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Hybrid Molecules with a Dual Mode of Action: Dream or Reality?
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Preparation and Antimalarial Activities of “Trioxaquines”, New Modular Molecules with a Trioxane Skeleton Linked to a 4-Aminoquinoline
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Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin
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From Protein Domains to Drug Candidates—Natural Products as Guiding Principles in the Design and Synthesis of Compound Libraries
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Carbon—Hydrogen Bonds of DNA Sugar Units as Targets for Chemical Nucleases and Drugs
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C10‐Modified Artemisinin Derivatives: Efficient Heme‐Alkylating Agents
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Heme Alkylation by Artesunic Acid and Trioxaquine DU1301, Two Antimalarial Trioxanes
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Synthesis and Antimalarial Activity of Trioxaquine Derivatives
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Protonic and Temperature Modulation of Constituent Expression by Component Selection in a Dynamic Combinatorial Library of Imines
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Heme alkylation by artemisinin and trioxaquines
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DNA breaks generated by the bleomycin-iron III complex in the presence of KHSO5, a single oxygen donor
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Evidence for high-valent iron-oxo species active in the DNA breaks mediated by iron-bleomycin
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Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: Evaluation of novel conjugates as cytotoxic agents
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The key role of heme to trigger the antimalarial activity of trioxanes
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Synthetic library design
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Combinatorial biosynthesis—Potential and problems
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Chemical genetics resulting from a passion for synthetic organic chemistry
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Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional Genomics
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Oxidative cleavage of DNA mediated by hybrid metalloporphyrin-ellipticine molecules and functionalized metalloporphyrin precursors
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Properties and products of the degradation of DNA by bleomycin and iron(II)
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Virtual Exploration of the Chemical Universe up to 11 Atoms of C, N, O, F: Assembly of 26.4 Million Structures (110.9 Million Stereoisomers) and Analysis for New Ring Systems, Stereochemistry, Physicochemical Properties, Compound Classes, and Drug Discovery
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Theory and Applications of NMR-Based Screening in Pharmaceutical Research
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Cleavage of Nucleic Acids by Bleomycin
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Total Synthesis of Deamido Bleomycin A2, the Major Catabolite of the Antitumor Agent Bleomycin
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A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially
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Direct Hydrogen-Atom Abstraction by Activated Bleomycin: An Experimental and Computational Study
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Proton-Shuffle Mechanism of O−O Activation for Formation of a High-Valent Oxo−Iron Species of Bleomycin
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Characterization of the First Covalent Adduct between Artemisinin and a Heme Model
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A Chloroquine-like Molecule Designed to Reverse Resistance in Plasmodium falciparum
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Alkylating Capacity and Reaction Products of Antimalarial Trioxanes after Activation by a Heme Model
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Natural Products as Sources of New Drugs over the Last 25 Years
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Antimalarial drug discovery: efficacy models for compound screening
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The evolving role of natural products in drug discovery
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The trouble with making combination drugs
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inferredcites →https://doi.org/10.1039/b514349gopenalex-snapshot
Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads
inferredcites →https://doi.org/10.1073/pnas.0500972102openalex-snapshot
The antimalarial drug artemisinin alkylates heme in infected mice
inferredcites →https://doi.org/10.1111/j.1365-2125.2006.02673.xopenalex-snapshot
Reflections on the ‘discovery’ of the antimalarial qinghao
inferredcites →https://doi.org/10.1126/science.1116364openalex-snapshot
The Renaissance of Natural Products as Drug Candidates
inferredcites →https://doi.org/10.1126/science.1139337openalex-snapshot
The ISSCR Guidelines for Human Embryonic Stem Cell Research
inferredcites →https://doi.org/10.1126/science.315.5813.760openalex-snapshot
Controversial Marrow Cells Coming Into Their Own?
inferredcites →https://doi.org/10.1128/aac.00967-06openalex-snapshot
Trioxaquines Are New Antimalarial Agents Active on All Erythrocytic Forms, Including Gametocytes
inferredcites →https://doi.org/10.1128/mmbr.60.2.301-315.1996openalex-snapshot
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
inferredcites →https://doi.org/10.1136/ard.2005.036715openalex-snapshot
Population based studies of biological antirheumatic drug use in southern Sweden: comparison with pharmaceutical sales
inferredcites →https://doi.org/10.1371/journal.pmed.0030373openalex-snapshot
Cost-Effectiveness Study of Three Antimalarial Drug Combinations in Tanzania
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National Health Spending In 2005: The Slowdown Continues
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Programmable DNA Binding Oligomers for Control of Transcription
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inferred← citeshttps://doi.org/10.1002/ejic.201001051openalex-snapshot
Synthesis and Characterization of Platinum(II) Complexes with a Diazenecarboxamide‐Appended Picolyl‐Triazole Ligand
inferred← citeshttps://doi.org/10.1002/ejoc.200800770openalex-snapshot
Synthesis of Hybrids of D ‐Glucose and D ‐Galactose with Pyrrolidine‐Based Iminosugars as Glycosidase Inhibitors
inferred← citeshttps://doi.org/10.1002/ejoc.201201303openalex-snapshot
Protoporphyrin IX/Cobyrinate Derived Hybrids – Novel Activators of Soluble Guanylyl Cyclase
inferred← citeshttps://doi.org/10.1002/ejoc.201301725openalex-snapshot
Design and Synthesis of Pironetin Analogue/Combretastatin A‐4 Hybrids and Evaluation of Their Cytotoxic Activity
inferred← citeshttps://doi.org/10.1002/ejoc.201301775openalex-snapshot
Highly Diastereoselective Reaction of α‐Diazoesters with Aryl Alcohols and Isatin Imines: Rapid Access to Oxindole‐Derived α‐Alkoxy‐β‐amino Acid Derivatives with Two Adjacent Quaternary Carbon Centers
inferred← citeshttps://doi.org/10.1002/ejoc.201601104openalex-snapshot
Divergent Synthesis of Styryl–Cinnamate Hybrid Analogues Inspired by the Natural Product Salvianolic Acid F as a Premise To Investigate Their Anticancer Activity and Its Metabolomic Profiling
inferred← citeshttps://doi.org/10.1002/ejoc.201900738openalex-snapshot
Copper‐Catalyzed Regio‐ and Diastereoselective 1,3‐Dipolar Cycloaddition Reactions of Glycine Imino Esters with 1‐Propene‐1,3‐sultone
inferred← citeshttps://doi.org/10.1002/ejoc.202200563openalex-snapshot
Asymmetric Total Synthesis of a Bioactive Lignanamide Using a 5‐endo‐tet‐Type Cyclization of Activated Cyclopropylcarbinols and Synthetic Support for the Reaction Mechanism
inferred← citeshttps://doi.org/10.1002/ejoc.202201484openalex-snapshot
Oxidative Coupling of 4‐Hydroxycoumarins with Quinoxalin‐2(1H)‐ones Induced by Visible Light under Aerobic Conditions
inferred← citeshttps://doi.org/10.1002/ejoc.202300604openalex-snapshot
Synthesis of [1,2,3]Triazolo[1,5‐a]quinoline‐3‐carboxamides Promoted by Organocatalyst and Base
inferred← citeshttps://doi.org/10.1002/hlca.201200015openalex-snapshot
Synthesis and Antimalarial‐Activity Evaluation of TetraoxaneTriazine Hybrids and Spiro[piperidine‐4,3′‐tetraoxanes]
inferred← citeshttps://doi.org/10.1002/jhet.194openalex-snapshot
Synthesis and biological screening of 4‐(3,3‐dimethylspiro{bicyclo[2.2.1]heptan‐2,5′‐isoxazoline‐2}‐ 3′‐yl)‐2‐aryl‐2,3‐dihydro‐1H‐1,5‐benzodiazepines
inferred← citeshttps://doi.org/10.1002/jhet.2620openalex-snapshot
Synthesis, Characterization, Antibacterial, and Antifungal Activity of Novel 2‐(2‐hydroxy‐5‐((aryl)‐diazenyl)phenyl)‐3‐(4‐hydroxyphenyl)‐thiazolidin‐4‐one
inferred← citeshttps://doi.org/10.1002/jhet.2639openalex-snapshot
Synthesis of Imidazole and Theophylline Derivatives Incorporating Pyrimidine‐Fused Heterocycles Using Magnetic Nanoparticles‐Supported Tungstic Acid (MNP‐TA) Catalyst
inferred← citeshttps://doi.org/10.1002/jhet.3189openalex-snapshot
Isatin Derivatives with Potential Antitubercular Activities
inferred← citeshttps://doi.org/10.1002/jhet.3296openalex-snapshot
Synthesis of Novel Bis(thiazolylchromen‐2‐one) Derivatives Linked to Alkyl Spacer via Phenoxy Group
inferred← citeshttps://doi.org/10.1002/jhet.3297openalex-snapshot
Novel Bridgehead Thiadiazolopyrimidine Derivatives with Antimicrobial and Antitumor Activities
inferred← citeshttps://doi.org/10.1002/jhet.3365openalex-snapshot
Design, Synthesis, Characterization, and In Vitro Evaluation of Isatin‐Pomalidomide Hybrids for Cytotoxicity against Multiple Myeloma Cell Lines
inferred← citeshttps://doi.org/10.1002/jhet.3474openalex-snapshot
Synthesis and Ameliorative Effect of Isatin–Mesalamine Conjugates on Acetic Acid‐induced Colitis in Rats
inferred← citeshttps://doi.org/10.1002/jhet.3803openalex-snapshot
Regioselective synthesis of spiro isoxazole‐oxindole‐tetrahydrothiophene hybrids via cascade reactions under catalyst‐free conditions
inferred← citeshttps://doi.org/10.1002/jhet.3923openalex-snapshot
Semisynthesis of ursolic acid‐2‐(2‐thienylidene)‐oxadiazole hybrid molecule and an evaluation of its COX inhibition property
inferred← citeshttps://doi.org/10.1002/jhet.3955openalex-snapshot
Microwave assisted synthesis, docking and antimalarial evaluation of hybrid PABA‐substituted 1,3,5‐triazine derivatives
inferred← citeshttps://doi.org/10.1002/med.20189openalex-snapshot
Retracted : Tetraoxanes: Synthetic and medicinal chemistry perspective
inferred← citeshttps://doi.org/10.1002/med.20223openalex-snapshot
Tetraoxanes: Synthetic and Medicinal Chemistry Perspective
inferred← citeshttps://doi.org/10.1002/med.21255openalex-snapshot
Fragment Informatics and Computational Fragment‐Based Drug Design: An Overview and Update
inferred← citeshttps://doi.org/10.1002/med.21486openalex-snapshot
Multistage inhibitors of the malaria parasite: Emerging hope for chemoprotection and malaria eradication
inferred← citeshttps://doi.org/10.1002/med.21643openalex-snapshot
Hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug‐resistant Plasmodium falciparum
inferred← citeshttps://doi.org/10.1002/med.21698openalex-snapshot
Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure‐activity relationship
inferred← citeshttps://doi.org/10.1002/med.21814openalex-snapshot
Artemisinin‐derived dimers from a chemical perspective
inferred← citeshttps://doi.org/10.1002/med.21979openalex-snapshot
An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes
inferred← citeshttps://doi.org/10.1002/open.201700005openalex-snapshot
Deeper Insight into the Six‐Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products
inferred← citeshttps://doi.org/10.1002/open.202200064openalex-snapshot
Synthesis and Antimalarial Activities of New Hybrid Atokel Molecules
inferred← citeshttps://doi.org/10.1002/slct.201601349openalex-snapshot
Ca(II)‐Catalyzed Regioselective Cascade Synthesis of Oxindolyl‐ Naphthofurans through Meyer‐Schuster type Rearrangement
inferred← citeshttps://doi.org/10.1002/slct.201701558openalex-snapshot
Aminoquinoline‐Pyrimidine‐Modified Anilines: Synthesis, In Vitro Antiplasmodial Activity, Cytotoxicity, Mechanistic Studies and ADME Predictions
inferred← citeshttps://doi.org/10.1002/slct.201802371openalex-snapshot
Synthesis and Antimicrobial Activity of New Isoxazolyl Benzo[1, 4] diazepine‐5‐one Derivatives
inferred← citeshttps://doi.org/10.1002/slct.201803508openalex-snapshot
Sodium Formate‐Catalyzed One‐Pot Synthesis of Functionalized Spiro[indoline‐3,5′‐pyrido[2,3‐ d ]pyrimidine]/Spiro[acenaphthylene‐1,5′‐pyrido[2,3‐ d ]‐pyrimidine] Derivatives
inferred← citeshttps://doi.org/10.1002/slct.201903031openalex-snapshot
Synthesis, In Silico Molecular Docking, ADME Evaluation and In Vitro Antiplasmodial Activity of Pyrimidine‐Based Hybrid Molecules
inferred← citeshttps://doi.org/10.1002/slct.201903179openalex-snapshot
Thiourea Derivatives Based on the Dapsone‐Naphthoquinone Hybrid as Anticancer and Antimicrobial Agents: In Vitro Screening and Molecular Docking Studies
inferred← citeshttps://doi.org/10.1002/slct.201903203openalex-snapshot
Design, Synthesis and Characterisation of Novel Phenothiazine‐Based Triazolopyridine Derivatives: Evaluation of Anti‐Breast Cancer Activity on Human Breast Carcinoma
inferred← citeshttps://doi.org/10.1002/slct.201903835openalex-snapshot
Synthesis, In Silico Studies, Antiprotozoal and Cytotoxic Activities of Quinoline‐Biphenyl Hybrids
inferred← citeshttps://doi.org/10.1002/slct.202000719openalex-snapshot
Metal‐Free Synthesis of Pyrazoles and Chromenopyrazoles from Hydrazones and Acetylenic Esters
inferred← citeshttps://doi.org/10.1002/slct.202002779openalex-snapshot
Antimicrobial, Antioxidant and Antiproliferative Activities of Novel Quinolones
inferred← citeshttps://doi.org/10.1002/slct.202003170openalex-snapshot
Design and Synthesis of New Tubulin Polymerization Inhibitors Inspired from Combretastatin A‐4: An Anticancer Agent
inferred← citeshttps://doi.org/10.1002/slct.202100790openalex-snapshot
Palladium‐Catalyzed Novel C(formyl)‐C(aryl)/C(aryl)‐N(amine) Coupling Sequence Between 2‐(Methylamino)nicotinaldehyde and 3‐Bromo‐2‐chlorothiophene: An Efficient Construction of 4‐Pyridone Fused Hybrid Scaffolds
inferred← citeshttps://doi.org/10.1002/slct.202101093openalex-snapshot
Synthesis of New Lansiumamide A/Alatamide (cis‐Isomer) Based Unnatural α‐Amino Acid Derivatives via the Suzuki‐Miyaura Cross Coupling as Key Step
inferred← citeshttps://doi.org/10.1002/slct.202101840openalex-snapshot
Synthesis and Antimicrobial, Antiproliferative Evaluation of Novel Quinolone and Conazole Analogues via Conventional and Microwave Techniques
inferred← citeshttps://doi.org/10.1002/slct.202101853openalex-snapshot
Design and Synthesis of Bioinspired Benzocoumarin‐Chalcones Chimeras as Potential Anti‐Breast Cancer Agents
inferred← citeshttps://doi.org/10.1002/slct.202102495openalex-snapshot
Enantioselective Synthesis of 3‐Acetyl Coumarin Substituted 3‐Hydroxy Oxindoles and Pyranocoumarin Fused Spirooxindoles
inferred← citeshttps://doi.org/10.1002/slct.202200730openalex-snapshot
Reaction of 1‐Phenacylidene pyrrolo[3,2,1‐ ij ]quinolin‐2‐ones with Cyclic/Acyclic Enaminones and the Anticoagulant Activity of Synthesized Pyrrole‐Quinoline Derivatives
inferred← citeshttps://doi.org/10.1002/slct.202202172openalex-snapshot
Synthesis of C2 ‐Formamide(thiophene)pyrazolyl‐ C4 ’‐carbaldehyde and their Transformation to Schiff's Bases and Stereoselective trans ‐β‐Lactams: Mechanistic and Theoretical Insights
inferred← citeshttps://doi.org/10.1002/slct.202202783openalex-snapshot
Synthesis, Anticancer Evaluation and Pharmacokinetic Studies of Quinoline‐Triazole Hybrid Derivatives
inferred← citeshttps://doi.org/10.1002/slct.202203981openalex-snapshot
Allylic and Retro‐Allylic Rearrangements upon Bromination of 8,9‐Substituted 4,4,6‐Trimethyl‐4 H ‐Pyrrolo[3,2,1‐ ij ]Quinoline‐1,2‐Diones. New Aspects and Synthetic Applications
inferred← citeshttps://doi.org/10.1002/slct.202204010openalex-snapshot
Synthesis of Amide Derivatives as Tubulin Polymerization Inhibiting Antiproliferative Agents
inferred← citeshttps://doi.org/10.1002/slct.202402738openalex-snapshot
Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis
inferred← citeshttps://doi.org/10.1002/slct.202402933openalex-snapshot
Isoniazid Hybrids As Potential Antitubercular Agents
inferred← citeshttps://doi.org/10.1002/slct.202404966openalex-snapshot
Development of Novel 1,2,3‐Triazole‐Benzoxazole Hybrids as an E. coli DNA Gyrase B Inhibitor: Design, Synthesis, in Silico, and in Vitro Antimicrobial Evaluation
inferred← citeshttps://doi.org/10.1002/slct.202405314openalex-snapshot
Anti‐Inflammatory and Anticancer Activities of New Monocyclic Indolo β ‐Lactam Hybrids
inferred← citeshttps://doi.org/10.1002/slct.202500902openalex-snapshot
Development of a New Melatonin/Coumarin Hybrid Scaffold Targeting Colorectal Cancer: Synthesis, Cytotoxic Activity, and ADME/ Tox Modeling
inferred← citeshttps://doi.org/10.1002/slct.202501972openalex-snapshot
Design, Synthesis, and Molecular Docking Studies of Triazolylpyridine and Triazolylpyridinylbenzofuran Hybrids as Potential EGFR Inhibitors
inferred← citeshttps://doi.org/10.1002/slct.202502679openalex-snapshot
Novel Coumarin Derivatives: Synthesis, Characterization, Cytogenetics Effects on Allium cepa Root Cells, In Silico Molecular Docking, Structural and Electronic Analysis Studies
inferred← citeshttps://doi.org/10.1002/slct.202504584openalex-snapshot
Imidazole–Oxadiazole‐Linked Sulfonyl‐1,2,3‐triazoles as Potential EGFR Inhibitors for Lung Cancer Treatment
inferred← citeshttps://doi.org/10.1002/slct.73821openalex-snapshot
Chiral Sulfamoyl‐Carbamate Derivatives Bearing a Naphthalene Motif as Potent Cholinesterase Inhibitors: Synthesis, Characterization, DFT Study, Molecular Docking, and Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1002/slct.74274openalex-snapshot
Rational Design and Synthesis of Benzothiophene–Quinoxaline–Oxadiazole Conjugates Targeting Bacterial and Fungal Pathogens
inferred← citeshttps://doi.org/10.1002/tcr.202400107openalex-snapshot
Comprehensive Review on the Synthesis of [1,2,3]Triazolo[1,5‐a]Quinolines
inferred← citeshttps://doi.org/10.1007/7355_2021_125openalex-snapshot
Pharmacological Treatment of Malaria
inferred← citeshttps://doi.org/10.1007/7355_2024_165openalex-snapshot
Medicinal Chemistry and Biotherapeutics: Overview and Definitions
inferred← citeshttps://doi.org/10.1007/978-1-60761-411-1_21openalex-snapshot
Design and Synthesis of Antioxidant α-Lipoic Acid Hybrids
inferred← citeshttps://doi.org/10.1007/978-3-031-04998-9_12openalex-snapshot
Polypharmacology in Drug Design and Discovery—Basis for Rational Design of Multitarget Drugs
inferred← citeshttps://doi.org/10.1007/978-3-031-04998-9_2openalex-snapshot
Strategies of Polypharmacology
inferred← citeshttps://doi.org/10.1007/978-3-0346-0480-2_2openalex-snapshot
4-Aminoquinolines: Chloroquine, Amodiaquine and Next-Generation Analogues
inferred← citeshttps://doi.org/10.1007/978-3-319-41421-8_13openalex-snapshot
Associating Drugs with Polymer Nanoparticles: A Challenge
inferred← citeshttps://doi.org/10.1007/978-3-319-74814-6_8openalex-snapshot
Metal-Based Drugs for Treatment of Malaria
inferred← citeshttps://doi.org/10.1007/978-981-19-6466-4_12openalex-snapshot
Biotechnological Avenues in Hybrid Beta-Glucanases
inferred← citeshttps://doi.org/10.1007/978-981-99-2302-1_10openalex-snapshot
Diverse Pharmacological Activities of 4-Aminoquinoline and its Derivatives
inferred← citeshttps://doi.org/10.1007/s00044-011-9886-8openalex-snapshot
Synthesis and leishmanicidal activity of quinoline–triclosan and quinoline–eugenol hybrids
inferred← citeshttps://doi.org/10.1007/s00044-014-0956-6openalex-snapshot
Synthesis and preliminary in vitro activity of mono- and bis-1H-1,2,3-triazole-tethered β-lactam–isatin conjugates against the human protozoal pathogen Trichomonas vaginalis
inferred← citeshttps://doi.org/10.1007/s00044-014-0973-5openalex-snapshot
Hybrid probes of aromatic amine and barbituric acid: highly promising leads for anti-bacterial, anti-fungal and anti-cancer activities
inferred← citeshttps://doi.org/10.1007/s00044-014-1196-5openalex-snapshot
A review on pharmacophoric designs of antiproliferative agents
inferred← citeshttps://doi.org/10.1007/s00044-015-1331-yopenalex-snapshot
Semisynthetic hybrids of boswellic acids: a novel class of potential anti-inflammatory and anti-arthritic agents
inferred← citeshttps://doi.org/10.1007/s00044-015-1350-8openalex-snapshot
Recent advances and therapeutic journey of coumarins: current status and perspectives
inferred← citeshttps://doi.org/10.1007/s00044-015-1474-xopenalex-snapshot
Synthesis and biological evaluation of some new β-lactam-triazole hybrids
inferred← citeshttps://doi.org/10.1007/s00044-017-2019-2openalex-snapshot
Synthesis, antiprotozoal activity and cytotoxicity in U-937 macrophages of triclosan–hydrazone hybrids
inferred← citeshttps://doi.org/10.1007/s00044-017-2076-6openalex-snapshot
Synthesis and antiprotozoal activity of furanchalcone–quinoline, furanchalcone–chromone and furanchalcone–imidazole hybrids
inferred← citeshttps://doi.org/10.1007/s00044-017-2085-5openalex-snapshot
Imidazole-thiazole coupled derivatives as novel lanosterol 14-α demethylase inhibitors: ionic liquid mediated synthesis, biological evaluation and molecular docking study
inferred← citeshttps://doi.org/10.1007/s00044-018-02287-0openalex-snapshot
Design, synthesis and biological evaluation of some novel diastereoselective β-lactams bearing 2-mercaptobenzothiazole and benzoquinoline
inferred← citeshttps://doi.org/10.1007/s00044-018-2202-0openalex-snapshot
Synthesis and antiproliferative activity of 3- and 7-styrylcoumarins
inferred← citeshttps://doi.org/10.1007/s00044-018-2242-5openalex-snapshot
Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates
inferred← citeshttps://doi.org/10.1007/s00044-019-02323-7openalex-snapshot
Furanchalcone–biphenyl hybrids: synthesis, in silico studies, antitrypanosomal and cytotoxic activities
inferred← citeshttps://doi.org/10.1007/s00044-019-02487-2openalex-snapshot
Styrylcoumarin 7-SC2 induces apoptosis in SW480 human colon adenocarcinoma cells and inhibits azoxymethane-induced aberrant crypt foci formation in BALB/c mice
inferred← citeshttps://doi.org/10.1007/s00044-022-02866-2openalex-snapshot
Design, synthesis and biological evaluation of 8-aminoquinoline-1,2,3-triazole hybrid derivatives as potential antimicrobial agents
inferred← citeshttps://doi.org/10.1007/s00044-022-02955-2openalex-snapshot
Synthesis, theoretical investigations and biological evaluation of ibuprofen drug hybrids
inferred← citeshttps://doi.org/10.1007/s00044-024-03223-1openalex-snapshot
Novel monastrol/melatonin hybrids as a new approach for colorectal cancer intervention: design, synthesis, biological activity, and drug-likeness modeling studies
inferred← citeshttps://doi.org/10.1007/s00044-025-03401-9openalex-snapshot
Discovery of novel pterostilbene/biphenyl tethered 5-FU based conjugates targeting colorectal cancer: synthesis, cytotoxic and ADMET modeling studies
inferred← citeshttps://doi.org/10.1007/s00044-026-03605-7openalex-snapshot
Dual-target carbonic anhydrase inhibitors in cancer therapy: progress, challenges, and opportunities
inferred← citeshttps://doi.org/10.1007/s00210-023-02815-9openalex-snapshot
In vitro and in vivo antiplasmodial activity of a synthetic dihydroartemisinin–eosin B hybrid
inferred← citeshttps://doi.org/10.1007/s00436-020-06786-1openalex-snapshot
Enhancing the antimalarial activity of artesunate
inferred← citeshttps://doi.org/10.1007/s00436-021-07374-7openalex-snapshot
Synthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity
inferred← citeshttps://doi.org/10.1007/s00436-023-07801-xopenalex-snapshot
Antimalarial activity assay of artesunate-3-chloro-4(4-chlorophenoxy) aniline in vitro and in mice models
inferred← citeshttps://doi.org/10.1007/s00706-017-2020-yopenalex-snapshot
Design, synthesis, structure elucidation, and biological activities of 3-(substituted amino)-1-(pyridin-4-yl)propenones and 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidine–adamantane hybrids
inferred← citeshttps://doi.org/10.1007/s00706-026-03436-7openalex-snapshot
Molecular modeling studies of novel breast cancer inhibitors using molecular docking, molecular dynamics, MEP, bioisosteric replacement, and ADME-Tox prediction
inferred← citeshttps://doi.org/10.1007/s10534-021-00308-xopenalex-snapshot
Selective anticancer activities of ruthenium(II)-tetrazole complexes and their mechanistic insights
inferred← citeshttps://doi.org/10.1007/s10593-018-2351-6openalex-snapshot
Efficient synthesis of substituted 8-(pyrazolo[3,4-d]pyrimidin-6-yl)-1,2-dihydroquinolines
inferred← citeshttps://doi.org/10.1007/s10593-021-02945-zopenalex-snapshot
Synthesis of 2H-pyrano[3,2-g]quinolin-2-ones containing a pyrimidinone moiety and characterization of their anticoagulant activity via inhibition of blood coagulation factors Xa and XIa
inferred← citeshttps://doi.org/10.1007/s10593-024-03334-yopenalex-snapshot
Schizocommunin-inspired heterocyclic hybrid molecules
inferred← citeshttps://doi.org/10.1007/s11030-016-9678-7openalex-snapshot
Design, synthesis and biological evaluation of novel 1,2,3-triazolyl $$\upbeta $$ β -hydroxy alkyl/carbazole hybrid molecules
inferred← citeshttps://doi.org/10.1007/s11030-019-10004-1openalex-snapshot
Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid–pyrimidine conjugates
inferred← citeshttps://doi.org/10.1007/s11030-021-10363-8openalex-snapshot
Iron-catalyzed intermolecular cross-dehydrogenative C(sp3)–H/C(sp)–H coupling of pyrimidine bearing 4-thiazolidinones with terminal alkynes
inferred← citeshttps://doi.org/10.1007/s11030-022-10457-xopenalex-snapshot
A diastereoselective three-component reaction for the assembly of succinimide and isatin hybrid molecules with potent anticancer activities
inferred← citeshttps://doi.org/10.1007/s11030-023-10626-6openalex-snapshot
Synthesis, antitumor evaluation and computational study of thiazolidinone derivatives of dehydroabietic acid-based B ring-fused-thiazole
inferred← citeshttps://doi.org/10.1007/s11030-023-10704-9openalex-snapshot
In vitro trypanocidal activities and structure–activity relationships of ciprofloxacin analogs
inferred← citeshttps://doi.org/10.1007/s11030-025-11112-xopenalex-snapshot
A review on pyrimidine-based pharmacophore as a template for the development of hybrid drugs with anticancer potential
inferred← citeshttps://doi.org/10.1007/s11094-021-02371-7openalex-snapshot
Synthesis of New 1-Substituted-3-(3-(2-Chlorophenyl)-4-Oxo-3,4-Dihydrobenzopyrimidin-2-Ylamino)Isothioureas as Anti-HIV and Antibacterial Agents
inferred← citeshttps://doi.org/10.1007/s11164-016-2524-9openalex-snapshot
Design, synthesis, and antiviral activity of novel purine derivatives containing 1,4-pentadien-3-one moiety
inferred← citeshttps://doi.org/10.1007/s11164-018-3292-5openalex-snapshot
Ultrasound-mediated synthesis, biological evaluation, docking and in vivo acute oral toxicity study of novel indolin-2-one coupled pyrimidine derivatives
inferred← citeshttps://doi.org/10.1007/s11172-017-2010-6openalex-snapshot
One-pot three-component green synthesis of [1H-(1,2,3-triazol-5-yl)methylidene] heterocycles based on element-substituted propynals
inferred← citeshttps://doi.org/10.1007/s11172-019-2527-yopenalex-snapshot
Synthesis of 4″O,5O-bis(2-amino-2-thioxoacetyl)ivermectin derivatives
inferred← citeshttps://doi.org/10.1007/s11172-020-2834-3openalex-snapshot
Synthesis of 4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones containing a piperazine fragment and study of their inhibitory properties against protein kinases
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