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Predicting Myelosuppression of Drugs from in Silico Models
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Assessment of QT liabilities in drug development
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The induction of clones of normal mast cells by a substance from conditioned medium
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Principal component analysis
inferredcites →https://doi.org/10.1016/j.chemolab.2004.12.011openalex-snapshot
Performance of some variable selection methods when multicollinearity is present
inferredcites →https://doi.org/10.1016/s0166-1280(99)00360-7openalex-snapshot
Molecular fields in quantitative structure–permeation relationships: the VolSurf approach
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Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay
inferredcites →https://doi.org/10.1016/s1093-3263(00)00066-8openalex-snapshot
Chemical information management in drug discovery: optimizing the computational and combinatorial chemistry interfaces
inferredcites →https://doi.org/10.1021/cc0000388openalex-snapshot
Chemography: The Art of Navigating in Chemical Space
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Pharmacokinetically Based Mapping Device for Chemical Space Navigation
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Electrotopological State Indices for Atom Types: A Novel Combination of Electronic, Topological, and Valence State Information
inferredcites →https://doi.org/10.1021/ci800037topenalex-snapshot
Development and Validation of AMANDA, a New Algorithm for Selecting Highly Relevant Regions in Molecular Interaction Fields
inferredcites →https://doi.org/10.1021/jm000941mopenalex-snapshot
GRid-INdependent Descriptors (GRIND): A Novel Class of Alignment-Independent Three-Dimensional Molecular Descriptors
inferredcites →https://doi.org/10.1021/jm0311240openalex-snapshot
Incorporating Molecular Shape into the Alignment-free GRid-INdependent Descriptors
inferredcites →https://doi.org/10.1023/a:1008245906772openalex-snapshot
Predicting hematological toxicity (myelosuppression) of cytotoxic drug therapy from in vitro tests
inferredcites →https://doi.org/10.1038/icb.1966.28openalex-snapshot
THE GROWTH OF MOUSE BONE MARROW CELLS IN VITRO
inferredcites →https://doi.org/10.1093/mutage/geh043openalex-snapshot
Three new consensus QSAR models for the prediction of Ames genotoxicity
inferredcites →https://doi.org/10.1093/toxsci/kfg188openalex-snapshot
Application of the CFU-GM Assay to Predict Acute Drug-Induced Neutropenia: An International Blind Trial to Validate a Prediction Model for the Maximum Tolerated Dose (MTD) of Myelosuppressive Xenobiotics
inferredcites →https://doi.org/10.1093/toxsci/kfi250openalex-snapshot
Validation and Development of a Predictive Paradigm for Hemotoxicology Using a Multifunctional Bioluminescence Colony-Forming Proliferation Assay
inferredcites →https://doi.org/10.1111/j.2042-7166.2002.tb05480.xopenalex-snapshot
Goodman and Gilman's the Pharmacological Basis of Therapeutics
inferredcites →https://doi.org/10.1177/019262339302100217openalex-snapshot
Roles for In Vitro Myelotoxicity Tests in Preclinical Drug Development and Clinical Trial Planning
inferredcites →https://doi.org/10.1289/ehp.98106541openalex-snapshot
Alternative Testing Systems for Evaluating Noncarcinogenic, Hematologic Toxicity
inferredcites →https://doi.org/10.1517/17425255.3.2.295openalex-snapshot
High-throughputin vitrohemotoxicity testing andin vitrocross-platform comparative toxicity
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Nonclinical Evaluation of Compound‐Related Cytopenias
inferred← citeshttps://doi.org/10.1002/wcms.70065openalex-snapshot
Toward Integrative Predictive Toxicology: Advanced Methods for Drug Toxicity and Safety Prediction
inferred← citeshttps://doi.org/10.1007/978-1-0716-1960-5_12openalex-snapshot
In Silico Models for Predicting Acute Systemic Toxicity
inferred← citeshttps://doi.org/10.1007/978-1-4939-3609-0_10openalex-snapshot
In Silico Models for Acute Systemic Toxicity
inferred← citeshttps://doi.org/10.1007/s11030-015-9613-3openalex-snapshot
In silico prediction of drug-induced myelotoxicity by using Naïve Bayes method
inferred← citeshttps://doi.org/10.1007/s11030-021-10255-xopenalex-snapshot
In silico prediction of chemical-induced hematotoxicity with machine learning and deep learning methods
inferred← citeshttps://doi.org/10.1016/j.jpba.2012.02.019openalex-snapshot
Evidence for the genotoxic effect of daunomycin in multipotent hematopoietic cells of mouse bone marrow: Chromatin proteins analysis
inferred← citeshttps://doi.org/10.1016/j.tiv.2013.11.002openalex-snapshot
Exploring QSTR modeling and toxicophore mapping for identification of important molecular features contributing to the chemical toxicity in Escherichia coli
inferred← citeshttps://doi.org/10.1021/acs.jcim.2c01088openalex-snapshot
Structural Analysis and Prediction of Hematotoxicity Using Deep Learning Approaches
inferred← citeshttps://doi.org/10.1021/acs.jcim.9b00629openalex-snapshot
MuLiMs-MCoMPAs: A Novel Multiplatform Framework to Compute Tensor Algebra-Based Three-Dimensional Protein Descriptors
inferred← citeshttps://doi.org/10.1038/s41598-024-77768-xopenalex-snapshot
A nomogram incorporating linezolid and metabolite concentrations for predicting linezolid induced thrombocytopenia in patients with renal impairment
inferred← citeshttps://doi.org/10.1080/17460441.2021.1931114openalex-snapshot
Modeling approaches for reducing safety-related attrition in drug discovery and development: a review on myelotoxicity, immunotoxicity, cardiovascular toxicity, and liver toxicity
inferred← citeshttps://doi.org/10.1093/jac/dkad191openalex-snapshot
Establishment and validation of a risk prediction model incorporating concentrations of linezolid and its metabolite PNU142300 for linezolid-induced thrombocytopenia
inferred← citeshttps://doi.org/10.1128/aac.00027-20openalex-snapshot
Accumulation of Major Linezolid Metabolites in Patients with Renal Impairment
inferred← citeshttps://doi.org/10.11606/t.9.2012.tde-13032013-100451openalex-snapshot
Estudos de síntese de fármacos dirigidos formadores de micelas de hidroximetilnitrofural e helenalina potencialmente antichagásicos e leishmanicidas
inferred← citeshttps://doi.org/10.3389/fphar.2022.844567openalex-snapshot
Dosage Strategy of Linezolid According to the Trough Concentration Target and Renal Function in Chinese Critically Ill Patients
inferred← citeshttps://doi.org/10.3390/ijerph9072479openalex-snapshot
Using Bioinformatic Approaches to Identify Pathways Targeted by Human Leukemogens
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