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Design, Synthesis, and Structure–Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors

https://doi.org/10.1021/acs.jmedchem.9b00664
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.287.10.1308openalex-snapshot
Hypertrophic Cardiomyopathy
inferredcites →https://doi.org/10.1002/cbf.3234openalex-snapshot
ZAKβ antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAKα
inferredcites →https://doi.org/10.1006/bbrc.2000.3236openalex-snapshot
Cloning and Expression of ZAK, a Mixed Lineage Kinase-like Protein Containing a Leucine-Zipper and a Sterile-Alpha Motif
inferredcites →https://doi.org/10.1007/s001090050275openalex-snapshot
Cellular mechanisms of cardiac hypertrophy
inferredcites →https://doi.org/10.1007/s11010-008-0021-1openalex-snapshot
ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells
inferredcites →https://doi.org/10.1007/s11010-015-2389-zopenalex-snapshot
ZAK induces cardiomyocyte hypertrophy and brain natriuretic peptide expression via p38/JNK signaling and GATA4/c-Jun transcriptional factor activation
inferredcites →https://doi.org/10.1016/j.bbapap.2009.11.008openalex-snapshot
Extended kinase profile and properties of the protein kinase inhibitor nilotinib
inferredcites →https://doi.org/10.1016/j.bbrc.2004.09.067openalex-snapshot
Transforming growth factor-β induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK
inferredcites →https://doi.org/10.1016/j.bbrc.2004.09.156openalex-snapshot
ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells
inferredcites →https://doi.org/10.1016/j.jjcc.2014.02.022openalex-snapshot
Advances in medical treatment of hypertrophic cardiomyopathy
inferredcites →https://doi.org/10.1016/s0021-9258(18)47183-9openalex-snapshot
Brain natriuretic peptide is induced by alpha 1-adrenergic agonists as a primary response gene in cultured rat cardiac myocytes
inferredcites →https://doi.org/10.1021/acs.jmedchem.7b00572openalex-snapshot
Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors
inferredcites →https://doi.org/10.1021/acschembio.6b00043openalex-snapshot
Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib
inferredcites →https://doi.org/10.1038/nbt.1990openalex-snapshot
Comprehensive analysis of kinase inhibitor selectivity
inferredcites →https://doi.org/10.1038/nbt1068openalex-snapshot
A small molecule–kinase interaction map for clinical kinase inhibitors
inferredcites →https://doi.org/10.1038/nrcardio.2016.140openalex-snapshot
Update on hypertrophic cardiomyopathy and a guide to the guidelines
inferredcites →https://doi.org/10.1038/s41467-018-06191-4openalex-snapshot
Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition
inferredcites →https://doi.org/10.1107/s0907444906019949openalex-snapshot
HKL -3000: the integration of data reduction and structure solution – from diffraction images to an initial model in minutes
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0561openalex-snapshot
Sorafenib Suppresses JNK-Dependent Apoptosis through Inhibition of ZAK
inferredcites →https://doi.org/10.2174/0929867323666160920104121openalex-snapshot
Leucine-zipper and Sterile-α Motif Kinase (ZAK): A Potential Target for Drug Discovery
inferredcites →https://doi.org/10.5935/abc.20140022openalex-snapshot
Hypertrophic Cardiomyopathy: How do Mutations Lead to Disease?

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4603948openalex-extracted
inferred← citeshttps://doi.org/10.1002/adsc.70223openalex-snapshot
Electrochemical Imidoyl Radical‐Involved Functionalization of Isocyanides to Construct Benzotriazole‐Sulfonamide and Guanidine Derivatives
inferred← citeshttps://doi.org/10.1007/s00044-023-03052-8openalex-snapshot
Recent advances in triazole-benzenesulfonamide hybrids and their biological activities
inferred← citeshttps://doi.org/10.1007/s12026-023-09401-4openalex-snapshot
Functions of MAP3Ks in antiviral immunity
inferred← citeshttps://doi.org/10.1007/s44371-026-00907-yopenalex-snapshot
Design, synthesis, and biological evaluation of novel sulfonamide-linked 1,2,3-triazole conjugates
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.113998openalex-snapshot
Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112675openalex-snapshot
Systemic review on B-RafV600E mutation as potential therapeutic target for the treatment of cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113952openalex-snapshot
One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111482openalex-snapshot
An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.molcel.2024.10.044openalex-snapshot
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2019.107457openalex-snapshot
Therapeutic potential of targeting mixed lineage kinases in cancer and inflammation
inferred← citeshttps://doi.org/10.1016/j.trsl.2022.03.002openalex-snapshot
Targeted inhibition of ZAK ameliorates renal interstitial fibrosis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01511openalex-snapshot
Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00088openalex-snapshot
Rational Design of Covalent Kinase Inhibitors by an Integrated Computational Workflow (Kin-Cov)
inferred← citeshttps://doi.org/10.1038/s41556-023-01248-zopenalex-snapshot
A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response
inferred← citeshttps://doi.org/10.1038/s41556-026-01936-6openalex-snapshot
The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress
inferred← citeshttps://doi.org/10.1038/s44321-025-00197-4openalex-snapshot
Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation
inferred← citeshttps://doi.org/10.1084/jem.20220837openalex-snapshot
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
inferred← citeshttps://doi.org/10.1084/jem.20230105openalex-snapshot
Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis
inferred← citeshttps://doi.org/10.1101/2022.01.17.476700openalex-snapshot
Collateral cleavage of 28s rRNA by RfxCas13d causes death of mice
inferred← citeshttps://doi.org/10.1101/2023.01.16.524188openalex-snapshot
Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria
inferred← citeshttps://doi.org/10.1111/jfbc.14041openalex-snapshot
Glycyrrhiza uralensis root extract ameliorates high glucose‐induced renal proximal tubular fibrosis by attenuating tubular epithelial‐myofibroblast transdifferentiation by targeting TGF‐β1/Smad/Stat3 pathway
inferred← citeshttps://doi.org/10.1161/circresaha.126.328649openalex-snapshot
Multimodality Molecular Profiling Nominates Targetable Mechanisms in Progressive RV Dysfunction
inferred← citeshttps://doi.org/10.1186/s13059-023-02860-wopenalex-snapshot
The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.2174/0929867330666221128142730openalex-snapshot
Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part C: Multicomponent Sulfonamide Hybrids
inferred← citeshttps://doi.org/10.3389/fcell.2026.1909993openalex-snapshot
ZAK kinase at the crossroads of cellular stress: functional plasticity, human pathobiology, and precision therapeutics
inferred← citeshttps://doi.org/10.3390/cells12060969openalex-snapshot
Computational and Functional Analysis of Structural Features in the ZAKα Kinase
inferred← citeshttps://doi.org/10.3390/ph15050504openalex-snapshot
The Design and Synthesis of a New Series of 1,2,3-Triazole-Cored Structures Tethering Aryl Urea and Their Highly Selective Cytotoxicity toward HepG2
inferred← citeshttps://doi.org/10.4018/979-8-3693-7267-8.ch005openalex-snapshot
Pharmacological Significance of 1,2,3-Triazoles
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609706openalex-snapshot
Additional file 1 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609709openalex-snapshot
Additional file 2 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609712openalex-snapshot
Additional file 3 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609715openalex-snapshot
Additional file 4 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609718openalex-snapshot
Additional file 5 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609721openalex-snapshot
Additional file 6 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609724openalex-snapshot
Additional file 7 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609727openalex-snapshot
Additional file 8 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609730openalex-snapshot
Additional file 9 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609733openalex-snapshot
Additional file 10 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.6084/m9.figshare.22609736openalex-snapshot
Additional file 11 of The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
inferred← citeshttps://doi.org/10.64898/2026.01.23.701189openalex-snapshot
Two orthogonal MAP3K-driven pathways of NLRP1 inflammasome activation revealed by poisonous beetles
inferred← citeshttps://doi.org/10.64898/2026.03.09.710504openalex-snapshot
Multimodality Molecular Profiling Nominates Targetable Mechanisms in Progressive RV Dysfunction
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