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Protein-Targeted Gadolinium-Based Magnetic Resonance Imaging (MRI) Contrast Agents: Design and Mechanism of Action
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Physicochemical Characterization of MS-325, a New Gadolinium Complex, by Multinuclear Relaxometry
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Multilocus Binding Increases the Relaxivity of Protein‐Bound MRI Contrast Agents
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When are Two Waters Worse Than One? Doubling the Hydration Number of a Gd–DTPA Derivative Decreases Relaxivity
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The effects of intramolecular H‐bond formation on the stability constant and water exchange rate of the Gd(III)‐diethylenetriamine‐N′‐(3‐amino‐1,1‐propylenephosphonic)‐N, N,N″,N″‐tetraacetate complex
inferredcites →https://doi.org/10.1002/cphc.200500250openalex-snapshot
Probing the Water Coordination of Protein‐Targeted MRI Contrast Agents by Pulsed ENDOR Spectroscopy
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Determination of the Hydration Number of Gadolinium( III ) Complexes by High‐Field Pulsed 17 O ENDOR Spectroscopy
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Molecular factors that determine Curie spin relaxation in dysprosium complexes
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Targeted relaxation enhancement agents for MRI
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Water exchange on metal ions: experiments and simulations
inferredcites →https://doi.org/10.1021/cr980440xopenalex-snapshot
Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications
inferredcites →https://doi.org/10.1021/ic001117ropenalex-snapshot
Thermodynamic Stability and Kinetic Inertness of MS-325, a New Blood Pool Agent for Magnetic Resonance Imaging
inferredcites →https://doi.org/10.1021/ic0102900openalex-snapshot
The Gd3+ Complex of a Fatty Acid Analogue of DOTP Binds to Multiple Albumin Sites with Variable Water Relaxivities
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The Gadolinium(III)−Water Hydrogen Distance in MRI Contrast Agents
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Protein Binding to Lanthanide(III) Complexes Can Reduce the Water Exchange Rate at the Lanthanide
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Albumin Binding, Relaxivity, and Water Exchange Kinetics of the Diastereoisomers of MS-325, a Gadolinium(III)-Based Magnetic Resonance Angiography Contrast Agent
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The Interaction of MS-325 with Human Serum Albumin and Its Effect on Proton Relaxation Rates
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inferredcites →https://doi.org/10.1021/jp0307811openalex-snapshot
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inferredcites →https://doi.org/10.1021/jp0372688openalex-snapshot
Photoinduced Electron and Energy Transfer Processes in a Bichromophoric Pyrene−Perylene Bisimide System
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inferredcites →https://doi.org/10.1039/b717390copenalex-snapshot
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inferredcites →https://doi.org/10.1063/1.1731684openalex-snapshot
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Gd3+ Complexes with Slowly Exchanging Bound-Water Molecules May Offer Advantages in the Design of Responsive MR Agents
inferredcites →https://doi.org/10.1097/00004424-200102000-00008openalex-snapshot
Stability of MRI Paramagnetic Contrast Media
inferredcites →https://doi.org/10.1097/01.rli.0000199293.86956.48openalex-snapshot
Species Dependence on Plasma Protein Binding and Relaxivity of the Gadolinium-Based MRI Contrast Agent MS-325
inferredcites →https://doi.org/10.1103/physrev.99.559openalex-snapshot
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inferredcites →https://doi.org/10.1148/radiology.207.2.9577506openalex-snapshot
MS-325: albumin-targeted contrast agent for MR angiography.
inferredcites →https://doi.org/10.1351/pac200577081445openalex-snapshot
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Synthesis of lanthanide(III) complexes appended with a diphenylphosphinamide and their interaction with human serum albumin
inferred← citeshttps://doi.org/10.1007/s10858-015-9925-8openalex-snapshot
Optimized co-solute paramagnetic relaxation enhancement for the rapid NMR analysis of a highly fibrillogenic peptide
inferred← citeshttps://doi.org/10.1007/s10895-016-1821-4openalex-snapshot
Synthesis and Characterization of Ln(III) Complexes and its Luminescence Properties
inferred← citeshttps://doi.org/10.1007/s11051-014-2292-7openalex-snapshot
Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects
inferred← citeshttps://doi.org/10.1007/s11426-022-1461-3openalex-snapshot
Molecular imaging: design mechanism and bioapplications
inferred← citeshttps://doi.org/10.1007/s12039-012-0332-3openalex-snapshot
Photocytotoxic lanthanide complexes
inferred← citeshttps://doi.org/10.1007/s12265-011-9275-1openalex-snapshot
Emerging MRI Methods in Translational Cardiovascular Research
inferred← citeshttps://doi.org/10.1007/s12265-011-9284-0openalex-snapshot
From Molecules to Myofibers: Multiscale Imaging of the Myocardium
inferred← citeshttps://doi.org/10.1007/s40242-019-8327-yopenalex-snapshot
One-pot Synthesis of PEGylated Gd-based Nanoparticles as High-performance and Biocompatibility Contrast Agents for T1-Weighted Magnetic Resonance Imaging In vivo
inferred← citeshttps://doi.org/10.1016/b0-08-043748-6/09007-1openalex-snapshot
Metal Complexes as MRI Contrast Enhancement Agents
inferred← citeshttps://doi.org/10.1016/b978-0-08-097774-4.00327-2openalex-snapshot
Protein‐Binding Metal Complexes: Noncovalent and Coordinative Interactions
inferred← citeshttps://doi.org/10.1016/b978-0-08-097774-4.00336-3openalex-snapshot
Metal-Based MRI Contrast Agents
inferred← citeshttps://doi.org/10.1016/b978-0-12-398456-2.00065-7openalex-snapshot
Polyphenols Nano-Formulations for Topical Delivery and Skin Tissue Engineering
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.11263-6openalex-snapshot
Metal Complexes as MRI Contrast Enhancement Agents
inferred← citeshttps://doi.org/10.1016/b978-0-12-816984-1.00016-0openalex-snapshot
Adsorption, delivery, and controlled release of therapeutic molecules from MOFs
inferred← citeshttps://doi.org/10.1016/b978-0-12-818433-2.00013-3openalex-snapshot
Organic nanoparticles and gadolinium chelates: seeking hypersensitive probes for T1 magnetic resonance imaging
inferred← citeshttps://doi.org/10.1016/b978-0-12-818655-8.00128-1openalex-snapshot
Ten-Membered Rings or Lager With One or More Nitrogen Atoms
inferred← citeshttps://doi.org/10.1016/bs.hpcre.2022.05.001openalex-snapshot
Importance of ligand design in lanthanide azamacrocyclic complexes relevant to biomedical applications
inferred← citeshttps://doi.org/10.1016/j.aca.2021.338905openalex-snapshot
Nanomolar determination of nitrofurans in water via excited-state inter-ligand proton transfer
inferred← citeshttps://doi.org/10.1016/j.addr.2011.03.013openalex-snapshot
Layer-by-layer capsules for magnetic resonance imaging and drug delivery
inferred← citeshttps://doi.org/10.1016/j.arabjc.2014.11.009openalex-snapshot
Amino-phenol complexes of Fe(III) as promising T1 accelerators
inferred← citeshttps://doi.org/10.1016/j.bcp.2010.07.021openalex-snapshot
Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2012.05.036openalex-snapshot
Water-stable NaLuF4-based upconversion nanophosphors with long-term validity for multimodal lymphatic imaging
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2013.06.057openalex-snapshot
Peptide targeted tripod macrocyclic Gd(III) chelates for cancer molecular MRI
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2020.120219openalex-snapshot
Novel ultrasmall multifunctional nanodots for dual-modal MR/NIR-II imaging-guided photothermal therapy
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2020.120406openalex-snapshot
Recent progress on nanoparticles for targeted aneurysm treatment and imaging
inferred← citeshttps://doi.org/10.1016/j.cbpa.2012.12.012openalex-snapshot
The importance of water exchange rates in the design of responsive agents for MRI
inferred← citeshttps://doi.org/10.1016/j.ccr.2010.02.025openalex-snapshot
Biomedical applications of macrocyclic ligand complexes
inferred← citeshttps://doi.org/10.1016/j.ccr.2011.07.010openalex-snapshot
Thermodynamics of lanthanide(III) complexation in non-aqueous solvents
inferred← citeshttps://doi.org/10.1016/j.ccr.2021.213908openalex-snapshot
AAZTA: The rise of mesocyclic chelating agents for metal coordination in medicine
inferred← citeshttps://doi.org/10.1016/j.ccr.2021.214398openalex-snapshot
Responsive gadolinium(III) complex-based small molecule magnetic resonance imaging probes: Design, mechanism and application
inferred← citeshttps://doi.org/10.1016/j.ccr.2026.218170openalex-snapshot
Non-activity-based and activatable bioresponsive peptide-conjugated Gd(III) complexes for tumor-targeted molecular MR imaging
inferred← citeshttps://doi.org/10.1016/j.ccr.2026.218563openalex-snapshot
Metal-phenolic networks in biomedical applications
inferred← citeshttps://doi.org/10.1016/j.cej.2026.182132openalex-snapshot
Bioengineered protein contrast agents with dual-targeting and stroma-priming capabilities to overcome biophysical barriers in pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2013.11.031openalex-snapshot
Mitochondrial dysfunction induced by different concentrations of gadolinium ion
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2016.03.082openalex-snapshot
Microcalorimetric studies on the energy release of isolated rat mitochondria under different concentrations of gadolinium (III)
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.142090openalex-snapshot
Biochemical and biophysical interaction of rare earth elements with biomacromolecules: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.drup.2023.100931openalex-snapshot
Hallmarks of anticancer and antimicrobial activities of corroles
inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.02.011openalex-snapshot
Photoactivated DNA cleavage and anticancer activity of pyrenyl-terpyridine lanthanide complexes
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.10.016openalex-snapshot
Gadolinium-based contrast agents targeted to amyloid aggregates for the early diagnosis of Alzheimer's disease by MRI
inferred← citeshttps://doi.org/10.1016/j.ica.2016.09.047openalex-snapshot
Luminescent Eu3+ complexes in acetonitrile solution: Anion sensing and effect of water on the speciation
inferred← citeshttps://doi.org/10.1016/j.ica.2017.06.014openalex-snapshot
Manganese porphyrin-incorporated conjugated polymer nanoparticles for T1-enhanced magnetic resonance and fluorescent imaging
inferred← citeshttps://doi.org/10.1016/j.ica.2017.09.021openalex-snapshot
Inner-sphere water and hydrogen bonds in lanthanide DOTAM complexes. A neutron diffraction study
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.137820openalex-snapshot
Modulation of antioxidant enzyme by light and heavy rare earth metals: A case study with catalase
inferred← citeshttps://doi.org/10.1016/j.jcis.2016.09.010openalex-snapshot
Terbium-doped manganese carbonate nanoparticles with intrinsic photoluminescence and magnetic resonance imaging capacity
inferred← citeshttps://doi.org/10.1016/j.jconrel.2011.09.069openalex-snapshot
Impact of albumin on drug delivery — New applications on the horizon
inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.05.029openalex-snapshot
Target-switchable Gd(III)-DOTA/protein cage nanoparticle conjugates with multiple targeting affibody molecules as target selective T1 contrast agents for high-field MRI
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2010.10.015openalex-snapshot
Strategies for the covalent conjugation of a bifunctional chelating agent to albumin: Synthesis and characterization of potential MRI contrast agents
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2011.11.004openalex-snapshot
PEGylation of protein-based MRI contrast agents improves relaxivities and biocompatibilities
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2014.01.016openalex-snapshot
Redox-activated MRI contrast agents based on lanthanide and transition metal ions
inferred← citeshttps://doi.org/10.1016/j.jneumeth.2013.07.013openalex-snapshot
Convection enhanced delivery of different molecular weight tracers of gadolinium-tagged polylysine
inferred← citeshttps://doi.org/10.1016/j.jorganchem.2013.05.027openalex-snapshot
Synthetic strategies for efficient conjugation of organometallic complexes with pendant protein reactive markers
inferred← citeshttps://doi.org/10.1016/j.mtchem.2026.103694openalex-snapshot
Targeting effects in manganese based MRI nanoarchitectures under corona and clearance constraints
inferred← citeshttps://doi.org/10.1016/j.poly.2015.10.027openalex-snapshot
Sandwich-type lanthanide(III) complexes of a tetraiminodiphenol macrocyclic ligand derived from 4-methyl-2,6-diformylphenol and 1,3-diaminopropane: structure, NMR and luminescence
inferred← citeshttps://doi.org/10.1016/j.tet.2011.10.034openalex-snapshot
Gadolinium(III)–fluorescein complex as a dual modal probe for MRI and fluorescence zinc sensing
inferred← citeshttps://doi.org/10.1016/j.tet.2014.06.126openalex-snapshot
Synthesis and characterization of a new lanthanide based MRI contrast agent, potential and versatile tracer for multimodal imaging
inferred← citeshttps://doi.org/10.1016/j.tetlet.2012.04.105openalex-snapshot
Design and synthesis of phosphorylated pyridine-based ligands for lanthanide complexation. Part 1
inferred← citeshttps://doi.org/10.1016/j.tetlet.2012.04.106openalex-snapshot
Preparation of phosphorylated bis-pyrazolyl–pyridine nonadendate ligands and their terbium complexes. Part 2
inferred← citeshttps://doi.org/10.1021/ac401751ropenalex-snapshot
Failure of ESI Spectra to Represent Metal-Complex Solution Composition: A Study of Lanthanide–Carboxylate Complexes
inferred← citeshttps://doi.org/10.1021/acs.accounts.0c00275openalex-snapshot
How the Ligand Field in Lanthanide Coordination Complexes Determines Magnetic Susceptibility Anisotropy, Paramagnetic NMR Shift, and Relaxation Behavior
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c01073openalex-snapshot
Enabling Liquid Scanning Electron Microscopy for Therapeutic Suspensions Using Vacuum-Compatible Liquid Capsules
inferred← citeshttps://doi.org/10.1021/acs.chemrev.1c00602openalex-snapshot
Coordination-Directed Self-Assembly of Functional Polynuclear Lanthanide Supramolecular Architectures
inferred← citeshttps://doi.org/10.1021/acs.chemrev.8b00363openalex-snapshot
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.0c00056openalex-snapshot
Solution Structure, Electronic Energy Levels, and Photophysical Properties of [Eu(MeOH)n−2m(NO3)m]3–m+ Complexes
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.0c01663openalex-snapshot
Effect of the Heteroaromatic Antenna on the Binding of Chiral Eu(III) Complexes to Bovine Serum Albumin
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.1c03660openalex-snapshot
Metal−Organic Polyhedron with Four Fe(III) Centers Producing Enhanced T 1 Magnetic Resonance Imaging Contrast in Tumors
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.4c01028openalex-snapshot
Chiral Pyclen-Based Heptadentate Chelates as Highly Stable MRI Contrast Agents
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.4c01715openalex-snapshot
Comprehensive Investigation of [Fe(EDTA)]−-Functionalized Derivatives and their Supramolecular Adducts with Human Serum Albumin
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.5b02535openalex-snapshot
Smart Grafting of Lanthanides onto Silica via N , N -Dialkylcarbamato Complexes
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.7b02912openalex-snapshot
Synthesis and Applications of Perfunctionalized Boron Clusters
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.7b03039openalex-snapshot
A New Bis(aquated) High Relaxivity Mn(II) Complex as an Alternative to Gd(III)-Based MRI Contrast Agent
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.9b00267openalex-snapshot
Lanthanide Complexes of DO3A–(Dibenzylamino)methylphosphinate: Effect of Protonation of the Dibenzylamino Group on the Water-Exchange Rate and the Binding of Human Serum Albumin
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.9b00887openalex-snapshot
Toward MRI and Optical Detection of Zwitterionic Neurotransmitters: Near-Infrared Luminescent and Magnetic Properties of Macrocyclic Lanthanide(III) Complexes Appended with a Crown Ether and a Benzophenone Chromophore
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00964openalex-snapshot
Manganese-Based Contrast Agents for Magnetic Resonance Imaging of Liver Tumors: Structure–Activity Relationships and Lead Candidate Evaluation
inferred← citeshttps://doi.org/10.1021/acs.joc.5b02464openalex-snapshot
Mono- and Bis-Alkylation of Glyoxal-Bridged Tetraazamacrocycles Using Mechanochemistry
inferred← citeshttps://doi.org/10.1021/acs.jpcb.5b04772openalex-snapshot
1H NMR Relaxation Study of a Magnetic Ionic Liquid as a Potential Contrast Agent
inferred← citeshttps://doi.org/10.1021/acs.jpcc.6b08362openalex-snapshot
Shape-Dependent Relaxivity of Nanoparticle-Based T1 Magnetic Resonance Imaging Contrast Agents
inferred← citeshttps://doi.org/10.1021/acsabm.1c00717openalex-snapshot
Amphiphilic DTPA Multimer Assembled on Icosahedral Closo-Borane Motif as High-Performance MRI Blood Pool Contrast Agent
inferred← citeshttps://doi.org/10.1021/acsabm.1c00724openalex-snapshot
Development of an Effective Tumor-Targeted Contrast Agent for Magnetic Resonance Imaging Based on Mn/H-Ferritin Nanocomplexes
inferred← citeshttps://doi.org/10.1021/acsami.0c16666openalex-snapshot
Exploring the Unique Contrast Properties of Aptamer–Gadolinium Conjugates in Magnetic Resonance Imaging for Targeted Imaging of Thrombi
inferred← citeshttps://doi.org/10.1021/acsami.5b09722openalex-snapshot
MoS2–Gd Chelate Magnetic Nanomaterials with Core–Shell Structure Used as Contrast Agents in in Vivo Magnetic Resonance Imaging
inferred← citeshttps://doi.org/10.1021/acsanm.5c03620openalex-snapshot
Colloidal Synthesis of Ag 2 MnSnS 4 Quantum Dots for Bioimaging Applications
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.5c01465openalex-snapshot
Long-Term Magnetic Resonance Imaging of Brain Tumors Using a Simple Manganese Complex
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.8b01618openalex-snapshot
Manganese-Based Magnetic Layered Double Hydroxide Nanoparticle: A pH-Sensitive and Concurrently Enhanced T1/T2-Weighted Dual-Mode Magnetic Resonance Imaging Contrast Agent
inferred← citeshttps://doi.org/10.1021/acscentsci.7b00253openalex-snapshot
Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors
inferred← citeshttps://doi.org/10.1021/acsnano.1c01251openalex-snapshot
Synergistic Enhancement of Fluorescence and Magnetic Resonance Signals Assisted by Albumin Aggregate for Dual-Modal Imaging
inferred← citeshttps://doi.org/10.1021/acsnano.5b07846openalex-snapshot
ZnO-Based Nanoplatforms for Labeling and Treatment of Mouse Tumors without Detectable Toxic Side Effects
inferred← citeshttps://doi.org/10.1021/acsomega.2c03055openalex-snapshot
Cerium Oxide Nanoparticles with Entrapped Gadolinium for High T1 Relaxivity and ROS-Scavenging Purposes
inferred← citeshttps://doi.org/10.1021/acsomega.8b01888openalex-snapshot
Interactions between Endohedral Metallofullerenes and Proteins: The Gd@C60–Lysozyme Model
inferred← citeshttps://doi.org/10.1021/am4041652openalex-snapshot
Highly Uniform Hollow GdF3 Spheres: Controllable Synthesis, Tuned Luminescence, and Drug-Release Properties
inferred← citeshttps://doi.org/10.1021/bc500254gopenalex-snapshot
Redox-Triggered Self-Assembly of Gadolinium-Based MRI Probes for Sensing Reducing Environment
inferred← citeshttps://doi.org/10.1021/bk-2012-1113.ch007openalex-snapshot
The Design of Hybrid Nanoparticles for Image-Guided Radiotherapy
inferred← citeshttps://doi.org/10.1021/bk-2012-1119.ch013openalex-snapshot
Nanobased Technological Applications for Central Nervous System Injuries
inferred← citeshttps://doi.org/10.1021/bm301425jopenalex-snapshot
Light-Triggered Concomitant Enhancement of Magnetic Resonance Imaging Contrast Performance and Drug Release Rate of Functionalized Amphiphilic Diblock Copolymer Micelles
inferred← citeshttps://doi.org/10.1021/bm901378aopenalex-snapshot
Multivalent Protein Polymer MRI Contrast Agents: Controlling Relaxivity via Modulation of Amino Acid Sequence
inferred← citeshttps://doi.org/10.1021/cm201297xopenalex-snapshot
Size-Tunable, Ultrasmall NaGdF4 Nanoparticles: Insights into Their T1 MRI Contrast Enhancement
inferred← citeshttps://doi.org/10.1021/cn300059ropenalex-snapshot
Bioengineered Probes for Molecular Magnetic Resonance Imaging in the Nervous System
inferred← citeshttps://doi.org/10.1021/cr100025topenalex-snapshot
Challenges for Molecular Magnetic Resonance Imaging
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