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Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.molcel.2008.04.013openalex-snapshot
“Nought May Endure but Mutability”: Spliceosome Dynamics and the Regulation of Splicing
inferredcites →https://doi.org/10.1016/s0968-0004(98)01208-0openalex-snapshot
A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance
inferredcites →https://doi.org/10.1017/s1462399408000744openalex-snapshot
p21 and p27: roles in carcinogenesis and drug resistance
inferredcites →https://doi.org/10.1038/35095083openalex-snapshot
A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase
inferredcites →https://doi.org/10.1038/nchembio.2007.16openalex-snapshot
Splicing factor SF3b as a target of the antitumor natural product pladienolide
inferredcites →https://doi.org/10.1038/nchembio.2007.18openalex-snapshot
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
inferredcites →https://doi.org/10.1038/sj.bjc.6604801openalex-snapshot
The spliceosome as target for anticancer treatment
inferredcites →https://doi.org/10.1074/jbc.m500866200openalex-snapshot
Molecular Dissection of the Interaction between p27 and Kip1 Ubiquitylation-promoting Complex, the Ubiquitin Ligase That Regulates Proteolysis of p27 in G1 Phase
inferredcites →https://doi.org/10.1074/jbc.m805468200openalex-snapshot
Nuclear Inhibitor of Protein Phosphatase-1 (NIPP1) Directs Protein Phosphatase-1 (PP1) to Dephosphorylate the U2 Small Nuclear Ribonucleoprotein Particle (snRNP) Component, Spliceosome-associated Protein 155 (Sap155)
inferredcites →https://doi.org/10.1093/emboj/16.17.5334openalex-snapshot
Phosphorylation‐dependent degradation of the cyclin‐dependent kinase inhibitor p27Kip1
inferredcites →https://doi.org/10.1093/emboj/19.24.6860openalex-snapshot
The spliceosome deposits multiple proteins 20–24 nucleotides upstream of mRNA exon–exon junctions
inferredcites →https://doi.org/10.1093/emboj/20.16.4536openalex-snapshot
A novel U2 and U11/U12 snRNP protein that associates with the pre‐mRNA branch site
inferredcites →https://doi.org/10.1093/emboj/20.17.4987openalex-snapshot
The exon–exon junction complex provides a binding platform for factors involved in mRNA export and nonsense‐mediated mRNA decay
inferredcites →https://doi.org/10.1093/emboj/cdf480openalex-snapshot
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein
inferredcites →https://doi.org/10.1101/gad.1566807openalex-snapshot
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function
inferredcites →https://doi.org/10.1126/science.7624798openalex-snapshot
Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27
inferredcites →https://doi.org/10.1128/mcb.18.8.4752openalex-snapshot
A Potential Role for U2AF-SAP 155 Interactions in Recruiting U2 snRNP to the Branch Site
inferredcites →https://doi.org/10.7164/antibiotics.55.855openalex-snapshot
GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. I. Taxonomy, Production, Isolation, Physicochemical Properties and Biological Activities.
inferredcites →https://doi.org/10.7164/antibiotics.55.863openalex-snapshot
GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. II. The Effects on Cell Cycle Progression and Gene Expression.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Inverse Electron Demand Diels-Alder Reaction in Total Synthesis of Bioactive Natural Products
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Splicing Inhibitors: From Small Molecule to RNA Metabolism
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Das Spliceosom als Angriffspunkt für Pharmaka
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Re2O7‐Mediated Dehydrative Cyclization Reactions: Total Synthesis of Herboxidiene and Its 12‐Desmethyl Analogue
inferred← citeshttps://doi.org/10.1002/anie.201701065openalex-snapshot
A Challenging Pie to Splice: Drugging the Spliceosome
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Re2O7‐Mediated Dehydrative Cyclization Reactions: Total Synthesis of Herboxidiene and Its 12‐Desmethyl Analogue
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inferred← citeshttps://doi.org/10.1002/cmdc.70309openalex-snapshot
Diene Substitution Patterns in the Conformation‐Activity Relationships of GEX1A
inferred← citeshttps://doi.org/10.1002/prp2.158openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/slct.201902742openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/wrna.1158openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/wrna.1381openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-981-10-8372-3_8openalex-snapshot
Modulation of Abnormal Splicing of RNA Diseases by Small Chemical Compounds
inferred← citeshttps://doi.org/10.1007/s00253-015-6431-6openalex-snapshot
Structural modification of herboxidiene by substrate-flexible cytochrome P450 and glycosyltransferase
inferred← citeshttps://doi.org/10.1007/s00253-015-6860-2openalex-snapshot
Herboxidiene biosynthesis, production, and structural modifications: prospect for hybrids with related polyketide
inferred← citeshttps://doi.org/10.1007/s00439-017-1789-4openalex-snapshot
Modulation of aberrant splicing in human RNA diseases by chemical compounds
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RETRACTED ARTICLE: Complex Effect of RNA Spliceosome Inhibition on Amyloid Precursor Protein Expression
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inferred← citeshttps://doi.org/10.1016/j.bcp.2026.118060openalex-snapshot
RNA splicing regulation and tumor: A focus on the multifunctional SRSF family as a therapeutic target
inferred← citeshttps://doi.org/10.1016/j.biocel.2017.04.006openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.biochi.2020.07.020openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.07.078openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.12.056openalex-snapshot
A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore
inferred← citeshttps://doi.org/10.1016/j.drudis.2012.07.013openalex-snapshot
The development and application of small molecule modulators of SF3b as therapeutic agents for cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118248openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.02.025openalex-snapshot
Mutation of Arabidopsis SME1 and Sm core assembly improves oxidative stress resilience
inferred← citeshttps://doi.org/10.1016/j.isci.2019.11.033openalex-snapshot
Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.108135openalex-snapshot
SF3B1 thermostability as an assay for splicing inhibitor interactions
inferred← citeshttps://doi.org/10.1016/j.jbior.2017.09.008openalex-snapshot
Splicing factor mutations in the myelodysplastic syndromes: target genes and therapeutic approaches
inferred← citeshttps://doi.org/10.1016/j.medcle.2015.11.005openalex-snapshot
Alternative splicing regulation: Implications in cancer diagnosis and treatment
inferred← citeshttps://doi.org/10.1016/j.medcli.2014.02.021openalex-snapshot
Regulación del splicing alternativo: Implicaciones en el diagnóstico y tratamiento del cáncer
inferred← citeshttps://doi.org/10.1016/j.molcel.2014.10.030openalex-snapshot
Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery
inferred← citeshttps://doi.org/10.1016/j.molcel.2018.03.011openalex-snapshot
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds
inferred← citeshttps://doi.org/10.1016/j.molmed.2012.06.006openalex-snapshot
Pre-mRNA splicing in disease and therapeutics
inferred← citeshttps://doi.org/10.1016/j.molmed.2015.11.005openalex-snapshot
Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy
inferred← citeshttps://doi.org/10.1016/j.omtn.2021.10.025openalex-snapshot
PHF5A promotes colorectal cancer progression by alternative splicing of TEAD2
inferred← citeshttps://doi.org/10.1016/j.omtn.2023.07.011openalex-snapshot
Branchpoints as potential targets of exon-skipping therapies for genetic disorders
inferred← citeshttps://doi.org/10.1016/j.plaphy.2025.109827openalex-snapshot
Identification of pine SF3B1 protein and cross-species comparison highlight its conservation and biological significance in pre-mRNA splicing regulation
inferred← citeshttps://doi.org/10.1016/j.tetlet.2012.09.035openalex-snapshot
Ruthenium-catalyzed olefin metathesis after tetra-n-butylammonium fluoride-mediated desilylation
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Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle
inferred← citeshttps://doi.org/10.1016/j.tplants.2017.09.019openalex-snapshot
Alternative Splicing Control of Abiotic Stress Responses
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Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01893openalex-snapshot
Stereochemical Control of Splice Modulation in FD-895 Analogues
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.8b00314openalex-snapshot
GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts
inferred← citeshttps://doi.org/10.1021/acs.orglett.6b01524openalex-snapshot
Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene)
inferred← citeshttps://doi.org/10.1021/acschembio.0c00001openalex-snapshot
Chemical Modulation of Pre-mRNA Splicing in Mammalian Systems
inferred← citeshttps://doi.org/10.1021/acschembio.6b00399openalex-snapshot
Selectivity in Small Molecule Splicing Modulation
inferred← citeshttps://doi.org/10.1021/acschembio.6b00562openalex-snapshot
Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry
inferred← citeshttps://doi.org/10.1021/acschembio.9b00833openalex-snapshot
Splice Modulation Synergizes Cell Cycle Inhibition
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.0c00153openalex-snapshot
Design and Synthesis of 1,2-Deoxy-pyranose Derivatives of Spliceostatin A toward Prostate Cancer Treatment
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.4c00510openalex-snapshot
Structure–Activity Relationship Study of Splicing Modulators on Hsh155/SF3B1 through Chemical Synthesis and Yeast Genetics
inferred← citeshttps://doi.org/10.1021/cb400695jopenalex-snapshot
Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives
inferred← citeshttps://doi.org/10.1021/cb500697fopenalex-snapshot
Modulation of Alternative Splicing with Chemical Compounds in New Therapeutics for Human Diseases
inferred← citeshttps://doi.org/10.1021/jacs.5b13427openalex-snapshot
A Carbohydrate-Derived Splice Modulator
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inferred← citeshttps://doi.org/10.1021/jm401370hopenalex-snapshot
Optimization of Antitumor Modulators of Pre-mRNA Splicing
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Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei
inferred← citeshttps://doi.org/10.1021/ol202210kopenalex-snapshot
Total Synthesis of (+)-Herboxidiene from Two Chiral Lactate-Derived Ketones
inferred← citeshttps://doi.org/10.1038/ja.2015.94openalex-snapshot
RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis
inferred← citeshttps://doi.org/10.1038/ja.2016.166openalex-snapshot
The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues
inferred← citeshttps://doi.org/10.1038/nature13735openalex-snapshot
Multifunctional organoboron compounds for scalable natural product synthesis
inferred← citeshttps://doi.org/10.1038/ncomms15522openalex-snapshot
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
inferred← citeshttps://doi.org/10.1038/nm.4165openalex-snapshot
Therapeutic targeting of splicing in cancer
inferred← citeshttps://doi.org/10.1038/nrd3823openalex-snapshot
The spliceosome as a target of novel antitumour drugs
inferred← citeshttps://doi.org/10.1038/s41388-024-03036-xopenalex-snapshot
Alternative splicing in prostate cancer progression and therapeutic resistance
inferred← citeshttps://doi.org/10.1038/s41416-022-01796-5openalex-snapshot
Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression
inferred← citeshttps://doi.org/10.1038/s41418-018-0231-3openalex-snapshot
Function, clinical application, and strategies of Pre-mRNA splicing in cancer
inferred← citeshttps://doi.org/10.1038/s41429-021-00450-1openalex-snapshot
Splicing modulators: on the way from nature to clinic
inferred← citeshttps://doi.org/10.1038/s41467-018-08150-5openalex-snapshot
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
inferred← citeshttps://doi.org/10.1038/s41467-020-19514-1openalex-snapshot
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly
inferred← citeshttps://doi.org/10.1038/s41467-025-59902-zopenalex-snapshot
Non-C2 symmetric chiral ligand dictating allyl-allyl coupling
inferred← citeshttps://doi.org/10.1038/s42003-021-02051-yopenalex-snapshot
Overlapping roles of spliceosomal components SF3B1 and PHF5A in rice splicing regulation
inferred← citeshttps://doi.org/10.1038/s43018-022-00384-zopenalex-snapshot
Dysregulation and therapeutic targeting of RNA splicing in cancer
inferred← citeshttps://doi.org/10.1039/c5np00110bopenalex-snapshot
Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1
inferred← citeshttps://doi.org/10.1039/c5ob00169bopenalex-snapshot
Design and synthesis of analogues of natural products
inferred← citeshttps://doi.org/10.1039/c6ob00321dopenalex-snapshot
Gold-catalyzed Hosomi–Sakurai type reaction for the total synthesis of herboxidiene
inferred← citeshttps://doi.org/10.1039/c7ob00072copenalex-snapshot
Total synthesis of (+)-herboxidiene/GEX 1A
inferred← citeshttps://doi.org/10.1039/d0ob02283gopenalex-snapshot
2-Nitroallyl carbonate-based green bifunctional reagents for catalytic asymmetric annulation reactions
inferred← citeshttps://doi.org/10.1039/d0sc01928copenalex-snapshot
Production of novel pladienolide analogues through native expression of a pathway-specific activator
inferred← citeshttps://doi.org/10.1055/a-1377-0346openalex-snapshot
Perrhenate Esters as Intermediates in Molecular Complexity-Increasing Reactions
inferred← citeshttps://doi.org/10.1073/pnas.1408300111openalex-snapshot
Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate–dependent dioxygenase
inferred← citeshttps://doi.org/10.1074/jbc.m113.515536openalex-snapshot
Coherence between Cellular Responses and in Vitro Splicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs
inferred← citeshttps://doi.org/10.1074/jbc.m114.590976openalex-snapshot
Identification of Small Molecule Inhibitors of Pre-mRNA Splicing
inferred← citeshttps://doi.org/10.1080/09168451.2016.1249451openalex-snapshot
The isoflavone fraction from soybean presents mRNA maturation inhibition activity
inferred← citeshttps://doi.org/10.1080/09168451.2018.1547107openalex-snapshot
Inhibition of mRNA processing activity from ginger-, clove- and cinnamon-extract, and by two ginger constituents, 6-gingerol and 6-shogaol
inferred← citeshttps://doi.org/10.1080/10409238.2019.1691497openalex-snapshot
Structural and functional modularity of the U2 snRNP in pre-mRNA splicing
inferred← citeshttps://doi.org/10.1080/15476286.2022.2146919openalex-snapshot
Inhibition of mitochondrial complex III or dihydroorotate dehydrogenase (DHODH) triggers formation of poly(A) + RNA foci adjacent to nuclear speckles following activation of ATM (ataxia telangiectasia mutated)
inferred← citeshttps://doi.org/10.1080/15476286.2023.2239601openalex-snapshot
Pre-mRNA splicing-associated diseases and therapies
inferred← citeshttps://doi.org/10.1093/nar/gkw1349openalex-snapshot
SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast
inferred← citeshttps://doi.org/10.1097/moh.0000000000000632openalex-snapshot
Therapeutic approaches targeting splicing factor mutations in myelodysplastic syndromes and acute myeloid leukemia
inferred← citeshttps://doi.org/10.1101/2024.06.26.600844openalex-snapshot
Inhibition of SF3B1 affects recruitment of P-TEFb to chromatin through multiple mechanisms
inferred← citeshttps://doi.org/10.1101/2025.05.01.651692openalex-snapshot
Integrative CRISPR Screens and RNA-Omics Discover an Essential Role for PUF60-3’ Splice Site Interactions in Cancer Progression
inferred← citeshttps://doi.org/10.1111/acel.14301openalex-snapshot
A defective splicing machinery promotes senescence through MDM4 alternative splicing
inferred← citeshttps://doi.org/10.1111/cas.12317openalex-snapshot
High antitumor activity of pladienolide B and its derivative in gastric cancer
inferred← citeshttps://doi.org/10.1111/j.1349-7006.2012.02356.xopenalex-snapshot
Splicing in oncogenesis and tumor suppression
inferred← citeshttps://doi.org/10.1126/sciadv.aed7513openalex-snapshot
Spliceosome buffers cryptic genetic variation to enforce phenotypic robustness in Arabidopsis
inferred← citeshttps://doi.org/10.1126/science.1250127openalex-snapshot
SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy
inferred← citeshttps://doi.org/10.1128/aem.06904-11openalex-snapshot
Identification of the Herboxidiene Biosynthetic Gene Cluster in Streptomyces chromofuscus ATCC 49982
inferred← citeshttps://doi.org/10.1128/genomea.00218-15openalex-snapshot
Draft Genome Sequence of Ochrobactrum anthropi Strain ML7 Isolated from Soil Samples in Vinhphuc Province, Vietnam
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-062124-035809openalex-snapshot
RNA Splicing as a Therapeutic Target in Cancer
inferred← citeshttps://doi.org/10.1155/2016/3681094openalex-snapshot
Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment
inferred← citeshttps://doi.org/10.11575/prism/24178openalex-snapshot
A study of the C. elegans teg-4 gene, using Tiling array analysis
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-13-2461openalex-snapshot
Test-Firing Ammunition for Spliceosome Inhibition in Cancer
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-11-0462openalex-snapshot
SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression
inferred← citeshttps://doi.org/10.11606/d.42.2022.tde-21082023-100133openalex-snapshot
Análise do efeito da ubistatina A no >i /i< de células de linhagens tumorais.
inferred← citeshttps://doi.org/10.11648/j.bmb.20170204.13openalex-snapshot
Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton
inferred← citeshttps://doi.org/10.1186/s12864-017-3656-zopenalex-snapshot
Herboxidiene triggers splicing repression and abiotic stress responses in plants
inferred← citeshttps://doi.org/10.1186/s12935-021-01932-wopenalex-snapshot
SNRPD1 confers diagnostic and therapeutic values on breast cancers through cell cycle regulation
inferred← citeshttps://doi.org/10.1186/s12935-023-03094-3openalex-snapshot
The role of alternative pre-mRNA splicing in cancer progression
inferred← citeshttps://doi.org/10.1186/s13046-025-03279-wopenalex-snapshot
Targeting RNA splicing modulation: new perspectives for anticancer strategy?
inferred← citeshttps://doi.org/10.1186/s13059-019-1680-9openalex-snapshot
CRISPR directed evolution of the spliceosome for resistance to splicing inhibitors
inferred← citeshttps://doi.org/10.1261/rna.053108.115openalex-snapshot
Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages
inferred← citeshttps://doi.org/10.1261/rna.065383.117openalex-snapshot
Inhibition of SF3B1 by molecules targeting the spliceosome results in massive aberrant exon skipping
inferred← citeshttps://doi.org/10.1261/rna.079866.123openalex-snapshot
Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain
inferred← citeshttps://doi.org/10.1371/journal.pone.0229315openalex-snapshot
Impact of cancer-associated mutations in Hsh155/SF3b1 HEAT repeats 9-12 on pre-mRNA splicing in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.15252/embj.201489478openalex-snapshot
NTR1 is required for transcription elongation checkpoints at alternative exons in Arabidopsis
inferred← citeshttps://doi.org/10.18632/aging.203924openalex-snapshot
Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B
inferred← citeshttps://doi.org/10.2174/15680096113139990083openalex-snapshot
Alternative Splicing in Chronic Myeloid Leukemia (CML): A Novel Therapeutic Target?
inferred← citeshttps://doi.org/10.32526/ennrj/19/202100050openalex-snapshot
Presence of Biosynthetic Gene Clusters (NRPS/PKS) in Actinomycetes of Mangrove Sediment in Semarang and Karimunjawa, Indonesia
inferred← citeshttps://doi.org/10.3389/fonc.2022.1019750openalex-snapshot
Emerging roles of alternative RNA splicing in oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.3389/fonc.2022.1051487openalex-snapshot
Multi-omics approach to identifying isoform variants as therapeutic targets in cancer patients
inferred← citeshttps://doi.org/10.3390/biomedicines10081972openalex-snapshot
Molecular Threat of Splicing Factor Mutations to Myeloid Malignancies and Potential Therapeutic Modulations
inferred← citeshttps://doi.org/10.3390/cancers14071827openalex-snapshot
Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer
inferred← citeshttps://doi.org/10.3390/genes17090984openalex-snapshot
Alternative RNA Splicing in Cancer: Molecular Mechanisms, Functional Consequences, Biomarkers and Therapeutic Opportunities
inferred← citeshttps://doi.org/10.3390/ijms21062026openalex-snapshot
Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds
inferred← citeshttps://doi.org/10.3390/ijms22105110openalex-snapshot
Biology of the mRNA Splicing Machinery and Its Dysregulation in Cancer Providing Therapeutic Opportunities
inferred← citeshttps://doi.org/10.3390/ijms23095240openalex-snapshot
Interplay between A-to-I Editing and Splicing of RNA: A Potential Point of Application for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/md22040143openalex-snapshot
Marine-Derived Leads as Anticancer Candidates by Disrupting Hypoxic Signaling through Hypoxia-Inducible Factors Inhibition
inferred← citeshttps://doi.org/10.3762/bjoc.8.19openalex-snapshot
Efficient, highly diastereoselective MS 4 Å-promoted one-pot, three-component synthesis of 2,6-disubstituted-4-tosyloxytetrahydropyrans via Prins cyclization
inferred← citeshttps://doi.org/10.3987/com-12-12597openalex-snapshot
A Total Synthesis of Herboxidiene Methyl Ester
inferred← citeshttps://doi.org/10.4014/jmb.1308.08063openalex-snapshot
Enhancement of Herboxidiene Production in Streptomyces chromofuscus ATCC 49982
inferred← citeshttps://doi.org/10.53846/goediss-8025openalex-snapshot
Investigation of the effects of the splicing inhibitor Pladienolide B and cancer-related mutations in the SF3b1 protein on pre-mRNA splicing in vitro
inferred← citeshttps://doi.org/10.6084/m9.figshare.14457084openalex-snapshot
Additional file 1 of SNRPD1 confers diagnostic and therapeutic values on breast cancers through cell cycle regulation
inferred← citeshttps://doi.org/10.6084/m9.figshare.14457087openalex-snapshot
Additional file 2 of SNRPD1 confers diagnostic and therapeutic values on breast cancers through cell cycle regulation
inferred← citeshttps://doi.org/10.64898/2026.06.26.734849openalex-snapshot
Inhibition of RNA splicing is a novel therapeutic strategy for disruption of nuclear replicating viruses
inferred← citeshttps://doi.org/10.70675/5dbeb7c7z1d18z474cz8456z0a523307e748openalex-snapshot
Chimiorésistance et implications pronostiques de l'expression et de l'épissage alternatif du transporteur ABCA3 dans les leucémies aiguës myéloïdes
inferred← citeshttps://doi.org/10.7554/elife.23533openalex-snapshot
Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation
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