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Overcoming Multidrug Resistance and Biofilms of Pseudomonas aeruginosa with a Single Dual-Function Potentiator of β‑Lactams

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Management of Chronic Wounds—2018
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Cationic Branched Polyethylenimine (BPEI) Disables Antibiotic Resistance in Methicillin‐Resistant Staphylococcus epidermidis (MRSE)
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Structural elucidation of the extracellular and cell-wall teichoic acids of Staphylococcus aureus MN8m, a biofilm forming strain
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Poly(ethyleneimines) in dermal applications: Biocompatibility and antimicrobial effects
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BPEI-Induced Delocalization of PBP4 Potentiates β-Lactams against MRSA
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Antibiofilm Synergy of β-Lactams and Branched Polyethylenimine against Methicillin-Resistant Staphylococcus epidermidis
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Antibacterial Diamines Targeting Bacterial Membranes
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The Effect of Lipopolysaccharide Core Oligosaccharide Size on the Electrostatic Binding of Antimicrobial Proteins to Models of the Gram Negative Bacterial Outer Membrane
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Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It
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Small-Molecule Potentiators for Conventional Antibiotics against Staphylococcus aureus
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Targeting Wall Teichoic Acid in Situ with Branched Polyethylenimine Potentiates β-Lactam Efficacy against MRSA
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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
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Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
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Efficacy of ampicillin against methicillin-resistant Staphylococcus aureus restored through synergy with branched poly(ethylenimine)
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Understanding biofilm resistance to antibacterial agents
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The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota
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Sensitization of Gram-negative bacteria to rifampin and OAK combinations
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Poly- N -acetylglucosamine and poly(glycerol phosphate) teichoic acid identification from staphylococcal biofilm extracts using excitation sculptured TOCSYNMR
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Interaction of uranium(vi) with lipopolysaccharide
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Hydration, ionic valence and cross-linking propensities of cations determine the stability of lipopolysaccharide (LPS) membranes
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Titration calorimetric studies to elucidate the specificity of the interactions of polymyxin B with lipopolysaccharides and lipid A
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Fluorometric assessment of Gram-negative bacterial permeabilization
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Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels
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Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix
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Clinical efficacy of piperacillin/tazobactam in the treatment of complicated skin and soft tissue infections
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Validation of the Infectious Diseases Society of America's Diabetic Foot Infection Classification System
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Clinical Practice Guidelines for the Diagnosis and Management of Intravascular Catheter-Related Infection: 2009 Update by the Infectious Diseases Society of America
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Emerging Infections in Burns
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Biofilms and Inflammation in Chronic Wounds
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Challenges in the Treatment of Chronic Wounds
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Executive Summary: IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults
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IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults
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Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America
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Executive Summary: Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America
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US Outpatient Antibiotic Prescribing Variation According to Geography, Patient Population, and Provider Specialty in 2011
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Editorial Commentary : Fortune Favors the Bold: Give a Beta-Lactam!
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Comparative Effectiveness of Cefazolin Versus Nafcillin or Oxacillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections Complicated by Bacteremia: A Nationwide Cohort Study
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Polyethyleneimine is an effective permeabilizer of Gram-negative bacteria
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Permeabilizing action of polyethyleneimine on Salmonella typhimurium involves disruption of the outer membrane and interactions with lipopolysaccharide
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Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH)
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Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development
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Polymyxin: Alternative Mechanisms of Action and Resistance
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Disturbance of the bacterial cell wall specifically interferes with biofilm formation
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Antibiotic Adjuvants: Diverse Strategies for Controlling Drug‐Resistant Pathogens
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Human skin wounds: A major and snowballing threat to public health and the economy
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Multiple bacterial species reside in chronic wounds: a longitudinal study
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Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds
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Bacterial Biofilms: A Common Cause of Persistent Infections
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Synergy between Polyethylenimine and Different Families of Antibiotics against a Resistant Clinical Isolate of Pseudomonas aeruginosa
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Polyamine Effects on Antibiotic Susceptibility in Bacteria
inferredcites →https://doi.org/10.1128/aac.26.1.48openalex-snapshot
Compounds which increase the permeability of the Pseudomonas aeruginosa outer membrane
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Use of the fluorescent probe 1-N-phenylnaphthylamine to study the interactions of aminoglycoside antibiotics with the outer membrane of Pseudomonas aeruginosa
inferredcites →https://doi.org/10.1128/aac.35.7.1309openalex-snapshot
Interaction of aminoglycosides with the outer membranes and purified lipopolysaccharide and OmpF porin of Escherichia coli
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Synthesis of lipopolysaccharide O side chains by Pseudomonas aeruginosa PAO1 requires the enzyme phosphomannomutase
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Nonrandom Distribution of Pseudomonas aeruginosa and Staphylococcus aureus in Chronic Wounds
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CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests
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Association between Methicillin Susceptibility and Biofilm Regulation in Staphylococcus aureus Isolates from Device-Related Infections
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The Calgary Biofilm Device: New Technology for Rapid Determination of Antibiotic Susceptibilities of Bacterial Biofilms
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Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria
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Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications
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Conserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosa
inferredcites →https://doi.org/10.12968/jowc.2015.24.8.366openalex-snapshot
Disrupting the biofilm matrix improves wound healing outcomes
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Understanding biofilm in practice: a global survey of health professionals
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Bifurcation kinetics of drug uptake by Gram-negative bacteria
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Clinical Practice Guideline for the Diagnosis and Management of Acute Bacterial Sinusitis in Children Aged 1 to 18 Years
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Clinical Practice Guideline for the Diagnosis and Management of Acute Bacterial Sinusitis in Children Aged 1 to 18 Years
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Pathogenesis of mucosal biofilm infections: challenges and progress
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A Practical Guide to the Treatment of Complicated Skin and Soft Tissue Infections
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Biomolecular Mechanisms of Staphylococcal Biofilm Formation
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Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens
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Microbial Biofilms and Chronic Wounds
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Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Dual-Function Potentiation by PEG-BPEI Restores Activity of Carbapenems and Penicillins against Carbapenem-Resistant Enterobacteriaceae
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PEGylation of Polyethylenimine Lowers Acute Toxicity while Retaining Anti-Biofilm and β-Lactam Potentiation Properties against Antibiotic-Resistant Pathogens
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Antibiofilm Activity of PEGylated Branched Polyethylenimine
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Neutralizing Staphylococcus aureus PAMPs that Trigger Cytokine Release from THP‑1 Monocytes
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