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Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei

https://doi.org/10.1021/acschembio.5b00308
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Chivosazole A—Elucidation of the Absolute and Relative Configuration
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Genomics-inspired discovery of natural products
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Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases
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A Tylosin Ketoreductase Reveals How Chirality Is Determined in Polyketides
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Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology
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“Function-First” Lead Discovery: Mode of Action Profiling of Natural Product Libraries Using Image-Based Screening
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Human African Trypanosomiasis
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Configurational Assignment of Polyene Macrolide Antibiotics Using the [13C]Acetonide Analysis
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A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics
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Almiramides A−C: Discovery and Development of a New Class of Leishmaniasis Lead Compounds
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Synthesis of Marine-Derived 3-Alkylpyridinium Alkaloids with Potent Antiprotozoal Activity
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Antitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine Sponge Plakortis sp.
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Sceliphrolactam, a Polyene Macrocyclic Lactam from a Wasp-Associated Streptomyces sp.
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A Unique Pathway for the 3-Aminobutyrate Starter Unit from l -Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine
inferredcites →https://doi.org/10.1038/ja.2009.64openalex-snapshot
Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2
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Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392
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Identification of micromonolactam, a new polyene macrocyclic lactam from two marine Micromonospora strains using chemical and molecular methods: clarification of the biosynthetic pathway from a glutamate starter unit
inferredcites →https://doi.org/10.1038/ja.2013.76openalex-snapshot
Identification of the incednine biosynthetic gene cluster: characterization of novel β-glutamate-β-decarboxylase IdnL3
inferredcites →https://doi.org/10.1073/pnas.0700962104openalex-snapshot
Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
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antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers
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Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness
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inferredcites →https://doi.org/10.1128/aem.00744-09openalex-snapshot
Insights into the Evolution of Macrolactam Biosynthesis through Cloning and Comparative Analysis of the Biosynthetic Gene Cluster for a Novel Macrocyclic Lactam, ML-449
inferredcites →https://doi.org/10.1136/injuryprev-2011-040294openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pmed.1000030openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pntd.0001007openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.pntd.0001151openalex-snapshot
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inferredcites →https://doi.org/10.2147/dddt.s16381openalex-snapshot
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inferredcites →https://doi.org/10.3390/md11104058openalex-snapshot
Trypanocidal Activity of Marine Natural Products
inferredcites →https://doi.org/10.4056/sigs.21137openalex-snapshot
Complete genome sequence of Actinosynnema mirum type strain (101T)
inferredcites →https://doi.org/10.7164/antibiotics.36.321openalex-snapshot
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inferredcites →https://doi.org/10.7164/antibiotics.45.868openalex-snapshot
A new macrocyclic lactam antibiotic, BE-14106. I. Taxonomy, isolation, biological activity and structural elucidation.
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Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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