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Identification of Direct Protein Targets of Small Molecules
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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A Planning Strategy for Diversity‐Oriented Synthesis
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DNA‐Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules
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Protein‐Reactive Natural Products
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Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies
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Synthesis of S‐Adenosyl‐ L ‐homocysteine Capture Compounds for Selective Photoinduced Isolation of Methyltransferases
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Difference gel electrophoresis. A single gel method for detecting changes in protein extracts
inferredcites →https://doi.org/10.1002/pmic.200700426openalex-snapshot
A label‐free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen
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MS‐driven protease substrate degradomics
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Atomic Structures of the Human Immunophilin FKBP-12 Complexes with FK506 and Rapamycin
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
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RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
inferredcites →https://doi.org/10.1016/0092-8674(95)90199-xopenalex-snapshot
The nuclear receptor superfamily: The second decade
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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
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The logic of chemical synthesis
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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
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Modulation of firefly luciferase stability and impact on studies of gene regulation
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High-level production and optimization of monodispersity of 11β-hydroxysteroid dehydrogenase type 1
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Tagged library approach to chemical genomics and proteomics
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Proteomic methods for drug target discovery
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Methods for the proteomic identification of protease substrates
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Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast
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Discovery of a Proneurogenic, Neuroprotective Chemical
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Zebrafish-Based Small Molecule Discovery
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Biochemical Target Isolation for Novices: Affinity-Based Strategies
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Natural products in drug discovery
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Molecular Crowding Inhibits Intramolecular Breathing Motions in Proteins
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Differential Responses of the Backbone and Side-Chain Conformational Dynamics in FKBP12 upon Binding the Transition-State Analog FK506: Implications for Transition-State Stabilization and Target Protein Recognition
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GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha.
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Ligand-induced Resistance of Staphylococcal Nuclease and Nuclease-T to Proteolysis by Subtilisin, α-Chymotrypsin, and Thermolysin
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Purification of Liver Flavokinase by Column Chromatography on Flavin-Cellulose Compounds
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Ligand-stabilized Conformations in Serum Albumin
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High resolution two-dimensional electrophoresis of proteins.
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Hydrogen Exchange Studies of Respiratory Proteins
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Substrate stabilization of lysozyme to thermal and guanidine hydrochloride denaturation.
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Membrane Receptors and Hormone Action
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Direct measurement of protein binding energetics by isothermal titration calorimetry
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Molecular recognition of DNA by small molecules
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Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
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Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis
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Small Molecule Affinity Fingerprinting
inferredcites →https://doi.org/10.1016/s1074-5521(03)00093-0openalex-snapshot
Chemical Genetic Modifier Screens
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Understanding and controlling the cell cycle with natural products
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A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics
inferredcites →https://doi.org/10.1021/bi00852a043openalex-snapshot
Colchicine-binding protein of mammalian brain and its relation to microtubules
inferredcites →https://doi.org/10.1021/bi963065gopenalex-snapshot
Hydrogen Exchange/Electrospray Ionization Mass Spectrometry Studies of Substrate and Inhibitor Binding and Conformational Changes of Escherichia coli Dihydrodipicolinate Reductase
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Mechanism-Based Profiling of Enzyme Families
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Mass spectrometric characterization of a protein-ligand interaction
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A Tandem Orthogonal Proteolysis Strategy for High-Content Chemical Proteomics
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Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1 H -pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
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Natural Products as Sources of New Drugs over the Last 25 Years
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Quantitative Profiling of Proteins in Complex Mixtures Using Liquid Chromatography and Mass Spectrometry
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Search for Cancer Markers from Endometrial Tissues Using Differentially Labeled Tags iTRAQ and cICAT with Multidimensional Liquid Chromatography and Tandem Mass Spectrometry
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Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
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Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
inferredcites →https://doi.org/10.1038/341755a0openalex-snapshot
A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
inferredcites →https://doi.org/10.1038/341758a0openalex-snapshot
A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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A mammalian protein targeted by G1-arresting rapamycin–receptor complex
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Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
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Large-scale analysis of the yeast proteome by multidimensional protein identification technology
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An antidepressant that extends lifespan in adult Caenorhabditis elegans
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Dynamic personalities of proteins
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Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
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Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling
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A role for chemistry in stem cell biology
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An integrated platform of genomic assays reveals small-molecule bioactivities
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Splicing factor SF3b as a target of the antitumor natural product pladienolide
inferredcites →https://doi.org/10.1038/nchembio.2007.17openalex-snapshot
High-throughput screening assays for the identification of chemical probes
inferredcites →https://doi.org/10.1038/nchembio.216openalex-snapshot
Target profiling of small molecules by chemical proteomics
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Activity-based probes that target diverse cysteine protease families
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Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding
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Targeting cancer with small molecule kinase inhibitors
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Target deconvolution strategies in drug discovery
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Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds
inferredcites →https://doi.org/10.1039/b814377copenalex-snapshot
High throughput methods of assessing protein stability and aggregation
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THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY
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Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia
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Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips
inferredcites →https://doi.org/10.1073/pnas.0605224103openalex-snapshot
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
inferredcites →https://doi.org/10.1073/pnas.0900191106openalex-snapshot
Identifying the proteins to which small-molecule probes and drugs bind in cells
inferredcites →https://doi.org/10.1073/pnas.0910040106openalex-snapshot
Target identification using drug affinity responsive target stability (DARTS)
inferredcites →https://doi.org/10.1073/pnas.1000148107openalex-snapshot
Quantitative proteomics approach for identifying protein–drug interactions in complex mixtures using protein stability measurements
inferredcites →https://doi.org/10.1073/pnas.39.4.232openalex-snapshot
A Biochemically Specific Method for Enzyme Isolation
inferredcites →https://doi.org/10.1073/pnas.54.1.253openalex-snapshot
Protein substrate conformation and proteolysis.
inferredcites →https://doi.org/10.1073/pnas.56.6.1891openalex-snapshot
ISOLATION OF THE LAC REPRESSOR
inferredcites →https://doi.org/10.1073/pnas.61.2.636openalex-snapshot
Selective enzyme purification by affinity chromatography.
inferredcites →https://doi.org/10.1073/pnas.87.23.9231openalex-snapshot
Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
inferredcites →https://doi.org/10.1073/pnas.91.26.12574openalex-snapshot
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.
inferredcites →https://doi.org/10.1073/pnas.96.18.10118openalex-snapshot
The propagation of binding interactions to remote sites in proteins: Analysis of the binding of the monoclonal antibody D1.3 to lysozyme
inferredcites →https://doi.org/10.1074/jbc.270.2.815openalex-snapshot
Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells
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Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics
inferredcites →https://doi.org/10.1083/jcb.34.2.525openalex-snapshot
THE MECHANISM OF ACTION OF COLCHICINE
inferredcites →https://doi.org/10.1083/jcb.34.2.535openalex-snapshot
THE MECHANISM OF ACTION OF COLCHICINE
inferredcites →https://doi.org/10.1083/jcb.34.2.549openalex-snapshot
ISOLATION OF A PROTEIN SUBUNIT FROM MICROTUBULES
inferredcites →https://doi.org/10.1083/jcb.38.2.304openalex-snapshot
PROPERTIES OF THE PROTEIN SUBUNIT OF CENTRAL-PAIR AND OUTER-DOUBLET MICROTUBULES OF SEA URCHIN FLAGELLA
inferredcites →https://doi.org/10.1088/2040-8978/12/9/095301openalex-snapshot
Detection of the specific binding on protein microarrays by oblique-incidence reflectivity difference method
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Purification and Properties of the Cholinergic Receptor Protein from Electrophorus electricus Electric Tissue
inferredcites →https://doi.org/10.1126/science.1062191openalex-snapshot
Global Analysis of Protein Activities Using Proteome Chips
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Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
inferredcites →https://doi.org/10.1126/science.1132939openalex-snapshot
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
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Atomic-Level Characterization of the Structural Dynamics of Proteins
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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
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Opiate Receptor: Demonstration in Nervous Tissue
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Identification of d -Peptide Ligands Through Mirror-Image Phage Display
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A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p
inferredcites →https://doi.org/10.1126/science.273.5272.239openalex-snapshot
Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP
inferredcites →https://doi.org/10.1126/science.274.5292.1531openalex-snapshot
Discovering High-Affinity Ligands for Proteins: SAR by NMR
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Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations
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Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A
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Controlling Signal Transduction with Synthetic Ligands
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Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin
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Protein-protein interactions. A molecular cloning manual
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Chemical Evolution as a Tool for Molecular Discovery
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Unnatural Ligands for Engineered Proteins: New Tools for Chemical Genetics
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STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
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Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex
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High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery
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Screening for Ligands Using a Generic and High-Throughput Light-Scattering-Based Assay
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Application of High-Throughput Isothermal Denaturation to Assess Protein Stability and Screen for Ligands
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Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets
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Bedeutung der Stereochemie für die Physiologie.
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Identification of a GABA A Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog
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Photochemical Fishing Approaches for Identifying Target Proteins and Elucidating the Structure of a Ligand-binding Region Using Carbene-generating Photoreactive Probes
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Photo-Affinity Labeling Strategies in Identifying the Protein Ligands of Bioactive Small Molecules: Examples of Targeted Synthesis of Drug Analog Photoprobes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Analysis of the Temporal Evolution of Plumeria Bud by Measuring Its Complex Impedance: Detection of the Fractal Element with Complex Conjugated Power-Law Exponents
inferred← citeshttps://doi.org/10.1007/978-3-642-29250-7_2openalex-snapshot
Nanomaterials for Biosensors and Implantable Biodevices
inferred← citeshttps://doi.org/10.1007/978-4-431-56529-1_1openalex-snapshot
Trends in Bioprobe Research
inferred← citeshttps://doi.org/10.1007/978-981-15-5534-3_8openalex-snapshot
Drug Target Identification and Validation
inferred← citeshttps://doi.org/10.1007/978-981-96-4154-3_1openalex-snapshot
Computational Simulation of Drug Delivery at the Molecular Level
inferred← citeshttps://doi.org/10.1007/978-981-96-8176-1_15openalex-snapshot
Artificial Intelligence in Drug Discovery and Drug Target Interactions
inferred← citeshttps://doi.org/10.1007/s00044-021-02750-5openalex-snapshot
Thiouracil SecA inhibitors: bypassing the effects of efflux pumps and attenuating virulence factor secretion in MRSA and Bacillus anthracis
inferred← citeshttps://doi.org/10.1007/s00204-025-04189-8openalex-snapshot
Identification of small GTPases as potential target proteins of the mycotoxin and renal carcinogen ochratoxin A
inferred← citeshttps://doi.org/10.1007/s10562-020-03110-5openalex-snapshot
Optical Characterization and Monitoring of Enzyme Catalyzed Short Chain Peptides in Cellular Environment
inferred← citeshttps://doi.org/10.1007/s10637-013-0041-xopenalex-snapshot
SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres
inferred← citeshttps://doi.org/10.1007/s11101-013-9312-6openalex-snapshot
Chemical genetics strategies for identification of molecular targets
inferred← citeshttps://doi.org/10.1007/s12272-015-0618-3openalex-snapshot
Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery
inferred← citeshttps://doi.org/10.1007/s12272-015-0635-2openalex-snapshot
Affinity purification in target identification: the specificity challenge
inferred← citeshttps://doi.org/10.1007/s12272-015-0643-2openalex-snapshot
Application of chemical biology in target identification and drug discovery
inferred← citeshttps://doi.org/10.1007/s12272-016-0791-zopenalex-snapshot
Target identification for biologically active small molecules using chemical biology approaches
inferred← citeshttps://doi.org/10.1007/s13361-014-0992-yopenalex-snapshot
SILAC-Pulse Proteolysis: A Mass Spectrometry-Based Method for Discovery and Cross-Validation in Proteome-Wide Studies of Ligand Binding
inferred← citeshttps://doi.org/10.1007/s13659-023-00422-yopenalex-snapshot
β-carboline derivative Z86 attenuates colorectal cancer cell proliferation and migration by directly targeting PI3K
inferred← citeshttps://doi.org/10.1016/b978-0-08-099420-8.00002-xopenalex-snapshot
Step II: Target Validation
inferred← citeshttps://doi.org/10.1016/b978-0-12-396481-6.00021-0openalex-snapshot
Toxoplasma gondii Chemical Biology
inferred← citeshttps://doi.org/10.1016/b978-0-12-397944-5.00017-1openalex-snapshot
Chemical Screening Methods for Flagellar Phenotypes in Chlamydomonas
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.12334-0openalex-snapshot
Systems Chemical Biology: Integrating Medicinal Chemistry and Systems Biology for Drug Discovery
inferred← citeshttps://doi.org/10.1016/b978-0-12-416603-5.00014-6openalex-snapshot
Hunting Molecular Targets for Anticancer Reagents by Chemical Proteomics
inferred← citeshttps://doi.org/10.1016/b978-0-12-417150-3.00019-3openalex-snapshot
Recent Advances in Small Molecule Target Identification Methods
inferred← citeshttps://doi.org/10.1016/b978-0-12-801814-9.00006-4openalex-snapshot
Genomics-Driven Drug Discovery Process
inferred← citeshttps://doi.org/10.1016/b978-0-12-802147-7.00021-8openalex-snapshot
Target Identification and Polypharmacology of Nutraceuticals
inferred← citeshttps://doi.org/10.1016/b978-0-12-812744-5.00003-5openalex-snapshot
Application of Systems Biology in the Research of TCM Formulae
inferred← citeshttps://doi.org/10.1016/b978-0-12-813629-4.00012-7openalex-snapshot
Application of affinity purification of drug target proteins with practical magnetic nanoparticles to drug development
inferred← citeshttps://doi.org/10.1016/b978-0-12-819132-3.00004-xopenalex-snapshot
Proteome-scale studies of protein stability
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00041-4openalex-snapshot
The Role of Natural Products as Sources of Therapeutic Agents for Innovative Drug Discovery
inferred← citeshttps://doi.org/10.1016/b978-0-12-821038-3.00023-9openalex-snapshot
Target identification and polypharmacology of nutraceuticals
inferred← citeshttps://doi.org/10.1016/b978-0-323-99283-1.00012-4openalex-snapshot
Targeting hepatocellular carcinoma by small-molecule inhibitors
inferred← citeshttps://doi.org/10.1016/b978-0-443-16013-4.00005-1openalex-snapshot
Molecular cloning of drug targets
inferred← citeshttps://doi.org/10.1016/b978-0-443-29808-0.00025-xopenalex-snapshot
Systems chemical biology: Integrating medicinal chemistry and systems biology for drug discovery
inferred← citeshttps://doi.org/10.1016/bs.mie.2016.09.049openalex-snapshot
Drug Target Identification Using an iTRAQ-Based Quantitative Chemical Proteomics Approach—Based on a Target Profiling Study of Andrographolide
inferred← citeshttps://doi.org/10.1016/bs.mie.2019.02.038openalex-snapshot
Identification of lamins as the molecular targets of LBL1 using a clickable photoaffinity probe
inferred← citeshttps://doi.org/10.1016/bs.pmbts.2024.03.035openalex-snapshot
Drug repurposing for neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.addr.2019.05.001openalex-snapshot
The significance of artificial intelligence in drug delivery system design
inferred← citeshttps://doi.org/10.1016/j.apsb.2022.08.022openalex-snapshot
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
inferred← citeshttps://doi.org/10.1016/j.bbrc.2017.03.052openalex-snapshot
Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation
inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114798openalex-snapshot
Drug affinity responsive target stability (DARTS) accelerated small molecules target discovery: Principles and application
inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.106620openalex-snapshot
A multidisciplinary functional proteomics-aided strategy as a tool for the profiling of a novel cytotoxic thiadiazolopyrimidone
inferred← citeshttps://doi.org/10.1016/j.biopha.2019.109624openalex-snapshot
Molecular targeted study in tumors: From western medicine to active ingredients of traditional Chinese medicine
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111833openalex-snapshot
Application of omics- and multi-omics-based techniques for natural product target discovery
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2016.11.003openalex-snapshot
Metabolic engineering of Bacillus subtilis fueled by systems biology: Recent advances and future directions
inferred← citeshttps://doi.org/10.1016/j.bmc.2011.10.088openalex-snapshot
Determining the mode of action of bioactive compounds
inferred← citeshttps://doi.org/10.1016/j.bmc.2011.12.022openalex-snapshot
Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound
inferred← citeshttps://doi.org/10.1016/j.bmc.2012.08.003openalex-snapshot
Hybrid stereoisomers of a compact molecular probe based on a jasmonic acid glucoside: Syntheses and biological evaluations
inferred← citeshttps://doi.org/10.1016/j.bmc.2016.01.002openalex-snapshot
2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmc.2019.115174openalex-snapshot
Mass spectrometry-based Cellular Thermal Shift Assay (CETSA®) for target deconvolution in phenotypic drug discovery
inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.07.043openalex-snapshot
Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids
inferred← citeshttps://doi.org/10.1016/j.canlet.2020.05.024openalex-snapshot
Direct targeting of HSP90 with daurisoline destabilizes β-catenin to suppress lung cancer tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.canlet.2024.216800openalex-snapshot
Poly-pharmacology of existing drugs: How to crack the code?
inferred← citeshttps://doi.org/10.1016/j.canlet.2025.217715openalex-snapshot
Identification and characterization of Bufalin as a novel EGFR degrader
inferred← citeshttps://doi.org/10.1016/j.cbpa.2013.06.005openalex-snapshot
Target identification of biologically active small molecules via in situ methods
inferred← citeshttps://doi.org/10.1016/j.cbpa.2019.02.006openalex-snapshot
Label-free target identification in drug discovery via phenotypic screening
inferred← citeshttps://doi.org/10.1016/j.cclet.2022.04.013openalex-snapshot
Unmodified methodologies in target discovery for small molecule drugs: A rising star
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.112045openalex-snapshot
Tetramethylpyrazine protects against myocardial ischemia/reperfusion injury via regulating Myl2-mediated NLRP3 signaling pathway inhibition
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.113686openalex-snapshot
Destruxin A inhibits the hemocytin-mediated hemolymph immunity of host insects to facilitate Metarhizium infection
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.09.020openalex-snapshot
The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains
inferred← citeshttps://doi.org/10.1016/j.drudis.2016.01.002openalex-snapshot
Defining the targets of antiparasitic compounds
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.02.076openalex-snapshot
Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112151openalex-snapshot
Activity-based protein profiling: Recent advances in medicinal chemistry
inferred← citeshttps://doi.org/10.1016/j.ejphar.2014.08.031openalex-snapshot
Small-molecule inhibitors for autoimmune arthritis: Success, failure and the future
inferred← citeshttps://doi.org/10.1016/j.eswa.2022.118744openalex-snapshot
A multi-scale multi-model deep neural network via ensemble strategy on high-throughput microscopy image for protein subcellular localization
inferred← citeshttps://doi.org/10.1016/j.fochx.2026.103685openalex-snapshot
An innovative strategy coupling cluster fraction with ultrafiltration UPLC-QTOF-MS/MS for screening α-glucosidase inhibitors from barley seedlings
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.04.003openalex-snapshot
Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma
inferred← citeshttps://doi.org/10.1016/j.fshw.2021.11.001openalex-snapshot
Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e24196openalex-snapshot
A label free chemoproteomic-based platform to disclose cannabidiol molecular mechanism of action on chronic myelogenous leukemia cancer cells
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2020.07.237openalex-snapshot
Direct label-free methods for identification of target proteins in agrochemicals
inferred← citeshttps://doi.org/10.1016/j.intimp.2013.04.031openalex-snapshot
Halofuginone suppresses T cell proliferation by blocking proline uptake and inducing cell apoptosis
inferred← citeshttps://doi.org/10.1016/j.jare.2020.12.010openalex-snapshot
A value-added application of eugenol as acaricidal agent: The mechanism of action and the safety evaluation
inferred← citeshttps://doi.org/10.1016/j.jep.2013.10.067openalex-snapshot
Investigation into the mechanism of Eucommia ulmoides Oliv. based on a systems pharmacology approach
inferred← citeshttps://doi.org/10.1016/j.jep.2015.07.043openalex-snapshot
Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula
inferred← citeshttps://doi.org/10.1016/j.jgr.2019.02.005openalex-snapshot
Protein target identification of ginsenosides in skeletal muscle tissues: discovery of natural small-molecule activators of muscle-type creatine kinase
inferred← citeshttps://doi.org/10.1016/j.jgr.2020.12.007openalex-snapshot
Identification and confirmation of 14-3-3 ζ as a novel target of ginsenosides in brain tissues
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.115107openalex-snapshot
Label-free target protein characterization for small molecule drugs: recent advances in methods and applications
inferred← citeshttps://doi.org/10.1016/j.jprot.2011.03.032openalex-snapshot
Mass spectrometry imaging for drugs and metabolites
inferred← citeshttps://doi.org/10.1016/j.jstrokecerebrovasdis.2024.108107openalex-snapshot
Hydroxysafflor Yellow A promotes angiogenesis of brain microvascular endothelial cells from ischemia/reperfusion injury via glycolysis pathway in vitro
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.117360openalex-snapshot
Progesterone attenuates Aβ25–35-induced neuronal toxicity by activating the Ras signalling pathway through progesterone receptor membrane component 1
inferred← citeshttps://doi.org/10.1016/j.mib.2015.05.007openalex-snapshot
Posttranslational regulation of microbial metabolism
inferred← citeshttps://doi.org/10.1016/j.mrl.2026.200287openalex-snapshot
A designed fusion tag improves soluble expression of nanobody in E. coli
inferred← citeshttps://doi.org/10.1016/j.omtn.2024.102313openalex-snapshot
Advancements and challenges in mRNA and ribonucleoprotein-based therapies: From delivery systems to clinical applications
inferred← citeshttps://doi.org/10.1016/j.pestbp.2024.105914openalex-snapshot
Unveiling fenpropathrin resistance levels in field populations of Tetranychus cinnabarinus (Boisduval): Insights, risks, and RNAi strategy
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107690openalex-snapshot
Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.07.022openalex-snapshot
Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets
inferred← citeshttps://doi.org/10.1016/j.phrs.2019.104373openalex-snapshot
Advances in exploring the therapeutic potential of marine natural products
inferred← citeshttps://doi.org/10.1016/j.plipres.2018.07.001openalex-snapshot
Innovations in improving lipid production: Algal chemical genetics
inferred← citeshttps://doi.org/10.1016/j.tibtech.2013.12.002openalex-snapshot
Small-molecule based musculoskeletal regenerative engineering
inferred← citeshttps://doi.org/10.1016/j.trac.2019.06.024openalex-snapshot
Modification-free approaches to screen drug targets at proteome level
inferred← citeshttps://doi.org/10.1016/j.ymeth.2012.05.008openalex-snapshot
Mass spectrometry approaches to monitor protein–drug interactions
inferred← citeshttps://doi.org/10.1016/j.ymeth.2012.06.013openalex-snapshot
Investigating metabolite–protein interactions: An overview of available techniques
inferred← citeshttps://doi.org/10.1016/j.ymeth.2014.08.001openalex-snapshot
Virtual screening: An in silico tool for interlacing the chemical universe with the proteome
inferred← citeshttps://doi.org/10.1016/j.ymeth.2018.06.005openalex-snapshot
MS methods to study macromolecule-ligand interaction: Applications in drug discovery
inferred← citeshttps://doi.org/10.1016/s1875-5364(15)60002-4openalex-snapshot
“Omics” in pharmaceutical research: overview, applications, challenges, and future perspectives
inferred← citeshttps://doi.org/10.1016/s1875-5364(25)60937-xopenalex-snapshot
Combining label-free quantitative proteomics and 2D-DIGE to identify the potential targets of Sini Decoction acting on myocardial infarction
inferred← citeshttps://doi.org/10.1017/erm.2024.6openalex-snapshot
Stability-based approaches in chemoproteomics
inferred← citeshttps://doi.org/10.1021/ac4030208openalex-snapshot
Ribosome Display and Photo-Cross-Linking Techniques for In Vitro Identification of Target Proteins of Bioactive Small Molecules
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c04978openalex-snapshot
Stability-Based Proteomics for Investigation of Structured RNA–Protein Interactions
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b04874openalex-snapshot
Analytical Cascades of Enzymes for Sensitive Detection of Structural Variations in Protein Samples
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00305openalex-snapshot
Identification of Targets of the HIF-1 Inhibitor IDF-11774 Using Alkyne-Conjugated Photoaffinity Probes
inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00020openalex-snapshot
Chalcone: A Privileged Structure in Medicinal Chemistry
inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00504openalex-snapshot
Using Genome Sequence to Enable the Design of Medicines and Chemical Probes
inferred← citeshttps://doi.org/10.1021/acs.jcim.7b00227openalex-snapshot
Structure-Based Kinase Profiling To Understand the Polypharmacological Behavior of Therapeutic Molecules
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01574openalex-snapshot
Discovery of a New Inhibitor of Myeloid Differentiation 2 from Cinnamamide Derivatives with Anti-Inflammatory Activity in Sepsis and Acute Lung Injury
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00627openalex-snapshot
Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator
inferred← citeshttps://doi.org/10.1021/acs.jproteome.0c00372openalex-snapshot
Techniques and Strategies for Potential Protein Target Discovery and Active Pharmaceutical Molecule Screening in a Pandemic
inferred← citeshttps://doi.org/10.1021/acs.jproteome.1c00653openalex-snapshot
Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and α-Synucleinopathy Reveals Age- and Disease-Related Differences
inferred← citeshttps://doi.org/10.1021/acs.jproteome.2c00550openalex-snapshot
Concentration-Dependent Enrichment Identifies Primary Protein Targets of Multitarget Bioactive Molecules
inferred← citeshttps://doi.org/10.1021/acs.jproteome.5b00057openalex-snapshot
Global Analysis of Protein Folding Thermodynamics for Disease State Characterization
inferred← citeshttps://doi.org/10.1021/acs.jproteome.8b00341openalex-snapshot
Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale
inferred← citeshttps://doi.org/10.1021/acsnano.6b02558openalex-snapshot
Rapid and Label-Free Strategy to Isolate Aptamers for Metal Ions
inferred← citeshttps://doi.org/10.1021/acsptsci.5c00220openalex-snapshot
Sinapic Acid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents That Target Transforming Growth Factor β-Activated Kinase 1 (TAK1)
inferred← citeshttps://doi.org/10.1021/cb500671jopenalex-snapshot
Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment
inferred← citeshttps://doi.org/10.1021/cr200355jopenalex-snapshot
Combinatorial Strategies in Fluorescent Probe Development
inferred← citeshttps://doi.org/10.1021/jasms.2c00248openalex-snapshot
Comparative Analysis of Protein Folding Stability-Based Profiling Methods for Characterization of Biological Phenotypes
inferred← citeshttps://doi.org/10.1021/jm201006xopenalex-snapshot
Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death
inferred← citeshttps://doi.org/10.1021/jm401144zopenalex-snapshot
Drug Design Targeting Protein–Protein Interactions (PPIs) Using Multiple Ligand Simultaneous Docking (MLSD) and Drug Repositioning: Discovery of Raloxifene and Bazedoxifene as Novel Inhibitors of IL-6/GP130 Interface
inferred← citeshttps://doi.org/10.1021/mc-2022-vol57.ch17openalex-snapshot
CELLULAR TARGET ENGAGEMENT ASSAYS FOR SMALL-MOLECULE DRUG DISCOVERY
inferred← citeshttps://doi.org/10.1021/nn501962yopenalex-snapshot
Multifunctional Biosensor Based on Localized Surface Plasmon Resonance for Monitoring Small Molecule–Protein Interaction
inferred← citeshttps://doi.org/10.1021/np300834qopenalex-snapshot
Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei
inferred← citeshttps://doi.org/10.1038/cddis.2013.438openalex-snapshot
Dichloroacetate induces protective autophagy in LoVo cells: involvement of cathepsin D/thioredoxin-like protein 1 and Akt-mTOR-mediated signaling
inferred← citeshttps://doi.org/10.1038/nature13264openalex-snapshot
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
inferred← citeshttps://doi.org/10.1038/nchembio.1199openalex-snapshot
Target identification and mechanism of action in chemical biology and drug discovery
inferred← citeshttps://doi.org/10.1038/nchembio.935openalex-snapshot
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells
inferred← citeshttps://doi.org/10.1038/s41419-018-0669-8openalex-snapshot
Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78
inferred← citeshttps://doi.org/10.1038/s41467-021-27137-3openalex-snapshot
A unified drug–target interaction prediction framework based on knowledge graph and recommendation system
inferred← citeshttps://doi.org/10.1038/s41467-022-35565-yopenalex-snapshot
Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis
inferred← citeshttps://doi.org/10.1038/s41573-022-00409-3openalex-snapshot
The emerging role of mass spectrometry-based proteomics in drug discovery
inferred← citeshttps://doi.org/10.1038/s41598-017-18764-2openalex-snapshot
Systems pharmacology analysis of synergy of TCM: an example using saffron formula
inferred← citeshttps://doi.org/10.1038/srep26125openalex-snapshot
Proteome-wide drug screening using mass spectrometric imaging of bead-arrays
inferred← citeshttps://doi.org/10.1039/9781849734745-00066openalex-snapshot
Neurodegradomics: The Source of Biomarkers for Mild Traumatic Brain Injury
inferred← citeshttps://doi.org/10.1039/c2cc00027jopenalex-snapshot
Isotope-coded, fluorous photoaffinity labeling reagents
inferred← citeshttps://doi.org/10.1039/c2cc35758eopenalex-snapshot
An efficient labeling strategy of drug like molecules with functionalized alkyl linkers using CH-activation
inferred← citeshttps://doi.org/10.1039/c2cs15301gopenalex-snapshot
The impact of plant–pathogen studies on medicinal drug discovery
inferred← citeshttps://doi.org/10.1039/c2ib20204bopenalex-snapshot
Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication
inferred← citeshttps://doi.org/10.1039/c2mb25468aopenalex-snapshot
Target identification of small molecules based on chemical biology approaches
inferred← citeshttps://doi.org/10.1039/c3dt00108copenalex-snapshot
Peculiar reactivity of a di-imine copper(ii) complex regarding its binding to albumin protein
inferred← citeshttps://doi.org/10.1039/c3md00276dopenalex-snapshot
Affinity-based target identification for bioactive small molecules
inferred← citeshttps://doi.org/10.1039/c4ra01800aopenalex-snapshot
Discovery of a novel fluorescent HSP90 inhibitor and its anti-lung cancer effect
inferred← citeshttps://doi.org/10.1039/c5np00107bopenalex-snapshot
Advances in identification and validation of protein targets of natural products without chemical modification
inferred← citeshttps://doi.org/10.1039/c5np00113gopenalex-snapshot
Target identification by image analysis
inferred← citeshttps://doi.org/10.1039/c6cc04030fopenalex-snapshot
Focusing on probe-modified peptides: a quick and effective method for target identification
inferred← citeshttps://doi.org/10.1039/c6cc09998jopenalex-snapshot
A conjugate Lewis base-Brønsted acid catalyst for the sulfenylation of nitrogen containing heterocycles under mild conditions
inferred← citeshttps://doi.org/10.1039/c7an00778gopenalex-snapshot
Limited proteolysis in porous membrane reactors containing immobilized trypsin
inferred← citeshttps://doi.org/10.1039/c9cc09595kopenalex-snapshot
A phenotypic approach to probing cellular outcomes using heterobivalent constructs
inferred← citeshttps://doi.org/10.1039/d0cb00226gopenalex-snapshot
The pursuit of mechanism of action: uncovering drug complexity in TB drug discovery
inferred← citeshttps://doi.org/10.1039/d1cb00103eopenalex-snapshot
Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N -arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity
inferred← citeshttps://doi.org/10.1039/d1cs00231gopenalex-snapshot
Chemoproteomic methods for covalent drug discovery
inferred← citeshttps://doi.org/10.1039/d1md00022eopenalex-snapshot
The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery
inferred← citeshttps://doi.org/10.1039/d4np00009aopenalex-snapshot
Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products
inferred← citeshttps://doi.org/10.1055/s-0031-1290460openalex-snapshot
The Chemistry and Biology of Nakiterpiosin – C-nor-D-Homosteroids
inferred← citeshttps://doi.org/10.1073/pnas.0910040106openalex-snapshot
Target identification using drug affinity responsive target stability (DARTS)
inferred← citeshttps://doi.org/10.1074/mcp.m115.055954openalex-snapshot
Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing
inferred← citeshttps://doi.org/10.1080/13880209.2018.1557699openalex-snapshot
The clickable activity-based probe of anti-apoptotic calenduloside E
inferred← citeshttps://doi.org/10.1080/14756366.2023.2252198openalex-snapshot
Potent inhibition of human tyrosinase inhibitor by verproside from the whole plant of Pseudolysimachion rotundum var. subintegrum
inferred← citeshttps://doi.org/10.1080/14789450.2024.2406785openalex-snapshot
Cellular thermal shift assay: an approach to identify and assess protein target engagement
inferred← citeshttps://doi.org/10.1080/17460441.2016.1227316openalex-snapshot
Identification of protein binding partners of small molecules using label-free methods
inferred← citeshttps://doi.org/10.1080/17460441.2017.1378178openalex-snapshot
Mass spectrometry methods to study protein-metabolite interactions
inferred← citeshttps://doi.org/10.1080/17460441.2025.2507382openalex-snapshot
The latest advances with natural products in drug discovery and opportunities for the future: a 2025 update
inferred← citeshttps://doi.org/10.1080/19490976.2026.2739666openalex-snapshot
Akkermansia muciniphila protects diabetes-associated cognitive decline by enhancing leucine catabolism and suppressing neuronal excessive mitophagy
inferred← citeshttps://doi.org/10.1089/adt.2015.656openalex-snapshot
Linking Phenotypes and Modes of Action Through High-Content Screen Fingerprints
inferred← citeshttps://doi.org/10.1093/bib/bbaa003openalex-snapshot
Exploration of databases and methods supporting drug repurposing: a comprehensive survey
inferred← citeshttps://doi.org/10.1093/bib/bbaa313openalex-snapshot
Protein subcellular localization based on deep image features and criterion learning strategy
inferred← citeshttps://doi.org/10.1093/bioinformatics/btac123openalex-snapshot
Multi-scale deep learning for the imbalanced multi-label protein subcellular localization prediction based on immunohistochemistry images
inferred← citeshttps://doi.org/10.1093/bioinformatics/btad006openalex-snapshot
Prediction of drug side effects with transductive matrix co-completion
inferred← citeshttps://doi.org/10.1093/carcin/bgu187openalex-snapshot
Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling
inferred← citeshttps://doi.org/10.1093/nsr/nwy124openalex-snapshot
Phenotype and target-based chemical biology investigations in cancers
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