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Using Small Molecules and Chemical Genetics To Interrogate Signaling Networks
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
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Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
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Nitrosothiol Reactivity Profiling Identifies S-Nitrosylated Proteins with Unexpected Stability
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Phosphoproteomic approaches to elucidate cellular signaling networks
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Chemical Genetic Analysis of the Time Course of Signal Transduction by JNK
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Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey
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Non-functional phosphorylations?
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The Hallmarks of Cancer
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Regulation and Specificity of S-Nitrosylation and Denitrosylation
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A Mechanism-Based Cross-Linker for the Identification of Kinase−Substrate Pairs
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Bio-orthogonal Affinity Purification of Direct Kinase Substrates
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Phosphoproteomic Analysis of Rat Liver by High Capacity IMAC and LC−MS/MS
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Protein microarrays for multiplex analysis of signal transduction pathways
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State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling
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Targeting cancer with small molecule kinase inhibitors
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Decoding signalling networks by mass spectrometry-based proteomics
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Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors
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EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
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Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors
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Large-scale characterization of HeLa cell nuclear phosphoproteins
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Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
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Signaling networks assembled by oncogenic EGFR and c-Met
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Suppression of p53-dependent senescence by the JNK signal transduction pathway
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A quantitative atlas of mitotic phosphorylation
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Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates
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Proteome-wide Identification of Cellular Targets Affected by Bisindolylmaleimide-type Protein Kinase C Inhibitors
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Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents
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Time-resolved Mass Spectrometry of Tyrosine Phosphorylation Sites in the Epidermal Growth Factor Receptor Signaling Network Reveals Dynamic Modules
inferredcites →https://doi.org/10.1074/mcp.m800186-mcp200openalex-snapshot
Temporal Perturbation of Tyrosine Phosphoproteome Dynamics Reveals the System-wide Regulatory Networks
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Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics
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Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns
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mTOR signaling in glioblastoma: lessons learned from bench to bedside
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γ‐Phosphate‐linked ATP‐Sepharose for the affinity purification of protein kinases
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A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis
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The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
inferredcites →https://doi.org/10.1126/science.1141478openalex-snapshot
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
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Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
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Induction of Chronic Myelogenous Leukemia in Mice by the P210 bcr/abl Gene of the Philadelphia Chromosome
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Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor–PI3K Axis
inferredcites →https://doi.org/10.1126/scisignal.2000475openalex-snapshot
Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis
inferredcites →https://doi.org/10.1126/scisignal.2000998openalex-snapshot
Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases
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Protein Tyrosine Phosphatases in Autoimmunity
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Global and Site-Specific Quantitative Phosphoproteomics: Principles and Applications
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Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells
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Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab
inferredcites →https://doi.org/10.1182/blood-2005-08-3399openalex-snapshot
A common phosphotyrosine signature for the Bcr-Abl kinase
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Identification of CDK2 substrates in human cell lysates
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Modeling HER2 Effects on Cell Behavior from Mass Spectrometry Phosphotyrosine Data
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis
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Développement d'outils de chémoinformatique pour l'identification d'inhibiteurs de protéines kinases à partir de fragments
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