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Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

https://doi.org/10.1021/acs.jmedchem.5b00599
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Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes
inferred← citeshttps://doi.org/10.1016/j.ejps.2017.02.008openalex-snapshot
A rational approach to elucidate human monoamine oxidase molecular selectivity
inferred← citeshttps://doi.org/10.1016/j.ejps.2017.08.004openalex-snapshot
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl)hydrazone: A water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.ibneur.2022.12.001openalex-snapshot
Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease
inferred← citeshttps://doi.org/10.1016/j.mencom.2019.11.010openalex-snapshot
Synthesis of uracil–coumarin conjugates as potential inhibitors of virus replication
inferred← citeshttps://doi.org/10.1016/j.molstruc.2021.131591openalex-snapshot
New Coumarin-Pyrazole hybrids: Synthesis, Docking studies and Biological evaluation as potential cholinesterase inhibitors
inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.141776openalex-snapshot
Synthesis, biological evaluation, ADMET studies, and molecular docking of novel coumarin–isoxazole derivatives as dual inhibitors of Hsp90 protein and acetylcholinesterase enzyme
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2016.02.005openalex-snapshot
Molecular aspects of monoamine oxidase B
inferred← citeshttps://doi.org/10.1016/j.rechem.2024.101492openalex-snapshot
Synthesis and evaluation of a highly selective cannabidiol amide cholinesterase inhibitor
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01784openalex-snapshot
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00562openalex-snapshot
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01417openalex-snapshot
Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline–Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1021/acschemneuro.0c00706openalex-snapshot
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents
inferred← citeshttps://doi.org/10.1021/acschemneuro.3c00588openalex-snapshot
Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer’s Disease Therapy
inferred← citeshttps://doi.org/10.1021/acschemneuro.7b00257openalex-snapshot
Rational Design and Multibiological Profiling of Novel Donepezil–Trolox Hybrids against Alzheimer’s Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.2c00001openalex-snapshot
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures
inferred← citeshttps://doi.org/10.1021/acsomega.5c06683openalex-snapshot
Synthesis and Properties of Star-Shaped Hydroxyl-Terminated Polybutadiene via RAFT Polymerization: A Model for a Binder Prepolymer
inferred← citeshttps://doi.org/10.1021/acsomega.9b03409openalex-snapshot
Chromenones as Multineurotargeting Inhibitors of Human Enzymes
inferred← citeshttps://doi.org/10.1021/acsptsci.2c00097openalex-snapshot
The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents
inferred← citeshttps://doi.org/10.1038/s41598-026-63421-2openalex-snapshot
Neuroprotective potential of synthesized coumarin-based glycinate and heterocyclic amide derivatives: an acetylcholinesterase inhibition study
inferred← citeshttps://doi.org/10.1039/c5cp07991hopenalex-snapshot
Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? Insight from the theoretical study
inferred← citeshttps://doi.org/10.1039/c6md00053copenalex-snapshot
Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/c6ra00302hopenalex-snapshot
Recent developments on the structure–activity relationship studies of MAO inhibitors and their role in different neurological disorders
inferred← citeshttps://doi.org/10.1039/c8md00446copenalex-snapshot
Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches
inferred← citeshttps://doi.org/10.1039/d0ra05172aopenalex-snapshot
Aryldiazoquinoline based multifunctional small molecules for modulating Aβ 42 aggregation and cholinesterase activity related to Alzheimer's disease
inferred← citeshttps://doi.org/10.1039/d6ra06655kopenalex-snapshot
Targeting DYRK1A with rationally designed pyrazine–guanidine hybrids for Alzheimer's disease: design, synthesis, and biological evaluation
inferred← citeshttps://doi.org/10.1080/07391102.2023.2224887openalex-snapshot
Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation
inferred← citeshttps://doi.org/10.1080/14756366.2016.1226298openalex-snapshot
Synthesis and molecular docking studies of some 4-phthalimidobenzenesulfonamide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors
inferred← citeshttps://doi.org/10.1080/14756366.2018.1488696openalex-snapshot
Design, synthesis and biological evaluation of tricyclic pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one scaffolds as selective BuChE inhibitors
inferred← citeshttps://doi.org/10.1080/14756366.2019.1687460openalex-snapshot
Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1080/14756366.2021.1913137openalex-snapshot
Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents
inferred← citeshttps://doi.org/10.1080/14756366.2023.2270781openalex-snapshot
Latest advances in dual inhibitors of acetylcholinesterase and monoamine oxidase B against Alzheimer’s disease
inferred← citeshttps://doi.org/10.1080/17460441.2019.1637415openalex-snapshot
Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?
inferred← citeshttps://doi.org/10.1080/17460441.2024.2322990openalex-snapshot
Molecular hybridization: a powerful tool for multitarget drug discovery
inferred← citeshttps://doi.org/10.1111/jphp.13264openalex-snapshot
Design of enamides as new selective monoamine oxidase-B inhibitors
inferred← citeshttps://doi.org/10.1146/annurev-biochem-030222-120000openalex-snapshot
The Art and Science of Molecular Docking
inferred← citeshttps://doi.org/10.1248/cpb.c17-00416openalex-snapshot
Synthesis of Amide and Ester Derivatives of Cinnamic Acid and Its Analogs: Evaluation of Their Free Radical Scavenging and Monoamine Oxidase and Cholinesterase Inhibitory Activities
inferred← citeshttps://doi.org/10.14233/ajchem.2018.21092openalex-snapshot
An Innovative Approach for the Synthesis of 7-Hydroxyquinolin-2(1H)-one: A Key Intermediate of Brexpiprazole
inferred← citeshttps://doi.org/10.2147/dddt.s432170openalex-snapshot
In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2174/1389557519666190719143112openalex-snapshot
Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents
inferred← citeshttps://doi.org/10.2174/1871527318666190906101326openalex-snapshot
Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2174/9789815079098122010012openalex-snapshot
Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors
inferred← citeshttps://doi.org/10.3389/fchem.2022.1002547openalex-snapshot
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules
inferred← citeshttps://doi.org/10.3389/fnins.2016.00375openalex-snapshot
Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration
inferred← citeshttps://doi.org/10.3390/molecules21030362openalex-snapshot
Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif
inferred← citeshttps://doi.org/10.3390/molecules21040410openalex-snapshot
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
inferred← citeshttps://doi.org/10.3390/molecules22071192openalex-snapshot
Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs
inferred← citeshttps://doi.org/10.3390/molecules23020250openalex-snapshot
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds
inferred← citeshttps://doi.org/10.3390/molecules25235773openalex-snapshot
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/molecules27134297openalex-snapshot
Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma
inferred← citeshttps://doi.org/10.4155/fmc-2017-0014openalex-snapshot
Melatonin as a Versatile Molecule to Design Novel Multitarget Hybrids Against Neurodegeneration
inferred← citeshttps://doi.org/10.4155/fmc-2017-0036openalex-snapshot
Dual Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’S Disease
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