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Strategies for the Use of Mixture-Based Synthetic Combinatorial Libraries: Scaffold Ranking, Direct Testing In Vivo, and Enhanced Deconvolution by Computational Methods
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries
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Peptide motif for the rat MHC class II molecule RT1.Da: similarities to the multiple sclerosis-associated HLA-DRB1*1501 molecule
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Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B
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Biochemical characterization of prostasin, a channel activating protease
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Design and synthesis of an optimized positional scanning library of peptoids: identification of novel multidrug resistance reversal agents
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De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library
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Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization
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A strategy to profile prime and non-prime proteolytic substrate specificity
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Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands: An example of lead optimization using mixture-based libraries
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Pyrrolidine bis-cyclic guanidines with antimicrobial activity against drug-resistant Gram-positive pathogens identified from a mixture-based combinatorial library
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New Peptide Inhibitors of Type IB Topoisomerases: Similarities and Differences Vis-a-vis Inhibitors of Tyrosine Recombinases
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Antinociceptive and Respiratory Effects of Intrathecal H-Tyr-d-Arg-Phe-Lys-NH2 (DALDA) and [Dmt1]DALDA
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Synthesis and in vitro opioid activity profiles of DALDA analogues
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Chemoinformatics – similarity and diversity in chemical libraries
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A Combinatorial Library of Indinavir Analogues and Its In Vitro and In Vivo Studies
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Positional-Scanning Combinatorial Libraries of Fluorescence Resonance Energy Transfer Peptides for Defining Substrate Specificity of the Angiotensin I-Converting Enzyme and Development of Selective C-Domain Substrates
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Diverse Viewpoints on Computational Aspects of Molecular Diversity
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Comprehensive Survey of Combinatorial Library Synthesis: 2003
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Comprehensive Survey of Combinatorial Library Synthesis: 2005
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The Current Status of Heterocyclic Combinatorial Libraries
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Mixture-Based Synthetic Combinatorial Libraries
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Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities
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FE200041 (d-Phe-d-Phe-d-Nle-d-Arg-NH2): A Peripheral Efficacious κ Opioid Agonist with Unprecedented Selectivity
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Increased Expression of Apoptosis Inhibitor Protein XIAP Contributes to Anoikis Resistance of Circulating Human Prostate Cancer Metastasis Precursor Cells
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Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
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High-Throughput Screening of Novel Peptide Inhibitors of an Integrin Receptor from the Hexapeptide Library by Using a Protein Microarray Chip
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Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532
inferredcites →https://doi.org/10.1182/blood-2004-08-3168openalex-snapshot
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
inferredcites →https://doi.org/10.1182/blood-2005-02-0695openalex-snapshot
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis
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Recognition of Conserved Amino Acid Motifs of Common Viruses and Its Role in Autoimmunity
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Combinatorial Peptide Libraries and Biometric Score Matrices Permit the Quantitative Analysis of Specific and Degenerate Interactions Between Clonotypic TCR and MHC Peptide Ligands
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Individual Nonobese Diabetic Mice Exhibit Unique Patterns of CD8+ T Cell Reactivity to Three Islet Antigens, Including the Newly Identified Widely Expressed Dystrophia Myotonica Kinase
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Requirement for Both H-2Db and H-2Kd for the Induction of Diabetes by the Promiscuous CD8+ T Cell Clonotype AI4
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Identification of Cross-Reactive Peptides Using Combinatorial Libraries Circumvents Tolerance against Her-2/neu-Immunodominant Epitope
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Redundancy in Antigen-Presenting Function of the HLA-DR and -DQ Molecules in the Multiple Sclerosis-Associated HLA-DR2 Haplotype
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Deng Xiaoping and the Chinese Revolution
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Identification of B Cell and T Cell Epitopes Using Synthetic Peptide Combinatorial Libraries
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Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery
inferred← citeshttps://doi.org/10.1021/co300060sopenalex-snapshot
A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries
inferred← citeshttps://doi.org/10.1021/co300152xopenalex-snapshot
Discovery of Novel Antinociceptive α-Conotoxin Analogues from the Direct In Vivo Screening of a Synthetic Mixture-Based Combinatorial Library
inferred← citeshttps://doi.org/10.1021/cr500043bopenalex-snapshot
NMR-Based Approaches for the Identification and Optimization of Inhibitors of Protein–Protein Interactions
inferred← citeshttps://doi.org/10.1021/ja907184gopenalex-snapshot
New Strategies for the Design of Folded Peptoids Revealed by a Survey of Noncovalent Interactions in Model Systems
inferred← citeshttps://doi.org/10.1021/jm3008739openalex-snapshot
Insights into the Structural Determinants Required for High-Affinity Binding of Chiral Cyclopropane-Containing Ligands to α4β2-Nicotinic Acetylcholine Receptors: An Integrated Approach to Behaviorally Active Nicotinic Ligands
inferred← citeshttps://doi.org/10.1021/jm401543hopenalex-snapshot
Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies
inferred← citeshttps://doi.org/10.1021/jm4019542openalex-snapshot
Novel Pyrrolidine Diketopiperazines Selectively Inhibit Melanoma Cells via Induction of Late-Onset Apoptosis
inferred← citeshttps://doi.org/10.1021/jm500064topenalex-snapshot
Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)
inferred← citeshttps://doi.org/10.1021/jm501628sopenalex-snapshot
Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens
inferred← citeshttps://doi.org/10.1038/nbt.3587openalex-snapshot
Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice
inferred← citeshttps://doi.org/10.1038/npp.2008.160openalex-snapshot
From rapid In Vitro screening to rapid In Vivo screening in the drug discovery process
inferred← citeshttps://doi.org/10.1039/9781839160721-00175openalex-snapshot
Use of Phenotypic Screening in Mice in the Development of a Novel Non-D2-Receptor-Targeting Drug for the Treatment of Schizophrenia
inferred← citeshttps://doi.org/10.1039/d3md00226hopenalex-snapshot
Restoring susceptibility to aminoglycosides: identifying small molecule inhibitors of enzymatic inactivation
inferred← citeshttps://doi.org/10.1073/pnas.2026668118openalex-snapshot
Identification and characterization of an atypical Gαs-biased β 2 AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis
inferred← citeshttps://doi.org/10.1074/jbc.m112.389114openalex-snapshot
Discovery of Novel Inhibitors of a Disintegrin and Metalloprotease 17 (ADAM17) Using Glycosylated and Non-glycosylated Substrates
inferred← citeshttps://doi.org/10.1080/17460441.2018.1413089openalex-snapshot
Improving the efficacy-safety balance of polypharmacology in multi-target drug discovery
inferred← citeshttps://doi.org/10.1101/561233openalex-snapshot
Mouse Model Systems of Autism Spectrum Disorder: Replicability and Informatics Signature
inferred← citeshttps://doi.org/10.1111/cbdd.12011openalex-snapshot
Molecular Scaffold Analysis of Natural Products Databases in the Public Domain
inferred← citeshttps://doi.org/10.1111/gbb.12405openalex-snapshot
Comprehensive analysis of two Shank3 and the Cacna1c mouse models of autism spectrum disorder
inferred← citeshttps://doi.org/10.1111/gbb.12676openalex-snapshot
Mouse model systems of autism spectrum disorder: Replicability and informatics signature
inferred← citeshttps://doi.org/10.1111/j.1747-0285.2011.01100.xopenalex-snapshot
Increased Diversity of Libraries from Libraries: Chemoinformatic Analysis of Bis‐Diazacyclic Libraries
inferred← citeshttps://doi.org/10.1124/mol.108.051334openalex-snapshot
Synthetic Small-Molecule Prohormone Convertase 2 Inhibitors
inferred← citeshttps://doi.org/10.1124/mol.113.086595openalex-snapshot
Selective Agonists and Antagonists of Formylpeptide Receptors: Duplex Flow Cytometry and Mixture-Based Positional Scanning Libraries
inferred← citeshttps://doi.org/10.1128/aac.00288-16openalex-snapshot
Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents
inferred← citeshttps://doi.org/10.1134/s0006297922140152openalex-snapshot
Malaria Parasite Plasmodium falciparum Proteins on the Surface of Infected Erythrocytes as Targets for Novel Drug Discovery
inferred← citeshttps://doi.org/10.1177/1087057110394181openalex-snapshot
A High-Content Screening (HCS) Assay for the Identification of Chemical Inducers of PML Oncogenic Domains (PODs)
inferred← citeshttps://doi.org/10.1177/1087057115578273openalex-snapshot
Flow Cytometry: Impact on Early Drug Discovery
inferred← citeshttps://doi.org/10.1177/2472555220926146openalex-snapshot
A Robust and Cost-Effective Luminescent-Based High-Throughput Assay for Fructose-1,6-Bisphosphate Aldolase A
inferred← citeshttps://doi.org/10.1186/1472-6750-11-44openalex-snapshot
Estimation of affinities of ligands in mixtures via magnetic recovery of target-ligand complexes and chromatographic analyses: chemometrics and an experimental model
inferred← citeshttps://doi.org/10.1208/s12248-010-9191-3openalex-snapshot
Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library
inferred← citeshttps://doi.org/10.1371/journal.pone.0056957openalex-snapshot
Identification of a Small Molecule That Selectively Inhibits Mouse PC2 over Mouse PC1/3: A Computational and Experimental Study
inferred← citeshttps://doi.org/10.1371/journal.pone.0069964openalex-snapshot
SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition
inferred← citeshttps://doi.org/10.1371/journal.pone.0134572openalex-snapshot
Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder
inferred← citeshttps://doi.org/10.1515/psr-2018-0103openalex-snapshot
Chemical space of naturally occurring compounds
inferred← citeshttps://doi.org/10.1517/17460441.2014.872624openalex-snapshot
Balancing novelty with confined chemical space in modern drug discovery
inferred← citeshttps://doi.org/10.2174/138620711795767866openalex-snapshot
Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug Discovery
inferred← citeshttps://doi.org/10.2174/1386207319666160324123844openalex-snapshot
Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library
inferred← citeshttps://doi.org/10.25148/etd.fidc004005openalex-snapshot
Drug Candidate Discovery: Targeting Bacterial Topoisomerase I Enzymes for Novel Antibiotic Leads
inferred← citeshttps://doi.org/10.25148/etd.fidc010242openalex-snapshot
Type I Topoisomerases As Potential Targets For Therapeutics
inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-60bwlopenalex-snapshot
Rapid Generation of Hyperdiverse Chemical Libraries
inferred← citeshttps://doi.org/10.29356/jmcs.v60i3.100openalex-snapshot
One Drug for Multiple Targets: A Computational Perspective
inferred← citeshttps://doi.org/10.3389/fphar.2014.00164openalex-snapshot
Composition and applications of focus libraries to phenotypic assays
inferred← citeshttps://doi.org/10.3390/ijms22115659openalex-snapshot
Small Molecule Compounds Identified from Mixture-Based Library Inhibit Binding between Plasmodium falciparum Infected Erythrocytes and Endothelial Receptor ICAM-1
inferred← citeshttps://doi.org/10.3390/jpm12030331openalex-snapshot
Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease
inferred← citeshttps://doi.org/10.3390/microorganisms9010086openalex-snapshot
Type IA Topoisomerases as Targets for Infectious Disease Treatments
inferred← citeshttps://doi.org/10.3390/molecules13123149openalex-snapshot
Parallel Synthesis of an Imidazole-4,5-dicarboxamide Library Bearing Amino Acid Esters and Alkanamines
inferred← citeshttps://doi.org/10.3390/molecules18066408openalex-snapshot
The Mathematics of a Successful Deconvolution: A Quantitative Assessment of Mixture-Based Combinatorial Libraries Screened Against Two Formylpeptide Receptors
inferred← citeshttps://doi.org/10.3390/molecules24061100openalex-snapshot
Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries
inferred← citeshttps://doi.org/10.5772/30199openalex-snapshot
Molecular Aspects of Opioid Receptors and Opioid Receptor Painkillers
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