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Pharmacokinetic, Biodistribution, and Biophysical Profiles of TNF Nanobodies Conjugated to Linear or Branched Poly(ethylene glycol)

https://doi.org/10.1021/bc300066a
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Outgoing claims: the papers this work cites, builds on, or argues with.

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The effects of poly(ethylene glycol) on the solution structure of human serum albumin
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Size comparison between proteins PEGylated with branched and linear poly(ethylene glycol) molecules
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Efficient tumor targeting by single‐domain antibody fragments of camels
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The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics
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Biodistribution of [125I]-labeled therapeutic proteins: Application in protein drug development beyond oncology**All authors are current or former employees of Wyeth, Inc.
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Distribution and Tissue Uptake of Poly(ethylene glycol) with Different Molecular Weights after Intravenous Administration to Mice
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ADAPTING PHARMACOKINETIC PROPERTIES OF A HUMANIZED ANTI-INTERLEUKIN-8 ANTIBODY FOR THERAPEUTIC APPLICATIONS USING SITE-SPECIFIC PEGYLATION
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PEGylated Protein Drugs: Basic Science and Clinical Applications
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Correlations between in vitro potency of polyethylene glycol–protein conjugates and their chromatographic behavior
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State of the art in PEGylation: The great versatility achieved after forty years of research
inferredcites →https://doi.org/10.1016/s0169-409x(02)00025-xopenalex-snapshot
Effects of PEG conjugation on insulin properties
inferredcites →https://doi.org/10.1016/s0169-409x(02)00180-1openalex-snapshot
Effective drug delivery by PEGylated drug conjugates
inferredcites →https://doi.org/10.1016/s0169-409x(03)00108-xopenalex-snapshot
Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates
inferredcites →https://doi.org/10.1021/bc00031a006openalex-snapshot
A Branched Monomethoxypoly(ethylene glycol) for Protein Modification
inferredcites →https://doi.org/10.1021/bc049843wopenalex-snapshot
Prediction of the Viscosity Radius and the Size Exclusion Chromatography Behavior of PEGylated Proteins
inferredcites →https://doi.org/10.1021/ja021264jopenalex-snapshot
NMR Structure of Two Novel Polyethylene Glycol Conjugates of the Human Growth Hormone-Releasing Factor, hGRF(1−29)−NH2
inferredcites →https://doi.org/10.1038/clpt.2008.170openalex-snapshot
Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
inferredcites →https://doi.org/10.1038/nrd1033openalex-snapshot
Effect of pegylation on pharmaceuticals
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Comparison of Body Distribution of Poly(vinyl alcohol) with Other Water-soluble Polymers after Intravenous Administration
inferredcites →https://doi.org/10.1177/088391159701200303openalex-snapshot
Branched and Linear Poly(Ethylene Glycol): Influence of the Polymer Structure on Enzymological, Pharmacokinetic, and Immunological Properties of Protein Conjugates
inferredcites →https://doi.org/10.1208/s12248-009-9081-8openalex-snapshot
Poly(ethylene glycol)-Modified Proteins: Implications for Poly(lactide-co-glycolide)-Based Microsphere Delivery
inferredcites →https://doi.org/10.2967/jnumed.107.048538openalex-snapshot
Comparison of the Biodistribution and Tumor Targeting of Two 99m Tc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT
inferredcites →https://doi.org/10.4331/wjbc.v3.i4.73openalex-snapshot
Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges

What points at this work

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Additional file 1 of Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
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