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Trypanosomal Dihydrofolate Reductase Reveals Natural Antifolate Resistance
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
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Effect of substrate decomposition on the spectrophotometric assay of dihydrofolate reductase
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Microbatch crystallization under oil — a new technique allowing many small-volume crystallization trials
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Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme
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2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase
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Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase
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Chemotherapy of human African trypanosomiasis: current and future prospects
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NECT trial: more than a small victory over sleeping sickness
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Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase
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Inhibitors of dihydrofolate reductase in leishmania and trypanosomes
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Loop and Subdomain Movements in the Mechanism of Escherichia coli Dihydrofolate Reductase: Crystallographic Evidence,
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Phenoxypropoxybiguanides, Prodrugs of DHFR−Inhibiting Diaminotriazine Antimalarials
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Inhibitors of Multiple Mutants of Plasmodium falciparum Dihydrofolate Reductase and Their Antimalarial Activities
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Highly Efficient Ligands for Dihydrofolate Reductase from Cryptosporidium hominis and Toxoplasma gondii Inspired by Structural Analysis
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Design, Synthesis, and Evaluation of Inhibitors of Trypanosomal and Leishmanial Dihydrofolate Reductase
inferredcites →https://doi.org/10.1038/nsb0394-186openalex-snapshot
Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase
inferredcites →https://doi.org/10.1038/nsb921openalex-snapshot
Insights into antifolate resistance from malarial DHFR-TS structures
inferredcites →https://doi.org/10.1073/pnas.0501747102openalex-snapshot
Crystal structure of dihydrofolate reductase from Plasmodium vivax : Pyrimethamine displacement linked with mutation-induced resistance
inferredcites →https://doi.org/10.1073/pnas.0704384105openalex-snapshot
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
inferredcites →https://doi.org/10.1073/pnas.94.4.1124openalex-snapshot
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase
inferredcites →https://doi.org/10.1074/jbc.272.21.13883openalex-snapshot
The Roles of Pteridine Reductase 1 and Dihydrofolate Reductase-Thymidylate Synthase in Pteridine Metabolism in the Protozoan Parasite Leishmania major
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Phylogenetic Classification of Protozoa Based on the Structure of the Linker Domain in the Bifunctional Enzyme, Dihydrofolate Reductase-Thymidylate Synthase
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ESPript: analysis of multiple sequence alignments in PostScript.
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PROCHECK: a program to check the stereochemical quality of protein structures
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Improved methods for building protein models in electron density maps and the location of errors in these models
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AMoRe: an automated package for molecular replacement
inferredcites →https://doi.org/10.1107/s0907444904001544openalex-snapshot
Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase–thymidylate synthase from Plasmodium falciparum
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Structures of dihydrofolate reductase-thymidylate synthase ofTrypanosoma cruziin the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate
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The CCP4 suite: programs for protein crystallography
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
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Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase fromTrypanosoma cruzi, the Chagas disease pathogen
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Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes
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New Azasterols against Trypanosoma brucei : Role of 24-Sterol Methyltransferase in Inhibitor Action
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Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda
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Continuous Cultivation of Trypanosoma brucei Blood Stream Forms in a Medium Containing a Low Concentration of Serum Protein without Feeder Cell Layers
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Repurposing FDA‐Approved Anticancer Drugs Offers a Strategy to Target Mutant‐Type Malaria by Inhibiting Parasite DHFR Without Affecting Human DHFR
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Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes
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Synthesis, In Silico Molecular Docking, ADME Evaluation and In Vitro Antiplasmodial Activity of Pyrimidine‐Based Hybrid Molecules
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Synthesis of novel 4,6-diaryl-2-aminopyrimidines as potential antiplasmodial agents
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inferred← citeshttps://doi.org/10.1016/j.actatropica.2024.107360openalex-snapshot
folA thyA knockout E. coli as a suitable surrogate model for evaluation of antifolate sensitivity against PfDHFR-TS
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Perturbation of genome integrity to fight pathogenic microorganisms
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Structure–activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase
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Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives
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Design and synthesis of guanylthiourea derivatives as potential inhibitors of Plasmodium falciparum dihydrofolate reductase enzyme
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The characteristic structural and functional dynamics of P. falciparum DHFR binding with pyrimidine chemotypes implicate malaria therapy design
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Bisbenzylisoquinolines from Cissampelos pareira L. as antimalarial agents: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies
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Integrated computational strategies for the identification of Plasmodium falciparum dihydrofolate reductase inhibitors
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Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities
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Structural Insight into Effective Inhibitors’ Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase
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Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents
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Structure-Based Targeting of Orthologous Pathogen Proteins Accelerates Antiparasitic Drug Discovery
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Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors
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Homology modeling of dihydrofolate reductase from T. gondii bonded to antagonists: molecular docking and molecular dynamics simulations
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Human dihydrofolate reductase and thymidylate synthase form a complexin vitroand co-localize in normal and cancer cells
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Multicomplex-based pharmacophore modeling in conjunction with multi-target docking and molecular dynamics simulations for the identification of PfDHFR inhibitors
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Key interactions of pyrimethamine derivatives specific to wild-type and mutant P. falciparum dihydrofolate reductase based on 3D-QSAR, MD simulations and quantum chemical calculations
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Oplodiol and nitidine as potential inhibitors of Plasmodium falciparum dihydrofolate reductase: insights from a computational study
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Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening
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Anti-trypanosomatid structure-based drug design – lessons learned from targeting the folate pathway
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Molecular Dynamics of Interactions between Rigid and Flexible Antifolates and Dihydrofolate Reductase from Pyrimethamine‐Sensitive and Pyrimethamine‐Resistant Plasmodium falciparum
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Combined Spatial Limitation around Residues 16 and 108 of Plasmodium falciparum Dihydrofolate Reductase Explains Resistance to Cycloguanil
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