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Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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High‐Yielding Synthesis of the Anti‐Influenza Neuramidase Inhibitor (−)‐Oseltamivir by Three “One‐Pot” Operations
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Synthesis and properties of some new polyimidosulfides with highly mobile backbones
inferredcites →https://doi.org/10.1002/rcm.1290081012openalex-snapshot
High performance liquid chromatography/ionspray mass spectrometry of N ‐ethylmaleimide and acrylic acid ester derivatives for bioanalysis of thiol compounds
inferredcites →https://doi.org/10.1006/jmre.1998.1405openalex-snapshot
Improved WATERGATE Pulse Sequences for Solvent Suppression in NMR Spectroscopy
inferredcites →https://doi.org/10.1007/bf00498497openalex-snapshot
Demonstration of sulfhydryl and disulfide groups by a fluorescent maleimide procedure
inferredcites →https://doi.org/10.1016/0003-2697(72)90111-xopenalex-snapshot
Fluorescent thiol reagents
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Polymerization of N,N′-bismaleimido-4,4′-diphenylmethane with arenedithiols. Synthesis of some new polyimidosulphides
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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
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Bioconjugate Techniques
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Reduction-sensitive polymers and bioconjugates for biomedical applications
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A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs
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Production of heparin-functionalized hydrogels for the development of responsive and controlled growth factor delivery systems
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Michael addition reactions in macromolecular design for emerging technologies
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Interactions of α, β-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1
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Utility of Thiol-Cross-Linked Fluorescent Dye Labeled Terminators for DNA Sequencing
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In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation
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Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates
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New Coupling Reagents for the Preparation of Disulfide Cross-Linked Conjugates with Increased Stability
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Use of Designed Peptide Linkers and Recombinant Hemoglobin Mutants for Drug Delivery: In VitroRelease of an Angiotensin II Analog and Kinetic Modeling of Delivery
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Maleimidocysteineamido-DOTA Derivatives: New Reagents for Radiometal Chelate Conjugation to Antibody Sulfhydryl Groups Undergo pH-Dependent Cleavage Reactions
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Role of Cross-Linking Agents in Determining the Biochemical and Pharmacokinetic Properties of Mgr6−Clavin Immunotoxins
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Polymeric Systems for Controlled Drug Release
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The Relative Nucleophilic Character of Several Mercaptans toward Ethylene Oxide1
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Cross-linking of Bovine Plasma Albumin and Wool Keratin
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Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides
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Synthesis and structure-activity relationship of some thiol adducts of ethacrynic acid
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Effects of Aromatic Thiols on Thiol−Disulfide Interchange Reactions That Occur during Protein Folding
inferredcites →https://doi.org/10.1021/tx800248xopenalex-snapshot
Reversibility of Covalent Electrophile−Protein Adducts and Chemical Toxicity
inferredcites →https://doi.org/10.1039/b915136bopenalex-snapshot
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inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a134065openalex-snapshot
Mild and Efficient Conjugation of Rabbit Fab' and Horseradish Peroxidase Using a Maleimide Compound and Its Use for Enzyme Immunoassay
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Development of growth factor fusion proteins for cell‐triggered drug delivery
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Review of "The Twelfth West Coast Retrovirus Meeting" and "The Twenty-third Annual Symposium on Nonhuman Primate Models for AIDS"
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1002/ange.202413644openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/anie.201609733openalex-snapshot
Stable and Rapid Thiol Bioconjugation by Light‐Triggered Thiomaleimide Ring Hydrolysis
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3D Laser Micro‐ and Nanoprinting: Challenges for Chemistry
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Precision Conjugation: An Emerging Tool for Generating Protein–Polymer Conjugates
inferred← citeshttps://doi.org/10.1002/anie.202108791openalex-snapshot
Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent
inferred← citeshttps://doi.org/10.1002/anie.202109713openalex-snapshot
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
inferred← citeshttps://doi.org/10.1002/anie.202203838openalex-snapshot
Enhancing Circulation and Tumor Accumulation of Carboplatin via an Erythrocyte‐Anchored Prodrug Strategy
inferred← citeshttps://doi.org/10.1002/anie.202213433openalex-snapshot
Dynamic Covalent Michael Acceptors to Penetrate Cells: Thiol‐Mediated Uptake with Tetrel‐Centered Exchange Cascades, Assisted by Halogen‐Bonding Switches
inferred← citeshttps://doi.org/10.1002/anie.202413644openalex-snapshot
Selective Activation of Peptide‐Thioester Precursors for Templated Native Chemical Ligations
inferred← citeshttps://doi.org/10.1002/anie.202417134openalex-snapshot
One‐Step Maleimide‐Based Dual Functionalization of Protein N‐Termini
inferred← citeshttps://doi.org/10.1002/anie.202517155openalex-snapshot
Synergistic SuFEx‐Driven Covalent Cancer Therapy Using a HER2/EGFR Bivalent Affinity Protein Drug
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Synthesis and biological evaluation of novel benzylidene-succinimide derivatives as noncytotoxic antiangiogenic inhibitors with anticolorectal cancer activity in vivo
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SMP-656: A self-catalyzed ring-opening hydrolysis linker-based ADC with enhanced stability and antitumor efficacy
inferred← citeshttps://doi.org/10.1016/j.ejpb.2019.03.021openalex-snapshot
Antibody-drug conjugates- stability and formulation
inferred← citeshttps://doi.org/10.1016/j.ejpb.2019.05.015openalex-snapshot
Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing
inferred← citeshttps://doi.org/10.1016/j.ejpb.2023.09.017openalex-snapshot
Site-specific PEGylation of recombinant tissue-type plasminogen activator
inferred← citeshttps://doi.org/10.1016/j.ejps.2019.105158openalex-snapshot
Pharmacokinetic profile of N-acetylcysteine amide and its main metabolite in mice using new analytical method
inferred← citeshttps://doi.org/10.1016/j.eurpolymj.2013.05.013openalex-snapshot
Collagen-like peptides and peptide–polymer conjugates in the design of assembled materials
inferred← citeshttps://doi.org/10.1016/j.eurpolymj.2019.08.009openalex-snapshot
In situ cross–linked chitosan hydrogels via Michael addition reaction based on water–soluble thiol–maleimide precursors
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2017.08.008openalex-snapshot
Assessment of glutathione/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.126114openalex-snapshot
Developing targeted drug delivery carriers for breast cancer using glutathione-sensitive doxorubicin-coupled glycated bovine serum albumin nanoparticles
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2017.06.074openalex-snapshot
Development of long-acting ciliary neurotrophic factor by site-specific conjugation with different-sized polyethylene glycols and transferrin
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2026.03.026openalex-snapshot
Evaluation of nanobodies engineered with extra-cysteines for site-specific functionalization
inferred← citeshttps://doi.org/10.1016/j.jchromb.2016.02.015openalex-snapshot
Pitfalls in the analysis of the physiological antioxidant glutathione (GSH) and its disulfide (GSSG) in biological samples: An elephant in the room
inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.02.030openalex-snapshot
Evaluation of a method for measuring the radioprotective metabolite WR-1065 in plasma using chemical derivatization combined with UHPLC-MS/MS
inferred← citeshttps://doi.org/10.1016/j.jconrel.2011.10.037openalex-snapshot
State of the art in PEGylation: The great versatility achieved after forty years of research
inferred← citeshttps://doi.org/10.1016/j.jconrel.2015.09.032openalex-snapshot
Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides
inferred← citeshttps://doi.org/10.1016/j.jconrel.2017.11.020openalex-snapshot
Extending antigen release from particulate vaccines results in enhanced antitumor immune response
inferred← citeshttps://doi.org/10.1016/j.jconrel.2018.01.018openalex-snapshot
Bioorthogonal strategies for site-directed decoration of biomaterials with therapeutic proteins
inferred← citeshttps://doi.org/10.1016/j.jconrel.2019.11.035openalex-snapshot
Critical design criteria for engineering a nanoparticulate HIV-1 vaccine
inferred← citeshttps://doi.org/10.1016/j.jconrel.2020.01.035openalex-snapshot
Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies
inferred← citeshttps://doi.org/10.1016/j.jconrel.2026.115132openalex-snapshot
Engineering the fourth dimension of cell-instructive hydrogels through dynamic bonding
inferred← citeshttps://doi.org/10.1016/j.jddst.2018.09.009openalex-snapshot
N-terminal site-specific PEGylation enhances the circulation half-life of Thymosin alpha 1
inferred← citeshttps://doi.org/10.1016/j.jddst.2024.106495openalex-snapshot
Navigating the future: Advancements in monoclonal antibody nanoparticle therapy for cancer
inferred← citeshttps://doi.org/10.1016/j.jfluchem.2013.02.028openalex-snapshot
Automated preparation of [18F]AFP and [18F]BFP: Two novel bifunctional 18F-labeling building blocks for Huisgen-click
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2024.109781openalex-snapshot
Inhibition of selenium supply function of selenoprotein p through adduct formation by sulforaphane
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116455openalex-snapshot
Determination of degradation for sulfo-SIAB, SM(PEG)2, and sulfo-GMBS by RPLC-UV analysis
inferred← citeshttps://doi.org/10.1016/j.lmd.2026.100143openalex-snapshot
Antibody-oligonucleotide conjugates for clinical diagnostics and RNA therapeutics: bridging ultrasensitive proteomics and targeted gene regulation
inferred← citeshttps://doi.org/10.1016/j.microc.2024.111025openalex-snapshot
On the utility of the extracted ion chromatograms for assigning the conjugation sites and side reactions in bioconjugates synthesized by the maleimide-thiol chemistry
inferred← citeshttps://doi.org/10.1016/j.mtcomm.2019.05.012openalex-snapshot
Chemical cross-linking methods for cell encapsulation in hydrogels
inferred← citeshttps://doi.org/10.1016/j.neurot.2025.e00726openalex-snapshot
Profiling the landscape of cysteine posttranslational modifications in brain aging and neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2020.05.002openalex-snapshot
Site-specific radioiodination of an anti-HER2 single domain antibody fragment with a residualizing prosthetic agent
inferred← citeshttps://doi.org/10.1016/j.polymdegradstab.2020.109336openalex-snapshot
Tailoring physical machinery and biodegradation properties of unsaturated polyesters through manipulation of synthesis and curing conditions
inferred← citeshttps://doi.org/10.1016/j.polymer.2023.125916openalex-snapshot
A highly efficient and specific “grafting to” route for stable protein-polymer conjugates based on Spy chemistry
inferred← citeshttps://doi.org/10.1016/j.reactfunctpolym.2017.06.005openalex-snapshot
Oxidized catechol-derived poly (ethylene glycol) for thiol-specific conjugation
inferred← citeshttps://doi.org/10.1016/j.redox.2018.02.012openalex-snapshot
A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome
inferred← citeshttps://doi.org/10.1016/j.snb.2020.128261openalex-snapshot
Photoelectrochemical assay for histone acetyltransferase based on polydopamine sensitized layered WS2
inferred← citeshttps://doi.org/10.1016/j.talanta.2024.126079openalex-snapshot
Direct electrochemical reduction of graphene oxide thin film for aptamer-based selective and highly sensitive detection of matrix metalloproteinase 2
inferred← citeshttps://doi.org/10.1016/j.tet.2020.131637openalex-snapshot
Thiol-based michael-type addition. A systematic evaluation of its controlling factors
inferred← citeshttps://doi.org/10.1016/j.tibtech.2024.11.018openalex-snapshot
Programmable ultrasound-mediated swarms manipulation of bacteria–red blood cell microrobots for tumor-specific thrombosis and robust photothermal therapy
inferred← citeshttps://doi.org/10.1016/j.trac.2021.116256openalex-snapshot
Recent trends in the developments of analytical probes based on lanthanide-doped upconversion nanoparticles
inferred← citeshttps://doi.org/10.1016/j.xphs.2015.11.037openalex-snapshot
Physical and Chemical Stability of Antibody Drug Conjugates: Current Status
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.10.063openalex-snapshot
Characterization of Ring-Opening Reaction of Succinimide Linkers in ADCs
inferred← citeshttps://doi.org/10.1016/j.ymeth.2025.09.005openalex-snapshot
Advancing antisense oligonucleotide delivery through click chemistry based chemical conjugation with designed short non-cationic peptides for Duchenne muscular dystrophy
inferred← citeshttps://doi.org/10.1021/ac3036316openalex-snapshot
Approach for Plasmonic Based DNA Sensing: Amplification of the Wavelength Shift and Simultaneous Detection of the Plasmon Modes of Gold Nanostructures
inferred← citeshttps://doi.org/10.1021/ac403860copenalex-snapshot
Measurement of in Vivo Drug Load Distribution of Cysteine-Linked Antibody–Drug Conjugates Using Microscale Liquid Chromatography Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.accounts.6b00547openalex-snapshot
On-Demand Dissolution of Chemically Cross-Linked Hydrogels
inferred← citeshttps://doi.org/10.1021/acs.analchem.0c01881openalex-snapshot
Real-Time Imaging of Intracellular Glutathione Levels Based on a Ratiometric Fluorescent Probe with Extremely Fast Response
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c04986openalex-snapshot
Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c05594openalex-snapshot
Stable Immobilization of DNA to Silica Surfaces by Sequential Michael Addition Reactions Developed with Insights from Confocal Raman Microscopy
inferred← citeshttps://doi.org/10.1021/acs.analchem.4c06851openalex-snapshot
SNAr-Based Labeling of Proteins with Trityl Radicals Enables High-Precision, High-Sensitivity, and Long-Range Distance Measurement
inferred← citeshttps://doi.org/10.1021/acs.analchem.6b00976openalex-snapshot
Where Did the Linker-Payload Go? A Quantitative Investigation on the Destination of the Released Linker-Payload from an Antibody-Drug Conjugate with a Maleimide Linker in Plasma
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b03021openalex-snapshot
Native-MS Analysis of Monoclonal Antibody Conjugates by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b00411openalex-snapshot
LC/MS/MS Bioanalysis of Protein–Drug Conjugates—The Importance of Incorporating Succinimide Hydrolysis Products
inferred← citeshttps://doi.org/10.1021/acs.analchem.9b01808openalex-snapshot
Characterization of Positional Isomers of Interchain Cysteine Linked Antibody−Drug Conjugates by High-Resolution Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00143openalex-snapshot
Pyrocinchonimides Conjugate to Amine Groups on Proteins via Imide Transfer
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00551openalex-snapshot
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00590openalex-snapshot
DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00710openalex-snapshot
New Bifunctional Chelators Incorporating Dibromomaleimide Groups for Radiolabeling of Antibodies with Positron Emission Tomography Imaging Radioisotopes
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00049openalex-snapshot
Cyclic Thiosulfinates as a Novel Class of Disulfide Cleavable Cross-Linkers for Rapid Hydrogel Synthesis
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00121openalex-snapshot
Synthesis and Comparative In Vivo Evaluation of Site-Specifically Labeled Radioimmunoconjugates for DLL3-Targeted ImmunoPET
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00137openalex-snapshot
Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00287openalex-snapshot
Pentafulvene–Maleimide Cycloaddition for Bioorthogonal Ligation
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00561openalex-snapshot
Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.2c00144openalex-snapshot
Preparation of Maleimide-Modified Oligonucleotides from the Corresponding Amines Using N-Methoxycarbonylmaleimide
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.2c00177openalex-snapshot
Structure–Activity Relationships of Antibody-Drug Conjugates: A Systematic Review of Chemistry on the Trastuzumab Scaffold
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.2c00280openalex-snapshot
Organometallic S-arylation Reagents for Rapid PEGylation of Biomolecules
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.2c00361openalex-snapshot
Site-Specific Albumin-Selective Ligation to Human Serum Albumin under Physiological Conditions
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.3c00322openalex-snapshot
Structure–Reactivity Studies of 2-Sulfonylpyrimidines Allow Selective Protein Arylation
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.3c00513openalex-snapshot
A Genetically Encoded Photocaged Cysteine for Facile Site-Specific Introduction of Conjugation-Ready Thiol Residues in Antibodies
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00399openalex-snapshot
Field Guide to Challenges and Opportunities in Antibody–Drug Conjugates for Chemists
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00420openalex-snapshot
Conjugation Approach To Produce a Staphylococcus aureus Synbody with Activity in Serum
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00430openalex-snapshot
Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00600openalex-snapshot
Insights on the Application of the Retro Michael-Type Addition on Maleimide-Functionalized Gold Nanoparticles in Biology and Nanomedicine
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00603openalex-snapshot
Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00625openalex-snapshot
Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5c00424openalex-snapshot
Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00117openalex-snapshot
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody–Maytansinoid Conjugates
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00133openalex-snapshot
One-Step Conjugation Method for Site-Specific Antibody–Drug Conjugates through Reactive Cysteine-Engineered Antibodies
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00424openalex-snapshot
Stable Disk Assemblies of a Tobacco Mosaic Virus Mutant as Nanoscale Scaffolds for Applications in Drug Delivery
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00673openalex-snapshot
Collagen-Like Peptide Bioconjugates
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.7b00365openalex-snapshot
Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody–Drug Conjugates
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.7b00678openalex-snapshot
Assembly of High-Potency Photosensitizer–Antibody Conjugates through Application of Dendron Multiplier Technology
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.7b00697openalex-snapshot
Environmentally Triggerable Retinoic Acid-Inducible Gene I Agonists Using Synthetic Polymer Overhangs
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.8b00081openalex-snapshot
Thiol-Reactive Bifunctional Chelators for the Creation of Site-Selectively Modified Radioimmunoconjugates with Improved Stability
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.8b00252openalex-snapshot
Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.8b00320openalex-snapshot
Tuning the Diels–Alder Reaction for Bioconjugation to Maleimide Drug-Linkers
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.8b00546openalex-snapshot
Manipulation of Glutathione-Mediated Degradation of Thiol–Maleimide Conjugates
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