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Spatially Defined Drug Targeting by in Situ Host–Guest Chemistry in a Living Animal

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.198800891openalex-snapshot
Supramolecular Chemistry—Scope and Perspectives Molecules, Supermolecules, and Molecular Devices (Nobel Lecture)
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Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper‐Free and Fast Huisgen Cycloadditions
inferredcites →https://doi.org/10.1002/anie.201309635openalex-snapshot
Cucurbit[7]uril⋅Guest Pair with an Attomolar Dissociation Constant
inferredcites →https://doi.org/10.1002/mabi.201800281openalex-snapshot
Dynamic Hydrogels from Host–Guest Supramolecular Interactions
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A Study of the Temperature-Dependent Micellization of Pluronic F127
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Polymeric anticancer drugs with pH-controlled activation
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Injectable network biomaterials via molecular or colloidal self-assembly
inferredcites →https://doi.org/10.1016/j.biomaterials.2018.05.005openalex-snapshot
Replenishable drug depot to combat post-resection cancer recurrence
inferredcites →https://doi.org/10.1016/j.biomaterials.2018.06.021openalex-snapshot
Pretargeting in nuclear imaging and radionuclide therapy: Improving efficacy of theranostics and nanomedicines
inferredcites →https://doi.org/10.1016/j.cbpa.2009.09.029openalex-snapshot
Near-infrared fluorescence: application to in vivo molecular imaging
inferredcites →https://doi.org/10.1016/j.jconrel.2010.08.027openalex-snapshot
To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
inferredcites →https://doi.org/10.1016/j.smim.2007.11.004openalex-snapshot
Foreign body reaction to biomaterials
inferredcites →https://doi.org/10.1016/s0927-7765(99)00061-2openalex-snapshot
Solubilization of hydrocarbons and resulting aggregate shape transitions in aqueous solutions of Pluronic® (PEO–PPO–PEO) block copolymers
inferredcites →https://doi.org/10.1016/s0939-6411(03)00095-xopenalex-snapshot
A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel
inferredcites →https://doi.org/10.1021/acs.chemrev.6b00577openalex-snapshot
Correction to Cucurbituril-Based Molecular Recognition
inferredcites →https://doi.org/10.1021/acs.chemrev.7b00183openalex-snapshot
The Hitchhiker’s Guide to Flow Chemistry
inferredcites →https://doi.org/10.1021/acsami.8b22151openalex-snapshot
Dynamic Supramolecular Hydrogels Spanning an Unprecedented Range of Host–Guest Affinity
inferredcites →https://doi.org/10.1021/acscentsci.6b00150openalex-snapshot
In Vivo Bioorthogonal Chemistry Enables Local Hydrogel and Systemic Pro-Drug To Treat Soft Tissue Sarcoma
inferredcites →https://doi.org/10.1021/acscentsci.8b00344openalex-snapshot
Bio-Orthogonal Chemistry and Reloadable Biomaterial Enable Local Activation of Antibiotic Prodrugs and Enhance Treatments against Staphylococcus aureus Infections
inferredcites →https://doi.org/10.1021/acsnano.8b03900openalex-snapshot
Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors
inferredcites →https://doi.org/10.1021/bc00020a001openalex-snapshot
Cyanine dye labeling reagents: Sulfoindocyanine succinimidyl esters
inferredcites →https://doi.org/10.1021/bc200490ropenalex-snapshot
Specific Pathogen Detection Using Bioorthogonal Chemistry and Diagnostic Magnetic Resonance
inferredcites →https://doi.org/10.1021/bc9002019openalex-snapshot
Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies
inferredcites →https://doi.org/10.1021/ja01856a061openalex-snapshot
Molecular Size Distribution in Three Dimensional Polymers. I. Gelation 1
inferredcites →https://doi.org/10.1021/ja201844copenalex-snapshot
Design and Synthesis of Highly Reactive Dienophiles for the Tetrazine– trans- Cyclooctene Ligation
inferredcites →https://doi.org/10.1021/ja209266xopenalex-snapshot
Guest Binding Dynamics with Cucurbit[7]uril in the Presence of Cations
inferredcites →https://doi.org/10.1021/ja3058502openalex-snapshot
Synthesis and Self-Assembly Processes of Monofunctionalized Cucurbit[7]uril
inferredcites →https://doi.org/10.1021/ja993376popenalex-snapshot
New Cucurbituril Homologues: Syntheses, Isolation, Characterization, and X-ray Crystal Structures of Cucurbit[ n ]uril ( n = 5, 7, and 8)
inferredcites →https://doi.org/10.1021/la701221fopenalex-snapshot
1 H NMR Spectroscopic Investigations on the Micellization and Gelation of PEO−PPO−PEO Block Copolymers in Aqueous Solutions
inferredcites →https://doi.org/10.1021/ma00046a049openalex-snapshot
Self-assembly in aqueous block copolymer solutions
inferredcites →https://doi.org/10.1021/ma00087a009openalex-snapshot
Micellization of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymers in Aqueous Solutions: Thermodynamics of Copolymer Association
inferredcites →https://doi.org/10.1021/ma00093a016openalex-snapshot
Phase Diagrams and Aggregation Behavior of Poly(oxyethylene)-Poly(oxypropylene)-Poly(oxyethylene) Triblock Copolymers in Aqueous Solutions
inferredcites →https://doi.org/10.1038/nbt832openalex-snapshot
Development of potent monoclonal antibody auristatin conjugates for cancer therapy
inferredcites →https://doi.org/10.1038/nchembio.1199openalex-snapshot
Target identification and mechanism of action in chemical biology and drug discovery
inferredcites →https://doi.org/10.1038/nmat4474openalex-snapshot
Supramolecular biomaterials
inferredcites →https://doi.org/10.1038/nrc1691openalex-snapshot
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
inferredcites →https://doi.org/10.1038/nrc903openalex-snapshot
Ligand-targeted therapeutics in anticancer therapy
inferredcites →https://doi.org/10.1038/nrd1957openalex-snapshot
Antibody targeted drugs as cancer therapeutics
inferredcites →https://doi.org/10.1038/nrd2468openalex-snapshot
Prodrugs: design and clinical applications
inferredcites →https://doi.org/10.1038/nri2747openalex-snapshot
Strategies and challenges for the next generation of therapeutic antibodies
inferredcites →https://doi.org/10.1039/b925555aopenalex-snapshot
Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study
inferredcites →https://doi.org/10.1039/c0cs00153hopenalex-snapshot
Cyclodextrin-based inclusion complexation bridging supramolecular chemistry and macromolecular self-assembly
inferredcites →https://doi.org/10.1039/c6cc03193eopenalex-snapshot
Predictive recognition of native proteins by cucurbit[7]uril in a complex mixture
inferredcites →https://doi.org/10.1039/c7cs00011aopenalex-snapshot
Synthetic mimics of biotin/(strept)avidin
inferredcites →https://doi.org/10.1039/c7cs00391aopenalex-snapshot
Drug delivery by supramolecular design
inferredcites →https://doi.org/10.1073/pnas.0911116107openalex-snapshot
Copper-free click chemistry in living animals
inferredcites →https://doi.org/10.1093/jnci/djn240openalex-snapshot
Antitumor Effects of Doxorubicin Followed by Zoledronic Acid in a Mouse Model of Breast Cancer
inferredcites →https://doi.org/10.1097/00006123-199512000-00013openalex-snapshot
Intratumoral Chemotherapy
inferredcites →https://doi.org/10.1126/science.1095833openalex-snapshot
Drug Delivery Systems: Entering the Mainstream
inferredcites →https://doi.org/10.1126/science.279.5349.377openalex-snapshot
Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
inferredcites →https://doi.org/10.1126/science.284.5418.1318openalex-snapshot
Bacterial Biofilms: A Common Cause of Persistent Infections
inferredcites →https://doi.org/10.1126/science.287.5460.1964openalex-snapshot
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery
inferredcites →https://doi.org/10.1201/b12801openalex-snapshot
Drug Delivery and Targeting
inferredcites →https://doi.org/10.1208/s12248-015-9738-4openalex-snapshot
Antibody Drug Conjugates: Preclinical Considerations
inferredcites →https://doi.org/10.1517/13543784.16.6.855openalex-snapshot
DOXO-EMCH (INNO-206): the first albumin-binding prodrug of doxorubicin to enter clinical trials
inferredcites →https://doi.org/10.1517/17425247.3.3.311openalex-snapshot
Nanoparticle–aptamer bioconjugates for cancer targeting

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Trehalose‐Guanosine Glycopolymer Hydrogels Direct Adaptive Glia Responses in CNS Injury
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Double‐Cavity Nor‐Seco‐Cucurbit[10]uril Enables Efficient and Rapid Separation of Pyridine from Mixtures of Toluene, Benzene, and Pyridine
inferred← citeshttps://doi.org/10.1002/anie.202216537openalex-snapshot
Transient and Dissipative Host–Guest Hydrogels Regulated by Consumption of a Reactive Chemical Fuel
inferred← citeshttps://doi.org/10.1002/anie.202500916openalex-snapshot
Ultrahigh‐Affinity Molecular Recognition in Water and Biomedical Applications
inferred← citeshttps://doi.org/10.1002/anie.202515594openalex-snapshot
A Noncovalent Click‐to‐Release Strategy to Control Bond Cleavage and Prodrug Activation
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Direct Cross‐Linking of Cucurbit[7]uril Pseudopolyrotaxanes to Prepare Slide‐Ring Hydrogels
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Recent Advances in Host‐Guest Supramolecular Hydrogels for Biomedical Applications
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Practical Applications of Supramolecular Macrocyclic Hosts in the Field of Herbal Medicines
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High‐Affinity Host–Guest Recognition for Efficient Assembly and Enzymatic Responsiveness of DNA Nanostructures
inferred← citeshttps://doi.org/10.1002/smll.202407702openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.actbio.2020.05.033openalex-snapshot
Click cross-linking improves retention and targeting of refillable alginate depots
inferred← citeshttps://doi.org/10.1016/j.actbio.2021.10.046openalex-snapshot
Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture
inferred← citeshttps://doi.org/10.1016/j.actbio.2022.08.077openalex-snapshot
Biomaterial-Targeted Precision Nanoparticle Delivery to the Injured Spinal Cord
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inferred← citeshttps://doi.org/10.1016/j.nantod.2025.102969openalex-snapshot
Biomimetic nanomaterial-based strategies for spinal cord injury repair
inferred← citeshttps://doi.org/10.1016/j.preme.2025.100035openalex-snapshot
Host–guest Architectures: Advancing pretargeting strategies for precision theranostics
inferred← citeshttps://doi.org/10.1016/j.progpolymsci.2023.101769openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.seppur.2022.122342openalex-snapshot
Selective gradient separation of aminophenol isomers by cucurbit[6]uril
inferred← citeshttps://doi.org/10.1016/j.talanta.2024.126386openalex-snapshot
Riboflavin-induced photo-ATRP electrochemical strategy for detection of biomarker trypsin
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00453openalex-snapshot
In Vivo Targeting Using Arylboronate/Nopoldiol Click Conjugation
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00326openalex-snapshot
Supramolecular “Click Chemistry” for Targeting in the Body
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.2c00242openalex-snapshot
Multivalent Cucurbituril Dendrons for Cell Membrane Engineering with Supramolecular Receptors
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inferred← citeshttps://doi.org/10.1021/acs.biomac.0c00950openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.biomac.1c00648openalex-snapshot
Affinity-Directed Dynamics of Host–Guest Motifs for Pharmacokinetic Modulation via Supramolecular PEGylation
inferred← citeshttps://doi.org/10.1021/acs.biomac.9b01267openalex-snapshot
Temperature-Responsive Supramolecular Hydrogels by Ternary Complex Formation with Subsequent Photo-Cross-linking to Alter Network Dynamics
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inferred← citeshttps://doi.org/10.1021/acs.joc.0c00237openalex-snapshot
Stimuli-Responsive Supramolecular Coaggregation and Disaggregation of Host–Guest Conjugates Having a Disulfide Linkage
inferred← citeshttps://doi.org/10.1021/acs.joc.0c01201openalex-snapshot
Kinetics and Thermodynamics of Binding between Zwitterionic Viologen Guests and the Cucurbit[7]uril Host
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Nonlinear Dependence on Na+ Ions for the Binding Dynamics of Cucurbit[6]uril with the trans-1-Methyl-4-(4-hydroxystyryl)pyridinium Cation
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Slide-Ring Hydrogel Networks via Host–Guest Complexation with Cucurbit[8]uril
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Cucurbituril-Oriented Nanoplatforms in Biomedical Applications
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Macromolecular Solute Transport in Supramolecular Hydrogels Spanning Dynamic to Quasi-Static States
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Enhancing Photothermal Therapy Efficacy by In Situ Self-Assembly in Glioma
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inferred← citeshttps://doi.org/10.1021/acsami.9b16283openalex-snapshot
Bio-orthogonal Supramolecular Latching inside Live Animals and Its Application for in Vivo Cancer Imaging
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.2c00979openalex-snapshot
Glucose-Responsive Injectable Thermogels via Dynamic-Covalent Cross-Linking of Pluronic Micelles
inferred← citeshttps://doi.org/10.1021/acscentsci.4c01080openalex-snapshot
Supramolecular Guest Exchange in Cucurbit[7]uril for Bioorthogonal Fluorogenic Imaging across the Visible Spectrum
inferred← citeshttps://doi.org/10.1021/acsinfecdis.2c00457openalex-snapshot
Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance Leishmania infantum Clinical Isolates
inferred← citeshttps://doi.org/10.1021/acsnano.3c06601openalex-snapshot
Supramolecular Click Chemistry for Surface Modification of Quantum Dots Mediated by Cucurbit[7]uril
inferred← citeshttps://doi.org/10.1021/jacs.2c06026openalex-snapshot
Chemical Mechanism-Dominated and Reporter-Tunable Surface-Enhanced Raman Scattering via Directional Supramolecular Assembly
inferred← citeshttps://doi.org/10.1021/jacs.4c04262openalex-snapshot
Reversible Control of Gene Expression by Guest-Modified Adenosines in a Cell-Free System via Host–Guest Interaction
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Tunable Adhesion from Stoichiometry-Controlled and Sequence-Defined Supramolecular Polymers Emerges Hierarchically from Cyanostar-Stabilized Anion–Anion Linkages
inferred← citeshttps://doi.org/10.1021/jacsau.3c00273openalex-snapshot
Challenges and Opportunities of Functionalized Cucurbiturils for Biomedical Applications
inferred← citeshttps://doi.org/10.1038/s43586-026-00495-2openalex-snapshot
Cucurbit[n]uril-type molecular containers
inferred← citeshttps://doi.org/10.1039/9781837070725-00134openalex-snapshot
Macrocycle-based supramolecular encapsulation of metallocenes
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Reversible hydrogel dynamics by physical–chemical crosslink photoswitching using a supramolecular macrocycle template
inferred← citeshttps://doi.org/10.1039/c9cc07153aopenalex-snapshot
Dynamic host–guest interaction enables autonomous single molecule blinking and super-resolution imaging
inferred← citeshttps://doi.org/10.1039/c9me00088gopenalex-snapshot
Single-molecule nanoscale drug carriers with quantitative supramolecular loading
inferred← citeshttps://doi.org/10.1039/c9nj05336kopenalex-snapshot
Triptycene walled glycoluril trimer: synthesis and recognition properties
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inferred← citeshttps://doi.org/10.1039/d0sc06860hopenalex-snapshot
Multiplexed optical barcoding of cells via photochemical programming of bioorthogonal host–guest recognition
inferred← citeshttps://doi.org/10.1039/d0tb01814gopenalex-snapshot
Temperature-responsive supramolecular hydrogels
inferred← citeshttps://doi.org/10.1039/d2py00243dopenalex-snapshot
Supramolecular topological hydrogels: from material design to applications
inferred← citeshttps://doi.org/10.1039/d2qi00147kopenalex-snapshot
A bioorthogonal assembly based on metallophilic interactions for selective imaging and PDT treatment of cancer cells
inferred← citeshttps://doi.org/10.1039/d3md00596hopenalex-snapshot
Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[ n ]uril assemblies for medical applications
inferred← citeshttps://doi.org/10.1039/d4qi01102copenalex-snapshot
Supramolecular delivery of dinuclear ruthenium and osmium MCU inhibitors
inferred← citeshttps://doi.org/10.1039/d4sc00204kopenalex-snapshot
Regulation of microtubule dynamics and function in living cells via cucurbit[7]uril host–guest assembly
inferred← citeshttps://doi.org/10.1039/d5cc01980jopenalex-snapshot
Macrocycle/ferrocene complexation-mediated smart supramolecular gel materials and their applications
inferred← citeshttps://doi.org/10.1039/d6ob01088aopenalex-snapshot
A tetrachloroanthracene-walled glycoluril trimer: solvent-dependent conformational switching and host–guest binding
inferred← citeshttps://doi.org/10.1093/chemle/upaf029openalex-snapshot
Branching and guanidinylation of side chains of cyclophanes bearing fluorescent pyrene as a water-soluble host
inferred← citeshttps://doi.org/10.1101/2023.04.24.538015openalex-snapshot
Supramolecular ‘catch-and-release’ strategy for bioorthogonal fluorogenic imaging across the visible spectrum
inferred← citeshttps://doi.org/10.1142/s108842462350058xopenalex-snapshot
Identification of mitochondrial proteins associated with cyanine 5 using a combination of affinity-based photocrosslinking with bio-orthogonal supramolecular latching
inferred← citeshttps://doi.org/10.1186/s12951-024-03024-zopenalex-snapshot
Supramolecular nanotherapeutics based on cucurbiturils
inferred← citeshttps://doi.org/10.1246/cl.200135openalex-snapshot
Guest Capture and Separation by Temperature Responsive Cyclophane-PNIPAM Conjugates
inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-kqt51openalex-snapshot
Sensitive Fluorometric Detection of Fentanyl-Class Agents by Competition-Mediated Supramolecular Displacement and Graphene Nanoparticle Quenching
inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-kqt51-v2openalex-snapshot
A Supramolecular–Quantum Dot System for Broad-Spectrum Detection of Fentanyl Analogues
inferred← citeshttps://doi.org/10.3389/fchem.2021.658548openalex-snapshot
Applications of Macrocyclic Host Molecules in Immune Modulation and Therapeutic Delivery
inferred← citeshttps://doi.org/10.3390/molecules26113097openalex-snapshot
Synthesis and Guest-Binding Properties of pH/Reduction Dual-Responsive Cyclophane Dimer
inferred← citeshttps://doi.org/10.3390/molecules27175440openalex-snapshot
Cucurbit[7]uril Complexation of Near-Infrared Fluorescent Azobenzene-Cyanine Conjugates
inferred← citeshttps://doi.org/10.3390/polym13234221openalex-snapshot
In Situ-Forming Cellulose/Albumin-Based Injectable Hydrogels for Localized Antitumor Therapy
inferred← citeshttps://doi.org/10.3762/bjoc.21.55openalex-snapshot
Acyclic cucurbit[ n ]uril bearing alkyl sulfate ionic groups
inferred← citeshttps://doi.org/10.5059/yukigoseikyokaishi.84.221openalex-snapshot
Development of Artificial Nucleic Acids for the Reversible Control of Gene Expression via Host-guest Interactions
inferred← citeshttps://doi.org/10.5812/ijpr-134282openalex-snapshot
Application of SPRA Technology for Delivery of Erythropoietin: Stability Evaluation of Conjugated Erythropoietin with Adamantane and in SPRA Inclusion Complex
inferred← citeshttps://doi.org/10.7150/thno.80857openalex-snapshot
Tumor polyamines as guest cues attract host-functionalized liposomes for targeting and hunting via a bio-orthogonal supramolecular strategy
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