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The Impact of Direct Nucleation Control on Crystal Size Distribution in Pharmaceutical Crystallization Processes
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Choosing an operating policy for seeded batch crystallization
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Robust nonlinear model predictive control of batch processes
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Utilization of Focused Beam Reflectance Measurement in the Control of Crystal Size Distribution in a Batch Cooled Crystallizer
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Fuzzy logic and rigid control of a seeded semi-batch, anti-solvent, isothermal crystallizer
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First-principles and direct design approaches for the control of pharmaceutical crystallization
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Comparative performance of concentration and temperature controlled batch crystallizations
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Chord length characterization using focused beam reflectance measurement probe - methodologies and pitfalls
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QUANTITATIVE INVESTIGATIONS OF AMINO ACIDS AND PEPTIDES
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The Solubility of Amino Acids and Two Glycine Peptides in Aqueous Ethanol and Dioxane Solutions
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Iterative learning control-based batch process control technique for integrated control of end product properties and transient profiles of process variables
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Advanced control of crystallization processes
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Paracetamol Crystallization Using Laser Backscattering and ATR-FTIR Spectroscopy: Metastability, Agglomeration, and Control
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Process Control of Seeded Batch Cooling Crystallization of the Metastable α-Form Glycine Using an In-Situ ATR-FTIR Spectrometer and an In-Situ FBRM Particle Counter
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Model-Based Optimization of Particle Size Distribution in Batch-Cooling Crystallization of Paracetamol
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Direct Design of Pharmaceutical Antisolvent Crystallization through Concentration Control
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Automated In-line Technique Using FBRM to Achieve Consistent Product Quality in Cooling Crystallization
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Adaptive Concentration Control of Cooling and Antisolvent Crystallization with Laser Backscattering Measurement
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An Online Strategy To Increase the Average Crystal Size during Organic Batch Cooling Crystallization
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In-Process ATR-FTIR Spectroscopy for Closed-Loop Supersaturation Control of a Batch Crystallizer Producing Monosodium Glutamate Crystals of Defined Size
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Application of Attenuated Total Reflectance−Fourier Transform Infrared (ATR−FTIR) Technique in the Monitoring and Control of Anti-solvent Crystallization
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Comparison between Open-Loop Temperature Control and Closed-Loop Supersaturation Control for Cooling Crystallization of Glycine
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Determination of the Kinetic Parameters for the Crystallization of Paracetamol from Water Using Metastable Zone Width Experiments
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A Review of the Use of Process Analytical Technology for the Understanding and Optimization of Production Batch Crystallization Processes
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Monitoring and Feedback Control of Supersaturation Using ATR-FTIR to Produce an Active Pharmaceutical Ingredient of a Desired Crystal Size
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Towards a PAT-Based Strategy for Crystallization Development
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Constant Supersaturation Control of Antisolvent-Addition Batch Crystallization
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Industrial crystallization process control
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Characterizing the Metastable Zone Width and Solubility Curve Using Lasentec FBRM and PVM
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Time Resolved Coarsening of Clathrate Crystals: The Case of Gas Hydrates
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Novel Design Integrating a Microwave Applicator into a Crystallizer for Rapid Temperature Cycling. A Direct Nucleation Control Study
inferred← citeshttps://doi.org/10.1021/acs.cgd.7b00837openalex-snapshot
Multi-Objective Path Planning for Single Crystal Size and Shape Modification
inferred← citeshttps://doi.org/10.1021/acs.cgd.7b00860openalex-snapshot
Model-Based Evaluation of Direct Nucleation Control Approaches for the Continuous Cooling Crystallization of Paracetamol in a Mixed Suspension Mixed Product Removal System
inferred← citeshttps://doi.org/10.1021/acs.cgd.7b01619openalex-snapshot
Controlling the Product Crystal Size Distribution by Strategic Application of Ultrasonication
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b00284openalex-snapshot
Ultrasonic Irradiation and Seeding To Prevent Metastable Liquid–Liquid Phase Separation and Intensify Crystallization
inferred← citeshttps://doi.org/10.1021/acs.cgd.8b01361openalex-snapshot
Plasmonic Trapping-Induced Crystallization of Acetaminophen
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b00340openalex-snapshot
Enhancement in Bulk Density of l -Methionine Agglomerates by Cooling Crystallization with pH Control Using Additives
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b00445openalex-snapshot
Feedback Control for the Size and Shape Evolution of Needle-like Crystals in Suspension. IV. Modeling and Control of Dissolution
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b00539openalex-snapshot
Polymorphic Concentration Control for Crystallization Using Raman and Attenuated Total Reflectance Ultraviolet Visible Spectroscopy
inferred← citeshttps://doi.org/10.1021/acs.cgd.9b01325openalex-snapshot
Influences and the Mechanism of Additives on Intensifying Nucleation and Growth of p -Methylacetanilide
inferred← citeshttps://doi.org/10.1021/acs.chemrev.2c00141openalex-snapshot
Applications of Artificial Intelligence and Machine Learning Algorithms to Crystallization
inferred← citeshttps://doi.org/10.1021/acs.iecr.0c03304openalex-snapshot
Overview of Secondary Nucleation: From Fundamentals to Application
inferred← citeshttps://doi.org/10.1021/acs.iecr.0c04923openalex-snapshot
A Selective Dissolution Process Featuring a Classification Device for the Removal of Fines in Crystallization
inferred← citeshttps://doi.org/10.1021/acs.iecr.0c04958openalex-snapshot
Experimental and Molecular Dynamics Simulation Study on the Primary Nucleation of Penicillamine Racemate and Its Enantiomers in the Mixture Solvent of Water and Ethanol
inferred← citeshttps://doi.org/10.1021/acs.iecr.1c01947openalex-snapshot
Computationally Efficient Algorithm for Solving Population Balances with Size-Dependent Growth, Nucleation, and Growth-Dissolution Cycles
inferred← citeshttps://doi.org/10.1021/acs.iecr.2c04648openalex-snapshot
Direct Crystal Growth Control: Controlling Crystallization Processes by Tracking an Analogue Twin
inferred← citeshttps://doi.org/10.1021/acs.iecr.3c00286openalex-snapshot
Optimal Control of Batch Crystallization Processes with Primary Nucleation
inferred← citeshttps://doi.org/10.1021/acs.iecr.4c02153openalex-snapshot
Residence Time Distribution Characterization and Proof-of-Concept of a Novel Stacked 7-Stage Continuous Crystallizer Cascade with Diaphragm-Driven Slurry Transfer
inferred← citeshttps://doi.org/10.1021/acs.iecr.4c04048openalex-snapshot
Real-Time Optimization and Genetic Algorithm for Enhanced Process Control of Coupling Cooling and Antisolvent Crystallization
inferred← citeshttps://doi.org/10.1021/acs.iecr.5b03024openalex-snapshot
Parametric, Optimization-Based Study on the Feasibility of a Multisegment Antisolvent Crystallizer for in Situ Fines Removal and Matching of Target Size Distribution
inferred← citeshttps://doi.org/10.1021/acs.iecr.5b03635openalex-snapshot
Data-Driven Modeling and Dynamic Programming Applied to Batch Cooling Crystallization
inferred← citeshttps://doi.org/10.1021/acs.iecr.5b04155openalex-snapshot
Antisolvent Crystallization of Erythromycin Ethylsuccinate in the Presence of Liquid–Liquid Phase Separation
inferred← citeshttps://doi.org/10.1021/acs.iecr.5c00456openalex-snapshot
Autonomous Control of the Crystal Size and Shape in Dense Suspensions via Imaging
inferred← citeshttps://doi.org/10.1021/acs.iecr.5c00957openalex-snapshot
Suppression of Secondary Nucleation via Crystal Fluidization in a Modified DTB Crystallizer: Preparation of Large Crystals with Narrow Crystal Size Distribution
inferred← citeshttps://doi.org/10.1021/acs.iecr.5c01241openalex-snapshot
Loose Bulk Density and Length-to-Diameter Ratio of Flexible Needle-like Crystals Crown via Antisolvent Crystallization
inferred← citeshttps://doi.org/10.1021/acs.iecr.5c04695openalex-snapshot
A Machine Learning Approach to Evaluate Impedance Spectra for Glycine Crystallization Monitoring
inferred← citeshttps://doi.org/10.1021/acs.iecr.6b04914openalex-snapshot
Modeling of Nucleation and Growth Kinetics for Unseeded Batch Cooling Crystallization
inferred← citeshttps://doi.org/10.1021/acs.iecr.6c00599openalex-snapshot
Modeling Batch Crystallization under Uncertainty Using Physics-Informed Machine Learning
inferred← citeshttps://doi.org/10.1021/acs.iecr.7b03964openalex-snapshot
Chord Length Distribution Based Modeling and Adaptive Model Predictive Control of Batch Crystallization Processes Using High Fidelity Full Population Balance Models
inferred← citeshttps://doi.org/10.1021/acs.iecr.9b04023openalex-snapshot
Quality by Statistical Control in Crystallization—Assessment of Mixing Conditions and Probability of Obtaining the Desired Particle Size
inferred← citeshttps://doi.org/10.1021/acs.jced.9b00753openalex-snapshot
Potassium Nitrate Solubility in (Water + Ethanol) Mixed Solvents at Different Temperatures and Hydrochloric Acid Concentrations. Experimental Study and Modeling Using the Extended UNIQUAC Model
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6b12590openalex-snapshot
Heterogeneous Nucleation of an n-Alkane on Tetrahedrally Coordinated Crystals
inferred← citeshttps://doi.org/10.1021/acs.oprd.0c00307openalex-snapshot
Effective Control of Crystal Size via an Integrated Crystallization, Wet Milling, and Annealing Recirculation System
inferred← citeshttps://doi.org/10.1021/acs.oprd.0c00398openalex-snapshot
Continuous Crystallization Processes in Pharmaceutical Manufacturing: A Review
inferred← citeshttps://doi.org/10.1021/acs.oprd.2c00043openalex-snapshot
Strategy for Non-Seeded Crystallization of Slow-to-Crystallize Compounds with an Oscillatory Dynamic Baffled Crystallizer: A Case Study with α-Lactose Monohydrate
inferred← citeshttps://doi.org/10.1021/acs.oprd.3c00505openalex-snapshot
ANFIS-Driven Machine Learning Automated Platform for Cooling Crystallization Process Development
inferred← citeshttps://doi.org/10.1021/acs.oprd.4c00182openalex-snapshot
Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization
inferred← citeshttps://doi.org/10.1021/acs.oprd.4c00201openalex-snapshot
PAT Aided Feasibility Study on Continuous Crystallization of Benzotriazole
inferred← citeshttps://doi.org/10.1021/acs.oprd.4c00390openalex-snapshot
Use of Population Balance Modelling to Derisk Scale-Up of an Integrated Crystallization–Wet Milling Process
inferred← citeshttps://doi.org/10.1021/acs.oprd.5b00373openalex-snapshot
Monitoring Continuous Crystallization of Paracetamol in the Presence of an Additive Using an Integrated PAT Array and Multivariate Methods
inferred← citeshttps://doi.org/10.1021/acs.oprd.5c00402openalex-snapshot
Automatic Design of Wet-Milling-Integrated Batch Crystallization Processes by Process Analytical Technology-Based Split-Range Direct Nucleation Control
inferred← citeshttps://doi.org/10.1021/acs.oprd.6b00242openalex-snapshot
Real-Time Image Processing Based Online Feedback Control System for Cooling Batch Crystallization
inferred← citeshttps://doi.org/10.1021/acs.oprd.6b00380openalex-snapshot
Heterogeneous Crystallization Inside Microporous Polymer Particles as a Process Intensification Technology for the Manufacture of Drug Formulations
inferred← citeshttps://doi.org/10.1021/acs.oprd.6c00057openalex-snapshot
Automation in Pharmaceutical Crystallization
inferred← citeshttps://doi.org/10.1021/acs.oprd.7b00087openalex-snapshot
Process Analytical Tools To Control Polymorphism and Particle Size in Batch Crystallization Processes
inferred← citeshttps://doi.org/10.1021/acs.oprd.8b00078openalex-snapshot
Cooling Crystallization of Indomethacin: Effect of Supersaturation, Temperature, and Seeding on Polymorphism and Crystal Size Distribution
inferred← citeshttps://doi.org/10.1021/acs.oprd.9b00052openalex-snapshot
Antisolvent Crystallization of Indomethacin from a Ternary Solvent System with High Productivity, Better Polymorphism, and Particle Size Control
inferred← citeshttps://doi.org/10.1021/acs.oprd.9b00348openalex-snapshot
Population Balance Modeling To Predict Particle Size Distribution upon Scale-Up of a Combined Antisolvent and Cooling Crystallization of an Active Pharmaceutical Ingredient
inferred← citeshttps://doi.org/10.1021/acs.oprd.9b00362openalex-snapshot
Recent Progress in Continuous Crystallization of Pharmaceutical Products: Precise Preparation and Control
inferred← citeshttps://doi.org/10.1021/acsomega.2c01596openalex-snapshot
Direct Crystallization Resolution of Racemates Enhanced by Chiral Nanorods: Experimental, Statistical, and Quantum Mechanics/Molecular Dynamics Simulation Studies
inferred← citeshttps://doi.org/10.1021/cg1002379openalex-snapshot
Investigation of the Effect of Temperature Cycling on Surface Features of Sulfathiazole Crystals during Seeded Batch Cooling Crystallization
inferred← citeshttps://doi.org/10.1021/cg100305wopenalex-snapshot
Evaluation of the Effect of Seed Preparation Method on the Product Crystal Size Distribution for Batch Cooling Crystallization Processes
inferred← citeshttps://doi.org/10.1021/cg100533nopenalex-snapshot
Implementation of Focused Beam Reflectance Measurement (FBRM) in Antisolvent Crystallization to Achieve Consistent Product Quality
inferred← citeshttps://doi.org/10.1021/cg101555uopenalex-snapshot
Internal Fines Removal Using Population Balance Model Based Control of Crystal Size Distribution under Dissolution, Growth and Nucleation Mechanisms
inferred← citeshttps://doi.org/10.1021/cg201269copenalex-snapshot
Comparative Investigation of Supersaturation and Automated Direct Nucleation Control of Crystal Size Distributions using ATR-UV/vis Spectroscopy and FBRM
inferred← citeshttps://doi.org/10.1021/cg3008574openalex-snapshot
Crystallization of Glycine by Drowning-Out Combined with Fines Dissolution and Cooling Process with in Situ Control using Focused Beam Reflectance Measurement and Attenuated Total Reflection–Fourier Transform Infrared Spectroscopy
inferred← citeshttps://doi.org/10.1021/cg301673gopenalex-snapshot
Novel, Calibration-Free Strategies for Supersaturation Control in Antisolvent Crystallization Processes
inferred← citeshttps://doi.org/10.1021/cg501368yopenalex-snapshot
Feedback Control of Multicomponent Salt Crystallization
inferred← citeshttps://doi.org/10.1021/cg501637mopenalex-snapshot
Crystal Size Control in a Continuous Tubular Crystallizer
inferred← citeshttps://doi.org/10.1021/cg501823wopenalex-snapshot
Control of Heterogeneous Nucleation via Rationally Designed Biocompatible Polymer Surfaces with Nanoscale Features
inferred← citeshttps://doi.org/10.1021/cg900108eopenalex-snapshot
A Process Analytical Technology Based Investigation of the Polymorphic Transformations during the Antisolvent Crystallization of Sodium Benzoate from IPA/Water Mixture
inferred← citeshttps://doi.org/10.1021/ie1010299openalex-snapshot
Stochastic Approach for the Prediction of PSD in Crystallization Processes: Formulation and Comparative Assessment of Different Stochastic Models
inferred← citeshttps://doi.org/10.1021/ie201314ropenalex-snapshot
Evaporation Crystallization of RDX by Ultrasonic Spray
inferred← citeshttps://doi.org/10.1021/ie202562uopenalex-snapshot
Crystallization of RDX by Drowning-Out Combined with Fines Dissolution and Cooling Process
inferred← citeshttps://doi.org/10.1021/ie301557bopenalex-snapshot
Evidence of Hydrogen-Bond Formation during Crystallization of Cefodizime Sodium from Induction-Time Measurements and In Situ Raman Spectroscopy
inferred← citeshttps://doi.org/10.1021/ie301610zopenalex-snapshot
Experimental Evaluation of the Targeted Direct Design of Temperature Trajectories for Growth-Dominated Crystallization Processes Using an Analytical Crystal Size Distribution Estimator
inferred← citeshttps://doi.org/10.1021/ie301626copenalex-snapshot
Operating Strategy to Produce Consistent CSD in Combined Antisolvent-Cooling Crystallization Using FBRM
inferred← citeshttps://doi.org/10.1021/ie404073popenalex-snapshot
Investigation of the Crystallization of Disodium 5′-Inosinate in a Water + Ethanol System: Solubility, Nucleation Mechanism, and Crystal Morphology
inferred← citeshttps://doi.org/10.1021/ie501800jopenalex-snapshot
Dynamic Modeling and Optimization of Batch Crystallization of Sugar Cane under Uncertainty
inferred← citeshttps://doi.org/10.1021/ie5034254openalex-snapshot
Combined Cooling and Antisolvent Crystallization in Continuous Mixed Suspension, Mixed Product Removal Cascade Crystallizers: Steady-State and Startup Optimization
inferred← citeshttps://doi.org/10.1021/ie900430topenalex-snapshot
Combined Quadrature Method of Moments and Method of Characteristics Approach for Efficient Solution of Population Balance Models for Dynamic Modeling and Crystal Size Distribution Control of Crystallization Processes
inferred← citeshttps://doi.org/10.1021/je3011997openalex-snapshot
Antisolvent Crystallization of Biapenem: Estimation of Growth and Nucleation Kinetics
inferred← citeshttps://doi.org/10.1021/je400714fopenalex-snapshot
Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents
inferred← citeshttps://doi.org/10.1021/op100334yopenalex-snapshot
Application of Internal Seeding and Temperature Cycling for Reduction of Liquid Inclusion in the Crystallization of RDX
inferred← citeshttps://doi.org/10.1021/op300062topenalex-snapshot
Implementation of Raman Signal Feedback to Perform Controlled Crystallization of Carvedilol
inferred← citeshttps://doi.org/10.1021/op500261yopenalex-snapshot
Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review
inferred← citeshttps://doi.org/10.1021/op800309fopenalex-snapshot
Combined PAT-Solid State Analytical Approach for the Detection and Study of Sodium Benzoate Hydrate
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