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Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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A Widely Distributed Bacterial Pathway for Siderophore Biosynthesis Independent of Nonribosomal Peptide Synthetases
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Protein–Protein Interactions in Multienzyme Megasynthetases
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The 2.1 Å crystal structure of an acyl‐CoA synthetase from Methanosarcina acetivorans reveals an alternate acyl‐binding pocket for small branched acyl substrates
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Glycyl-tRNA synthetase uses a negatively charged pit for specific recognition and activation of glycine 1 1Edited by R. Huber
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Kinetics of acetyl-CoA synthetase—I. Mode of addition of substrates
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Mechanistic studies of the long chain acyl-CoA synthetase Faa1p from Saccharomyces cerevisiae
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Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes
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Structure of the EntB Multidomain Nonribosomal Peptide Synthetase and Functional Analysis of Its Interaction with the EntE Adenylation Domain
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Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides
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Biochemical and Structural Characterization of the Paralogous Benzoate CoA Ligases from Burkholderia xenovorans LB400: Defining the Entry Point into the Novel Benzoate Oxidation (box) Pathway
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Crystal Structure of Bacillus cereus d-Alanyl Carrier Protein Ligase (DltA) in Complex with ATP
inferredcites →https://doi.org/10.1016/j.jmb.2009.03.064openalex-snapshot
Structural Snapshots for the Conformation-dependent Catalysis by Human Medium-chain Acyl-coenzyme A Synthetase ACSM2A
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Structure and function of enzymes involved in the biosynthesis of phenylpropanoids
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The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes.
inferredcites →https://doi.org/10.1016/s0021-9258(18)43172-9openalex-snapshot
ENZYMATIC SYNTHESIS OF ACETYL PHOSPHATE
inferredcites →https://doi.org/10.1016/s0021-9258(18)98948-9openalex-snapshot
Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. Molecular characterization of the acvA gene encoding the first enzyme of the penicillin biosynthetic pathway
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Purification and biochemical characterization of phenylacetyl-CoA ligase from Pseudomonas putida. A specific enzyme for the catabolism of phenylacetic acid.
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ACYL ADENYLATES: AN ENZYMATIC MECHANISM OF ACETATE ACTIVATION
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Proteins of the penicillin biosynthesis pathway
inferredcites →https://doi.org/10.1016/s0969-2126(96)00033-0openalex-snapshot
Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes
inferredcites →https://doi.org/10.1016/s1074-5521(00)00091-0openalex-snapshot
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
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The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
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The Chemical Versatility of Natural-Product Assembly Lines
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Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases
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Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product
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Characterization of the Propionyl-CoA Synthetase (PrpE) Enzyme of Salmonella enterica: Residue Lys592 Is Required for Propionyl-AMP Synthesis
inferredcites →https://doi.org/10.1021/bi0271603openalex-snapshot
The 1.75 Å Crystal Structure of Acetyl-CoA Synthetase Bound to Adenosine-5‘-propylphosphate and Coenzyme A
inferredcites →https://doi.org/10.1021/bi035911aopenalex-snapshot
Crystal Structure of Yeast Acetyl-Coenzyme A Synthetase in Complex with AMP
inferredcites →https://doi.org/10.1021/bi047903fopenalex-snapshot
Mutagenesis Evidence that the Partial Reactions of Firefly Bioluminescence Are Catalyzed by Different Conformations of the Luciferase C-Terminal Domain
inferredcites →https://doi.org/10.1021/bi049384mopenalex-snapshot
Crystal Structure of 4-Chlorobenzoate:CoA Ligase/Synthetase in the Unliganded and Aryl Substrate-Bound States,
inferredcites →https://doi.org/10.1021/bi061979popenalex-snapshot
Carrier Protein Structure and Recognition in Polyketide and Nonribosomal Peptide Biosynthesis
inferredcites →https://doi.org/10.1021/bi6026506openalex-snapshot
Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase ,
inferredcites →https://doi.org/10.1021/bi800696yopenalex-snapshot
Structural Characterization of a 140° Domain Movement in the Two-Step Reaction Catalyzed by 4-Chlorobenzoate:CoA Ligase
inferredcites →https://doi.org/10.1021/bi800698mopenalex-snapshot
Mechanism of 4-Chlorobenzoate:Coenzyme A Ligase Catalysis
inferredcites →https://doi.org/10.1021/bi801311dopenalex-snapshot
Bacillus anthracis o -Succinylbenzoyl-CoA Synthetase: Reaction Kinetics and a Novel Inhibitor Mimicking Its Reaction Intermediate
inferredcites →https://doi.org/10.1021/bi801363bopenalex-snapshot
Crystal Structure and Enantiomer Selection by d -Alanyl Carrier Protein Ligase DltA from Bacillus cereus
inferredcites →https://doi.org/10.1021/bi801500zopenalex-snapshot
DNA Polymerases and Aminoacyl-tRNA Synthetases: Shared Mechanisms for Ensuring the Fidelity of Gene Expression
inferredcites →https://doi.org/10.1021/bi9002327openalex-snapshot
The Mechanism of Domain Alternation in the Acyl-Adenylate Forming Ligase Superfamily Member 4-Chlorobenzoate: Coenzyme A Ligase,
inferredcites →https://doi.org/10.1021/bi971262popenalex-snapshot
Acyl-Adenylate Motif of the Acyl-Adenylate/Thioester-Forming Enzyme Superfamily: A Site-Directed Mutagenesis Study with the Pseudomonas sp. Strain CBS3 4-Chlorobenzoate:Coenzyme A Ligase
inferredcites →https://doi.org/10.1021/bi9726584openalex-snapshot
Reconstitution and Characterization of the Escherichia coli Enterobactin Synthetase from EntB, EntE, and EntF
inferredcites →https://doi.org/10.1021/bi9928804openalex-snapshot
The Role of Lysine 529, a Conserved Residue of the Acyl-Adenylate-Forming Enzyme Superfamily, in Firefly Luciferase
inferredcites →https://doi.org/10.1021/cr0503097openalex-snapshot
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
inferredcites →https://doi.org/10.1021/cr960029eopenalex-snapshot
Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis
inferredcites →https://doi.org/10.1021/ja063238hopenalex-snapshot
Localized Protein Interaction Surfaces on the EntB Carrier Protein Revealed by Combinatorial Mutagenesis and Selection
inferredcites →https://doi.org/10.1038/nature02384openalex-snapshot
Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria
inferredcites →https://doi.org/10.1038/nature04542openalex-snapshot
Structural basis for the spectral difference in luciferase bioluminescence
inferredcites →https://doi.org/10.1038/nature07161openalex-snapshot
Structural basis for the selectivity of the external thioesterase of the surfactin synthetase
inferredcites →https://doi.org/10.1038/nature07162openalex-snapshot
Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase
inferredcites →https://doi.org/10.1038/nchembio.143openalex-snapshot
Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1038/nchembio.145openalex-snapshot
AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis
inferredcites →https://doi.org/10.1038/nchembio731openalex-snapshot
Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
inferredcites →https://doi.org/10.1038/nsb738openalex-snapshot
Domain alternation switches B12-dependent methionine synthase to the activation conformation
inferredcites →https://doi.org/10.1039/b603921aopenalex-snapshot
The ubiquitous carrier protein—a window to metabolite biosynthesis
inferredcites →https://doi.org/10.1042/bj1090275openalex-snapshot
Studies on medium-chain fatty acyl-coenzyme A synthetase. Enzyme fraction I: mechanism of reaction and allosteric properties
inferredcites →https://doi.org/10.1042/bj1090283openalex-snapshot
Studies of medium-chain fatty acyl-coenzyme A synthetase. Enzyme fraction II: mechanism of reaction and specific properties
inferredcites →https://doi.org/10.1042/bj2970327openalex-snapshot
Steady-state kinetics of malonyl-CoA synthetase from Bradyrhizobium japonicum and evidence for malonyl-AMP formation in the reaction
inferredcites →https://doi.org/10.1046/j.1365-2958.2000.01941.xopenalex-snapshot
Assembly of aryl‐capped siderophores by modular peptide synthetases and polyketide synthases
inferredcites →https://doi.org/10.1073/pnas.0601038103openalex-snapshot
A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection
inferredcites →https://doi.org/10.1073/pnas.182156699openalex-snapshot
Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases
inferredcites →https://doi.org/10.1074/jbc.m400100200openalex-snapshot
Structural Basis of the Substrate-specific Two-step Catalysis of Long Chain Fatty Acyl-CoA Synthetase Dimer
inferredcites →https://doi.org/10.1074/jbc.m800557200openalex-snapshot
Crystal Structure of DltA
inferredcites →https://doi.org/10.1093/emboj/16.14.4174openalex-snapshot
Structural basis for the activation of phenylalanine in the non‐ribosomal biosynthesis of gramicidin S
inferredcites →https://doi.org/10.1093/emboj/cdg053openalex-snapshot
ATP binding by glutamyl‐tRNA synthetase is switched to the productive mode by tRNA binding
inferredcites →https://doi.org/10.1093/nar/gki885openalex-snapshot
Specificity prediction of adenylation domains in nonribosomal peptide synthetases (NRPS) using transductive support vector machines (TSVMs)
inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a122909openalex-snapshot
Molecular Cloning and Nucleotide Sequence of the Gramicidin S Synthetase 1 Gene1
inferredcites →https://doi.org/10.1107/s1744309106005938openalex-snapshot
Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of FadD28, a fatty-acyl AMP ligase fromMycobacterium tuberculosis
inferredcites →https://doi.org/10.1111/j.1365-2958.1992.tb01451.xopenalex-snapshot
Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate‐forming enzymes
inferredcites →https://doi.org/10.1111/j.1365-2958.1992.tb01498.xopenalex-snapshot
Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate‐forming enzymes
inferredcites →https://doi.org/10.1126/science.1122928openalex-snapshot
Conformational Switches Modulate Protein Interactions in Peptide Antibiotic Synthetases
inferredcites →https://doi.org/10.1126/science.1159850openalex-snapshot
Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase
inferredcites →https://doi.org/10.1126/science.157.3785.150openalex-snapshot
Molecular Uniformity in Biological Catalyses
inferredcites →https://doi.org/10.1128/jb.176.9.2654-2662.1994openalex-snapshot
Analysis of core sequences in the D-Phe activating domain of the multifunctional peptide synthetase TycA by site-directed mutagenesis
inferredcites →https://doi.org/10.1146/annurev.biochem.70.1.209openalex-snapshot
Divergent Evolution of Enzymatic Function: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Unprecedented Noncanonical Features of the Nonlinear Nonribosomal Peptide Synthetase Assembly Line for WS9326A Biosynthesis
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An Atypical Acyl‐CoA Synthetase Enables Efficient Biosynthesis of Extender Units for Engineering a Polyketide Carbon Scaffold
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FRET Monitoring of a Nonribosomal Peptide Synthetase Elongation Module Reveals Carrier Protein Shuttling between Catalytic Domains
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Carrier Protein Interaction with Competing Adenylation and Epimerization Domains in a Nonribosomal Peptide Synthetase Analyzed by FRET
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Enzymatic Basis of “Hybridity” in Thiomarinol Biosynthesis
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New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis
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Nonribosomal Peptide Synthesis—Principles and Prospects
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The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides
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Unprecedented Noncanonical Features of the Nonlinear Nonribosomal Peptide Synthetase Assembly Line for WS9326A Biosynthesis
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An Atypical Acyl‐CoA Synthetase Enables Efficient Biosynthesis of Extender Units for Engineering a Polyketide Carbon Scaffold
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FRET Monitoring of a Nonribosomal Peptide Synthetase Elongation Module Reveals Carrier Protein Shuttling between Catalytic Domains
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Carrier Protein Interaction with Competing Adenylation and Epimerization Domains in a Nonribosomal Peptide Synthetase Analyzed by FRET
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Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6
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Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases
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inferred← citeshttps://doi.org/10.1007/82_2016_24openalex-snapshot
Natural Products from Photorhabdus and Other Entomopathogenic Bacteria
inferred← citeshttps://doi.org/10.1007/978-1-0716-3214-7_1openalex-snapshot
The Assembly-Line Enzymology of Nonribosomal Peptide Biosynthesis
inferred← citeshttps://doi.org/10.1007/978-1-0716-3214-7_12openalex-snapshot
Probing Substrate-Loaded Carrier Proteins by Nuclear Magnetic Resonance
inferred← citeshttps://doi.org/10.1007/978-1-0716-3214-7_2openalex-snapshot
Structural Studies of Modular Nonribosomal Peptide Synthetases
inferred← citeshttps://doi.org/10.1007/978-1-4939-1191-2_15openalex-snapshot
Fungal NRPS-Dependent Siderophores: From Function to Prediction
inferred← citeshttps://doi.org/10.1007/978-1-4939-3375-4_1openalex-snapshot
Structural Biology of Nonribosomal Peptide Synthetases
inferred← citeshttps://doi.org/10.1007/978-1-4939-3375-4_3openalex-snapshot
Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay
inferred← citeshttps://doi.org/10.1007/978-1-4939-6940-1_8openalex-snapshot
Ultrasensitive Firefly Luminescent Intermediate-Based Protein-Protein Interaction Assay (FlimPIA) Based on the Functional Complementation of Mutant Firefly Luciferases
inferred← citeshttps://doi.org/10.1007/978-3-319-91352-0_5openalex-snapshot
Structural Biology of Jasmonic Acid Metabolism and Responses in Plants
inferred← citeshttps://doi.org/10.1007/s00239-011-9480-1openalex-snapshot
The Phylogenomic Roots of Modern Biochemistry: Origins of Proteins, Cofactors and Protein Biosynthesis
inferred← citeshttps://doi.org/10.1007/s00253-014-5803-7openalex-snapshot
Identification of a gene cluster responsible for the biosynthesis of cyclic lipopeptide verlamelin
inferred← citeshttps://doi.org/10.1007/s00775-022-01941-8openalex-snapshot
Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD
inferred← citeshttps://doi.org/10.1007/s10295-018-02130-wopenalex-snapshot
Refining and expanding nonribosomal peptide synthetase function and mechanism
inferred← citeshttps://doi.org/10.1007/s10295-018-2084-7openalex-snapshot
Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products
inferred← citeshttps://doi.org/10.1007/s10482-015-0557-5openalex-snapshot
Comparative analysis of oligonucleotide primers for high-throughput screening of genes encoding adenylation domains of nonribosomal peptide synthetases in actinomycetes
inferred← citeshttps://doi.org/10.1007/s10858-015-9943-6openalex-snapshot
Assignment of methyl NMR resonances of a 52 kDa protein with residue-specific 4D correlation maps
inferred← citeshttps://doi.org/10.1007/s10930-017-9714-1openalex-snapshot
Substrate-Induced Conformational Changes of the Tyrocidine Synthetase 1 Adenylation Domain Probed by Intrinsic Trp Fluorescence
inferred← citeshttps://doi.org/10.1007/s11306-014-0622-5openalex-snapshot
Luciferase does not alter metabolism in cancer cells
inferred← citeshttps://doi.org/10.1007/s12010-024-04977-5openalex-snapshot
Biochemical Characterization of a Marine Pseudoalteromonas citrea-Derived Fatty Acyl-AMP Ligase That Exhibits N-Acyl Amino Acid Synthetic Activity
inferred← citeshttps://doi.org/10.1007/s12038-017-9663-zopenalex-snapshot
Non-ribosomal peptide synthetases: Identifying the cryptic gene clusters and decoding the natural product
inferred← citeshttps://doi.org/10.1007/s12257-020-0265-5openalex-snapshot
Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines
inferred← citeshttps://doi.org/10.1007/s13562-018-0477-3openalex-snapshot
Identification and initial characterization of a new subgroup in the GH3 gene family in woody plants
inferred← citeshttps://doi.org/10.1007/s41745-018-0084-2openalex-snapshot
Fatty Acyl-AMP Ligases as Mechanistic Variants of ANL Superfamily and Molecular Determinants Dictating Substrate Specificities
inferred← citeshttps://doi.org/10.1007/s43630-020-00007-5openalex-snapshot
Influence of the C-terminal domain on the bioluminescence activity and color determination in green and red emitting beetle luciferases and luciferase-like enzyme
inferred← citeshttps://doi.org/10.1007/s43630-023-00515-0openalex-snapshot
The orange light emitting luciferase from the rare Euryopa clarindae adult railroadworm (Coleoptera:Phengodidae): structural/functional and evolutionary relationship with green and red emitting luciferases
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14634-7openalex-snapshot
Rings of Power: Enzymatic Routes to β-Lactones
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14733-xopenalex-snapshot
Structural Biology of Nonribosomal Peptide Synthetases
inferred← citeshttps://doi.org/10.1016/bs.mie.2024.06.012openalex-snapshot
Kinetic analysis of the three-substrate reaction mechanism of an NRPS-independent siderophore (NIS) synthetase
inferred← citeshttps://doi.org/10.1016/j.ab.2010.04.033openalex-snapshot
A continuous kinetic assay for adenylation enzyme activity and inhibition
inferred← citeshttps://doi.org/10.1016/j.ab.2015.01.006openalex-snapshot
Hydroxamate-based colorimetric assay to assess amide bond formation by adenylation domain of nonribosomal peptide synthetases
inferred← citeshttps://doi.org/10.1016/j.apsb.2026.02.010openalex-snapshot
DeepHalo: Deep learning-powered exploration of halogenated metabolites uncovering antibacterial depsipeptides
inferred← citeshttps://doi.org/10.1016/j.bbagen.2019.03.017openalex-snapshot
Characterization of acetyl-CoA synthetase kinetics and ATP-binding
inferred← citeshttps://doi.org/10.1016/j.bbapap.2014.04.021openalex-snapshot
Point mutations in firefly luciferase C-domain demonstrate its significance in green color of bioluminescence
inferred← citeshttps://doi.org/10.1016/j.bbapap.2015.05.001openalex-snapshot
Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy
inferred← citeshttps://doi.org/10.1016/j.bbapap.2016.09.007openalex-snapshot
Color-shifting mutations in the C-domain of L. mingrelica firefly luciferase provide new information about the domain alternation mechanism
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.151960openalex-snapshot
Structural enzymological studies of the long chain fatty acyl-CoA synthetase FadD5 from the mce1 operon of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.153750openalex-snapshot
A novel engineered malonyl-CoA synthetase from Astragalus mongholicus with improved catalytic performance
inferred← citeshttps://doi.org/10.1016/j.biortech.2022.128064openalex-snapshot
Recent advances and challenges in the bioconversion of acetate to value-added chemicals
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2020.107575openalex-snapshot
Coenzyme A thioester-mediated carbon chain elongation as a paintbrush to draw colorful chemical compounds
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107813openalex-snapshot
Recent advances in biocatalysis of nitrogen-containing heterocycles
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2022.107989openalex-snapshot
Towards engineered yeast as production platform for capsaicinoids
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.04.006openalex-snapshot
Synthesis and inhibitory activity of mechanism-based 4-coumaroyl-CoA ligase inhibitors
inferred← citeshttps://doi.org/10.1016/j.bpj.2025.06.021openalex-snapshot
Denaturation of firefly luciferase at heat shock temperatures captured in silico
inferred← citeshttps://doi.org/10.1016/j.cbpa.2016.09.005openalex-snapshot
Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases
inferred← citeshttps://doi.org/10.1016/j.cbpa.2017.10.006openalex-snapshot
Carboxylic acid reductase enzymes (CARs)
inferred← citeshttps://doi.org/10.1016/j.cbpa.2018.05.009openalex-snapshot
Advances in bioluminescence imaging: new probes from old recipes
inferred← citeshttps://doi.org/10.1016/j.cbpa.2022.102212openalex-snapshot
Recent advances in the structural analysis of adenylation domains in natural product biosynthesis
inferred← citeshttps://doi.org/10.1016/j.cbpa.2026.102737openalex-snapshot
Ligase enzymes for the synthesis of peptide therapeutics
inferred← citeshttps://doi.org/10.1016/j.chembiol.2010.05.012openalex-snapshot
Illuminating Insights into Firefly Luciferase and Other Bioluminescent Reporters Used in Chemical Biology
inferred← citeshttps://doi.org/10.1016/j.chembiol.2011.11.013openalex-snapshot
Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.02.002openalex-snapshot
Flexing and Stretching in Nonribosomal Peptide Synthetases
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.03.013openalex-snapshot
The Antibiotic CJ-15,801 Is an Antimetabolite that Hijacks and Then Inhibits CoA Biosynthesis
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.10.020openalex-snapshot
Engineering the Substrate Specificity of the DhbE Adenylation Domain by Yeast Cell Surface Display
inferred← citeshttps://doi.org/10.1016/j.chembiol.2013.10.010openalex-snapshot
Proofreading of Noncognate Acyl Adenylates by an Acyl-Coenzyme A Ligase
inferred← citeshttps://doi.org/10.1016/j.chembiol.2015.04.015openalex-snapshot
A Subdomain Swap Strategy for Reengineering Nonribosomal Peptides
inferred← citeshttps://doi.org/10.1016/j.chembiol.2017.06.008openalex-snapshot
Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement
inferred← citeshttps://doi.org/10.1016/j.chempr.2025.102740openalex-snapshot
Distal peptide elongation by a protease-like ligase and two distinct carrier proteins
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.04.045openalex-snapshot
Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily
inferred← citeshttps://doi.org/10.1016/j.gene.2016.09.045openalex-snapshot
Lipid metabolism in Rhodnius prolixus : Lessons from the genome
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.124526openalex-snapshot
Carboxylic acid reductases: Structure, catalytic requirements, and applications in biotechnology
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.102166openalex-snapshot
An acyl-adenylate mimic reveals the structural basis for substrate recognition by the iterative siderophore synthetase DesD
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107879openalex-snapshot
A single Leishmania adenylate–forming enzyme of the ANL superfamily generates both acetyl- and acetoacetyl-CoA
inferred← citeshttps://doi.org/10.1016/j.jbc.2025.108413openalex-snapshot
The structural basis of substrate selectivity of the acinetobactin biosynthetic adenylation domain, BasE
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113208openalex-snapshot
Structure of a stand-alone homodimeric nonribosomal peptide synthetase condensation domain reveals occlusion of the canonical carrier-protein interface
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2017.07.025openalex-snapshot
Computational study of the binding mechanism of medium chain acyl-CoA synthetase with substrate in Methanosarcina acetivorans
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2019.10.002openalex-snapshot
Carboxylic acid reductases in metabolic engineering
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2019.10.010openalex-snapshot
Carboxylic acid reductase: Structure and mechanism
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.03.012openalex-snapshot
An efficient lysate-based approach for biosynthesis of the pyrrolobenzodiazepine natural product tilimycin
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2026.143163openalex-snapshot
Adaptive genetic trade-offs govern the enantioselective degradation and horizontal transfer of ibuprofen catabolic genes
inferred← citeshttps://doi.org/10.1016/j.jip.2016.07.013openalex-snapshot
Revisiting protein structure, function, and evolution in the genomic era
inferred← citeshttps://doi.org/10.1016/j.jmb.2010.12.011openalex-snapshot
Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila
inferred← citeshttps://doi.org/10.1016/j.jmb.2011.12.031openalex-snapshot
Molecular Basis of the Functional Divergence of Fatty Acyl-AMP Ligase Biosynthetic Enzymes of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1016/j.jmb.2019.05.027openalex-snapshot
Structures of 2-Hydroxyisobutyric Acid-CoA Ligase Reveal Determinants of Substrate Specificity and Describe a Multi-Conformational Catalytic Cycle
inferred← citeshttps://doi.org/10.1016/j.micres.2014.02.007openalex-snapshot
Fungal extrolites as a new source for therapeutic compounds and as building blocks for applications in synthetic biology
inferred← citeshttps://doi.org/10.1016/j.micres.2025.128413openalex-snapshot
Microbial acetyl-CoA synthesis as an emerging metabolic and regulatory hub in plant-microbe interactions
inferred← citeshttps://doi.org/10.1016/j.molcatb.2011.01.008openalex-snapshot
Enantiodifferentiation of ketoprofen by Japanese firefly luciferase from Luciola lateralis
inferred← citeshttps://doi.org/10.1016/j.molp.2016.06.002openalex-snapshot
Crystal Structures of Arabidopsis thaliana Oxalyl-CoA Synthetase Essential for Oxalate Degradation
inferred← citeshttps://doi.org/10.1016/j.pbi.2022.102194openalex-snapshot
Connecting primary and specialized metabolism: Amino acid conjugation of phytohormones by GRETCHEN HAGEN 3 (GH3) acyl acid amido synthetases
inferred← citeshttps://doi.org/10.1016/j.plantsci.2019.110364openalex-snapshot
Discovery of modules involved in the biosynthesis and regulation of maize phenolic compounds
inferred← citeshttps://doi.org/10.1016/j.procbio.2023.11.004openalex-snapshot
Efficient synthesis of malonyl-CoA by an acyl-CoA synthetase from Streptomyces sp.
inferred← citeshttps://doi.org/10.1016/j.sbi.2010.01.009openalex-snapshot
Nonribosomal peptide synthetases: structures and dynamics
inferred← citeshttps://doi.org/10.1016/j.sbi.2018.01.011openalex-snapshot
Piecing together nonribosomal peptide synthesis
inferred← citeshttps://doi.org/10.1016/j.sbi.2018.01.015openalex-snapshot
Nonribosomal peptides for iron acquisition: pyochelin biosynthesis as a case study
inferred← citeshttps://doi.org/10.1016/j.str.2013.02.017openalex-snapshot
Adaptation of Aminoacyl-tRNA Synthetase Catalytic Core to Carrier Protein Aminoacylation
inferred← citeshttps://doi.org/10.1016/j.str.2015.08.012openalex-snapshot
Structural Basis for Specificity and Flexibility in a Plant 4-Coumarate:CoA Ligase
inferred← citeshttps://doi.org/10.1016/j.str.2017.03.014openalex-snapshot
X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture
inferred← citeshttps://doi.org/10.1016/j.str.2024.01.010openalex-snapshot
Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains
inferred← citeshttps://doi.org/10.1016/j.synbio.2022.01.007openalex-snapshot
Complex peptide natural products: Biosynthetic principles, challenges and opportunities for pathway engineering
inferred← citeshttps://doi.org/10.1016/j.synbio.2022.02.006openalex-snapshot
Protein-protein interface analysis of the non-ribosomal peptide synthetase peptidyl carrier protein and enzymatic domains
inferred← citeshttps://doi.org/10.1016/j.tcb.2017.03.004openalex-snapshot
rAMPing Up Stress Signaling: Protein AMPylation in Metazoans
inferred← citeshttps://doi.org/10.1016/j.tet.2013.03.050openalex-snapshot
Development of simple firefly luciferin analogs emitting blue, green, red, and near-infrared biological window light
inferred← citeshttps://doi.org/10.1016/j.tet.2018.12.004openalex-snapshot
A generic platform for the immobilisation of engineered biocatalysts
inferred← citeshttps://doi.org/10.1021/ac4016825openalex-snapshot
A Protein–Protein Interaction Assay Based on the Functional Complementation of Mutant Firefly Luciferases
inferred← citeshttps://doi.org/10.1021/ac403065vopenalex-snapshot
Improved Protein–Protein Interaction Assay FlimPIA by the Entrapment of Luciferase Conformation
inferred← citeshttps://doi.org/10.1021/acs.biochem.0c00250openalex-snapshot
The Siderophore Synthetase IucA of the Aerobactin Biosynthetic Pathway Uses an Ordered Mechanism
inferred← citeshttps://doi.org/10.1021/acs.biochem.4c00336openalex-snapshot
Enzyme Catalyzed Formation of CoA Adducts of Fluorinated Hexanoic Acid Analogues using a Long-Chain acyl-CoA Synthetase from Gordonia sp. Strain NB4-1Y
inferred← citeshttps://doi.org/10.1021/acs.biochem.4c00770openalex-snapshot
Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks
inferred← citeshttps://doi.org/10.1021/acs.biochem.5b00966openalex-snapshot
Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents
inferred← citeshttps://doi.org/10.1021/acs.biochem.6b00889openalex-snapshot
Mechanistic Insights from the Crystal Structure of Bacillus subtilis o-Succinylbenzoyl-CoA Synthetase Complexed with the Adenylate Intermediate
inferred← citeshttps://doi.org/10.1021/acs.biochem.7b00884openalex-snapshot
Manipulating Protein–Protein Interactions in Nonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00411openalex-snapshot
Mechanism of Integrated β-Lactam Formation by a Nonribosomal Peptide Synthetase during Antibiotic Synthesis
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b01153openalex-snapshot
Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents
inferred← citeshttps://doi.org/10.1021/acs.biochem.9b00003openalex-snapshot
Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE
inferred← citeshttps://doi.org/10.1021/acs.biochem.9b00272openalex-snapshot
Non-Steady State Analysis of Enzyme Kinetics in Real Time Elucidates Substrate Association and Dissociation Rates: Demonstration with Analysis of Firefly Luciferase Mutants
inferred← citeshttps://doi.org/10.1021/acs.biochem.9b00719openalex-snapshot
Mutagenesis and Structural Studies Reveal the Basis for the Activity and Stability Properties That Distinguish the Photinus Luciferases scintillans and pyralis
inferred← citeshttps://doi.org/10.1021/acs.chemrev.5c01091openalex-snapshot
Enzymatic Strategies for Nitrogen–Nitrogen Bond Formation in Natural Product Biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.est.5c11041openalex-snapshot
Role of Acyl-CoA Synthetase (ACS) from Dietzia aurantiaca Strain J3 and Glutathione (GSH) in Fluorotelomer Biotransformation
inferred← citeshttps://doi.org/10.1021/acs.est.6c09885openalex-snapshot
From Destruction to Reconstruction: Substrate-Driven Biosynthesis of Antioxidants from Antibiotic Residues in Hyperthermophilic Composting
inferred← citeshttps://doi.org/10.1021/acs.jafc.6c05226openalex-snapshot
From Biosynthetic Mechanisms to Rational Design of Next-Generation Surfactin Biopesticides: A Review
inferred← citeshttps://doi.org/10.1021/acs.jcim.8b00763openalex-snapshot
Computational Insights into the Catalytic Mechanism of Bacterial Carboxylic Acid Reductase
inferred← citeshttps://doi.org/10.1021/acs.jctc.0c00074openalex-snapshot
Same Luciferin in Different Luciferases Emitting Different-Color Light. A Theoretical Study on Beetle Bioluminescence
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01349openalex-snapshot
Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00807openalex-snapshot
Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401
inferred← citeshttps://doi.org/10.1021/acs.joc.2c00813openalex-snapshot
BODIPY Photocatalyzed Beckmann Rearrangement and Hydrolysis of Oximes under Visible Light
inferred← citeshttps://doi.org/10.1021/acs.joc.5b00550openalex-snapshot
Investigation and Conformational Analysis of Fluorinated Nucleoside Antibiotics Targeting Siderophore Biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.joc.8b00367openalex-snapshot
Discovery of a Diazo-Forming Enzyme in Cremeomycin Biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.jpcb.7b08000openalex-snapshot
Electrostatic Catalysis Induced by Luciferases in the Decomposition of the Firefly Dioxetanone and Its Analogue
inferred← citeshttps://doi.org/10.1021/acscatal.0c00929openalex-snapshot
Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System
inferred← citeshttps://doi.org/10.1021/acscatal.2c02954openalex-snapshot
Coupled Natural Fusion Enzymes in a Novel Biocatalytic Cascade Convert Fatty Acids to Amines
inferred← citeshttps://doi.org/10.1021/acscatal.3c05656openalex-snapshot
Broad Spectrum Enantioselective Amide Bond Synthetase from Streptoalloteichus hindustanus
inferred← citeshttps://doi.org/10.1021/acschembio.0c00403openalex-snapshot
Structural Characterization of Complex of Adenylation Domain and Carrier Protein by Using Pantetheine Cross-Linking Probe
inferred← citeshttps://doi.org/10.1021/acschembio.1c00484openalex-snapshot
Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases
inferred← citeshttps://doi.org/10.1021/acschembio.1c00500openalex-snapshot
Structure and Cooperativity in Substrate–Enzyme Interactions: Perspectives on Enzyme Engineering and Inhibitor Design
inferred← citeshttps://doi.org/10.1021/acschembio.1c00623openalex-snapshot
Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase
inferred← citeshttps://doi.org/10.1021/acschembio.2c00523openalex-snapshot
Essential Role of Loop Dynamics in Type II NRPS Biomolecular Recognition
inferred← citeshttps://doi.org/10.1021/acschembio.4c00169openalex-snapshot
Fluorometric Analysis of Carrier-Protein-Dependent Biosynthesis through a Conformationally Sensitive Solvatochromic Pantetheinamide Probe
inferred← citeshttps://doi.org/10.1021/acschembio.4c00512openalex-snapshot
Expanding the Substrate Selectivity of the Fimsbactin Biosynthetic Adenylation Domain, FbsH
inferred← citeshttps://doi.org/10.1021/acschembio.5b00346openalex-snapshot
A Fluorescent, Reagentless Biosensor for ATP, Based on Malonyl-Coenzyme A Synthetase
inferred← citeshttps://doi.org/10.1021/acschembio.5b00500openalex-snapshot
Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis
inferred← citeshttps://doi.org/10.1021/acschembio.5b00595openalex-snapshot
Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains
inferred← citeshttps://doi.org/10.1021/acschembio.5c00014openalex-snapshot
Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation
inferred← citeshttps://doi.org/10.1021/acschembio.5c00237openalex-snapshot
Characterizing the Biochemical Role of an Unusual Fatty Acyl-AMP Ligase from a Hybrid PKS-NRPS Pathway in Nematodes
inferred← citeshttps://doi.org/10.1021/acschembio.6b00575openalex-snapshot
Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa
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