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EMBM − A New Enzyme Mechanism-Based Method for Rational Design of Chemical Sites of Covalent Inhibitors

https://doi.org/10.1021/ci100330y
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Enzyme Isoselective Inhibitors: A Tool for Binding‐Trend Analysis
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Enzyme Isoselective Inhibitors: Application to Drug Design
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Anionic Tetrahedral Complexes as Serine Protease Inhibitors
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inferredcites →https://doi.org/10.1016/j.sbi.2005.10.017openalex-snapshot
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Analysis of Conformational Coverage. 1. Validation and Estimation of Coverage
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Analysis of Conformational Coverage. 2. Applications of Conformational Models
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Electrostatic Basis for Enzyme Catalysis
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Comparison of carboxypeptidase A and thermolysin: inhibition by phosphonamidates
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Peptidyl .alpha.-ketoheterocyclic inhibitors of human neutrophil elastase. 2. Effect of varying the heterocyclic ring on in vitro potency
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Discovery and Development of Fatty Acid Amide Hydrolase (FAAH) Inhibitors
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Design, Synthesis, and Evaluation of Nonpeptidic Inhibitors of Human Rhinovirus 3C Protease
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Transition State Analogues for Enzyme Catalysis
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/ijch.201300144openalex-snapshot
From Catalytic Mechanism to Rational Design of Reversible Covalent Inhibitors of Serine and Cysteine Hydrolases
inferred← citeshttps://doi.org/10.1002/minf.201300099openalex-snapshot
Application of EMBM to Structure‐Based Design of Warheads for Protease Inhibitors
inferred← citeshttps://doi.org/10.1007/978-3-031-51552-1_3openalex-snapshot
Methods of Enzyme Kinetics
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11519-3openalex-snapshot
Modeling Covalent Protein-Ligand Interactions
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.02.059openalex-snapshot
A new method for filtering of reactive “warheads” of transition-state analog protease inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jcim.1c01278openalex-snapshot
Mechanism-Based and Computational-Driven Covalent Drug Design
inferred← citeshttps://doi.org/10.1021/jp409604nopenalex-snapshot
Quantum Mechanics-Based Scoring Rationalizes the Irreversible Inactivation of ParasiticSchistosoma mansoniCysteine Peptidase by Vinyl Sulfone Inhibitors
inferred← citeshttps://doi.org/10.1038/s42004-025-01606-yopenalex-snapshot
Structure-based rational design of covalent probes
inferred← citeshttps://doi.org/10.1101/2025.08.20.671340openalex-snapshot
Tunable nucleofugality in carbamoyl-bearing covalent cholinesterase inhibitors
inferred← citeshttps://doi.org/10.1186/1471-2105-15-150openalex-snapshot
From sequence to enzyme mechanism using multi-label machine learning
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