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Discovery and SAR of Natural-Product-Inspired RXR Agonists with Heterodimer Selectivity to PPARδ‑RXR

https://doi.org/10.1021/acschembio.0c00146

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Identification of a Naturally Occurring Rexinoid, Honokiol, That Activates the Retinoid X Receptor

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Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators

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Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid

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Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

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PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

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Functional Evidence for Retinoid X Receptor (RXR) as a Nonsilent Partner in the Thyroid Hormone Receptor/RXR Heterodimer

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Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis

inferredcites →https://doi.org/10.1194/jlr.m046037openalex-snapshot

PPARδ activation attenuates hepatic steatosis in Ldlr mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

inferredcites →https://doi.org/10.1210/en.2005-0690openalex-snapshot

Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes

inferredcites →https://doi.org/10.1210/me.16.5.987openalex-snapshot

Molecular Recognition of Agonist Ligands by RXRs

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Isolation and Characterization of Phenolic Compounds from Magnoliae Cortex Produced in China.

inferredcites →https://doi.org/10.1517/14656566.2014.876992openalex-snapshot

New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease

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