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Daphnane Diterpenoids from Daphne genkwa Inhibit PI3K/Akt/mTOR Signaling and Induce Cell Cycle Arrest and Apoptosis in Human Colon Cancer Cells

https://doi.org/10.1021/acs.jnatprod.0c00003

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Test Detects Prosthetic Joint Infection in Synovial Fluid

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Three New Daphne Diterpenes from the Buds of Daphne genkwa Sieb . et Zucc . Processed by Rice Vinegar

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Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti‐complement activity

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Antitumor Activity of Total Flavonoids from Daphne genkwa in Colorectal Cancer

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Isolation and enzymatic formation of lignans ofDaphne genkwa andDaphne odora

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Genkwadaphnin, a potent antileukemic diterpene from Daphne genkwa

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Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa

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Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure–activity relationship of potent inhibitory activity against DNA topoisomerase I

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Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa

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The PI3K Pathway in Human Disease

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Antitumor activity of daphnodorins from Daphne genkwa roots

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Cell Death

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hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala

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Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells

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Guaiane-Type Sesquiterpenoids from the Roots of Daphne genkwa and Evaluation of Their Neuroprotective Effects

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Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Daphne genkwa Guided by UPLC-MSn

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Labdane-Type Diterpenoids from the Fruits of Vitex trifolia

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Neogenkwanines A–H: daphnane-type diterpenes containing 4,7 or 4,6-ether groups from the flower bud of Daphne genkwa

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Root extractive from Daphne genkwa benefits in wound healing of anal fistula through up-regulation of collagen genes in human skin fibroblasts

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Sesquiterpenes and lignans from the flower buds of Daphne genkwa and their nitric oxide inhibitory activities

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Challenges for the Clinical Development of PI3K Inhibitors: Strategies to Improve Their Impact in Solid Tumors

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Daphnane and Phorbol Diterpenes, Anti-neuroinflammatory Compounds with Nurr1 Activation from the Roots and Stems of Daphne genkwa

inferredcites →https://doi.org/10.1248/cpb.58.234openalex-snapshot

Daphnane Diterpene Esters with Anti-proliferative Activities against Human Lung Cancer Cells from Daphne genkwa

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Resiniferonol-related diterpene esters from Daphne odora Thunb. and their ornithine decarboxylase-inducing activity in mouse skin.

inferredcites →https://doi.org/10.21147/j.issn.1000-9604.2018.01.01openalex-snapshot

Cancer incidence and mortality in China, 2014

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Cancer statistics, 2019

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Circulating microRNAs as Promising Biomarkers in Colorectal Cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Drug discovery from daphnane-type diterpenoids: a balance between the anti-HIV effect and toxicity

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Diterpenoids from the flower buds of Daphne genkwa induced the pyroptosis of HCT-116 cells by inhibiting STAT3 phosphorylation

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