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Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette–Guérin (BCG) via Synergistic Activation of Innate Immune Receptors

https://doi.org/10.1021/acs.molpharmaceut.7b00795
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Outgoing claims: the papers this work cites, builds on, or argues with.

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CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses
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Layer-by-layer nanocoating of live Bacille-Calmette-Guérin mycobacteria with poly(I:C) and chitosan enhances pro-inflammatory activation and bactericidal capacity in murine macrophages
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Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type I responses
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Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection
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Chitosan-based biomaterials for tissue engineering
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Poly(I:C) coated PLGA microparticles induce dendritic cell maturation
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Triggering Intracellular Receptors for Vaccine Adjuvantation
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Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro
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Chitosan-based siRNA delivery systems
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Toll-like receptor pathways in the immune responses to mycobacteria
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TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells
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TLR-based immune adjuvants
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Schistosomiasis vaccine candidate Sm14/GLA-SE: Phase 1 safety and immunogenicity clinical trial in healthy, male adults
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inferredcites →https://doi.org/10.1016/s0168-3659(01)00412-6openalex-snapshot
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inferredcites →https://doi.org/10.1016/s0168-3659(01)00549-1openalex-snapshot
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inferredcites →https://doi.org/10.1021/bm4000713openalex-snapshot
Ionization Behavior of Chitosan and Chitosan–DNA Polyplexes Indicate That Chitosan Has a Similar Capability to Induce a Proton-Sponge Effect as PEI
inferredcites →https://doi.org/10.1021/la001754uopenalex-snapshot
Chitosan-Induced Perturbation of Dipalmitoyl-sn-glycero-3-phosphocholine Membrane Bilayer
inferredcites →https://doi.org/10.1021/mp200553xopenalex-snapshot
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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
inferredcites →https://doi.org/10.1038/ni.1990openalex-snapshot
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
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'TaiLoRing' the response of dendritic cells to pathogens
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Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
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inferredcites →https://doi.org/10.1078/1438-4221-00157openalex-snapshot
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Sizing of protein A-colloidal gold probes for immunoelectron microscopy.
inferredcites →https://doi.org/10.1084/jem.20041964openalex-snapshot
A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
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Degradation of Poly(inosinic acid) · poly(cytidylic acid) [(I)n· (Cn)] by Human Plasma
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Necessity and sufficiency of beta interferon for nitric oxide production in mouse peritoneal macrophages
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inferredcites →https://doi.org/10.1128/microbiolspec.mgm2-0005-2013openalex-snapshot
Evasion of Innate and Adaptive Immunity by Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1155/2010/690438openalex-snapshot
Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant
inferredcites →https://doi.org/10.1155/2011/405310openalex-snapshot
Innate Immune Recognition ofMycobacterium tuberculosis
inferredcites →https://doi.org/10.1159/000364945openalex-snapshot
M1 and M2 Macrophages: The Chicken and the Egg of Immunity
inferredcites →https://doi.org/10.1172/jci39293openalex-snapshot
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inferredcites →https://doi.org/10.1177/1753425912450346openalex-snapshot
Delivery system for the enhanced efficiency of immunostimulatory nucleic acids
inferredcites →https://doi.org/10.1189/jlb.0103026openalex-snapshot
TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG
inferredcites →https://doi.org/10.1242/jcs.121814openalex-snapshot
Polylactide-co-glycolide-rifampicin-nanoparticles efficiently clearMycobacterium bovisBCG infection in macrophages and remain membrane-bound in phago-lysosomes
inferredcites →https://doi.org/10.1371/journal.pone.0146372openalex-snapshot
The TLR4 Agonist Vaccine Adjuvant, GLA-SE, Requires Canonical and Atypical Mechanisms of Action for TH1 Induction
inferredcites →https://doi.org/10.1586/14760584.2013.811185openalex-snapshot
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inferredcites →https://doi.org/10.1586/14760584.2015.966085openalex-snapshot
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inferredcites →https://doi.org/10.3109/08830185.2014.921164openalex-snapshot
TLR Cross-talk Confers Specificity to Innate Immunity
inferredcites →https://doi.org/10.3181/00379727-133-34492openalex-snapshot
Inhibition of Biologic Activity of Poly I: Poly C by Human Plasma
inferredcites →https://doi.org/10.3389/fcimb.2012.00145openalex-snapshot
Mycobacterial signaling through toll-like receptors
inferredcites →https://doi.org/10.3389/fcimb.2013.00013openalex-snapshot
Vaccine delivery using nanoparticles
inferredcites →https://doi.org/10.3389/fimmu.2014.00491openalex-snapshot
Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
inferredcites →https://doi.org/10.3390/vaccines3030730openalex-snapshot
Chitosan-Poly (I:C)-PADRE Based Nanoparticles as Delivery Vehicles for Synthetic Peptide Vaccines
inferredcites →https://doi.org/10.3390/vaccines5010006openalex-snapshot
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inferredcites →https://doi.org/10.4049/jimmunol.172.6.3491openalex-snapshot
Prolonged Antigen Presentation, APC-, and CD8+ T Cell Turnover during Mycobacterial Infection: Comparison with Listeria monocytogenes
inferredcites →https://doi.org/10.4049/jimmunol.172.7.4425openalex-snapshot
Toll-Like Receptor 2 (TLR2)-Dependent-Positive and TLR2-Independent-Negative Regulation of Proinflammatory Cytokines by Mycobacterial Lipomannans
inferredcites →https://doi.org/10.4049/jimmunol.176.7.4337openalex-snapshot
Distinct Roles of TLR2 and the Adaptor ASC in IL-1β/IL-18 Secretion in Response to Listeria monocytogenes
inferredcites →https://doi.org/10.4049/jimmunol.178.2.1164openalex-snapshot
MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists
inferredcites →https://doi.org/10.4049/jimmunol.179.1.211openalex-snapshot
A Reduced Antigen Load In Vivo, Rather Than Weak Inflammation, Causes a Substantial Delay in CD8+ T Cell Priming against Mycobacterium bovis (Bacillus Calmette-Guerin)
inferredcites →https://doi.org/10.4049/jimmunol.181.3.1849openalex-snapshot
Dual Signaling of MyD88 and TRIF Is Critical for Maximal TLR4-Induced Dendritic Cell Maturation

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