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(+/−)-Lucidumone, a COX-2 Inhibitory Caged Fungal Meroterpenoid from Ganoderma lucidum

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.201814581openalex-snapshot
Lugdunomycin, an Angucycline‐Derived Molecule with Unprecedented Chemical Architecture
inferredcites →https://doi.org/10.1016/j.ejmech.2016.11.015openalex-snapshot
A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-A y mice
inferredcites →https://doi.org/10.1021/acs.orglett.5b00448openalex-snapshot
(±)-Sinensilactam A, a Pair of Rare Hybrid Metabolites with Smad3 Phosphorylation Inhibition from Ganoderma sinensis
inferredcites →https://doi.org/10.1021/acs.orglett.5b01353openalex-snapshot
Two New Classes of T-Type Calcium Channel Inhibitors with New Chemical Scaffolds from Ganoderma cochlear
inferredcites →https://doi.org/10.1021/acs.orglett.6b00542openalex-snapshot
An approach to (±)-Lingzhiol
inferredcites →https://doi.org/10.1021/acs.orglett.8b00380openalex-snapshot
Total Synthesis of Sinensilactam A
inferredcites →https://doi.org/10.1021/acs.orglett.8b01608openalex-snapshot
Mangelonoids A and B, Two Pairs of Macrocyclic Diterpenoid Enantiomers from Croton mangelong
inferredcites →https://doi.org/10.1021/acs.orglett.8b04123openalex-snapshot
(+)- and (−)-Preuisolactone A: A Pair of Caged Norsesquiterpenoidal Enantiomers with a Tricyclo[4.4.01,6.02,8]decane Carbon Skeleton from the Endophytic Fungus Preussia isomera
inferredcites →https://doi.org/10.1021/acs.orglett.9b00108openalex-snapshot
Isolation, Structure Elucidation, and Total Synthesis of Myrtuspirone A from Myrtus communis
inferredcites →https://doi.org/10.1021/acs.orglett.9b00312openalex-snapshot
(±)-Xylaridines A and B, Highly Conjugated Alkaloids from the Fungus Xylaria longipes
inferredcites →https://doi.org/10.1021/acs.orglett.9b01440openalex-snapshot
Meroindenon and Merochlorins E and F, Antibacterial Meroterpenoids from a Marine-Derived Sediment Bacterium of the Genus Streptomyces
inferredcites →https://doi.org/10.1021/acs.orglett.9b01901openalex-snapshot
Total Synthesis of Applanatumol B
inferredcites →https://doi.org/10.1021/ja305665fopenalex-snapshot
Merochlorins A–D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases
inferredcites →https://doi.org/10.1021/ol4026364openalex-snapshot
Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum
inferredcites →https://doi.org/10.1038/ncomms13083openalex-snapshot
Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
inferredcites →https://doi.org/10.1038/ncomms6707openalex-snapshot
Asymmetric total synthesis of (−)-lingzhiol via a Rh-catalysed [3+2] cycloaddition
inferredcites →https://doi.org/10.1038/nrd.2016.39openalex-snapshot
Resolution of inflammation: a new therapeutic frontier
inferredcites →https://doi.org/10.1038/nrd.2018.97openalex-snapshot
Targeting the NLRP3 inflammasome in inflammatory diseases
inferredcites →https://doi.org/10.1038/nrd1034openalex-snapshot
The development of COX2 inhibitors
inferredcites →https://doi.org/10.1039/b820413fopenalex-snapshot
Meroterpenoids produced by fungi
inferredcites →https://doi.org/10.1039/c5np00090dopenalex-snapshot
Biosynthesis of fungal meroterpenoids
inferredcites →https://doi.org/10.1039/c8ob00615fopenalex-snapshot
A concise total synthesis of cochlearoid B
inferredcites →https://doi.org/10.1074/jbc.m116.725713openalex-snapshot
Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone
inferredcites →https://doi.org/10.1136/bmj.329.7471.867openalex-snapshot
Lessons from the withdrawal of rofecoxib: ***
inferredcites →https://doi.org/10.1194/jlr.r800042-jlr200openalex-snapshot
Cyclooxygenases: structural and functional insights

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2021.112970zenodo-depositor-declared
Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity
inferred← citeshttps://doi.org/10.1002/ajoc.202300633openalex-snapshot
Total Synthesis of Ganoderma Meroterpenoids – Progresses since 2014
inferred← citeshttps://doi.org/10.1002/ajoc.202500116openalex-snapshot
Recent Developments in Prins Cyclization Toward the Synthesis of Spirocyclic Scaffolds
inferred← citeshttps://doi.org/10.1002/ange.202304132openalex-snapshot
Total Synthesis of Lucidumone through Convenient One‐pot Preparation of the Tetracyclic Skeleton by Claisen Rearrangement and Subsequent Intramolecular Aldol Reaction
inferred← citeshttps://doi.org/10.1002/anie.202304132openalex-snapshot
Total Synthesis of Lucidumone through Convenient One‐pot Preparation of the Tetracyclic Skeleton by Claisen Rearrangement and Subsequent Intramolecular Aldol Reaction
inferred← citeshttps://doi.org/10.1002/cjoc.202300231openalex-snapshot
Meroterpenoids Possessing Diverse Rearranged Skeletons with Anti‐inflammatory Activity from the Mangrove‐Derived Fungus Penicillium sp. HLLG ‐122
inferred← citeshttps://doi.org/10.1002/ejoc.70395openalex-snapshot
Recent Approaches for the Synthesis of Lucidumone
inferred← citeshttps://doi.org/10.1002/med.22006openalex-snapshot
Insights into Ganoderma fungi meroterpenoids opening a new era of racemic natural products in mushrooms
inferred← citeshttps://doi.org/10.1007/978-3-032-09901-3_1openalex-snapshot
The Diels–Alder Reaction as a Key Step in Natural Product Synthesis
inferred← citeshttps://doi.org/10.1007/978-981-99-5696-8_13openalex-snapshot
Fungal Enzyme Inhibitors: Potent Repository of Lead Compounds to Curb Cancer
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.104774openalex-snapshot
Lucidumones B-H, racemic meroterpenoids that inhibit tumor cell migration from Ganoderma lucidum
inferred← citeshttps://doi.org/10.1016/j.chmed.2025.03.003openalex-snapshot
From natural laboratory to drug discovery: Chemical structures, bioactivities, and biosynthesis of meroterpenoids from Ganoderma species
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112860openalex-snapshot
Meroterpenoids produced by fungi: Occurrence, structural diversity, biological activities, and their molecular targets
inferred← citeshttps://doi.org/10.1016/j.fitote.2022.105390openalex-snapshot
COX-2 and iNOS inhibitory epimeric meroterpenoids from Ganoderma cochlear and structure revision of cochlearol Q
inferred← citeshttps://doi.org/10.1016/j.phytol.2025.104072openalex-snapshot
New 6/6/6/6 tetracyclic Rhododendron chromane meroterpenoids from flowers of Rhododendron rubiginosum Franch. var. rubiginosum with COX-2 inhibitory activity
inferred← citeshttps://doi.org/10.1016/j.tet.2025.135101openalex-snapshot
Diels-Alder reaction: A versatile synthetic tool for the synthesis of terpenoids and alkaloids: A review
inferred← citeshttps://doi.org/10.1016/j.tetlet.2020.152715openalex-snapshot
(±)-Pabmaragramin, a scalemic meroterpenoid produced by Marasmius graminum via precursor-assisted biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.joc.0c00842openalex-snapshot
Meroapplanins A–E: Five Meroterpenoids with a 2,3,4,5-Tetrahydropyridine Motif from Ganoderma applanatum
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c00452openalex-snapshot
Ganoderma cochlear Metabolites as Probes to Identify a COX-2 Active Site and as in Vitro and in Vivo Anti-Inflammatory Agents
inferred← citeshttps://doi.org/10.1021/acs.orglett.2c02023openalex-snapshot
Construction of the Skeleton of Lucidumone
inferred← citeshttps://doi.org/10.1021/acs.orglett.4c00411openalex-snapshot
Asymmetric Total Synthesis of (+)-Chuanxiongnolide L1 via a Stereoselective Oxidative Dearomatization/Diels–Alder Strategy
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c03142openalex-snapshot
Chizhiaroterpenoids A–C: Benzofused Rearranged Lanostane-Type Triterpenoids from Ganoderma lucidum
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c03633openalex-snapshot
Enantioselective Total Synthesis of (+)-Lucidumone via Organocatalytic Double Michael Addition
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b04666openalex-snapshot
Revision of the Structure of Hypatulone A by NMR, Computations, and Biosynthetic Considerations
inferred← citeshttps://doi.org/10.1021/jacs.0c06179openalex-snapshot
Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones
inferred← citeshttps://doi.org/10.1021/jacs.0c06306openalex-snapshot
Bisketene Equivalents as Diels–Alder Dienes
inferred← citeshttps://doi.org/10.1021/jacs.2c08760openalex-snapshot
Gram-Scale Enantioselective Synthesis of (+)-Lucidumone
inferred← citeshttps://doi.org/10.1038/s41467-024-46896-3openalex-snapshot
Enantioselective total synthesis of (‒)-lucidumone enabled by tandem prins cyclization/cycloetherification sequence
inferred← citeshttps://doi.org/10.1038/s41467-024-54117-0openalex-snapshot
Photoinduced formal [4 + 2] cycloaddition of two electron-deficient olefins and its application to the synthesis of lucidumone
inferred← citeshttps://doi.org/10.1039/c9np90045dopenalex-snapshot
Hot off the Press
inferred← citeshttps://doi.org/10.1039/d0ob02162hopenalex-snapshot
The chemistry and biology of fungal meroterpenoids (2009–2019)
inferred← citeshttps://doi.org/10.1039/d0ra05532hopenalex-snapshot
Fused multicyclic polyketides with a two-spiro-carbon skeleton from mangrove-derived endophytic fungus Epicoccum nigrum SCNU-F0002
inferred← citeshttps://doi.org/10.1039/d1qo00294eopenalex-snapshot
Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2
inferred← citeshttps://doi.org/10.1039/d3np00006kopenalex-snapshot
Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids
inferred← citeshttps://doi.org/10.1039/d4sc06010eopenalex-snapshot
Biosynthesis of a bacterial meroterpenoid reveals a non-canonical class II meroterpenoid cyclase
inferred← citeshttps://doi.org/10.1039/d5ra09257dopenalex-snapshot
Total synthesis of natural products facilitated by prins reaction: a review
inferred← citeshttps://doi.org/10.1055/s-0042-1751412openalex-snapshot
Retro-[4+2]/Intramolecular Diels–Alder Cascade Allows a Concise Total Synthesis of Lucidumone
inferred← citeshttps://doi.org/10.1055/s-0042-1751529openalex-snapshot
Total Synthesis of Lucidumone: Attempted Shortcuts, Dead Ends and Lessons Learnt
inferred← citeshttps://doi.org/10.1080/10286020.2020.1844675openalex-snapshot
Survey of natural products reported by Asian research groups in 2019
inferred← citeshttps://doi.org/10.1142/s0192415x23500878openalex-snapshot
A Comprehensive Review on the Chemical Composition, Pharmacology and Clinical Applications of Ganoderma
inferred← citeshttps://doi.org/10.3389/fchem.2021.772740openalex-snapshot
Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.3390/molecules27041279openalex-snapshot
Natural Enantiomers: Occurrence, Biogenesis and Biological Properties
inferred← citeshttps://doi.org/10.3390/molecules27072346openalex-snapshot
Computational Analysis and Biological Activities of Oxyresveratrol Analogues, the Putative Cyclooxygenase-2 Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules28124668openalex-snapshot
Design, Synthesis, and Evaluation of the COX-2 Inhibitory Activities of New 1,3-Dihydro-2H-indolin-2-one Derivatives
inferred← citeshttps://doi.org/10.3390/ph15121520openalex-snapshot
Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom Ganoderma australe
inferred← citeshttps://doi.org/10.3724/abbs.2026162openalex-snapshot
Wogonin combined with cinnamaldehyde synergistically induces ferroptosis by increasing PTGS2 in breast cancer
inferred← citeshttps://doi.org/10.5059/yukigoseikyokaishi.82.348openalex-snapshot
Collective Synthesis of Meroterpenoids Derived from Ganoderma Family
inferred← citeshttps://doi.org/10.59761/rcr5237openalex-snapshot
Stereoselective reactions of nitro compounds in the synthesis of natural compound analogs and active pharmaceutical ingredients: recent advances
inferred← citeshttps://doi.org/10.6023/a25040131openalex-snapshot
Total Synthesis of Complex Natural Products Via Radical-Mediated Formal Diels-Alder Reaction
inferred← citeshttps://doi.org/10.6023/cjoc202409039openalex-snapshot
Advances in the Total Synthesis of Ganoderma Meroterpenoids
inferred← citeshttps://doi.org/10.6023/cjoc202509001openalex-snapshot
Study on Dearomatization [4+2] Reactions of Allene Substrates
inferred← citeshttps://doi.org/10.70675/7a39ae48z55f0z4d97z82c6z274c76ec1d02openalex-snapshot
Asymmetric inverse-electron-demand Diels-Alder cycloaddition between 2-pyrones and acyclic enol ethers : gram-scale total synthesis of (+)-lucidumone
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