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Collagen and Alginate Hydrogels Support Chondrocytes Redifferentiation In Vitro without Supplementation of Exogenous Growth Factors

https://doi.org/10.1021/acsomega.4c01675

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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TGFβ signaling in cartilage development and maintenance

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Stirred culture of cartilaginous microtissues promotes chondrogenic hypertrophy through exposure to intermittent shear stress

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Chondrocyte redifferentiation and construct mechanical property development in single‐component photocrosslinkable hydrogels

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3D bioprinting of photo‐crosslinkable silk methacrylate ( SilMA )‐polyethylene glycol diacrylate ( PEGDA ) bioink for cartilage tissue engineering

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TGF β‐1 administration during Ex vivo expansion of human articular chondrocytes in a serum‐free medium redirects the cell phenotype toward hypertrophy

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Modular Tissue Assembly Strategies for Biofabrication of Engineered Cartilage

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Scaffold Free Microtissue Formation for Enhanced Cartilage Repair

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Spinner-flask culture induces redifferentiation of de-differentiated chondrocytes

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Oxidative stress, senescence and Mediterranean diet effects on osteoarthritis

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Freshwater Microbiology

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Chondrocyte dedifferentiation and osteoarthritis (OA)

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Injectable hydrogel microspheres in cartilage repair

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Scaffold degradation in bone tissue engineering: An overview

inferredcites →https://doi.org/10.1016/j.joca.2004.02.010openalex-snapshot

Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity

inferredcites →https://doi.org/10.1016/j.joca.2010.09.002openalex-snapshot

Endoglin differentially regulates TGF-β-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes

inferredcites →https://doi.org/10.1016/j.joca.2012.06.016openalex-snapshot

Redifferentiation of dedifferentiated human articular chondrocytes: comparison of 2D and 3D cultures

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ChondroGELesis: Hydrogels to harness the chondrogenic potential of stem cells

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Clinical outcome is significantly better with spheroid-based autologous chondrocyte implantation manufactured with more stringent cell culture criteria

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Comparison of multiple synthetic chondroinductive factors in pellet culture against a TGF-β positive control

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Bioinspired Injectable Hydrogels Dynamically Stiffen and Contract to Promote Mechanosensing-Mediated Chondrogenic Commitment of Stem Cells

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Incorporation of a Collagen-Binding Chondroitin Sulfate Molecule to a Collagen Type I and II Blend Hydrogel for Cartilage Tissue Engineering

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Cell–Cell Interactions Enhance Cartilage Zonal Development in 3D Gradient Hydrogels

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Collagen Type I and II Blend Hydrogel with Autologous Mesenchymal Stem Cells as a Scaffold for Articular Cartilage Defect Repair

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Mechanical stress determines the configuration of TGFβ activation in articular cartilage

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Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine

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Biosafety evaluation of culture-expanded human chondrocytes with growth factor cocktail: a preclinical study

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Mussel-inspired injectable chitosan hydrogel modified with catechol for cell adhesion and cartilage defect repair

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Cellular interactions and signaling in cartilage development

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Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes.

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Regulation of SOX9 mRNA in Human Articular Chondrocytes Involving p38 MAPK Activation and mRNA Stabilization

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Active and latent forms of transforming growth factor beta activity in synovial effusions.

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Dual crosslinked pullulan–gelatin cryogel scaffold for chondrocyte-mediated cartilage repair: synthesis, characterization and in vitro evaluation

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Cartilage tissue engineering by extrusion bioprinting utilizing porous hyaluronic acid microgel bioinks

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Effect of Matrix Elasticity on the Maintenance of the Chondrogenic Phenotype

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Direct Cell–Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis

inferredcites →https://doi.org/10.1089/ten.tea.2016.0262openalex-snapshot

Formation of Hyaline Cartilage Tissue by Passaged Human Osteoarthritic Chondrocytes

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The clinical effectiveness and safety of using epidermal growth factor, fibroblast growth factor and granulocyte-macrophage colony stimulating factor as therapeutics in acute skin wound healing: a systematic review and meta-analysis

inferredcites →https://doi.org/10.1093/rb/rbab030openalex-snapshot

The effect of collagen hydrogels on chondrocyte behaviors through restricting the contraction of cell/hydrogel constructs

inferredcites →https://doi.org/10.1093/stcltm/szac074openalex-snapshot

Hyaline Cartilage Microtissues Engineered from Adult Dedifferentiated Chondrocytes: Safety and Role of WNT Signaling

inferredcites →https://doi.org/10.11005/jbm.2018.25.2.65openalex-snapshot

Differential Role of Transforming Growth Factor-beta in an Osteoarthritic or a Healthy Joint

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Clinical Profiling in Cartilage Regeneration

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Redifferentiated Chondrocytes in Fibrin Gel for the Repair of Articular Cartilage Lesions

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Long-term Results of Arthroscopic Matrix-Assisted Autologous Chondrocyte Transplantation: A Prospective Follow-up at 15 Years

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Fabrication of chondrocytes/chondrocyte-microtissues laden fibrin gel auricular scaffold for microtia reconstruction

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Fully Dedifferentiated Chondrocytes Expanded in Specific Mesenchymal Stem Cell Growth Medium with FGF2 Obtains Mesenchymal Stem Cell Phenotype In Vitro but Retains Chondrocyte Phenotype In Vivo

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An Innovative Laboratory Procedure to Expand Chondrocytes with Reduced Dedifferentiation

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Soft substrates direct stem cell differentiation into the chondrogenic lineage without the use of growth factors

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A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis

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Maintenance of human chondrogenic phenotype on a dendrimer-immobilized surface for an application of cell sheet engineering

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Chondrogenic induction of mesenchymal stromal/stem cells from Wharton’s jelly embedded in alginate hydrogel and without added growth factor: an alternative stem cell source for cartilage tissue engineering

inferredcites →https://doi.org/10.1186/s13287-022-03094-6openalex-snapshot

Co-culture pellet of human Wharton’s jelly mesenchymal stem cells and rat costal chondrocytes as a candidate for articular cartilage regeneration: in vitro and in vivo study

inferredcites →https://doi.org/10.18632/oncotarget.20509openalex-snapshot

TGFβ1 induces hypertrophic change and expression of angiogenic factors in human chondrocytes

inferredcites →https://doi.org/10.22203/ecm.v035a16openalex-snapshot

Comprehensive high-resolution genomic profiling and cytogenetics of human chondrocyte cultures by GTG-banding, locus-specific FISH, SKY and SNP array

inferredcites →https://doi.org/10.3389/fbioe.2020.00373openalex-snapshot

Stiffness Matters: Fine-Tuned Hydrogel Elasticity Alters Chondrogenic Redifferentiation

inferredcites →https://doi.org/10.3389/fbioe.2020.00484openalex-snapshot

Hybrid Bioprinting of Chondrogenically Induced Human Mesenchymal Stem Cell Spheroids

inferredcites →https://doi.org/10.3389/fbioe.2021.603408openalex-snapshot

Influence of the Mechanical Environment on the Regeneration of Osteochondral Defects

inferredcites →https://doi.org/10.3389/fcell.2023.1099287openalex-snapshot

Single-cell RNA sequencing analysis of human chondrocytes reveals cell–cell communication alterations mediated by interactive signaling pathways in osteoarthritis

inferredcites →https://doi.org/10.3390/biom13040609openalex-snapshot

Biocompatible Macroion/Growth Factor Assemblies for Medical Applications

inferredcites →https://doi.org/10.3390/biomedicines10071621openalex-snapshot

Tuning the Degradation Rate of Alginate-Based Bioinks for Bioprinting Functional Cartilage Tissue

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Tissue Specific Differentiation of Human Chondrocytes Depends on Cell Microenvironment and Serum Selection

inferredcites →https://doi.org/10.3390/ijms20020316openalex-snapshot

Redifferentiation of Articular Chondrocytes by Hyperacute Serum and Platelet Rich Plasma in Collagen Type I Hydrogels

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Genetic Stability of Mesenchymal Stromal Cells for Regenerative Medicine Applications: A Fundamental Biosafety Aspect

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Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function

inferredcites →https://doi.org/10.3390/ijms23031147openalex-snapshot

Application of Alginate Hydrogels for Next-Generation Articular Cartilage Regeneration

inferredcites →https://doi.org/10.3390/jfb12010020openalex-snapshot

Mechanical and Degradation Properties of Hybrid Scaffolds for Tissue Engineered Heart Valve (TEHV)

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Synthesis and Characterization of k-Carrageenan/PVA Nanocomposite Hydrogels in Combination with MgZnO Nanoparticles to Evaluate the Catechin Release

inferredcites →https://doi.org/10.3892/ijmm.2012.1042openalex-snapshot

TGF-β1 and IGF-1 influence the re-differentiation capacity of human chondrocytes in 3D pellet cultures in relation to different oxygen concentrations

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Engineering Cartilage Scaffolds with Tailored Pore Architecture and Cell Distribution Via Cryogel-Melt Electrowriting

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Vertical Membrane‐Free Organ‐on‐a‐Chip for High‐Throughput In Vitro Studies and Drug Screening

inferred← citeshttps://doi.org/10.1002/bit.28915openalex-snapshot

Recent Research on Chondrocyte Dedifferentiation and Insights for Regenerative Medicine

inferred← citeshttps://doi.org/10.1002/btm2.70022openalex-snapshot

Bionic scaffolds with integrated structural components based on low‐temperature deposition manufacturing 3D printing technology for the treatment of meniscus defects

inferred← citeshttps://doi.org/10.1007/s10439-026-04170-1openalex-snapshot

Microcavitary Alginate Hydrogel Reverses Chondrocyte Dedifferentiation via Temporal Modulation of the p53 Pathway

inferred← citeshttps://doi.org/10.1007/s12015-026-11079-8openalex-snapshot

Species-Specific Chondrogenesis in Growth Factor-Free Hydrogels: Translational Lessons from Ovine and Human MSCs

inferred← citeshttps://doi.org/10.1007/s40883-025-00526-6openalex-snapshot

Engineering Cellulose for Regenerative Medicine: Bacterial Cellulose and Beyond

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Cell Encapsulation

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3D printing of a beehive-inspired tissue-engineered auricular cartilage scaffold for reconstruction of autologous microtia

inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113725openalex-snapshot

An injectable hydrogel loaded with Icariin attenuates cartilage damage in rabbit knee osteoarthritis via Wnt/β-catenin signaling pathway

inferred← citeshttps://doi.org/10.1016/j.intimp.2026.116418openalex-snapshot

SIRT3 alleviates periodontitis inflammation by inhibiting macrophage M1 polarization regulation via FOXO3/NRF2

inferred← citeshttps://doi.org/10.1177/20417314251349669openalex-snapshot

Advances in biomaterial-based composite spheroid for articular cartilage regeneration

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FGF-2 signaling dominance in TGF-β1/FGF-2–primed nasoseptal chondrocytes for cartilage tissue engineering

inferred← citeshttps://doi.org/10.2139/ssrn.5149063openalex-snapshot

Biofabrication of a Beehive-Inspired Hybrid Auricular Scaffold for Reconstruction of Autologous Microtia

inferred← citeshttps://doi.org/10.2147/dddt.s494841openalex-snapshot

The Roles of Forkhead Box O3a (FOXO3a) in Bone and Cartilage Diseases – A Narrative Review

inferred← citeshttps://doi.org/10.3390/ijms262110291openalex-snapshot

2D Chitosan-Based Films: A Proteomic Mass Spectrometry Study of Chondrocyte Phenotype as a Function of Cell–Biomaterial Interactions

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