid identification of 6PPD-Q and 6PPD metabolites in Raphidocelis subcapitata
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.139008openalex-snapshot
Effect of different solution chemistry conditions on the transport of tire additives in porous media
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.139214openalex-snapshot
Toxicity of 6PPD to the stony coral Pocillopora damicornis in different developmental stages
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.139337openalex-snapshot
Trade-off strategy under stress: Growth, reproduction, and antioxidant defense in Daphnia magna exposed to 6PPD-Q
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.140856openalex-snapshot
Ecotoxicity of 6PPD and 6PPD-Q in aquatic ecosystems: Mechanisms, influencing factors, and mitigation strategies
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.141037openalex-snapshot
Genome wide responses of the water flea, Daphnia carinata, to 6PPD and its oxidation product 6PPD-quinone
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.141599openalex-snapshot
Dual effects of 6PPD at environmentally relevant concentrations on freshwater algae: Multi-omics reveals a shift in survival strategies from lipid-mediated adaptation to carbon-energy reallocation
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.142781openalex-snapshot
6PPD-quinone induces systemic and transgenerational effects in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.142926openalex-snapshot
Unraveling jasmonic acid-mediated mitigation of 6PPD toxicity in tomato plants using multi-omics approaches
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.143254openalex-snapshot
The emergence of rubber-derived quinones in environment: From Evidence-based toxicological views to policy interventions
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.143266openalex-snapshot
Physiological vulnerability drives species-specific toxicity of 6PPD-Q in salmonids revealed by a damage-coupled biokinetic model
inferred← citeshttps://doi.org/10.1016/j.jiec.2024.03.024openalex-snapshot
Boosting mechanical and aging resistance performances of filled-rubber with MgO and ZnO co-cure activators in diverse vulcanization systems
inferred← citeshttps://doi.org/10.1016/j.jwpe.2025.108464openalex-snapshot
Repeated versus single exposure to 6PPDQ induces differential toxicity in Escherichia coli revealed by oxidative stress, energy metabolism, extracellular polymeric substances structure, and metabolic response
inferred← citeshttps://doi.org/10.1016/j.jwpe.2026.110733openalex-snapshot
Tire wear particles in the environment: A critical review on key challenges and future perspectives in fate, risk, and mitigation
inferred← citeshttps://doi.org/10.1016/j.marpolbul.2023.115002openalex-snapshot
Toxicological effects of tire rubber-derived 6PPD-quinone, a species-specific toxicant, and dithiobisbenzanilide (DTBBA) in the marine rotifer Brachionus koreanus
inferred← citeshttps://doi.org/10.1016/j.marpolbul.2025.117981openalex-snapshot
Characterization of PAHs in environmentally relevant concentrations of crude oil WAF and its effects on enzymatic biomarkers on Artemia parthenogenetica
inferred← citeshttps://doi.org/10.1016/j.marpolbul.2025.118482openalex-snapshot
Occurrences, profiles, and mass inventories of sediment p-phenylenediamine and their quinones in the northern South China Sea
inferred← citeshttps://doi.org/10.1016/j.marpolbul.2025.119040openalex-snapshot
Multi-media distribution, partitioning, and risks of tire additives and their transformation products in coastal waters of China
inferred← citeshttps://doi.org/10.1016/j.neuro.2026.103491openalex-snapshot
Combined exposure to 6PPD and 6PPD-Q induced neurotoxic responses in zebrafish and SH-SY5Y cells: Evidence from neurotransmitter disruption, oxidative damage, and apoptosis
inferred← citeshttps://doi.org/10.1016/j.psep.2026.109140openalex-snapshot
Occurrence, fate, and ecological risk of rubber-derived chemicals in a municipal wastewater treatment plant: Insights from unit-scale removal analysis
inferred← citeshttps://doi.org/10.1016/j.rsma.2025.104291openalex-snapshot
Tire wear particles and leachable compounds: Occurrence and fate in the aquatic environment
inferred← citeshttps://doi.org/10.1016/j.rsma.2025.104396openalex-snapshot
The research trend on tire wear particles: A bibliometric review for 1999–2024
inferred← citeshttps://doi.org/10.1016/j.scib.2023.12.045openalex-snapshot
Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.153785openalex-snapshot
Occurrence of Tire and Road Wear Particles in Urban and Peri-Urban Snowbanks, and Their Potential Environmental Implications
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.154675openalex-snapshot
The joint effects of salt and 6PPD contamination on a freshwater herbivore
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.156013openalex-snapshot
Multiview behavior and neurotransmitter analysis of zebrafish dyskinesia induced by 6PPD and its metabolites
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.157447openalex-snapshot
Chronic toxicity of tire crumb rubber particles to mummichog (Fundulus heteroclitus) in episodic exposures
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.158468openalex-snapshot
Tyre Additive Chemicals, Tyre Road Wear Particles and High Production Polymers in Surface Water at 5 Urban Centres in Queensland, Australia
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.160591openalex-snapshot
Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.161373openalex-snapshot
A new toxicity mechanism of N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone: Formation of DNA adducts in mammalian cells and aqueous organisms
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.161836openalex-snapshot
Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.163595openalex-snapshot
Characterization of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD)-induced cardiotoxicity in larval zebrafish (Danio rerio)
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.165240openalex-snapshot
Environmental concentrations of tire rubber-derived 6PPD-quinone alter CNS function in zebrafish larvae
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.166679openalex-snapshot
Accelerated aging of tire and road wear particles by elevated temperature, artificial sunlight and mechanical stress — A laboratory study on particle properties, extractables and leachables
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.168933openalex-snapshot
Evaluation of tire tread particle toxicity to fish using rainbow trout cell lines
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.171153openalex-snapshot
Where the rubber meets the road: Emerging environmental impacts of tire wear particles and their chemical cocktails
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.171393openalex-snapshot
A nation-wide study for the occurrence of PPD antioxidants and 6PPD-quinone in road dusts of China
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.171622openalex-snapshot
Non-targeted screening and photolysis transformation of tire-related compounds in roadway runoff
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.174449openalex-snapshot
P-phenylenediamine antioxidants and their quinone derivatives: A review of their environmental occurrence, accessibility, potential toxicity, and human exposure
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.175018openalex-snapshot
Effects of environmental concentrations of 6PPD and its quinone metabolite on the growth and reproduction of freshwater cladoceran
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.175057openalex-snapshot
Potential human health risk of the emerging environmental contaminant 6-PPD quinone
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.175592openalex-snapshot
Comparative toxic effect of tire wear particle-derived compounds 6PPD and 6PPD-quinone to Chlorella vulgaris
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.175736openalex-snapshot
Environmental concentrations of 6PPD and 6PPD-Q cause oxidative damage and alter metabolism in Eichhornia crassipes
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.177627openalex-snapshot
Comparative growth inhibition of 6PPD and 6PPD-Q on microalgae Selenastrum capricornutum, with insights into 6PPD-induced phototoxicity and oxidative stress
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.177742openalex-snapshot
Environmental occurrence, fate, human exposure, and human health risks of p-phenylenediamines and their quinones
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2025.179240openalex-snapshot
Long term biodegradation study on tire and road wear particles and chemicals thereof
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2025.179821openalex-snapshot
Toxicity of 6PPD-quinone in European seabass (Dicentrarchus labrax) under baseline and Vibrio alginolyticus challenge conditions: Protective insights from astaxanthin mitigation
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2025.180047openalex-snapshot
Feasibility of using Pleurozium schreberi as a biomonitor to study antiozonant dispersion: A case study in Southern Quebec
inferred← citeshttps://doi.org/10.1016/j.talanta.2023.125072openalex-snapshot
Fabrication of nitrogen-carbon mediated γ-Mo2N nanocomposite based electrochemical sensor for rapid and sensitive determination of antioxidant 6-PPD in the environment
inferred← citeshttps://doi.org/10.1016/j.tox.2025.154285openalex-snapshot
Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induces intestinal toxicity in mice
inferred← citeshttps://doi.org/10.1016/j.trac.2022.116756openalex-snapshot
Mass spectrometry analysis of a ubiquitous tire rubber-derived quinone in the environment
inferred← citeshttps://doi.org/10.1016/j.trac.2025.118449openalex-snapshot
Occurrence, analytical methods, and ecotoxicological effects of 6PPD-Quinone in aquatic environments: A review
inferred← citeshttps://doi.org/10.1016/j.watres.2022.118122openalex-snapshot
Abiotic oxidative transformation of 6-PPD and 6-PPD quinone from tires and occurrence of their products in snow from urban roads and in municipal wastewater
inferred← citeshttps://doi.org/10.1016/j.watres.2022.119129openalex-snapshot
Microplastics in urban runoff: Global occurrence and fate
inferred← citeshttps://doi.org/10.1016/j.watres.2022.119528openalex-snapshot
Formation of disinfection by-products from microplastics, tire wear particles, and other polymer-based materials
inferred← citeshttps://doi.org/10.1016/j.watres.2023.121070openalex-snapshot
Transformation of 6PPDQ during disinfection: Kinetics, products, and eco-toxicity assessment
inferred← citeshttps://doi.org/10.1016/j.watres.2024.121322openalex-snapshot
Leaching of tire particles and simultaneous biodegradation of leachables
inferred← citeshttps://doi.org/10.1016/j.watres.2024.122254openalex-snapshot
Cotransport of 6PPD-Q and pristine/aged microplastics in porous media: An insight based on transport forms and mechanisms
inferred← citeshttps://doi.org/10.1016/j.watres.2024.122408openalex-snapshot
Development and application of diffusive gradients in thin-films for in-situ monitoring of 6PPD-Quinone in urban waters
inferred← citeshttps://doi.org/10.1016/j.watres.2025.124366openalex-snapshot
Rainfall, seasonal variation, and stream type governing the multi-media fate and ecological risks of tire additives and their transformation products in mega-urban streams
inferred← citeshttps://doi.org/10.1016/j.watres.2026.126063openalex-snapshot
Increased aquatic toxicity of tire wear particles following oxidative aging: mechanism insights into matrix loosening and transformation products
inferred← citeshttps://doi.org/10.1016/j.xinn.2024.100630openalex-snapshot
6PPD-quinone affects the photosynthetic carbon fixation in cyanobacteria by extracting photosynthetic electrons
inferred← citeshttps://doi.org/10.1021/acs.est.1c04500openalex-snapshot
p-Phenylenediamine Antioxidants in PM2.5: The Underestimated Urban Air Pollutants
inferred← citeshttps://doi.org/10.1021/acs.est.1c07376openalex-snapshot
New Evidence of Rubber-Derived Quinones in Water, Air, and Soil
inferred← citeshttps://doi.org/10.1021/acs.est.2c04291openalex-snapshot
Bioaccessibility of Organic Compounds Associated with Tire Particles Using a Fish In Vitro Digestive Model: Solubilization Kinetics and Effects of Food Coingestion
inferred← citeshttps://doi.org/10.1021/acs.est.2c05784openalex-snapshot
Contamination Pattern and Risk Assessment of Polar Compounds in Snow Melt: An Integrative Proxy of Road Runoffs
inferred← citeshttps://doi.org/10.1021/acs.est.2c07014openalex-snapshot
Screening p-Phenylenediamine Antioxidants, Their Transformation Products, and Industrial Chemical Additives in Crumb Rubber and Elastomeric Consumer Products
inferred← citeshttps://doi.org/10.1021/acs.est.2c08717openalex-snapshot
Computational Studies of Rubber Ozonation Explain the Effectiveness of 6PPD as an Antidegradant and the Mechanism of Its Quinone Formation
inferred← citeshttps://doi.org/10.1021/acs.est.3c01040openalex-snapshot
Tire-Derived Transformation Product 6PPD-Quinone Induces Mortality and Transcriptionally Disrupts Vascular Permeability Pathways in Developing Coho Salmon
inferred← citeshttps://doi.org/10.1021/acs.est.3c01932openalex-snapshot
Formulation Controls the Potential Neuromuscular Toxicity of Polyethylene Photoproducts in Developing Zebrafish
inferred← citeshttps://doi.org/10.1021/acs.est.3c02819openalex-snapshot
Uptake and Biotransformation of the Tire Rubber-derived Contaminants 6-PPD and 6-PPD Quinone in the Zebrafish Embryo (Danio rerio)
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