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Development of a Highly Visual, Simple, and Rapid Test for the Discovery of Novel Insulin Mimetics in Living Vertebrates
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/bdrc.20214openalex-snapshot
Zebrafish—As an integrative model for twenty‐first century toxicity testing
inferredcites →https://doi.org/10.1002/pro.33openalex-snapshot
Discovery of amyloid‐beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility
inferredcites →https://doi.org/10.1016/j.ab.2012.07.003openalex-snapshot
Development of a cell-based nonradioactive glucose uptake assay system for SGLT1 and SGLT2
inferredcites →https://doi.org/10.1016/j.amjmed.2006.05.070openalex-snapshot
Sliding Scale Insulin Use: Myth or Insanity?
inferredcites →https://doi.org/10.1016/j.bbrc.2006.11.134openalex-snapshot
Emodin with PPARγ ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells
inferredcites →https://doi.org/10.1016/j.biochi.2011.04.013openalex-snapshot
Berberine acutely activates the glucose transport activity of GLUT1
inferredcites →https://doi.org/10.1016/j.chembiol.2011.10.001openalex-snapshot
A Triazine Compound S06 Inhibits Proinvasive Crosstalk between Carcinoma Cells and Stromal Fibroblasts via Binding to Heat Shock Protein 90
inferredcites →https://doi.org/10.1016/j.cmet.2007.08.011openalex-snapshot
Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress
inferredcites →https://doi.org/10.1016/j.diabet.2006.11.004openalex-snapshot
Nutritional deficiency after gastric bypass: diagnosis, prevention and treatment
inferredcites →https://doi.org/10.1016/j.exger.2003.10.022openalex-snapshot
Comparative aspects of zebrafish (Danio rerio) as a model for aging research
inferredcites →https://doi.org/10.1016/j.fitote.2009.08.020openalex-snapshot
Anti-diabetic effects of emodin involved in the activation of PPARγ on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice
inferredcites →https://doi.org/10.1016/j.ygcen.2010.10.010openalex-snapshot
Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish
inferredcites →https://doi.org/10.1016/s0944-7113(00)80075-6openalex-snapshot
Antihyperglycemic activity of Teramnus labialis (Fabaceae)
inferredcites →https://doi.org/10.1016/s1262-3636(07)70257-4openalex-snapshot
Meglitinide analogues: a review of clinical data focused on recent trials
inferredcites →https://doi.org/10.1021/cb200532vopenalex-snapshot
Small Molecules That Recapitulate the Early Steps of Urodele Amphibian Limb Regeneration and Confer Multipotency
inferredcites →https://doi.org/10.1021/cb700009mopenalex-snapshot
Invertebrate Animal Models of Diseases as Screening Tools in Drug Discovery
inferredcites →https://doi.org/10.1021/ja035334dopenalex-snapshot
Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening
inferredcites →https://doi.org/10.1038/nchembio.1136openalex-snapshot
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism
inferredcites →https://doi.org/10.1038/nchembio833openalex-snapshot
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling
inferredcites →https://doi.org/10.1038/nrd1086openalex-snapshot
Hit and lead generation: beyond high-throughput screening
inferredcites →https://doi.org/10.1039/c0mb00089bopenalex-snapshot
Novel use of fluorescent glucose analogues to identify a new class of triazine-based insulin mimetics possessing useful secondary effects
inferredcites →https://doi.org/10.1039/c2mb05501eopenalex-snapshot
A novel zebrafish human tumor xenograft model validated for anti-cancer drug screening
inferredcites →https://doi.org/10.1055/s-0030-1265219openalex-snapshot
Amelioration of Insulin Resistance by Scopoletin in High-Glucose-Induced, Insulin-Resistant HepG2 Cells
inferredcites →https://doi.org/10.1073/pnas.1002471107openalex-snapshot
Flow of energy in the outer retina in darkness and in light
inferredcites →https://doi.org/10.1073/pnas.91.11.4854openalex-snapshot
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
inferredcites →https://doi.org/10.1074/jbc.272.2.971openalex-snapshot
Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction
inferredcites →https://doi.org/10.1074/jbc.m109.079343openalex-snapshot
Akt2 Modulates Glucose Availability and Downstream Apoptotic Pathways during Development
inferredcites →https://doi.org/10.1074/jbc.m601881200openalex-snapshot
GLUT1 Deficiency Links Nutrient Availability and Apoptosis during Embryonic Development
inferredcites →https://doi.org/10.1089/adt.2010.0346openalex-snapshot
The Zebrafish: A Powerful Platform for In Vivo , HTS Drug Discovery
inferredcites →https://doi.org/10.1101/gr.144700openalex-snapshot
The Syntenic Relationship of the Zebrafish and Human Genomes
inferredcites →https://doi.org/10.1111/j.1463-1326.2012.01604.xopenalex-snapshot
Increase in overall mortality risk in patients with type 2 diabetes receiving glipizide, glyburide or glimepiride monotherapy versus metformin: a retrospective analysis
inferredcites →https://doi.org/10.1111/j.1471-4159.2009.05885.xopenalex-snapshot
Kinetic validation of 6‐NBDG as a probe for the glucose transporter GLUT1 in astrocytes
inferredcites →https://doi.org/10.1111/j.1476-5381.2010.00725.xopenalex-snapshot
High‐throughput screening and small animal models, where are we?
inferredcites →https://doi.org/10.1111/j.1530-0277.2010.01407.xopenalex-snapshot
Drinks Like a Fish: Using Zebrafish to Understand Alcoholic Liver Disease
inferredcites →https://doi.org/10.1117/1.3259364openalex-snapshot
Evaluation and clinically relevant applications of a fluorescent imaging analog to fluorodeoxyglucose positron emission tomography
inferredcites →https://doi.org/10.1126/science.282.5396.2012openalex-snapshot
Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology
inferredcites →https://doi.org/10.1146/annurev-bioeng-071910-124703openalex-snapshot
Technologies for Micromanipulating, Imaging, and Phenotyping Small Invertebrates and Vertebrates
inferredcites →https://doi.org/10.1146/annurev.genom.7.080505.115758openalex-snapshot
Of Flies and Man:Drosophilaas a Model for Human Complex Traits
inferredcites →https://doi.org/10.1152/ajpregu.00180.2009openalex-snapshot
Specific expression and regulation of glucose transporters in zebrafish ionocytes
inferredcites →https://doi.org/10.1248/bpb.30.2075openalex-snapshot
Maslinic Acid Reduces Blood Glucose in KK-Ay Mice
inferredcites →https://doi.org/10.1248/cpb.56.1181openalex-snapshot
Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes
inferredcites →https://doi.org/10.1371/journal.pone.0018292openalex-snapshot
An Invertebrate Hyperglycemic Model for the Identification of Anti-Diabetic Drugs
inferredcites →https://doi.org/10.1517/14656566.7.8.1055openalex-snapshot
Exenatide: a GLP-1 receptor agonist as novel therapy for Type 2 diabetes mellitus
inferredcites →https://doi.org/10.1677/jme-06-0037openalex-snapshot
Larval zebrafish as a model for glucose metabolism: expression of phosphoenolpyruvate carboxykinase as a marker for exposure to anti-diabetic compounds
inferredcites →https://doi.org/10.3390/molecules16119764openalex-snapshot
Hypoglycemic and Hypolipidemic Effects of Polyphenols from Burs of Castanea mollissima Blume
inferredcites →https://doi.org/10.3390/s120405005openalex-snapshot
Visualizing Sweetness: Increasingly Diverse Applications for Fluorescent-Tagged Glucose Bioprobes and Their Recent Structural Modifications
inferredcites →https://doi.org/10.7326/0003-4819-147-6-200709180-00178openalex-snapshot
Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes Mellitus
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.phytochem.2018.02.013zenodo-depositor-declared
Discrimination of different geographic varieties of Gymnema sylvestre , an anti-sweet plant used for the treatment of type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113513zenodo-depositor-declared
Insulin-mimetic activity of 23-glycosyl oleanane triterpenoids isolated from Gymnema latifolium
inferred← citeshttps://doi.org/10.1002/ardp.201400223openalex-snapshot
5‐Nitro‐5′hydroxy‐indirubin‐3′oxime Is a Novel Inducer of Somatic Cell Transdifferentiation
inferred← citeshttps://doi.org/10.1002/jbt.23223openalex-snapshot
RETRACTED: Exposure to environmental pollutant bisphenol A causes oxidative damage and lipid accumulation in Zebrafish larvae: Protective role of WL15 peptide derived from cysteine and glycine‐rich protein 2
inferred← citeshttps://doi.org/10.1002/jbt.23520openalex-snapshot
RETRACTED: Impact of butylparaben on β‐cell damage and insulin/PEPCK expression in zebrafish larvae: Protective effects of morin
inferred← citeshttps://doi.org/10.1007/978-981-16-5217-2_6openalex-snapshot
Evolution of Zebrafish as a Novel Pharmacological Model in Endocrine Research
inferred← citeshttps://doi.org/10.1007/s10695-024-01371-0openalex-snapshot
Textile azo dye, Sudan Black B, inducing hepatotoxicity demonstrated in in vivo zebrafish larval model
inferred← citeshttps://doi.org/10.1007/s11033-022-07882-4openalex-snapshot
β-cells regeneration by WL15 of cysteine and glycine-rich protein 2 which reduces alloxan induced β-cell dysfunction and oxidative stress through phosphoenolpyruvate carboxykinase and insulin pathway in zebrafish in-vivo larval model
inferred← citeshttps://doi.org/10.1007/s11418-024-01816-zopenalex-snapshot
Hinokione: an abietene diterpene with pancreatic β cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara
inferred← citeshttps://doi.org/10.1007/s13659-024-00440-4openalex-snapshot
Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others
inferred← citeshttps://doi.org/10.1007/s43440-026-00837-7openalex-snapshot
The PERK inhibitor GSK2606414 evokes developmental defects in zebrafish consistent with Wolcott-Rallison syndrome phenotypes
inferred← citeshttps://doi.org/10.1016/b978-0-12-812431-4.00051-8openalex-snapshot
Zebrafish as a Platform for Drug Screening
inferred← citeshttps://doi.org/10.1016/bs.mcb.2016.02.009openalex-snapshot
Zebrafish pancreas as a model for development and disease
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116798openalex-snapshot
Amphiphilic hydroxyethyl starch-based nanoparticles carrying linoleic acid modified berberine inhibit the expression of krasv12 oncogene in zebrafish
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.04.007openalex-snapshot
Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects
inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.11.034openalex-snapshot
Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.09.031openalex-snapshot
PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation
inferred← citeshttps://doi.org/10.1016/j.chembiol.2014.08.017openalex-snapshot
Chemical Targeting of GAPDH Moonlighting Function in Cancer Cells Reveals Its Role in Tubulin Regulation
inferred← citeshttps://doi.org/10.1016/j.coph.2017.08.007openalex-snapshot
Catching new targets in metabolic disease with a zebrafish
inferred← citeshttps://doi.org/10.1016/j.metabol.2017.02.002openalex-snapshot
A synthetic Nitraria alkaloid, isonitramine protects pancreatic β-cell and attenuates postprandial hyperglycemia
inferred← citeshttps://doi.org/10.1016/j.phytochem.2016.02.001openalex-snapshot
Elucidation of hypoglycemic action and toxicity studies of insulin-like protein from Costus igneus
inferred← citeshttps://doi.org/10.1016/j.phytochem.2018.08.008openalex-snapshot
Hypoglycemic triterpenes from Gynostemma pentaphyllum
inferred← citeshttps://doi.org/10.1016/j.phytol.2019.08.013openalex-snapshot
Tamariscinols U–W, new dihydrobenzofuran-type norneolignans with tyrosinase inhibitory activity from Selaginella tamariscina
inferred← citeshttps://doi.org/10.1016/j.phytol.2022.01.003openalex-snapshot
Insulin mimetic lanostane triterpenes from the cultivated mushroom Ganoderma orbiforme
inferred← citeshttps://doi.org/10.1016/j.procbio.2024.04.012openalex-snapshot
Furan-based chalcone protects β-cell damage and improves glucose uptake in alloxan-induced zebrafish diabetic model via influencing Peroxisome Proliferator-Activated Receptor agonists (PPAR-γ) signaling
inferred← citeshttps://doi.org/10.1016/s1875-5364(25)60856-9openalex-snapshot
Novel araucarene diterpenes from Agathis dammara exert hypoglycemic activity by promoting pancreatic β cell regeneration and glucose uptake
inferred← citeshttps://doi.org/10.1021/acs.jafc.5b00027openalex-snapshot
Synergistic Potentials of Coffee on Injured Pancreatic Islets and Insulin Action via KATPChannel Blocking in Zebrafish
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00645openalex-snapshot
Glucose Uptake-Stimulating Galloyl Ester Triterpenoids from Castanopsis sieboldii
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b00651openalex-snapshot
Polyoxygenated Steroids from the Sponge Clathria gombawuiensis
inferred← citeshttps://doi.org/10.1021/np400533hopenalex-snapshot
Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors from Morinda citrifolia (Noni) and Their Insulin Mimetic Activity
inferred← citeshttps://doi.org/10.1021/np500231gopenalex-snapshot
Delineation of the Role of Glycosylation in the Cytotoxic Properties of Quercetin using Novel Assays in Living Vertebrates
inferred← citeshttps://doi.org/10.1021/np5005856openalex-snapshot
Insulin-Mimetic Selaginellins fromSelaginella tamariscinawith Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity
inferred← citeshttps://doi.org/10.1038/s41536-021-00163-xopenalex-snapshot
The Warburg effect is necessary to promote glycosylation in the blastema during zebrafish tail regeneration
inferred← citeshttps://doi.org/10.1038/s41598-024-83986-0openalex-snapshot
Phenotypic screening in zebrafish larvae identifies promising cyanobacterial strains and pheophorbide a as insulin mimetics
inferred← citeshttps://doi.org/10.1039/c4cc00955jopenalex-snapshot
Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3
inferred← citeshttps://doi.org/10.1039/d0ob00327aopenalex-snapshot
Synthesis of disaccharide modified berberine derivatives and their anti-diabetic investigation in zebrafish using a fluorescence-based technology
inferred← citeshttps://doi.org/10.1039/d3fo00997aopenalex-snapshot
Metabolic regulation and antihyperglycemic properties of diet-derived PGG through transcriptomic and metabolomic profiling
inferred← citeshttps://doi.org/10.1042/bst20140201openalex-snapshot
Chemical genetics and its application to moonlighting in glycolytic enzymes
inferred← citeshttps://doi.org/10.1089/jmf.2018.4235openalex-snapshot
Synergistic Effect of Two Major Components of Malva verticillata in the Recovery of Alloxan-Damaged Pancreatic Islet Cells in Zebrafish
inferred← citeshttps://doi.org/10.1093/hmg/ddz053openalex-snapshot
Genomic knockout of alms1 in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypes
inferred← citeshttps://doi.org/10.1101/2024.04.16.589737openalex-snapshot
PERK inhibition with GSK2606414 in zebrafish evokes developmental defects consistent with Wolcott-Rallison syndrome phenotypes
inferred← citeshttps://doi.org/10.1111/1753-0407.12860openalex-snapshot
Sweet fish: Fish models for the study of hyperglycemia and diabetes
inferred← citeshttps://doi.org/10.1155/2015/287847openalex-snapshot
Fishing for Nature’s Hits: Establishment of the Zebrafish as a Model for Screening Antidiabetic Natural Products
inferred← citeshttps://doi.org/10.1186/s12302-015-0040-yopenalex-snapshot
The value of zebrafish as an integrative model in effect-directed analysis - a review
inferred← citeshttps://doi.org/10.1242/dmm.035220openalex-snapshot
One month of hyperglycemia alters spectral responses of the zebrafish photopic electroretinogram
inferred← citeshttps://doi.org/10.12659/msm.909606openalex-snapshot
Assessment of Toxicity and Absorption of the Novel AA Derivative AA-Pme in SGC7901 Cancer Cells In Vitro and in Zebrafish In Vivo
inferred← citeshttps://doi.org/10.2147/dmso.s284295openalex-snapshot
Natural Compound α-PGG and Its Synthetic Derivative 6Cl-TGQ Alter Insulin Secretion: Evidence for Diminishing Glucose Uptake as a Mechanism
inferred← citeshttps://doi.org/10.3389/fendo.2022.864631openalex-snapshot
Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish
inferred← citeshttps://doi.org/10.3390/ani11010054openalex-snapshot
Wild-Type Zebrafish (Danio rerio) Larvae as a Vertebrate Model for Diabetes and Comorbidities: A Review
inferred← citeshttps://doi.org/10.3390/beverages10040111openalex-snapshot
The Bioactivities of Lactic Acid-Fermented Arthrospira platensis and Its Application in Functional Beverages
inferred← citeshttps://doi.org/10.3390/ijms21030724openalex-snapshot
Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network
inferred← citeshttps://doi.org/10.3390/ijms24108767openalex-snapshot
A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline
inferred← citeshttps://doi.org/10.3390/jdb9010010openalex-snapshot
Metabolism in the Zebrafish Retina
inferred← citeshttps://doi.org/10.3390/metabo12111011openalex-snapshot
A New Mechanism for Ginsenoside Rb1 to Promote Glucose Uptake, Regulating Riboflavin Metabolism and Redox Homeostasis
inferred← citeshttps://doi.org/10.3390/molecules23040833openalex-snapshot
Flavonoid 8-O-Glucuronides from the Aerial Parts of Malva verticillata and Their Recovery Effects on Alloxan-Induced Pancreatic Islets in Zebrafish
inferred← citeshttps://doi.org/10.3390/molecules25143158openalex-snapshot
The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies
inferred← citeshttps://doi.org/10.3390/ph14070662openalex-snapshot
Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics
inferred← citeshttps://doi.org/10.4155/tde-2022-0037openalex-snapshot
Low-dose nano-gel Incorporated With Bile Acids Enhanced Pharmacology of Surgical Implants
inferred← citeshttps://doi.org/10.7554/elife.42209openalex-snapshot
Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists
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