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Diverse Polycyclic Polyprenylated Acylphloroglucinol Congeners with Anti-Nonalcoholic Steatohepatitis Activity from Hypericum forrestii

https://doi.org/10.1021/acs.jnatprod.0c01202

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Polycyclic Polyprenylated Acylphloroglucinols and Chromone O‐Glucosides from Hypericum henryi subsp. uraloides

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New Cell Growth‐Inhibitory Cyclohexadienone Derivatives from Hypericum calycinum L.

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Polyprenylated Phloroglucinol Derivatives from Hypericum sampsonii

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Molecular pathways of nonalcoholic fatty liver disease development and progression

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Polyprenylated acylphloroglucinols from the fruits of Hypericum henryi

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Hypercohones D–G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens

inferredcites →https://doi.org/10.1007/s13659-019-00229-wopenalex-snapshot

Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi

inferredcites →https://doi.org/10.1007/s13659-020-00245-1openalex-snapshot

Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile

inferredcites →https://doi.org/10.1016/j.bioorg.2019.103075openalex-snapshot

Human neutrophil elastase (HNE) inhibitory polyprenylated acylphloroglucinols from the flowers of Hypericum ascyron

inferredcites →https://doi.org/10.1016/j.fitote.2014.02.011openalex-snapshot

Cytotoxic polycyclic polyprenylated acylphloroglucinols from Hypericum attenuatum

inferredcites →https://doi.org/10.1016/j.jep.2020.112686openalex-snapshot

Ethnopharmacology of Hypericum species in China: A comprehensive review on ethnobotany, phytochemistry and pharmacology

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Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling

inferredcites →https://doi.org/10.1016/j.phytochem.2006.09.018openalex-snapshot

Hyperforin and its analogues inhibit CYP3A4 enzyme activity

inferredcites →https://doi.org/10.1016/j.phytochem.2018.08.002openalex-snapshot

Structural diversity and biological activities of phloroglucinol derivatives from Hypericum species

inferredcites →https://doi.org/10.1016/j.tet.2005.06.030openalex-snapshot

Structural revision of clusianone and 7-epi-clusianone and anti-HIV activity of polyisoprenylated benzophenones

inferredcites →https://doi.org/10.1016/j.tet.2016.06.035openalex-snapshot

Hyperhexanone A, a crucial intermediate from bicyclo[3.3.1]- to cyclohexanone monocyclic-polycyclic polyprenylated acylphloroglucinols

inferredcites →https://doi.org/10.1016/j.tetasy.2017.09.015openalex-snapshot

Features of electronic circular dichroism and tips for its use in determining absolute configuration

inferredcites →https://doi.org/10.1016/j.tetlet.2015.02.056openalex-snapshot

Two new adamantyl-like polyprenylated acylphloroglucinols from Hypericum attenuatum choisy

inferredcites →https://doi.org/10.1016/j.tetlet.2015.08.033openalex-snapshot

Hypercohin K, a polycyclic polyprenylated acylphloroglucinol with an unusual spiro-fused cyclopropane ring from Hypericum cohaerens

inferredcites →https://doi.org/10.1016/j.tetlet.2017.04.044openalex-snapshot

seco-Polycyclic polyprenylated acylphloroglucinols with unusual carbon skeletons from Hypericum ascyron

inferredcites →https://doi.org/10.1016/j.tetlet.2018.09.071openalex-snapshot

Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi

inferredcites →https://doi.org/10.1016/s0040-4020(98)01203-4openalex-snapshot

Prenylated benzophenone derivatives from Caribbean Clusia species (Guttiferae). Plukenetiones B-G and xerophenone A

inferredcites →https://doi.org/10.1016/s0040-4039(00)00832-7openalex-snapshot

On the structures of plukenetiones B, D, and E and their relationships to other polycyclic polyprenylated acylphloroglucinols

inferredcites →https://doi.org/10.1016/s1875-5364(20)30044-3openalex-snapshot

New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens

inferredcites →https://doi.org/10.1021/acs.chemrev.7b00551openalex-snapshot

Research Progress of Polycyclic Polyprenylated Acylphloroglucinols

inferredcites →https://doi.org/10.1021/acs.jmedchem.0c00618openalex-snapshot

Design and Structural Optimization of Dual FXR/PPARδ Activators

inferredcites →https://doi.org/10.1021/acs.jmedchem.9b01701openalex-snapshot

The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease

inferredcites →https://doi.org/10.1021/acs.jmedchem.9b02056openalex-snapshot

Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Cav3.1 Low Voltage-Gated Ca2+ Channel

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00057openalex-snapshot

Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00066openalex-snapshot

Hypermongones A–J, Rare Methylated Polycyclic Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00667openalex-snapshot

Polycyclic Polyprenylated Derivatives from Hypericum uralum: Neuroprotective Effects and Antidepressant-like Activity of Uralodin A

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00830openalex-snapshot

1,9-seco-Bicyclic Polyprenylated Acylphloroglucinols from Hypericum uralum

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b01063openalex-snapshot

Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum

inferredcites →https://doi.org/10.1021/acs.jnatprod.9b00354openalex-snapshot

Hypascyrins A–E, Prenylated Acylphloroglucinols from Hypericum ascyron

inferredcites →https://doi.org/10.1021/acs.jnatprod.9b01285openalex-snapshot

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

inferredcites →https://doi.org/10.1021/acs.orglett.6b02725openalex-snapshot

Hypatulins A and B, Meroterpenes from Hypericum patulum

inferredcites →https://doi.org/10.1021/acs.orglett.9b03098openalex-snapshot

Hyperberins A and B, Type B Polycyclic Polyprenylated Acylphloroglucinols with Bicyclo[5.3.1]hendecane Core from Hypericum beanii

inferredcites →https://doi.org/10.1021/cr0500582openalex-snapshot

Polycyclic Polyprenylated Acylphloroglucinols

inferredcites →https://doi.org/10.1021/cr200055gopenalex-snapshot

Semipinacol Rearrangement in Natural Product Synthesis

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Syntheses of (+)-30-epi-, (−)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations

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Modulation of Chemoselectivity by Protein Additives. Remarkable Effects in the Oxidation of Hyperforin

inferredcites →https://doi.org/10.1021/jo500027kopenalex-snapshot

Biomimetic Total Synthesis of (±)-Doitunggarcinone A and (+)-Garcibracteatone

inferredcites →https://doi.org/10.1021/np400287ropenalex-snapshot

Bioactive Polyprenylated Acylphloroglucinol Derivatives from Hypericum cohaerens

inferredcites →https://doi.org/10.1021/np980339nopenalex-snapshot

A Polyisoprenylated Benzophenone from Cuban Propolis

inferredcites →https://doi.org/10.1021/np9903752openalex-snapshot

Hyperforin Analogues from St. John's Wort (Hypericum perforatum)

inferredcites →https://doi.org/10.1021/ol302524qopenalex-snapshot

Biomimetic Total Synthesis of (±)-Garcibracteatone

inferredcites →https://doi.org/10.1021/ol500808popenalex-snapshot

New Acylphloroglucinol Derivatives with Diverse Architectures from Hypericum henryi

inferredcites →https://doi.org/10.1021/ol502425fopenalex-snapshot

Hyperuralones A and B, New Acylphloroglucinol Derivatives with Intricately Caged Cores from Hypericum uralum

inferredcites →https://doi.org/10.1021/ol9907825openalex-snapshot

Cytotoxic Polyprenylated Benzoylphloroglucinol Derivatives with an Unusual Adamantyl Skeleton from Hypericum sampsonii (Guttiferae)

inferredcites →https://doi.org/10.1038/nchem.2479openalex-snapshot

Counting on natural products for drug design

inferredcites →https://doi.org/10.1038/nrd.2017.146openalex-snapshot

Directing evolution: the next revolution in drug discovery?

inferredcites →https://doi.org/10.1038/nrd.2018.116openalex-snapshot

Expanding the medicinal chemistry synthetic toolbox

inferredcites →https://doi.org/10.1038/s41591-018-0104-9openalex-snapshot

Mechanisms of NAFLD development and therapeutic strategies

inferredcites →https://doi.org/10.1039/c8ob02067aopenalex-snapshot

Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum

inferredcites →https://doi.org/10.1039/c9cc09433dopenalex-snapshot

Taxodisones A and B: bioactive C 30 -terpenes with new skeletons from Taxodium distichum and their biosynthetic origin

inferredcites →https://doi.org/10.1039/c9ob01500kopenalex-snapshot

Przewalcyrones A–F, epoxychromene-containing polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum przewalskii Maxim.

inferredcites →https://doi.org/10.1039/d0qo00152jopenalex-snapshot

Hyperforones A–C, benzoyl-migrated [5.3.1]-type polycyclic polyprenylated acylphloroglucinols from Hypericum forrestii

inferredcites →https://doi.org/10.1039/d0qo00259copenalex-snapshot

Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors

inferredcites →https://doi.org/10.1074/jbc.m011538200openalex-snapshot

The Desymmetrization of Bicyclic β-Diketones by an Enzymatic Retro-Claisen Reaction

inferredcites →https://doi.org/10.1136/gutjnl-2016-312431openalex-snapshot

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

inferredcites →https://doi.org/10.3390/cells9010037openalex-snapshot

Anti-NASH Drug Development Hitches a Lift on PPAR Agonism

inferredcites →https://doi.org/10.3724/sp.j.1143.2008.00515openalex-snapshot

A New Polyisoprenylated Benzoylphloroglucinol Derivative from Hypericum henryi subsp. uraloides (Guttiferae

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113166zenodo-depositor-declared

Kiiacylphnols A−H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim

inferred← citeshttps://doi.org/10.1002/chem.202401908openalex-snapshot

Unique Reactivity of the 1,4‐Bis(silyloxy)‐1,3‐cyclopentadiene Moiety: Application to the Synthesis of 7‐Norbornanone Derivatives

inferred← citeshttps://doi.org/10.1002/chir.23393openalex-snapshot

ECD exciton chirality method today: a modern tool for determining absolute configurations

inferred← citeshttps://doi.org/10.1002/cjoc.202400739openalex-snapshot

Hyperkouytones A—O, New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity

inferred← citeshttps://doi.org/10.1002/hep.32651openalex-snapshot

RNA helicase DEAD‐box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling

inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.106005openalex-snapshot

Diverse polycyclic polyprenylated acylphloroglucinols with anti-neuroinflammatory activity from Hypericum beanii

inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110638openalex-snapshot

Structurally diverse polyprenylated acylphloroglucinols from Hypericum addingtonii with anti-hepatocellular carcinoma activity

inferred← citeshttps://doi.org/10.1016/j.cclet.2021.11.011openalex-snapshot

Hyperbenzones A and B, two 1,2-seco and rearranged polycyclic polyprenylated acylphloroglucinols from Hypericum beanii

inferred← citeshttps://doi.org/10.1016/j.fitote.2022.105389openalex-snapshot

Hyperxylones A and B, two polycyclic polyprenylated acylphloroglucinols with a benzoyl substituted bicyclo[3.2.1]octane core from Hypericum beanii

inferred← citeshttps://doi.org/10.1016/j.fitote.2024.105985openalex-snapshot

(±)-hypermonanones A-G, seven pairs of monoterpenoid polyprenylated acylphloroglucinol enantiomers from Hypericum monanthemum

inferred← citeshttps://doi.org/10.1016/j.lfs.2024.123031openalex-snapshot

Identification of protein partners for small molecules reshapes the understanding of nonalcoholic steatohepatitis and drug discovery

inferred← citeshttps://doi.org/10.1016/j.phymed.2025.157159openalex-snapshot

Hyperacmotone A alleviates Non-alcoholic Steatohepatitis via regulating PPARα signaling

inferred← citeshttps://doi.org/10.1016/j.phymed.2026.157936openalex-snapshot

Hypercohin A alleviates hepatic steatosis via the mammalian target of rapamycin (mTOR)-dependent suppression of de novo lipogenesis and ferroptosis

inferred← citeshttps://doi.org/10.1016/j.phytochem.2024.114167openalex-snapshot

Garciyunnanones A–R: Caged polycyclic polyprenylated acylphloroglucinols decorated with a lavandulyl substituent from Garcinia yunnanensis

inferred← citeshttps://doi.org/10.1016/j.tetlet.2022.153987openalex-snapshot

In(OTf)3 catalyzed regioselective acyloin rearrangement of 1-acyl-1-indanols

inferred← citeshttps://doi.org/10.1016/s1875-5364(22)60199-7openalex-snapshot

Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury

inferred← citeshttps://doi.org/10.1016/s1875-5364(24)60599-6openalex-snapshot

Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum

inferred← citeshttps://doi.org/10.1016/s1875-5364(25)60910-1openalex-snapshot

First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research

inferred← citeshttps://doi.org/10.1016/s1875-5364(25)60911-3openalex-snapshot

Naturally occurring seco- and nor-polycyclic polyprenylated acylphloroglucinols: distribution, structural diversity, andbiological activity

inferred← citeshttps://doi.org/10.1021/acs.orglett.3c02374openalex-snapshot

Influence of Ring Strain on the Formation of Rearrangement vs Cyclization Isotwistane Products in the Acyl Radical Reaction of Bicyclo[2.2.2]octanone

inferred← citeshttps://doi.org/10.1039/d2ob01851aopenalex-snapshot

Hyperpatone A, a polycyclic polyprenylated acylphloroglucinol with a rare 8/6/5/6/5 pentacyclic skeleton from Hypericum patulum

inferred← citeshttps://doi.org/10.2139/ssrn.7519518openalex-snapshot

Anemarrhenones G and H, epimeric polycyclic benzophenones with a novel cage-like skeleton from the fibrous roots of Anemarrhena asphodeloides

inferred← citeshttps://doi.org/10.3389/fntpr.2022.1086897openalex-snapshot

Computational methods and points for attention in absolute configuration determination

inferred← citeshttps://doi.org/10.3390/compounds4020025openalex-snapshot

New Compounds from Terrestrial Plants: A Perspective View

inferred← citeshttps://doi.org/10.3390/plants11192509openalex-snapshot

Hypericum Genus as a Natural Source for Biologically Active Compounds

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