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Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells

https://doi.org/10.1021/acschembio.7b00339

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Cell Biology of Heme

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Multiple regulatory elements control expression of the gene encoding the Saccharomyces cerevisiae cytochrome P450, lanosterol 14 alpha-demethylase (ERG11).

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Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

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inferredcites →https://doi.org/10.1056/nejm199401273300407openalex-snapshot

Oral Azole Drugs as Systemic Antifungal Therapy

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Crystal structure of cytochrome P450 14α-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

inferredcites →https://doi.org/10.1073/pnas.1324245111openalex-snapshot

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

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Global access to antifungal therapy and its variable cost

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Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

inferredcites →https://doi.org/10.1099/0022-1317-49-11-977openalex-snapshot

In-vivo selection of an azole-resistant petite mutant of Candida glabrata

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Mechanisms of Action of the Antimycotic Imidazoles

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Hidden Killers: Human Fungal Infections

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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase

inferredcites →https://doi.org/10.1128/aac.01520-12openalex-snapshot

Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants

inferredcites →https://doi.org/10.1128/aac.01645-09openalex-snapshot

Genetic Dissection of Azole Resistance Mechanisms in Candida albicans and Their Validation in a Mouse Model of Disseminated Infection

inferredcites →https://doi.org/10.1128/aac.03470-14openalex-snapshot

Contribution of Clinically Derived Mutations in ERG11 to Azole Resistance in Candida albicans

inferredcites →https://doi.org/10.1128/aac.21.6.912openalex-snapshot

Primary site of action of ketoconazole on Candida albicans

inferredcites →https://doi.org/10.1128/aac.26.1.22openalex-snapshot

Direct membrane-damaging effect of ketoconazole and tioconazole on Candida albicans demonstrated by bioluminescent assay of ATP

inferredcites →https://doi.org/10.1128/aac.48.5.1788-1796.2004openalex-snapshot

Mechanisms of Azole Resistance in Petite Mutants of Candida glabrata

inferredcites →https://doi.org/10.1128/ec.00245-13openalex-snapshot

Distinct Roles of Candida albicans Drug Resistance Transcription Factors TAC1 , MRR1 , and UPC2 in Virulence

inferredcites →https://doi.org/10.1128/ec.00456-07openalex-snapshot

The Asexual Yeast Candida glabrata Maintains Distinct a and α Haploid Mating Types

inferredcites →https://doi.org/10.1128/ec.05184-11openalex-snapshot

Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

inferredcites →https://doi.org/10.1128/jb.100.1.370-376.1969openalex-snapshot

Differential Effect of Respiratory Inhibitors on Ergosterol Synthesis bySaccharomyces cerevisiaeDuring Adaptation to Oxygen

inferredcites →https://doi.org/10.1128/jb.175.10.2853-2858.1993openalex-snapshot

Sterol composition of yeast organelle membranes and subcellular distribution of enzymes involved in sterol metabolism

inferredcites →https://doi.org/10.1128/jcm.39.7.2513-2517.2001openalex-snapshot

Standardization of Antifungal Susceptibility Variables for a Semiautomated Methodology

inferredcites →https://doi.org/10.1128/jcm.40.3.826-836.2002openalex-snapshot

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inferredcites →https://doi.org/10.1128/mbio.00655-16openalex-snapshot

Heteroresistance to Fluconazole Is a Continuously Distributed Phenotype among Candida glabrata Clinical Strains Associated with In Vivo Persistence

inferredcites →https://doi.org/10.1371/journal.pbio.1001692openalex-snapshot

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

inferredcites →https://doi.org/10.1371/journal.ppat.1001126openalex-snapshot

Azole Drugs Are Imported By Facilitated Diffusion in Candida albicans and Other Pathogenic Fungi

inferredcites →https://doi.org/10.1534/genetics.105.054767openalex-snapshot

A Mutation in Tac1p, a Transcription Factor Regulating CDR1 and CDR2 , Is Coupled With Loss of Heterozygosity at Chromosome 5 to Mediate Antifungal Resistance in Candida albicans

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles

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“Illuminating” Echinocandins’ Mechanism of Action

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