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Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Synthesis and in vitro Biological Evaluation of Ferrocenyl Side‐Chain‐Functionalized Paclitaxel Derivatives
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Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program
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BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo
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Development of anticancer agents: wizardry with osmium
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Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents
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PLK1, A Potential Target for Cancer Therapy
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Drug-selected cell line panels for evaluation of the pharmacokinetic consequences of multidrug resistance proteins
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Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.
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Antioxidant activity applying an improved ABTS radical cation decolorization assay
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Impact of the Halogen Substitution Pattern on the Biological Activity of Organoruthenium 8-Hydroxyquinoline Anticancer Agents
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Ferrocenyl 2,5-Piperazinediones as Tubulin-Binding Organometallic ABCB1 and ABCG2 Inhibitors Active against MDR Cells
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Natural Taxanes: Developments Since 1828
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Silicate Esters of Paclitaxel and Docetaxel: Synthesis, Hydrophobicity, Hydrolytic Stability, Cytotoxicity, and Prodrug Potential
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Development of a New Benzophenone–Diketopiperazine-Type Potent Antimicrotubule Agent Possessing a 2-Pyridine Structure
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Synthesis and biological activities of ferrocenyl derivatives of paclitaxel
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Ferrocifen type anti cancer drugs
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Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development
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Synthesis and evaluation of biological properties of ferrocenyl–podophyllotoxin conjugates
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Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines
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Correction: Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines
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Structural and solution equilibrium studies on half-sandwich organorhodium complexes of (N,N) donor bidentate ligands
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Arene ruthenium(II) complexes formed by dehydrogenation of cyclohexadienes with ruthenium(III) trichloride
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A ruthenium complexes of monastrol and its pyrimidine analogues: Synthesis and biological properties
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Anti-mitotic therapies in cancer
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Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential
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NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent
inferredcites →https://doi.org/10.1107/s0907444912027965openalex-snapshot
The structure of the ternary Eg5–ADP–ispinesib complex
inferredcites →https://doi.org/10.1126/science.286.5441.971openalex-snapshot
Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen
inferredcites →https://doi.org/10.1158/1078-0432.ccr-09-1498openalex-snapshot
Activity of the Kinesin Spindle Protein Inhibitor Ispinesib (SB-715992) in Models of Breast Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-2506openalex-snapshot
Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies
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ARRY-429520, a Novel KSP Inhibitor with Potent Anti-Proliferative Activity in Leukemic Cell Lines.
inferredcites →https://doi.org/10.1517/13543776.18.3.253openalex-snapshot
Therapeutic potential of mitotic kinesin inhibitors in cancer
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Development of new cancer therapeutic agents targeting mitosis
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Aurora kinases: novel therapy targets in cancers
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Medicinal Chemistry of Paclitaxel and its Analogues
inferredcites →https://doi.org/10.2174/156800907783220499openalex-snapshot
Novel Mitotic Targets and Their Small-Molecule Inhibitors
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The novel kinesin spindle protein (KSP) inhibitor SB-743921 exhibits marked activity inin vivoandin vitromodels of aggressive large B-cell lymphoma
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Aurora Kinase Inhibitors: Current Status and Outlook
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Update on Taxanes in the First-Line Treatment of Advanced Non-Small-Cell Lung Cancer
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A Convenient Entry to New C-7-Modified Colchicinoids through Azide Alkyne [3+2] Cycloaddition: Application of Ring-Contractive Rearrangements
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Recent Findings and Future Directions for Interpolar Mitotic Kinesin Inhibitors in Cancer Therapy
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Natural products as new antimitotic compounds for anticancer drug development

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Preparation of novel Rh (III) half-sandwich complexes bearing 5-phenyl-2-(pyridin-2-yl)-1,2-dihydro-3H-pyrazol-3-one ligands, and their anti-cancer properties
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Design, Synthesis, and Evaluation of Biological Activity of Ferrocene‐Ispinesib Hybrids: Impact of a Ferrocenyl Group on the Antiproliferative and Kinesin Spindle Protein Inhibitory Activity
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A Rhein‐Based Rh( III ) Arene Complex with Anti‐tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO
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Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes
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Cancer on motors: How kinesins drive prostate cancer progression?
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Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands
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The interaction of rhodium compounds with proteins: A structural overview
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Theoretical investigation of mechanism and ligand effects on half-sandwich iridium complexes for direct reductive amination
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Increasing Anticancer Activity with Phosphine Ligation in Zwitterionic Half-Sandwich Iridium(III), Rhodium(III), and Ruthenium(II) Complexes
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Ruthenocenyl and 1-Adamantyl Paclitaxel Analogs Disrupt the Balance between βIII- and βIVa-Tubulin and Inhibit the Growth and Invasiveness of Colon Cancer
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c01956openalex-snapshot
Ferrocene–Diiron(I) Bis(cyclopentadienyl) Conjugates Exhibit Potent In Vitro Cytotoxicity and Selectivity toward Cancer Cells Associated with ROS Scavenging
inferred← citeshttps://doi.org/10.1021/acsomega.3c10482openalex-snapshot
Development of Half-Sandwich Ru, Os, Rh, and Ir Complexes Bearing the Pyridine-2-ylmethanimine Bidentate Ligand Derived from 7-Chloroquinazolin-4(3H)-one with Enhanced Antiproliferative Activity
inferred← citeshttps://doi.org/10.1039/d1dt03553copenalex-snapshot
Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates
inferred← citeshttps://doi.org/10.1039/d2dt01929aopenalex-snapshot
Cell nucleus localization and high anticancer activity of quinoline–benzopyran rhodium( iii ) metal complexes as therapeutic and fluorescence imaging agents
inferred← citeshttps://doi.org/10.1039/d3dt01217dopenalex-snapshot
Organometallic Ru, Os, Rh and Ir half-sandwich conjugates of ispinesib – impact of the organometallic group on the antimitotic activity
inferred← citeshttps://doi.org/10.1039/d4dt01853bopenalex-snapshot
Design and synthesis of ferrocenyl 1,4-dihydropyridines and their evaluation as kinesin-5 inhibitors
inferred← citeshttps://doi.org/10.1039/d4dt03219eopenalex-snapshot
A comprehensive survey of cytotoxic active half-sandwich Ir( iii ) complexes: structural perspective, and mechanism of action
inferred← citeshttps://doi.org/10.1039/d4qi02472aopenalex-snapshot
Anticancer iridium( iii ) cyclopentadienyl complexes
inferred← citeshttps://doi.org/10.2144/fsoa-2021-0116openalex-snapshot
Kinesin Spindle Protein Inhibitors in Cancer: From High Throughput Screening to Novel Therapeutic Strategies
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