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Adsorptive-Mediated Endocytosis of Sulfo-Cy5-Labeled IgG Causes Aberrant IgG Processing by Brain Endothelial-Like Cells

https://doi.org/10.1021/acs.molpharmaceut.0c00712
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jnr.23457openalex-snapshot
Temporal effects of vascular endothelial growth factor and 3,5‐cyclic monophosphate on blood–brain barrier solute permeability in vivo
inferredcites →https://doi.org/10.1016/0169-409x(95)00005-ropenalex-snapshot
Antibody delivery through the blood-brain barrier
inferredcites →https://doi.org/10.1016/j.cbpa.2013.03.023openalex-snapshot
Bispecific antibodies for delivery into the brain
inferredcites →https://doi.org/10.1016/j.cell.2015.10.067openalex-snapshot
Establishment and Dysfunction of the Blood-Brain Barrier
inferredcites →https://doi.org/10.1016/j.celrep.2017.11.055openalex-snapshot
Sorting Tubules Regulate Blood-Brain Barrier Transcytosis
inferredcites →https://doi.org/10.1016/j.conb.2018.12.014openalex-snapshot
Transcytosis at the blood–brain barrier
inferredcites →https://doi.org/10.1016/j.jim.2017.07.009openalex-snapshot
Long-term direct visualization of passively transferred fluorophore-conjugated antibodies
inferredcites →https://doi.org/10.1016/j.tips.2018.07.007openalex-snapshot
Targeting FcRn to Generate Antibody-Based Therapeutics
inferredcites →https://doi.org/10.1016/s0022-3565(25)20384-6openalex-snapshot
Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate.
inferredcites →https://doi.org/10.1021/acs.molpharmaceut.5b00472openalex-snapshot
Impact of C4′- O -Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates
inferredcites →https://doi.org/10.1021/acs.molpharmaceut.6b00818openalex-snapshot
Minimum Transendothelial Electrical Resistance Thresholds for the Study of Small and Large Molecule Drug Transport in a Human in Vitro Blood–Brain Barrier Model
inferredcites →https://doi.org/10.1021/acs.molpharmaceut.6b01091openalex-snapshot
Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance
inferredcites →https://doi.org/10.1021/acs.molpharmaceut.8b00662openalex-snapshot
Efflux Pump Substrates Shuttled to Cytosolic or Vesicular Compartments Exhibit Different Permeability in a Quantitative Human Blood–Brain Barrier Model
inferredcites →https://doi.org/10.1021/acsami.9b09395openalex-snapshot
Carboxylated Cy5-Labeled Comb Polymers Passively Diffuse the Cell Membrane and Target Mitochondria
inferredcites →https://doi.org/10.1038/s41467-018-03061-xopenalex-snapshot
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
inferredcites →https://doi.org/10.1038/s41598-020-60438-zopenalex-snapshot
Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn
inferredcites →https://doi.org/10.1039/c9bm00957dopenalex-snapshot
Polymer design and component selection contribute to uptake, distribution & trafficking behaviours of polyethylene glycol hyperbranched polymers in live MDA-MB-468 breast cancer cells
inferredcites →https://doi.org/10.1073/pnas.1322356111openalex-snapshot
Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae
inferredcites →https://doi.org/10.1073/pnas.1802155115openalex-snapshot
Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier
inferredcites →https://doi.org/10.1080/19420862.2015.1016696openalex-snapshot
Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics
inferredcites →https://doi.org/10.1080/19420862.2015.1075109openalex-snapshot
The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies
inferredcites →https://doi.org/10.1080/19420862.2016.1208330openalex-snapshot
Target-independent variable region mediated effects on antibody clearance can be FcRn independent
inferredcites →https://doi.org/10.1093/intimm/13.12.1551openalex-snapshot
Differences in promiscuity for antibody–FcRn interactions across species: implications for therapeutic antibodies
inferredcites →https://doi.org/10.1093/intimm/dxg018openalex-snapshot
Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans
inferredcites →https://doi.org/10.1111/jnc.14482openalex-snapshot
Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood–brain barrier in vitro is dependent on its binding affinity
inferredcites →https://doi.org/10.1177/0271678x17740031openalex-snapshot
Endosomal trafficking regulates receptor-mediated transcytosis of antibodies across the blood brain barrier
inferredcites →https://doi.org/10.1186/s12967-016-1115-2openalex-snapshot
Near infrared fluorescent imaging of brain tumor with IR780 dye incorporated phospholipid nanoparticles
inferredcites →https://doi.org/10.1208/s12248-008-9055-2openalex-snapshot
CNS Delivery Via Adsorptive Transcytosis
inferredcites →https://doi.org/10.3389/fphar.2019.00510openalex-snapshot
Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4115859openalex-extracted
Brain Resident Memory T Cells Rapidly Expand and Initiate Neuroinflammatory Responses Following CNS Injury and Viral Infection
inferred← citeshttps://doi.org/10.1007/978-3-031-62604-3_2openalex-snapshot
Mechanisms and Methods for Evaluating Drug Delivery via Transcytosis to the Brain
inferred← citeshttps://doi.org/10.1016/j.addr.2022.114536openalex-snapshot
Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107308openalex-snapshot
Brain gliomas: Diagnostic and therapeutic issues and the prospects of drug-targeted nano-delivery technology
inferred← citeshttps://doi.org/10.1021/acs.analchem.6c00331openalex-snapshot
Molecular Behavior of Antibodies IgG-1 and IgG-4 at Buried Polymer/Solution Interfaces Probed by Sum Frequency Generation Vibrational Spectroscopy
inferred← citeshttps://doi.org/10.7717/peerj.15571openalex-snapshot
Functionalized nanoparticles crossing the brain–blood barrier to target glioma cells
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