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The Most Common Chemical Replacements in Drug-Like Compounds

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The [(methyloxy)imino]methyl moiety (MOIMM) in the design of a new type of β-adrenergic blocking agent
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The Practice of Medicinal Chemistry

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Molecular similarity: a key technique in molecular informatics
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A matched molecular pair analysis of in vitro human microsomal metabolic stability measurements for methylene substitution or replacements – identification of those transforms more likely to have beneficial effects
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Matched molecular pairs derived by retrosynthetic fragmentation
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Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes
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SCRIPDB: a portal for easy access to syntheses, chemicals and reactions in patents
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Bioisosterism reveals new structure-odor relationships
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Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes
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Activity of an Antimicrobial Peptide Mimetic against Planktonic and Biofilm Cultures of Oral Pathogens
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Discovery and Preclinical Development of Antigiardiasis Fumagillol Derivatives
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Medical chemistry for brain function correction
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The Adjacency Matrix and Related Matrices
inferred← citeshttps://doi.org/10.1360/zb2007-37-3-288openalex-snapshot
基于药物数据报道数据库的虚拟组合片段库构建
inferred← citeshttps://doi.org/10.1371/journal.pone.0116570openalex-snapshot
UFSRAT: Ultra-Fast Shape Recognition with Atom Types –The Discovery of Novel Bioactive Small Molecular Scaffolds for FKBP12 and 11βHSD1
inferred← citeshttps://doi.org/10.1517/17460441.2.5.707openalex-snapshot
Enhanced hit-to-lead process using bioanalogous lead evolution and chemogenomics: application in designing selective matrix metalloprotease inhibitors
inferred← citeshttps://doi.org/10.1517/17460441.2012.712513openalex-snapshot
The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors
inferred← citeshttps://doi.org/10.2174/0115701786287193240215101054openalex-snapshot
Apigenin Bioisosteres: Synthesis and Evaluation of their Antioxidant, Antimicrobial, and Anticancer Activities
inferred← citeshttps://doi.org/10.2174/1573406418666220127124228openalex-snapshot
Bioisosterism in Drug Discovery and Development - An Overview
inferred← citeshttps://doi.org/10.2751/jcac.16.15openalex-snapshot
A Mini-review on Chemoinformatics Approaches for Drug Discovery
inferred← citeshttps://doi.org/10.3390/molecules27175647openalex-snapshot
Scalable (Enantioselective) Syntheses of Novel 3-Methylated Analogs of Pazinaclone, (S)-PD172938 and Related Biologically Relevant Isoindolinones
inferred← citeshttps://doi.org/10.3390/molecules29030689openalex-snapshot
Medicinal Chemistry Strategies for the Modification of Bioactive Natural Products
inferred← citeshttps://doi.org/10.4155/fmc.10.277openalex-snapshot
Computational Medicinal Chemistry in Fragment-Based Drug Discovery: What, How and When
inferred← citeshttps://doi.org/10.4155/fmc.10.293openalex-snapshot
Large-Scale Exploration of Bioisosteric Replacements on the Basis of Matched Molecular Pairs
inferred← citeshttps://doi.org/10.70675/2b63c353z8184z4bbbzbfbcz9ce124edd263openalex-snapshot
New methods of multiscale chemical space analysis : visualization of structure-activity relationships and structural pattern extraction
inferred← citeshttps://doi.org/10.70675/de51bc89z33fez456fz9467z959329cc603bopenalex-snapshot
Optimisation de méthodes de criblage virtuel et synthèse de molécules à visée thérapeutique pour le traitement des maladies auto-immunes.
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