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Synthesis and Evaluation of a Series of 1,2,4,5-Tetrazines for Bioorthogonal Conjugation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Reaktivitätsfolge von Dienen gegenüber Maleinsäureanhydrid bei der Diels‐Alder‐Reaktion
inferredcites →https://doi.org/10.1002/ange.19620741006openalex-snapshot
Diels‐Alder‐Additionen mit „inversem” Elektronenbedarf
inferredcites →https://doi.org/10.1002/ange.196407613122openalex-snapshot
Diels-Alder-Reaktionen der 1.2.4.5-Tetrazine
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inferredcites →https://doi.org/10.1002/anie.200903233openalex-snapshot
Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/ trans ‐Cyclooctene Cycloaddition
inferredcites →https://doi.org/10.1002/anie.200906120openalex-snapshot
Bioorthogonal Turn‐On Probes for Imaging Small Molecules inside Living Cells
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inferredcites →https://doi.org/10.1002/cber.19821150228openalex-snapshot
Zur Kenntnis von Reaktionen des 1,2,4,5‐Tetrazin‐3,6‐dicarbonsäure‐dimethylesters mit Nucleophilen
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High‐Yielding, Two‐Step 18F Labeling Strategy for 18F‐PARP1 Inhibitors
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Inverse‐electron‐demand Diels‐Alder reaction as a highly efficient chemoselective ligation procedure: Synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells
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Structure-reactivity problem in cycloaddition reactions to form heterocyclic compounds
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Reaktivität einfacher offenkettiger und cyclischer dienophile bei Diels-Alder-reaktionen mit inversem elektronenbedarf
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Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging
inferredcites →https://doi.org/10.1021/ja01525a060openalex-snapshot
Reactions of Tetrazines with Unsaturated Compounds. A New Synthesis of Pyridazines
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inferredcites →https://doi.org/10.1021/ja201844copenalex-snapshot
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inferredcites →https://doi.org/10.1021/ja8053805openalex-snapshot
Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity
inferredcites →https://doi.org/10.1021/jo00242a014openalex-snapshot
Inverse electron demand Diels-Alder reactions of 3,6-bis(methylthio)-1,2,4,5-tetrazine. 1,2-Diazine introduction and direct implementation of a divergent 1,2,4,5-tetrazine .fwdarw. 1,2-diazine .fwdarw. benzene (indoline/indole) Diels-Alder strategy
inferredcites →https://doi.org/10.1021/jo020713vopenalex-snapshot
Synthesis and Inverse Electron Demand Diels−Alder Reactions of 3,6-Bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine
inferredcites →https://doi.org/10.1038/nnano.2010.148openalex-snapshot
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inferredcites →https://doi.org/10.1039/c0cc03078copenalex-snapshot
Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes
inferredcites →https://doi.org/10.1073/pnas.0911116107openalex-snapshot
Copper-free click chemistry in living animals
inferredcites →https://doi.org/10.1126/science.1155106openalex-snapshot
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inferredcites →https://doi.org/10.7150/ijms.5.273openalex-snapshot
TMZ-BioShuttle – a reformulated Temozolomide
inferredcites →https://doi.org/10.7150/ijms.7.19openalex-snapshot
The Diels-Alder-Reaction with inverse-Electron-Demand, a very efficient versatile Click-Reaction Concept for proper Ligation of variable molecular Partners
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Bioorthogonal Reaction Pairs Enable Simultaneous, Selective, Multi‐Target Imaging
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Metal‐Catalyzed One‐Pot Synthesis of Tetrazines Directly from Aliphatic Nitriles and Hydrazine
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The inverse electron demand Diels–Alder cycloaddition with carbon‐11 and fluorine‐18: A gateway to pretargeted imaging across the blood–brain barrier
inferred← citeshttps://doi.org/10.1002/mabi.202200226openalex-snapshot
Investigation of the Impact of Hydrolytically Cleavable Groups on the Stability of Poly(ethylene glycol) Based Hydrogels Cross‐Linked via the Inverse Electron Demand Diels–Alder (iEDDA) Reaction
inferred← citeshttps://doi.org/10.1002/marc.201900510openalex-snapshot
Systematic Screening of Different Polyglycerin‐Based Dienophile Macromonomers for Efficient Nanogel Formation through IEDDA Inverse Nanoprecipitation
inferred← citeshttps://doi.org/10.1002/open.201200014openalex-snapshot
Efficient 18F‐Labeling of Synthetic Exendin‐4 Analogues for Imaging Beta Cells
inferred← citeshttps://doi.org/10.1002/open.201700105openalex-snapshot
Specific Binding of Liposomal Nanoparticles through Inverse Electron‐Demand Diels–Alder Click Chemistry
inferred← citeshttps://doi.org/10.1002/open.202000128openalex-snapshot
Bioorthogonal Ligations and Cleavages in Chemical Biology
inferred← citeshttps://doi.org/10.1002/poc.4674openalex-snapshot
Bioorthogonal Reactions of Oxadiazinones With Strained trans‐Cyclooctenes
inferred← citeshttps://doi.org/10.1002/pol.20240593openalex-snapshot
Exploring the reactivity and interactions of a poly(fluorene‐co‐tetrazine)‐conjugated polymer with Single‐walled Carbon Nanotubes
inferred← citeshttps://doi.org/10.1002/pol.20250863openalex-snapshot
Crosslinking Poly(Tetrazine) Decorated Single‐Walled Carbon Nanotubes via Inverse Electron Demand Diels‐Alder Reaction for Film Fabrication
inferred← citeshttps://doi.org/10.1002/pola.70226openalex-snapshot
Supramolecular Surface Functionalization of Single‐Walled Carbon Nanotubes With Conjugated Graft Copolymers
inferred← citeshttps://doi.org/10.1002/psc.3141openalex-snapshot
Inverse electron demand Diels–Alder (IEDDA) reactions in peptide chemistry
inferred← citeshttps://doi.org/10.1002/slct.202103139openalex-snapshot
Recent advances in the synthesis of five‐ and six‐membered heterocycles as bioactive skeleton: A concise overview
inferred← citeshttps://doi.org/10.1002/slct.202200541openalex-snapshot
Click Chemistry Mediated by Photochemical Energy
inferred← citeshttps://doi.org/10.1002/smll.201502972openalex-snapshot
Bioorthogonal Click Chemistry-Based Synthetic Cell Glue
inferred← citeshttps://doi.org/10.1007/7081_2025_102openalex-snapshot
Click Chemistry for Protein Modification in Live Cells and In Vivo
inferred← citeshttps://doi.org/10.1007/978-1-0716-4905-3_12openalex-snapshot
Innovative Methods to Label, Track, and Quantitate Extracellular Vesicle Uptake
inferred← citeshttps://doi.org/10.1007/978-1-4939-7265-4_6openalex-snapshot
STED Imaging of Golgi Dynamics with Cer-SiR: A Two-Component, Photostable, High-Density Lipid Probe for Live Cells
inferred← citeshttps://doi.org/10.1007/978-1-4939-7574-7_13openalex-snapshot
Site-Specific Protein Labeling with Tetrazine Amino Acids
inferred← citeshttps://doi.org/10.1007/978-1-4939-7574-7_23openalex-snapshot
Site-Specific Protein Labeling Utilizing Lipoic Acid Ligase (LplA) and Bioorthogonal Inverse Electron Demand Diels-Alder Reaction
inferred← citeshttps://doi.org/10.1007/978-1-4939-7808-3_37openalex-snapshot
Integrated Methods to Manufacture Hydrogel Microparticles with High Protein Conjugation Capacity and Binding Kinetics via Viral Nanotemplate Display
inferred← citeshttps://doi.org/10.1007/978-3-030-62226-8_18openalex-snapshot
Syntheses and Biological Applications of Fluorescent Probes
inferred← citeshttps://doi.org/10.1007/978-3-319-67720-0_13openalex-snapshot
Preservation of Ligand Functionality by Click Chemistry
inferred← citeshttps://doi.org/10.1007/978-3-319-98947-1openalex-snapshot
Radiopharmaceutical Chemistry
inferred← citeshttps://doi.org/10.1007/978-3-319-98947-1_26openalex-snapshot
Click Chemistry in Radiopharmaceutical Chemistry
inferred← citeshttps://doi.org/10.1007/978-3-642-29268-2_9openalex-snapshot
Diagnostic Magnetic Resonance Technology
inferred← citeshttps://doi.org/10.1007/978-981-97-4596-8_6openalex-snapshot
Bioorthogonal Click Chemistry: Invention to Applications in Living Systems
inferred← citeshttps://doi.org/10.1007/s00706-016-1668-zopenalex-snapshot
Efficient low-cost preparation of trans-cyclooctenes using a simplified flow setup for photoisomerization
inferred← citeshttps://doi.org/10.1007/s00706-017-2110-xopenalex-snapshot
A computational model to predict the Diels–Alder reactivity of aryl/alkyl-substituted tetrazines
inferred← citeshttps://doi.org/10.1007/s00726-016-2204-5openalex-snapshot
Chemical tags for site-specific fluorescent labeling of biomolecules
inferred← citeshttps://doi.org/10.1007/s12223-018-0620-5openalex-snapshot
3,6-Di(pyridin-2-yl)-1,2,4,5-tetrazine (pytz)-capped silver nanoparticles (TzAgNPs) inhibit biofilm formation of Pseudomonas aeruginosa: a potential approach toward breaking the wall of biofilm through reactive oxygen species (ROS) generation
inferred← citeshttps://doi.org/10.1007/s41061-015-0004-0openalex-snapshot
Cycloadditions for Studying Nucleic Acids
inferred← citeshttps://doi.org/10.1007/s41061-015-0005-zopenalex-snapshot
Inverse Electron-Demand Diels–Alder Bioorthogonal Reactions
inferred← citeshttps://doi.org/10.1007/s41061-022-00385-7openalex-snapshot
Functionalized Triazines and Tetrazines: Synthesis and Applications
inferred← citeshttps://doi.org/10.1007/s41061-024-00467-8openalex-snapshot
Mutually Orthogonal Bioorthogonal Reactions: Selective Chemistries for Labeling Multiple Biomolecules Simultaneously
inferred← citeshttps://doi.org/10.1007/s41061-025-00495-yopenalex-snapshot
Toward Realization of Bioorthogonal Chemistry in the Clinic
inferred← citeshttps://doi.org/10.1016/b978-0-12-818655-8.00096-2openalex-snapshot
1,2,4,5-Tetrazines
inferred← citeshttps://doi.org/10.1016/b978-0-323-96025-0.00109-5openalex-snapshot
Chemistry of Antibody-Small Molecule Drug Conjugates
inferred← citeshttps://doi.org/10.1016/bs.aihch.2018.10.003openalex-snapshot
Fluorescent heterocycles: Recent trends and new developments
inferred← citeshttps://doi.org/10.1016/bs.mie.2020.02.020openalex-snapshot
Fast phosphine-activated control of protein function using unnatural lysine analogues
inferred← citeshttps://doi.org/10.1016/bs.mie.2020.04.034openalex-snapshot
Enzyme- or light-triggered cyclopropenes for bioorthogonal ligation
inferred← citeshttps://doi.org/10.1016/j.addr.2026.115961openalex-snapshot
Engineering responsive polymeric drug delivery systems via bioorthogonal and click chemistry: From molecular design to function
inferred← citeshttps://doi.org/10.1016/j.bbapap.2014.07.017openalex-snapshot
Multifunctionalization of cetuximab with bioorthogonal chemistries and parallel EGFR profiling of cell-lines using imaging, FACS and immunoprecipitation approaches
inferred← citeshttps://doi.org/10.1016/j.bej.2018.04.012openalex-snapshot
Controlled network structures of chitosan-poly(ethylene glycol) hydrogel microspheres and their impact on protein conjugation
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2015.01.048openalex-snapshot
Versatile click alginate hydrogels crosslinked via tetrazine–norbornene chemistry
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2023.122353openalex-snapshot
Smart chemistry for traceless release of anticancer therapeutics
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2025.123590openalex-snapshot
Clicktetrazine dECM–alginate hydrogels for injectable, mechanically mimetic, and biologically active vocal fold biomaterials
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107304openalex-snapshot
Selective activation of prodrugs in breast cancer using metabolic glycoengineering and the tetrazine ligation bioorthogonal reaction
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.06.046openalex-snapshot
Synthesis of an amphiphilic tetrazine derivative and its application as a liposomal component to accelerate release of encapsulated drugs
inferred← citeshttps://doi.org/10.1016/j.bmc.2022.116721openalex-snapshot
Photoaffinity labeling and bioorthogonal ligation: Two critical tools for designing “Fish Hooks” to scout for target proteins
inferred← citeshttps://doi.org/10.1016/j.carbpol.2024.123142openalex-snapshot
The inverse electron demand diels-alder (IEDDA): A facile bioorthogonal click reaction for development of injectable polysaccharide-based hydrogels for biomedical applications
inferred← citeshttps://doi.org/10.1016/j.cbpa.2013.07.031openalex-snapshot
trans-Cyclooctene — a stable, voracious dienophile for bioorthogonal labeling
inferred← citeshttps://doi.org/10.1016/j.cbpa.2013.08.004openalex-snapshot
Expanding room for tetrazine ligations in the in vivo chemistry toolbox
inferred← citeshttps://doi.org/10.1016/j.cbpa.2014.07.002openalex-snapshot
Building better bioorthogonal reactions
inferred← citeshttps://doi.org/10.1016/j.cbpa.2015.07.006openalex-snapshot
Orthogonal bioorthogonal chemistries
inferred← citeshttps://doi.org/10.1016/j.cbpa.2020.09.002openalex-snapshot
Recent developments in bioorthogonal chemistry and the orthogonality within
inferred← citeshttps://doi.org/10.1016/j.ccr.2026.218312openalex-snapshot
Site-specific click chemistry-mediated scaffold engineering to bioorthogonally functionalize cell surface in cell-based therapeutics
inferred← citeshttps://doi.org/10.1016/j.cej.2025.159295openalex-snapshot
Test and tune: evaluating, adjusting and optimising the stiffness of hydrogels to influence cell fate
inferred← citeshttps://doi.org/10.1016/j.chembiol.2014.09.002openalex-snapshot
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation
inferred← citeshttps://doi.org/10.1016/j.chembiol.2025.06.002openalex-snapshot
Site-resolved assessment of targeted protein degradation
inferred← citeshttps://doi.org/10.1016/j.chempr.2017.11.007openalex-snapshot
Light Harvesting for Rapid and Selective Reactions: Click Chemistry with Strain-Loadable Alkenes
inferred← citeshttps://doi.org/10.1016/j.chempr.2025.102752openalex-snapshot
The AMI-isonitrile ligation 2.0: Fast, selective, and pH sensitive
inferred← citeshttps://doi.org/10.1016/j.crmeth.2026.101416openalex-snapshot
Efficiency landscape of bioorthogonal click reactions producing bispecific antibody conjugates
inferred← citeshttps://doi.org/10.1016/j.ebiom.2025.105884openalex-snapshot
Tumour extracellular vesicle surface Protein-mRNA integration assay for early detection of epithelial ovarian cancer
inferred← citeshttps://doi.org/10.1016/j.ejps.2024.106944openalex-snapshot
Towards a switchable nanoparticle behavior using inverse electron-demand Diels-Alder chemistry and ectoenzyme-based ligand activation
inferred← citeshttps://doi.org/10.1016/j.eurpolymj.2021.110286openalex-snapshot
A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2025.125929openalex-snapshot
Dual cross-linked hydrogels as promising materials for drug delivery
inferred← citeshttps://doi.org/10.1016/j.jmb.2022.167524openalex-snapshot
Selective Inhibition of Cysteine-Dependent Enzymes by Bioorthogonal Tethering
inferred← citeshttps://doi.org/10.1016/j.jorganchem.2015.05.033openalex-snapshot
Synthesis, characterization and radiolabeling of carborane-functionalized tetrazines for use in inverse electron demand Diels–Alder ligation reactions
inferred← citeshttps://doi.org/10.1016/j.jorganchem.2015.10.030openalex-snapshot
Reprint of: Synthesis, characterization and radiolabeling of carborane-functionalized tetrazines for use in inverse electron demand Diels–Alder ligation reactions
inferred← citeshttps://doi.org/10.1016/j.matbio.2019.05.006openalex-snapshot
Covalent cross-linking of basement membrane-like matrices physically restricts invasive protrusions in breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.mencom.2019.03.031openalex-snapshot
Inverse electron demand Diels–Alder reaction as a novel method for functionalization of natural chlorins
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2018.10.001openalex-snapshot
Efficient cartridge purification for producing high molar activity [18F]fluoro-glycoconjugates via oxime formation
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2024.108911openalex-snapshot
Synthesis and evaluation of novel trifunctional chelating agents for pretargeting approach using albumin binder to improve tumor accumulation
inferred← citeshttps://doi.org/10.1016/j.progpolymsci.2015.07.006openalex-snapshot
“Click” reactions in polysaccharide modification
inferred← citeshttps://doi.org/10.1016/j.progpolymsci.2022.101590openalex-snapshot
Clickable polysaccharides for biomedical applications: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.snb.2014.05.036openalex-snapshot
Synthesis of 3,6-di(pyridin-2-yl)-1,2,4,5-tetrazine (pytz) capped silver nanoparticles using 3,6-di(pyridin-2-yl)-1,4-dihydro-1,2,4,5-tetrazine as reducing agent: Application in naked eye sensing of Cu2+, Ni2+ and Ag+ ions in aqueous solution and paper platform
inferred← citeshttps://doi.org/10.1016/j.tet.2025.134520openalex-snapshot
Click synthesis via 1,3-dipolar addition- A versatile route to tetrazine derivatives and In silico corroboration as anti-muscular dystrophy agent
inferred← citeshttps://doi.org/10.1016/j.tetlet.2013.08.010openalex-snapshot
Facile and efficient Lewis acid catalyzed synthesis of an asymmetric tetrazine useful for bio-orthogonal click chemistry applications
inferred← citeshttps://doi.org/10.1016/j.tetlet.2014.07.002openalex-snapshot
Kinetic studies of inverse electron demand Diels–Alder reactions (iEDDA) of norbornenes and 3,6-dipyridin-2-yl-1,2,4,5-tetrazine
inferred← citeshttps://doi.org/10.1016/j.tetlet.2018.06.071openalex-snapshot
An efficient metal catalyst free approach to synthesize 5-(4-(1,2,4,5 tetrazin-3-yl)benzylamino)-5-oxopentanoic acid
inferred← citeshttps://doi.org/10.1016/j.tetlet.2018.07.043openalex-snapshot
Facile method for the synthesis of triazole- and tetrazole-containing peptoids on a solid support
inferred← citeshttps://doi.org/10.1021/acs.accounts.6c00091openalex-snapshot
Bioorthogonal Click Chemistry-Enabled Enrichment of Extracellular Vesicles for Integrated Molecular and Functional Liquid Biopsy
inferred← citeshttps://doi.org/10.1021/acs.accounts.7b00606openalex-snapshot
Constructing New Bioorthogonal Reagents and Reactions
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b05139openalex-snapshot
Covalent “Click Chemistry”-Based Attachment of DNA onto Solid Phase Enables Iterative Molecular Analysis
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00002openalex-snapshot
A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00072openalex-snapshot
Postsynthetic Modifications of DNA and RNA by Means of Copper-Free Cycloadditions as Bioorthogonal Reactions
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00107openalex-snapshot
SNAP/CLIP-Tags and Strain-Promoted Azide–Alkyne Cycloaddition (SPAAC)/Inverse Electron Demand Diels–Alder (IEDDA) for Intracellular Orthogonal/Bioorthogonal Labeling
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00497openalex-snapshot
Temporal Control of Efficient In Vivo Bioconjugation Using a Genetically Encoded Tetrazine-Mediated Inverse-Electron-Demand Diels–Alder Reaction
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